:00:11. > :00:13.David Cameron continues his frantic diplomacy, today in Brussels trying
:00:14. > :00:17.Just two days to go before the crucial summit and he's told
:00:18. > :00:20.there are still tough negotiations ahead.
:00:21. > :00:22.But back home, a speech by Prince William is interpreted
:00:23. > :00:26.by some as support to keep the UK within the EU.
:00:27. > :00:31.In an increasingly turbulent world, our ability to unite in common
:00:32. > :00:35.action with other nations is essential.
:00:36. > :00:37.The palace though says Prince William's comments were not
:00:38. > :00:43.Also tonight: A new cancer treatment that's showing unprecedented success
:00:44. > :00:47.in trials - appearing to make the cancer vanish.
:00:48. > :00:51.Growing international pressure on Russia as Moscow is forced
:00:52. > :00:57.to deny again it bombed hospitals in Syria.
:00:58. > :01:02.I'll be explaining how scientific understanding of mental health
:01:03. > :01:05.illness is being advanced by these - miniature human brains being grown
:01:06. > :01:13.And the joke's on George Clooney in the Coen Brothers' latest film -
:01:14. > :01:24.Later on BBC London: A man goes on trial accused of planning
:01:25. > :01:27.to attack British or American military personnel in the UK.
:01:28. > :01:30.And captured on camera - can Nasa technology help cut
:01:31. > :01:54.David Cameron has completed a day of frantic diplomacy in Brussels
:01:55. > :01:57.trying to muster support for his EU reform proposals before the meeting
:01:58. > :02:01.on Thursday at which he hopes European leaders will approve them.
:02:02. > :02:03.Here a speech given by Prince William at the Foreign Office
:02:04. > :02:06.has been interpreted by campaigners as a signal
:02:07. > :02:10.he supports their call to keep Britain in the EU.
:02:11. > :02:13.Kensington Palace deny he was doing any such thing.
:02:14. > :02:16.Our political editor Laura Kuenssberg reports
:02:17. > :02:18.on the Prime Minister's efforts in Brussels - and those
:02:19. > :02:24.The Foreign Office is as grand as a palace, so Prince William might
:02:25. > :02:31.Kensington Palace denies it, but just as the Government
:02:32. > :02:37.prepares its fight to stay in the EU, was the Duke taking sides?
:02:38. > :02:40.In an increasingly turbulent world, our ability to unite in common
:02:41. > :02:44.action with other nations is essential.
:02:45. > :02:49.Right now, the big questions with which you wrestle,
:02:50. > :02:52.in the UN, Nato, the Middle East and elsewhere are predicated
:02:53. > :02:56.on your commitment to working in partnership with others.
:02:57. > :03:02.Whatever William meant, for the Prime Minister "technical
:03:03. > :03:07.He'll most likely get other leaders to agree to a new relationship,
:03:08. > :03:10.but after that and after you've voted in a referendum,
:03:11. > :03:14.probably in June, the European Parliament gets its say.
:03:15. > :03:17.Its leader made plain that MEPs could block Britain's changes.
:03:18. > :03:21.No government can go to a parliament and say -
:03:22. > :03:23.this is our proposal, can you give a guarantee
:03:24. > :03:30.But the main groups in Brussels do believe
:03:31. > :03:38.For those who want to leave the EU, the threat of wrecking the deal
:03:39. > :03:42.If we vote to remain and then we find the European Parliament have
:03:43. > :03:45.scuppered it, well then actually the British people have been sold
:03:46. > :03:48.And if it feels like the Prime Minister is making
:03:49. > :03:51.a last-minute dash, that's because he is,
:03:52. > :03:53.still trying to secure support to cut child benefit for EU
:03:54. > :03:57.migrants, to delay paying tax credit to EU workers, too.
:03:58. > :04:01.Persuading Europe's power players the UK is entitled
:04:02. > :04:08.But for all the nerves at home, the expectation is the deal
:04:09. > :04:13.For weeks there's not been talk of much else in this place.
:04:14. > :04:16.The backwards and forwards between Westminster and Brussels has
:04:17. > :04:20.dominated what the Government's been doing, but before long this decision
:04:21. > :04:26.comes to all of us and it's coming soon to a town near you.
:04:27. > :04:30.We hope for better world, for a better country for ourselves.
:04:31. > :04:34.On winter nights, in pub back rooms, campaigners are starting to gather.
:04:35. > :04:36.In Surrey, for some like the Woodhouses',
:04:37. > :04:40.leaving the EU is about controlling who lives here.
:04:41. > :04:43.Now, if I had to take up arms at my age, at 72,
:04:44. > :04:46.to protect my country, I would do it and give my life for it.
:04:47. > :04:49.And, for you, this choice is as serious as that?
:04:50. > :04:59.We want doctors, we want nurses, we want people with skills.
:05:00. > :05:02.We need them, there's no doubt about that, but we don't
:05:03. > :05:08.I'm going to be taking time off work and I'm going to be campaigning
:05:09. > :05:10.night and day because this is a unique opportunity.
:05:11. > :05:13.A very different crowd in East London, for staying in,
:05:14. > :05:19.What is it that makes you care enough to come here on a week
:05:20. > :05:22.day night, after work, on a cold winter's evening?
:05:23. > :05:24.I think it's hard to be, sort of, passionate
:05:25. > :05:28.about being pro-European, but I think that it's something that
:05:29. > :05:33.I think we could easily sleepwalk out of the EU.
:05:34. > :05:35.It is really important, it's also part of my identity.
:05:36. > :05:43.I think people like us, who are trade unionists,
:05:44. > :05:46.need to make sure that we engage in the debate because otherwise it's
:05:47. > :05:49.going to be pro-business Tories fighting little England
:05:50. > :05:57.As the big day in Brussels approaches, the campaigns
:05:58. > :06:02.If the deal's done, you'll vote within months to stay or leave
:06:03. > :06:12.Let's speak to our Europe Editor Katya Adler in Brussels.
:06:13. > :06:19.David Cameron yet again doing the rounds, this time where you are in
:06:20. > :06:25.Brussels, does it look like he will succeed? Well, Fiona, here in EU
:06:26. > :06:29.headquarters, it is very rarely described as a hotbed of excitement
:06:30. > :06:34.and drama, but there is a real air of tension tonight. To be or not to
:06:35. > :06:38.be, tweeted the European Council president when he published David
:06:39. > :06:43.Cameron's draft reform proposals a couple of weeks ago, and that is the
:06:44. > :06:55.burning question now. Can the Prime Minister get his reforms passed
:06:56. > :06:58.when the countries of Central and Eastern Europe are still wrangling
:06:59. > :07:01.over the details of cutting EU migrant benefits, and France is
:07:02. > :07:03.growling in the face of safeguards for eurozone legislation. Every
:07:04. > :07:06.single country has to sign up for this deal and that means every
:07:07. > :07:12.single EU leader has the potential to scupper it. That said, after
:07:13. > :07:20.hours of the gauche Asians probably a fudge will be merged. France will
:07:21. > :07:25.probably crowed that it stopped Britain getting a veto over eurozone
:07:26. > :07:29.legislation, even though David Cameron never actually asked for
:07:30. > :07:34.one. He knows whatever the deal he gets here in Brussels, it will be
:07:35. > :07:39.dismissed by the critics at home. If he does get a deal this week, it
:07:40. > :07:48.will enable him to call a referendum as early as June. His strategy will
:07:49. > :07:49.be if he can claim to tackle the issue of migration, he can win over
:07:50. > :07:53.the voters he needs. Thank you. Scientists in America believe
:07:54. > :07:55.they may have found a potentially They've managed to retrain cells
:07:56. > :07:59.in the body's own immune system In a trial, more than 90%
:08:00. > :08:03.of terminally-ill patients with blood cancers went
:08:04. > :08:05.into complete remission. This is the body's natural
:08:06. > :08:10.defence mechanism at work, an immune cell attacking
:08:11. > :08:14.and neutrualising a cancer cell, but when that doesn't function
:08:15. > :08:19.properly intervention's needed. This new study shows that specially
:08:20. > :08:21.engineered immune cells, injected back into the patient,
:08:22. > :08:27.can suppress a type of blood cancer. The study was published
:08:28. > :08:30.in the United States and British researchers, working in this field,
:08:31. > :08:32.say it offers exciting potential We know the immune system
:08:33. > :08:37.is incredibly powerful, we know we can harness cells
:08:38. > :08:40.from the immune system, engineer them and give
:08:41. > :08:42.them back to patients. These effects are not just for a few
:08:43. > :08:45.weeks or a couple of months, they're long-lasting
:08:46. > :08:47.effects over many months So we think the enormous power
:08:48. > :08:53.of the immune system in these kind of settings is there to be
:08:54. > :08:57.harnessed, actually. This is how the new therapy worked,
:08:58. > :09:00.a blood sample was taken from the patient and immune cells
:09:01. > :09:05.were separated out and removed. Each one was modified
:09:06. > :09:09.and transformed into a targeted immune cell to seek out
:09:10. > :09:13.and destroy cancer cells. The cells were then grown
:09:14. > :09:18.in a laboratory and stored. Later they were returned
:09:19. > :09:20.to the patient's bloodstream where they were ready to detect
:09:21. > :09:25.and then attack the cancer cells. The patients helped by the therapy
:09:26. > :09:28.had all undergone other forms of treatment which had failed,
:09:29. > :09:31.including chemotherapy and radiotherapy, but cancer experts
:09:32. > :09:35.say more extensive trials These results are quite exciting,
:09:36. > :09:40.but it's important to know this These still early steps
:09:41. > :09:46.towards making this treatment George knows all about the struggle
:09:47. > :09:51.with leukaemia, a type He was diagnosed in 2005,
:09:52. > :09:57.was treated and got better. The cancer returned
:09:58. > :09:59.and he had another successful The latest trial won't necessarily
:10:00. > :10:05.help him, but he says its success is heartening for everyone
:10:06. > :10:07.with the cancer. Any kind of research that might lead
:10:08. > :10:12.to another option for people with cancers is
:10:13. > :10:18.definitely good news. I try not to get too
:10:19. > :10:23.excited about it because, as with all these trials,
:10:24. > :10:27.it's in the early stages. There's some caution as only a small
:10:28. > :10:31.number of patients were involved, but there's agreement that this
:10:32. > :10:34.study is an important development International pressure is mounting
:10:35. > :10:44.on Russia after claims that it has The Turkish foreign ministry blames
:10:45. > :10:48.Russia for missile attacks on several hospitals and schools
:10:49. > :10:51.in Syria yesterday In another development,
:10:52. > :10:57.the United Nations says Syria has agreed to let convoys take aid
:10:58. > :11:00.to people trapped in Here's our diplomatic
:11:01. > :11:18.correspondent Bridget Kendall. What looks like a Russian fighter
:11:19. > :11:26.jet in the skies over northern Syria and then this. Suspected cluster
:11:27. > :11:34.bombs. Imagine being in one of those buildings, north of the city of
:11:35. > :11:39.Aleppo yesterday. And this is the sort of damage being caused,
:11:40. > :11:43.according to footage supplied by Syrian opposition activists. These
:11:44. > :11:49.strikes are being widely blamed on Syrian and Russian forces. And after
:11:50. > :11:54.yesterday's direct hits on hospital Sunday school where they are still
:11:55. > :11:57.looking for victims, the chorus of outrage is growing. Tonight,
:11:58. > :12:04.Britain's Defence Secretary added his voice, to those who say it could
:12:05. > :12:10.amount to a war crime. If these reports are true, then these amount
:12:11. > :12:13.to war crimes. These are crimes against the civilian population, a
:12:14. > :12:17.breach of the law of armed conflict, in breach of all international
:12:18. > :12:23.humanitarian law. Russia needs to be held to account for what it is now
:12:24. > :12:30.doing, bombing innocent civilians, it is an abomination. The Syrian
:12:31. > :12:33.army with its Russian and Iranian battlers insist their advance into
:12:34. > :12:40.northern Syria is to liberate areas from terrorists. Today, Russia
:12:41. > :12:47.angrily denied suspicions that its air strikes had hit hospitals,
:12:48. > :12:51.implying this was a propaganda ploy. TRANSLATION: Reports in the Western
:12:52. > :12:55.media about supposedly Russian air strikes on victims in the media have
:12:56. > :13:04.grown like a snowball. It started with one hospital in the province of
:13:05. > :13:07.Idlib in the morning. By the end of the day, a risen to five hospitals
:13:08. > :13:09.and then schools. There is no excuse for targeting
:13:10. > :13:13.innocent civilians of course, but the battlefield around Aleppo is
:13:14. > :13:18.complicated. Not only moderate rebels backed by the west are being
:13:19. > :13:24.attacked, more extreme fighters linked to Al-Qaeda and designated
:13:25. > :13:31.terror group by the United Nations, which is why Russia and Syria as
:13:32. > :13:36.they are bombing the just targets. What's more, also attacking rebel
:13:37. > :13:39.positions in northern Syria are the Syrian Kurds, keen to extend their
:13:40. > :13:44.enclaves coloured green. The Kurds were working with the Americans
:13:45. > :13:48.against so-called Islamic State or ices controlling the territory in
:13:49. > :13:53.red. Now they are using the Syrian and Russian push for their own ends,
:13:54. > :13:59.alarming Turkey which sees any Kurdish advanced near the border as
:14:00. > :14:03.a security threat. But at least one fragile ray of hope today from
:14:04. > :14:07.Damascus. They pledged secured by the UN special envoy that food aid
:14:08. > :14:11.May be let into some besieged areas tomorrow.
:14:12. > :14:22.Let's take a brief look at some of the day's other news stories.
:14:23. > :14:25.German investigators say human error was probably to blame for the
:14:26. > :14:29.11 people died and 80 were injured in the head-on collision
:14:30. > :14:33.An area controller whom it's alleged sent a wrong signal to the
:14:34. > :14:35.two trains is likely to be charged with involuntary manslaughter.
:14:36. > :14:38.The trial has begun of a Luton man charged with planning terror attacks
:14:39. > :14:40.on British and American military personnel at air bases
:14:41. > :14:47.Junead Khan, who's 25, is also accused with his uncle,
:14:48. > :14:48.Shazib Khan, of planning to travel to Syria
:14:49. > :15:08.Inflation has risen very slightly to its highest level for a year,
:15:09. > :15:10.0.2% to 0.3% as measured by the Consumer Prices Index.
:15:11. > :15:12.The cost of fuel falling less quickly than before
:15:13. > :15:21.The figure is still well below the Bank of England's target of 2%.
:15:22. > :15:22.The Metropolitan Police Commissioner,
:15:23. > :15:24.Sir Bernard Hogan-Howe, has met Lord Brittan's widow and apologised
:15:25. > :15:27.in person about Scotland Yard's handling of its investigation
:15:28. > :15:29.into an allegation of rape against the former Home Secretary.
:15:30. > :15:32.Officers questioned Lord Brittan and he died in January last year
:15:33. > :15:33.without knowing the outcome of the inquiry.
:15:34. > :15:36.Our home affairs correspondent Tom Symonds is at New Scotland Yard.
:15:37. > :15:37.The Commissioner phrased his apology very carefully.
:15:38. > :15:42.His force has been under extreme pressure about its investigation
:15:43. > :15:49.into some past sexual abuse cases. He appeared intent on not offering
:15:50. > :15:52.an unreserved apology. Lady Brittan, we're told, was more interested in
:15:53. > :15:55.explanations than apologies. They emerged from this meeting with
:15:56. > :16:02.different impressions of what was said.
:16:03. > :16:04.In Lord Brittan's final years, he was accused
:16:05. > :16:12.He was questioned and, after he died, his home
:16:13. > :16:15.Today, his wife received a face-to-face apology.
:16:16. > :16:17.The family described it as a "full apology" which was accepted.
:16:18. > :16:20.But on BBC Radio London, Sir Bernard Hogan-Howe described it
:16:21. > :16:28.I confirm the apology that we made, two months ago now, was an apology
:16:29. > :16:31.for not telling her at an earlier stage about the fact that
:16:32. > :16:34.Lord Brittan, who by that stage unfortunately had died,
:16:35. > :16:37.was not to be prosecuted in the future, and there was no
:16:38. > :16:53.This all results from claims on an investigative website that
:16:54. > :16:56.Lord Brittan raped a woman, known as Jane, in 1967.
:16:57. > :16:58.She reported it to the police four years ago.
:16:59. > :17:00.But the claim proved difficult to fully corroborate.
:17:01. > :17:02.And, in August 2013, the Crown Prosecution Service
:17:03. > :17:03.advised there was insufficient evidence to continue
:17:04. > :17:07.But the Met interviewed Lord Brittan in May 2014,
:17:08. > :17:09.and then spent months trying to get prosecutors to review the case,
:17:10. > :17:14.during which, in January 2015, Lord Brittan died.
:17:15. > :17:17.The inquiry finally came to an end on April 2015.
:17:18. > :17:22.But the Met failed to tell Lord Brittan's family until October,
:17:23. > :17:25.and it's for this the force has apologised.
:17:26. > :17:28.But Scotland Yard's made no apology for its other big investigation.
:17:29. > :17:30.Operation Midland is hunting for evidence of a paedophile
:17:31. > :17:41.His family has asked for answers to a further 30 questions.
:17:42. > :17:44.However cordial, today's meeting is unlikely to silence critics
:17:45. > :17:52.Reputations have been damaged by a clumsy, ham-fisted
:17:53. > :17:53.Metropolitan Police investigation, presided over by a Commissioner
:17:54. > :17:55.who seems totally incapable of understanding how revolted
:17:56. > :18:03.the public are by what we now know has happened.
:18:04. > :18:05.The Met insists, in Lord Brittan's case and others, it's trying
:18:06. > :18:08.to balance the requirements of justice with the need for fairness.
:18:09. > :18:14.With a hostile media constantly watching.
:18:15. > :18:23.Our understanding of the human brain is undergoing a revolution,
:18:24. > :18:25.according to some of the world's top neuroscientists.
:18:26. > :18:27.Advances in genetics and brain imaging are enabling researchers
:18:28. > :18:29.to discover more about mental illness, opening up
:18:30. > :18:30.the possibilities for new treatments.
:18:31. > :18:32.Our medical correspondent, Fergus Walsh, has been investigating
:18:33. > :18:36.It is a privilege to be able to examine this,
:18:37. > :18:40.the right hemisphere of a human brain, one of hundreds of brains
:18:41. > :18:44.donated in the UK for medical research every year.
:18:45. > :18:52.This delicate structure is responsible for thought,
:18:53. > :19:01.memory, language, emotion, consciousness - the very things
:19:02. > :19:04.Yet despite all our scientific knowledge, there is still a huge
:19:05. > :19:07.amount yet to discover about how the brain works and why
:19:08. > :19:12.But the brain is beginning to give up its secrets.
:19:13. > :19:16.Advances in biology mean many genes implicated in mental illness have
:19:17. > :19:18.been identified and new scanning techniques are creating something
:19:19. > :19:21.extraordinary - a complete map of the brain's intricate
:19:22. > :19:29.These coloured lines represent bundles of nerve fibres linking
:19:30. > :19:36.different parts of the brain through a number of highly connected hubs.
:19:37. > :19:39.There are bits of the brain that you can talk of as being hubs
:19:40. > :19:42.in the brain in the same way that Heathrow is a hub
:19:43. > :19:46.Researchers have found that people with schizophrenia tend to have
:19:47. > :19:48.fewer hubs, so their brain networks are less well-connected
:19:49. > :19:56.Where the excitement is building at the moment is linking the network
:19:57. > :20:00.diagrams that we can get out of imaging to what we're learning
:20:01. > :20:04.If we can bring those two things together,
:20:05. > :20:07.then we may be able to understand more clearly
:20:08. > :20:10.what are the mechanisms, the genetic mechanisms,
:20:11. > :20:13.that drive network development to go off on a somewhat different path
:20:14. > :20:21.And if we can understand mechanisms, then we can design new treatments.
:20:22. > :20:24.As well as deciphering the brain's network of connections,
:20:25. > :20:28.scientists are also learning more about its earliest stages
:20:29. > :20:33.of development, by growing miniature brains.
:20:34. > :20:37.Known as organoids, here they are in the hands
:20:38. > :20:40.of the scientist who invented the technique, incubating
:20:41. > :20:45.in a Medical Research Council lab in Cambridge.
:20:46. > :20:48.These tiny balls of tissue mimic what the early foetal brain
:20:49. > :20:55.Each was grown from a single cell donated by a patient.
:20:56. > :21:00.In those with mental illness, their mini brains can help explore
:21:01. > :21:05.We can actually then compare the organoids to the patient and see
:21:06. > :21:09.if we can see some of the features of the disorder and try
:21:10. > :21:11.to understand what caused those features.
:21:12. > :21:14.I think it's a really huge step towards some hopefully really
:21:15. > :21:17.amazing breakthroughs in what has been a desert
:21:18. > :21:21.Mental health disorders have been incredibly lacking in terms
:21:22. > :21:27.of new medications to treat these really devastating disorders.
:21:28. > :21:38.So when will this research pay dividends in delivering
:21:39. > :21:42.In the next five to ten years you can expect two things
:21:43. > :21:46.One, we'll be able to use neuroscience and genetics to target
:21:47. > :21:48.treatments better to patients, and this could happen
:21:49. > :21:53.The second is that, based on the knowledge we have now,
:21:54. > :21:55.we could actually have new medications, not for an entire
:21:56. > :22:02.Of course, our mental health is determined by our life
:22:03. > :22:11.experiences as well as the genes we inherit.
:22:12. > :22:13.The more we discover about this masterpiece of evolution,
:22:14. > :22:16.the greater the chance we have of treating it when it goes wrong.
:22:17. > :22:21.There's plenty more from BBC One's season on mental health.
:22:22. > :22:24.All the details are on our special website at bbc.co.uk/inthemind.
:22:25. > :22:35.You can follow us on social media at #inthemind.
:22:36. > :22:38.There's anger tonight amongst Scottish National Party politicians
:22:39. > :22:40.trying to finalise the funding for Scotland's new powers agreed
:22:41. > :22:46.Talks are currently at a stalemate and the Scottish Parliament has set
:22:47. > :22:48.next Tuesday as a deadline for an agreement.
:22:49. > :22:51.Our Scotland editor, Sarah Smith, is in Edinburgh for us tonight.
:22:52. > :22:55.Sarah, the mood of the SNP hasn't been helped by a key minister
:22:56. > :22:58.in the negotiations going on holiday?
:22:59. > :23:05.Well, that's right. The SNP are absolutely furious that they are at
:23:06. > :23:13.a critical point in these negotiations. The Chief Secretary to
:23:14. > :23:16.the Treasury has gone on holiday to France. They are approaching a
:23:17. > :23:19.deadline in these talks because if they don't do a deal by the
:23:20. > :23:24.beginning of next week, the Scottish Parliament say there may not be time
:23:25. > :23:29.to enact all those new powers Holyrood were promised in the wake
:23:30. > :23:39.of the 2014 referendum they won't won't be in place for time for the
:23:40. > :23:43.Scottish elections in May. The Treasury say he is prepared to cut
:23:44. > :23:46.the holiday short if the Scottish Government make a substantial move
:23:47. > :23:49.in the negotiations. What they are arguing about is how much they
:23:50. > :23:54.should cut the block grant that the UK Government gives to the Scottish
:23:55. > :23:57.Parliament once Holyrood takes control of income taxes in Scotland.
:23:58. > :24:00.The negotiations do not seem to be going very well. They are not
:24:01. > :24:03.anywhere close to reaching agreement. If they don't get it done
:24:04. > :24:06.in time, if they don't get it agreed by the deadline this issue could
:24:07. > :24:12.really dominate the Scottish elections in May. You'll have the
:24:13. > :24:15.SNP complaining that Westminster are trying to cheat Scotland out of
:24:16. > :24:18.billions of pounds in funding. Tory ministers are saying the Scottish
:24:19. > :24:22.Government are trying to have their cake and each other people's cases
:24:23. > :24:31.as well. Sarah in Edinburgh, thank you.
:24:32. > :24:33.In America, former President, George W Bush, has emerged
:24:34. > :24:35.from self-imposed political hibernation to hit the campaign
:24:36. > :24:38.trail in his brother's bid to make it to the White House.
:24:39. > :24:40.His younger sibling, Jeb, is battling to win
:24:41. > :24:41.the Republican presidential nomination.
:24:42. > :24:44.The pair appeared together at a rally in South Carolina
:24:45. > :24:46.as our North America editor, Jon Sopel, assesses
:24:47. > :24:49.whether the family name will be a help or a hindrance.
:24:50. > :24:51.Hold on, one second, Mr President, here we go...
:24:52. > :24:53.This is the lesser spotted George W Bush.
:24:54. > :24:55.Since leaving office seven years ago, he's assiduously stayed out
:24:56. > :24:58.But he's back, to help his kid brother.
:24:59. > :25:06.This is the Bush family engaged in mission, Stop Donald Trump.
:25:07. > :25:16.Real strength, strength of purpose, comes from integrity and character.
:25:17. > :25:18.And in my experience, the strongest person usually isn't
:25:19. > :25:25.Donald Trump has shown nothing but disdain for Jeb Bush
:25:26. > :25:31.This ferocious debate took place at the weekend.
:25:32. > :25:33.George Bush made a mistake, we can make mistakes,
:25:34. > :25:39.I couldn't care less about the insults that Donald Trump
:25:40. > :25:44.It's blood sport for him, he enjoys it and I'm glad he's
:25:45. > :25:48.But I am sick and tired of him going after my family.
:25:49. > :25:51.The World Trade Center came down during your brother's reign.
:25:52. > :25:53.He's had the gall to go after my mother.
:25:54. > :25:57.Almost the most striking thing about Jeb's campaign is the logo.
:25:58. > :26:00.His first name, an exclamation mark and no mention
:26:01. > :26:08.It's as if he wants to put the maximum distance between himself
:26:09. > :26:11.and his big brother and his father, President George HW Bush.
:26:12. > :26:14.But as this lacklustre campaign has faltered,
:26:15. > :26:17.so the need to rely on the family has grown.
:26:18. > :26:22.And the great matriarch of the Bush family, Barbara,
:26:23. > :26:25.First Lady a quarter of a century ago, has also been out and about.
:26:26. > :26:42.But for the moment, this dynastic family might have to accept that
:26:43. > :26:44.for this generation, the Bush brand of Republicanism
:26:45. > :26:47.is going to lose out to a more populist and raucous variety
:26:48. > :26:48.being offered by the irrepressible Donald Trump.
:26:49. > :26:59.Football, and a mixed night for Chelsea as they returned
:27:00. > :27:05.Despite losing to runaway French league leaders Paris Saint Germain,
:27:06. > :27:07.they scored a valuable away goal ahead of the second leg.
:27:08. > :27:12.Our correspondent, Katie Gornall, was watching the action.
:27:13. > :27:24.Two teams, two very different seasons. While Paris St-Germain are
:27:25. > :27:31.towering over their rivals in France's top division Chelsea's
:27:32. > :27:38.defence has struggled. Ibrahimovic PSG post one of the big hitters in
:27:39. > :27:42.world football. One swing of of his boot and they had the lead.
:27:43. > :27:47.Ibrahimovic has been a long source of goals. This was Mikel's sixth
:27:48. > :27:53.goal in ten years, a rare sight indeed. It sent PSG into the
:27:54. > :27:56.second-half in a hurry. Finding the necessary urgency, if not the
:27:57. > :28:02.necessariy accuracy. Chelsea's defence was proving a significant
:28:03. > :28:06.obstacle. The arrival of Cavani would overcome that. He reopened an
:28:07. > :28:10.entertaining contest with one powerful strike. Europe has been a
:28:11. > :28:20.place of respite for Chelsea this season, now it's another place where
:28:21. > :28:27.they need to regain control. Katie Gornall, BBC News.
:28:28. > :28:32.They're the directors behind some of the most memorable movies
:28:33. > :28:36.From Fargo and the Big Lebowski to No Country For Old Men
:28:37. > :28:39.and True Grit - the Coen Brothers are famous for working across
:28:40. > :28:41.a diverse range of film plots and genres.
:28:42. > :28:44.Now, they're tackling Hollywood - 1950s Hollywood - with a comedy
:28:45. > :28:46.in which George Clooney plays an incompetent actor
:28:47. > :28:49.Our arts editor, Will Gompertz, has been talking to the brothers.
:28:50. > :28:51.Hop, would that it were so simple.
:28:52. > :28:54.Hail, Caesar is a classic Coen brothers movie,
:28:55. > :28:59.in so much as it's a stylised, surreal comic tale, undercut
:29:00. > :29:11.An original sort of idea or the movie, when we first started
:29:12. > :29:13.thinking about it, was - OK, 24-hours in the life
:29:14. > :29:16.as a sort of architecture for a movie.
:29:17. > :29:19.A marriage doesn't have to last forever, but then having a child
:29:20. > :29:21.without a father would present a public relations problem
:29:22. > :29:24.The aquatic pictures did very nicely for us.
:29:25. > :29:26.Josh Brolin is Eddie Mannix, a legendary 1950s Hollywood fixer.
:29:27. > :29:32.What does it look like and then how do you between you evolve it?
:29:33. > :29:34.The scripts kind of develop out of essentially just a long
:29:35. > :29:39.conversation and then the conversation gets more and more
:29:40. > :29:46.It's like - oh, I don't like that sentence, I don't like that word,
:29:47. > :29:51.I mean, that's just the nature of movie-making is that it's a...
:29:52. > :29:55.It's all about collaboration and the good collaborations
:29:56. > :30:12.are the ones where you always know what's right, where you know
:30:13. > :30:18.Gather $100,000 and await instructions.
:30:19. > :30:28.There are so many familiar structural devices we see in Coen
:30:29. > :30:30.Brothers movies, do you ever worry why about repeating ourselves?
:30:31. > :30:34.I think it was when we were shooting Fargo, we were out on the street,
:30:35. > :30:36.shooting the sort of approaching car coming down and I literally turned
:30:37. > :30:40.to Ethan and said, "haven't we shot this exact same thing before?"
:30:41. > :30:43.We realise, to a certain extent, you keep reverting to the same shots
:30:44. > :30:48.Mr Mannix, I know it sounds screwy, but someone's calling
:30:49. > :30:53.What would happen if one of you said - look, I don't want
:30:54. > :31:03.Well, we have talked about...
:31:04. > :31:06.At one point we said, when we've made 10 movies we'll quit.
:31:07. > :31:11.It gets too alarming thinking about that.
:31:12. > :31:15.How many you've done and that, in ways you're not even aware of,
:31:16. > :31:19.You think you're like an old musician, now on the road
:31:20. > :31:21.because he doesn't know anything else and he's just
:31:22. > :31:40.Zac Goldsmith, the Tory candidate for London Mayor will be with me.
:31:41. > :31:42.We'll talk about housing, Europe and how an Etonian
:31:43. > :31:44.millionaire can ever understand the lives of ordinary Londoners.
:31:45. > :31:48.Join me now on BBC Two, 11.00pm in Scotland.
:31:49. > :31:51.Here, on BBC One, it's time for the news where you are.