:00:09. > :00:11.Leicester City defy the odds to win the Premier League.
:00:12. > :00:14.Delirious fans celebrate as the club - written off
:00:15. > :00:16.at the start of the season - wins the title for the first
:00:17. > :00:28.It's a dream! A dream come true! Amazing! It is epic! Speechless!
:00:29. > :00:31.Amazing! We'll be looking at how Leicester
:00:32. > :00:33.became the Premier League's Scientists hail a "milestone"
:00:34. > :00:41.in understanding what It could lead to new
:00:42. > :00:46.methods of treatment. The US Secretary of State insists
:00:47. > :00:50.a peace deal in Syria must include the city of Aleppo - the focus
:00:51. > :01:16.of recent intense fighting. Leicester City are tonight champions
:01:17. > :01:19.of the Premier League in one of the most extraordinary stories
:01:20. > :01:21.in the history of the game. Written off at the beginning
:01:22. > :01:23.of the season, the club defied the critics and upset huge odds
:01:24. > :01:27.to clinch the title And they did so without even kicking
:01:28. > :01:31.a ball, after their nearest rivals, Spurs, failed to win
:01:32. > :01:34.against Chelsea. For a second day in a row,
:01:35. > :01:38.fans packed into pubs and bars across the city of Leicester to see
:01:39. > :01:43.if the fairytale would come true. Our sports editor,
:01:44. > :01:57.Dan Roan, is outside This is what it means for Leicester
:01:58. > :02:01.City to become the new, the least likely and probably the most popular
:02:02. > :02:05.Premier League Champions there has ever been. Thousands of fans have
:02:06. > :02:10.flooded out on to the streets of the city, many of them, as you can
:02:11. > :02:12.probably see and hear, are behind me at their home, the King Power
:02:13. > :02:18.Stadium, where, at the weekend, they will be presented with the Premier
:02:19. > :02:22.League Trophy. Let's not forget, they were 5,000-1, rank outsiders to
:02:23. > :02:28.win this league before the season began. They have done it. They have
:02:29. > :02:30.turned the football, no, the sport's world upside-down, fairy tale
:02:31. > :02:34.complete, they are the new champions. Yes, the new champions of
:02:35. > :02:39.the Premier League. Here is the story of the night.
:02:40. > :02:42.The final chapter in sport's greatest story.
:02:43. > :02:45.This, what it means to the city of Leicester tonight
:02:46. > :02:47.to see their team become the new and most unlikely
:02:48. > :02:51.Premier League Champions there's ever been.
:02:52. > :02:54.This afternoon, mastermind Claudio Ranieri had
:02:55. > :02:57.rearranged his travel plans, the manager flying back early
:02:58. > :03:00.from a day trip to Rome to watch the decisive
:03:01. > :03:04.His players choosing to view the game together at the home
:03:05. > :03:11.Leicester knew that if Spurs failed to beat Chelsea,
:03:12. > :03:15.The early signs were good, Cesc Fabregas going
:03:16. > :03:21.But then the viewing became painful for Leicester's followers watching
:03:22. > :03:25.in pubs around the city, Spurs taking the lead.
:03:26. > :03:31.Spurs intent on keeping the title race alive.
:03:32. > :03:36.TV cameras picking up this from Moussa Dembele,
:03:37. > :03:43.But the second half belonged to Chelsea.
:03:44. > :03:49.Gary Cahill pulling one back and then the equaliser.
:03:50. > :03:58.This, the moment Leicester's unlikely dream
:03:59. > :04:03.For those who have followed them for years,
:04:04. > :04:25.It's insane! It is epic! Speechless! Champions of England!
:04:26. > :04:27.Leicester City's achievement arguably surpasses
:04:28. > :04:30.sport's other great triumphs in defiance of the odds.
:04:31. > :04:33.Goran Ivanisevic was a 250-1 wildcard when he won
:04:34. > :04:35.Wimbledon, while unheralded golfer Ben Curtis was a rank 300-1 outsider
:04:36. > :04:43.Brian Clough's Nottingham Forest team won
:04:44. > :04:46.the league, the season after being promoted and then successive
:04:47. > :04:49.European Cups and a member of that legendary side sees parallels.
:04:50. > :04:54.Leicester City have done absolutely magnificently this season.
:04:55. > :05:01.I would say in football, it's probably the biggest
:05:02. > :05:06.story since Nottingham Forest in 1977/78.
:05:07. > :05:10.And so the ultimate underdogs come out on top.
:05:11. > :05:18.Proof that in sport anything is possible.
:05:19. > :05:24.So resolute, so consistent have Leicester City been, it is easy to
:05:25. > :05:28.forget what a big sporting shock this is. Let's not forget that
:05:29. > :05:31.Leicester City, at the start of the season, were favourites to be
:05:32. > :05:35.relegated. Their squad cost a fraction of their richer rivals,
:05:36. > :05:38.some of the wealthiest clubs in the world. Their manager, Claudio
:05:39. > :05:44.Ranieri, had a reputation for being the nearly man of football. No
:05:45. > :05:48.longer, here is Andy Swiss trying to make sense of how Leicester did it.
:05:49. > :05:50.It is a story straight out of a comic book,
:05:51. > :05:52.of a team staring at relegation barely a year ago, who turned
:05:53. > :05:57.So how do you explain the seemingly inexplicable?
:05:58. > :06:04.Leicester found stars where others barely looked.
:06:05. > :06:07.Jamie Vardy, from lowly Fleetwood Town.
:06:08. > :06:10.Riyad Mahrez, from the French Second Division.
:06:11. > :06:13.COMMENTARY: Leicester are proving what a team they are!
:06:14. > :06:17.Their entire first 11 cost just ?23 million.
:06:18. > :06:21.In Premier League terms, little more than loose change.
:06:22. > :06:23.Recruitment is the hardest thing in football.
:06:24. > :06:25.Leicester have been magnificent at that.
:06:26. > :06:28.Vardy, in non-league football not so long ago.
:06:29. > :06:33.There is a lot of those players in that team that have been
:06:34. > :06:39.To go with those unlikely stars, an unlikely star manager.
:06:40. > :06:41.When he arrived last summer, Claudio Ranieri had just been
:06:42. > :06:47.And at first, his new team struggled defensively.
:06:48. > :06:51.So the Italian gave them a very Italian incentive.
:06:52. > :06:55.I said, when we make clean sheet, I pay to everybody a pizza.
:06:56. > :06:58.Sure enough, when that clean sheet arrived,
:06:59. > :07:01.he treated them to a pizza class and, in the process,
:07:02. > :07:08.That pizza-making session in this very room proved a turning point
:07:09. > :07:14.Their leaky defence became the tightest in the league,
:07:15. > :07:17.but it also summed up the spirit and the unity which their manager
:07:18. > :07:25.I don't think too many managers do that, but not only that,
:07:26. > :07:28.he talks to all the players, we are having fun with each other.
:07:29. > :07:32.But, at the same time, we can switch around and be very
:07:33. > :07:35.focussed, be very concentrated on what we need to do.
:07:36. > :07:39.But, for all their talent, their timing has been key.
:07:40. > :07:42.This was a rare season when Chelsea, Manchester City, Manchester United
:07:43. > :07:48.Leicester have also been fortunate with injuries,
:07:49. > :07:52.using just 23 players - fewer than anyone else.
:07:53. > :07:55.The underperforming big clubs have helped Leicester and they have
:07:56. > :07:59.It wouldn't surprise me if, next season, Leicester
:08:00. > :08:08.I think this is a one season wonder, which will never happen again.
:08:09. > :08:10.Indeed, this is ultimately fantasy football.
:08:11. > :08:17.The impossible dream that's become a glorious reality.
:08:18. > :08:29.These are some of the most jubilant scenes of celebration that the
:08:30. > :08:34.Premier League has ever witnessed. It is not just the fans who are
:08:35. > :08:39.celebrating, Leicester City's squad too, they gathered at the house of
:08:40. > :08:44.Jamie Vardy, and this is what it meant to them when they knew that
:08:45. > :08:48.they were, each and every one of them, Premier League Champions. Many
:08:49. > :08:52.of those players have never experienced anything quite like that
:08:53. > :08:57.before. This is a victory, a triumph that has resonated across the world
:08:58. > :09:01.of sport, not just here, but across the globe. Leicester City's players
:09:02. > :09:05.can look forward to Champions League football next season in Europe. It
:09:06. > :09:09.truly is a victory, the like of which modern sport, where money
:09:10. > :09:12.rules, wasn't meant to produce anymore, but it's a victory that has
:09:13. > :09:16.put the smile back on the face of sport, too. Dan Roan, thank you.
:09:17. > :09:19.Scientists say a new study has given them a near-perfect picture
:09:20. > :09:22.of the genetic mutations that cause breast cancer.
:09:23. > :09:24.The study, in the journal Nature, has been described
:09:25. > :09:29.It's hoped the analysis could help unlock new ways of treating
:09:30. > :09:37.Here's our health correspondent, Dominic Hughes.
:09:38. > :09:40.Enjoying a spot of Bank Holiday Monday gardening, Vanessa Babbage
:09:41. > :09:44.But Vanessa has fought a long, arduous battle
:09:45. > :09:49.After extensive surgery, chemo and radiotherapy, she
:09:50. > :09:53.knows how devastating the disease and its treatment can be.
:09:54. > :10:00.It's actually worse than the cancer itself,
:10:01. > :10:05.because you are constantly ill, so they do try to help you to
:10:06. > :10:07.minimise the side-effects by giving you other drugs to help the nausea
:10:08. > :10:15.and things like that, so the treatment is very, very harsh.
:10:16. > :10:18.Scanners like this one are used to detect and monitor cancerous tumours
:10:19. > :10:22.once they've already developed, but to understand the underlying
:10:23. > :10:25.causes of cancer, scientists have had to go much deeper,
:10:26. > :10:28.to the level of DNA, to try and work out what happens
:10:29. > :10:36.An international team of scientists, led by the Sanger Institute
:10:37. > :10:40.in Cambridge, examined all 3 billion letters in the genetic code of every
:10:41. > :10:47.What they've found has transformed the understanding of what happens
:10:48. > :10:55.Getting a comprehensive collection of information, including the
:10:56. > :10:59.mutations that are causing cancer, tells us something about why that
:11:00. > :11:02.cancer is going wrong, why that cell is turning
:11:03. > :11:05.into a cancerous cell, and if you can understand that,
:11:06. > :11:08.you can understand the causes of the cancer, and then you can
:11:09. > :11:14.This opens up the possibility of much greater individualised
:11:15. > :11:17.treatments for cancer, targeting each of the mutations.
:11:18. > :11:20.That's already happening with some treatments, like the drug
:11:21. > :11:24.Herceptin, but experts believe this could be a big step forward.
:11:25. > :11:26.What this study might achieve is finding
:11:27. > :11:28.better treatments, matching them better to women.
:11:29. > :11:33.By understanding the causes that underline the biology
:11:34. > :11:36.of different types of the disease, we might be able to match better
:11:37. > :11:38.treatments and offer them things that are more likely to work for
:11:39. > :11:44.Back at home, Vanessa Babbage is moving on with her life after
:11:45. > :11:46.cancer, and she is optimistic that science is starting to make real
:11:47. > :11:50.headway in the fight against the disease.
:11:51. > :11:54.It gives people hope, because when people are affected
:11:55. > :11:58.by someone that they love and they have breast cancer,
:11:59. > :12:01.they hope for a better future for other women that are going to be
:12:02. > :12:07.This research has transformed the understanding of cancer,
:12:08. > :12:10.and offers the tantalising prospect it could prevent the disease
:12:11. > :12:18.In talks in Geneva to try to save the ceasefire in Syria,
:12:19. > :12:21.the US Secretary of State, John Kerry, said foreign powers
:12:22. > :12:24.were "getting closer to a place of understanding."
:12:25. > :12:27.There's been a two-month pause in hostilities in the country,
:12:28. > :12:30.but the last ten days have seen an upsurge in violence.
:12:31. > :12:34.Mr Kerry said a renewed ceasefire must include the besieged city
:12:35. > :12:39.of Aleppo, where more than 250 civilians have died in recent days.
:12:40. > :12:42.This is the moment to try to make certain that what everybody
:12:43. > :12:46.has signed up to is, in fact, being delivered,
:12:47. > :12:52.being lived up to, without hypocrisy and without variation.
:12:53. > :12:55.And that's what we're working for and I'm hopeful that,
:12:56. > :13:00.over the course of the next day or so, greater clarity will be
:13:01. > :13:07.available as to exactly what progress has been made.
:13:08. > :13:09.A 36-year-old man has been shot dead during an operation
:13:10. > :13:14.Officers were called to a property near Maidstone last night
:13:15. > :13:17.as part of an inquiry into the murder of Roy Blackman,
:13:18. > :13:19.who was beaten to death during a burglary at his
:13:20. > :13:33.The Independent Police Complaints Commission is now investigating.
:13:34. > :13:35.This Thursday voters across most of England and Wales will be able go
:13:36. > :13:38.to the polls to elect their Police and Crime Commissioners.
:13:39. > :13:40.PCCs were introduced in 2012, with the aim of making police
:13:41. > :13:41.forces accountable and more responsive to public needs.
:13:42. > :13:44.But voting then suggested widespread apathy for the new role.
:13:45. > :13:46.Our home editor, Mark Easton, reports from the campaign trail
:13:47. > :13:52.32 million people get the chance to vote for their Police and Crime
:13:53. > :13:56.Commissioner in England and Wales on Thursday.
:13:57. > :13:57.Here in Northamptonshire, three candidates are up for
:13:58. > :14:06.The first thing I'll do is reduce the cost
:14:07. > :14:08.of the office of Police and Crime Commissioner.
:14:09. > :14:11.Local people should help decide where police resources are
:14:12. > :14:17.The idea behind PCCs is the elected commissioner would be
:14:18. > :14:20.impartial, setting police priorities for all the people, whatever their
:14:21. > :14:26.But there are concerns that candidates should
:14:27. > :14:31.Of the 188 PCC candidates across England and
:14:32. > :14:46.Turn-out last time was a miserable 15%, a little higher in
:14:47. > :14:49.But hopes that the public would start to
:14:50. > :14:52.embrace this new elected official with the power
:14:53. > :14:54.to hire and fire the
:14:55. > :14:57.Chief Constable, well let's say this election could be seen as a
:14:58. > :15:11.To be honest, I don't really know what's going on.
:15:12. > :15:13.Do you think people are excited about it?
:15:14. > :15:16.I don't think they are excited about it at all.
:15:17. > :15:22.Their previous PCC, Tory Adam Simmonds, is standing
:15:23. > :15:26.Praised by the Home Secretary for helping cut crime, he was
:15:27. > :15:29.criticised locally for increasing his office budget while the police
:15:30. > :15:39.I spent 30 years in business from a technology point
:15:40. > :15:42.of view, so I want to see body-worn video
:15:43. > :15:46.cameras, the latest technology - that will make the difference.
:15:47. > :15:48.We have lost over 105 police officers in
:15:49. > :15:52.Northamptonshire since 2010 and at the same time
:15:53. > :15:53.crime has doubled over the
:15:54. > :15:59.past two years, so we need a better policing presence on our streets.
:16:00. > :16:01.We have seen over the years that the established political
:16:02. > :16:03.parties have failed to address the problems of
:16:04. > :16:08.Ukip is the party to change that, and so am I.
:16:09. > :16:11.Turnout is likely to be higher this time than last
:16:12. > :16:15.PCC elections coincide with council elections.
:16:16. > :16:19.But whatever the local situation, there seems there is
:16:20. > :16:22.plenty of scope for increasing public enthusiasm.
:16:23. > :16:26.Mark Easton, BBC News, Northamptonshire.
:16:27. > :16:30.You can see more on all of today's stories on the BBC News Channel.
:16:31. > :16:34.Stay with us on BBC One, it's time for the news where you are.