:00:00. > :00:10.A former Prime Minister launches a scathing attack on the campaign
:00:11. > :00:12.for Britain to leave the European Union.
:00:13. > :00:17.who wants Britain to stay in the EU - says the claims being made
:00:18. > :00:22.What they have said about leaving is fundamentally dishonest,
:00:23. > :00:26.and it's dishonest about the cost of Europe.
:00:27. > :00:28.For the Leave campaign, Boris Johnson defends the approach
:00:29. > :00:35.Yes, there's our borders but there are also very,
:00:36. > :00:37.very important aspects of our economic life that,
:00:38. > :00:44.Muhammad Ali's coffin is flown home to Kentucky ahead of the funeral
:00:45. > :00:47.on Friday in the town where he was born.
:00:48. > :00:49.How scientists are using animals to grow human organs -
:00:50. > :00:57.This sow is pregnant with embryos which contain human cells.
:00:58. > :01:00.I'll be reporting on why scientists think it could be the answer
:01:01. > :01:12.And Novak Djokovic defeats Andy Murray to win the French Open -
:01:13. > :01:34.he now holds all four grand slams at the same time.
:01:35. > :01:39.The former Conservative Prime Minister Sir John Major,
:01:40. > :01:41.who wants Britain to remain in the EU, has made a fierce
:01:42. > :01:43.attack on the campaign for Britain to leave,
:01:44. > :01:50.With little more than two weeks to go before the vote,
:01:51. > :01:52.Sir John said the claims being made were deceitful and,
:01:53. > :01:55.on the issue of immigration, verging on the squalid.
:01:56. > :01:57.Boris Johnson has responded for the Leave campaign,
:01:58. > :02:00.defending the emphasis on immigration and claiming the UK's
:02:01. > :02:06.population could rise to 80 million if it is not brought under control.
:02:07. > :02:10.Our political correspondent Ben Wright reports
:02:11. > :02:17.But today, the former Tory Prime Minister let rip,
:02:18. > :02:24.I am angry at the way the British people are being misled.
:02:25. > :02:28.I think their campaign is verging on the squalid.
:02:29. > :02:31.What they have said about leaving is fundamentally dishonest.
:02:32. > :02:35.I think this is a deceitful campaign.
:02:36. > :02:38.He used to be caricatured as grey, but this was a technicolor assault
:02:39. > :02:44.Vote Leave have said some of the cash Britain currently
:02:45. > :02:47.spends on being a member of the European Union could be
:02:48. > :02:51.But Sir John Major said leading Conservatives could not be trusted
:02:52. > :02:58.Boris wanted to charge people for using it,
:02:59. > :03:02.and Iain Duncan Smith wanted a social insurance system.
:03:03. > :03:06.The NHS is about as safe with them as a pet hamster would be
:03:07. > :03:11.He then turned to Turkey, saying the Leave campaign's claim
:03:12. > :03:16.the country would soon join the EU was misleading.
:03:17. > :03:18.Is it seriously suggested, as they do, that all 88 million
:03:19. > :03:24.Apparently, for our higher National Living Wage?
:03:25. > :03:26.On the one hand, they say migrants are depressing wages,
:03:27. > :03:29.and on the other, people are flooding in to get our
:03:30. > :03:34.Turkey has applied to join the European Union, and the UK does
:03:35. > :03:38.The Government insists that's decades away,
:03:39. > :03:40.but Boris Johnson defended the Leave campaign's decision
:03:41. > :03:46.The statement that Turkey is joining the EU is not true, is it?
:03:47. > :03:49.Turkey has been joining the EU since 1963.
:03:50. > :03:52.You join or you don't join, but it isn't true, is it?
:03:53. > :03:54.That is what John Major was talking about.
:03:55. > :03:57.Frankly, I don't mind whether Turkey joins the EU, provided
:03:58. > :04:05.Turkey is bound up with the issue of immigration, and the Leave
:04:06. > :04:07.campaign says outside the EU, total net migration to Britain
:04:08. > :04:10.could be cut to the tens of thousands, a pledge
:04:11. > :04:13.the Government has been unable to meet.
:04:14. > :04:17.Uncontrolled numbers coming in here not only depress
:04:18. > :04:20.wages for working people, it is also the case that they put
:04:21. > :04:22.considerable strain on public services, on housing,
:04:23. > :04:26.on the National Health Service, and of course on school places.
:04:27. > :04:29.We grew very successfully in the 1980s and 1990s with
:04:30. > :04:36.This referendum is laying bare deep Tory divisions over Europe that have
:04:37. > :04:40.existed since John Major was in Number 10 himself,
:04:41. > :04:43.and somehow the Government's going to have to move beyond this,
:04:44. > :04:48.Tory civil war over Europe is probably not a drama most
:04:49. > :04:51.voters are interested in, and both sides are trying
:04:52. > :04:55.to wrestle the arguments back to the issue at stake.
:04:56. > :04:58.We have a very short time to go until the referendum,
:04:59. > :05:00.and what people want to hear are the arguments.
:05:01. > :05:04.What we're setting out on the Leave side of the campaign is, I think,
:05:05. > :05:09.an agenda for the Government to take back control on June 23rd of a lot
:05:10. > :05:14.of things that really matter to the people of this country.
:05:15. > :05:17.There is a huge choice in front of voters,
:05:18. > :05:19.the biggest in a generation, and in Leeds today, the rival
:05:20. > :05:22.campaigns were trying to clinch the undecided.
:05:23. > :05:24.The political arguments is now fierce, because
:05:25. > :05:38.Our deputy political editor John Pienaar is with me now.
:05:39. > :05:44.What you think the impact of what John Major said today will be?
:05:45. > :05:48.Coming from John Major, a respected former Prime Minister, we have never
:05:49. > :05:52.seen a so-called blue on blue attack of this kind in living memory,
:05:53. > :05:57.Margaret Thatcher never let rip like this, nor did Ted Heath before her.
:05:58. > :06:01.It is true that John Major is a great pro-European, I think he never
:06:02. > :06:06.forgave the Eurosceptics that made his premiership a misery, as they
:06:07. > :06:09.did. Day after day, we have seen senior politicians on both sides,
:06:10. > :06:14.that rely on public trust, accusing each other of being barefaced liars.
:06:15. > :06:19.It can't be good for the party and power, it can't be good for
:06:20. > :06:24.politics. Tomorrow, the Leave aside will say that unpaid bills in the EU
:06:25. > :06:30.will mean Britain getting landed with a bill, and as soon as that is
:06:31. > :06:34.said, it will be called a lie. People might decide they can't
:06:35. > :06:38.believe what is being said and they will make up their own mind. Maybe
:06:39. > :06:41.that is not all bad, that is what people will have to do in the end,
:06:42. > :06:45.use their own judgment, at least those that can be bothered to vote
:06:46. > :06:49.on June the 23rd, in the biggest decision this country has faced for
:06:50. > :06:54.many years. The day after, the Conservatives have to start to mend
:06:55. > :06:57.fences, how will they do it? It is an extraordinary campaign, it will
:06:58. > :07:00.put a lot of strain on David Cameron's future management of his
:07:01. > :07:07.party and the Government. He will need a big win for Remain to have
:07:08. > :07:10.any chance of stabilising his party and the government. Mutinous MPs are
:07:11. > :07:13.muttering the whole time about stopping the Government doing
:07:14. > :07:20.anything they don't like. There will be split in the Cabinet which will
:07:21. > :07:27.erode his authority. I think he has a tough time coming. He might put
:07:28. > :07:29.off choosing his own time and place to go, but he might end up hanging
:07:30. > :07:32.on and wishing he had gone sooner. The funeral of Muhammad Ali,
:07:33. > :07:35.one of the most internationally celebrated people of our time,
:07:36. > :07:38.will be held in his home town His body was flown home from Arizona
:07:39. > :07:42.this evening and his family have said people from anywhere
:07:43. > :07:44.in the world are welcome Our correspondent Aleem Maqbool
:07:45. > :07:58.reports from Louisville. For the final time, the man they
:07:59. > :08:03.call the greatest of them all has travelled home. His casket, arriving
:08:04. > :08:10.back in Louisville, where he grew up and where he wanted to be laid to
:08:11. > :08:15.rest. In their own small ways, people across this city are
:08:16. > :08:16.remembering Muhammad Ali. There is a steady stream of mourners to his
:08:17. > :08:19.childhood home. I am so beyond devastated,
:08:20. > :08:22.but he is in a better place. He is at peace, and there
:08:23. > :08:27.is no more suffering. Young boxers here, of course,
:08:28. > :08:31.are thinking of him, too. He said whatever he wanted to say
:08:32. > :08:39.to whoever he wanted to say it. My biggest lesson from him
:08:40. > :08:47.is, be yourself. Flags across the city
:08:48. > :08:49.of Louisville at half-mast, including here outside the huge
:08:50. > :08:52.arena where Muhammad Ali's funeral His family said he was a citizen
:08:53. > :08:59.of the world, and would have wanted as many people as possible
:09:00. > :09:02.from all walks of life to be And the tributes from further afield
:09:03. > :09:07.keep coming, including from the man who famously cried after beating
:09:08. > :09:09.Muhammad Ali in the He didn't care about
:09:10. > :09:18.money or anything else. If he walked down the street
:09:19. > :09:23.and people would say, hi, Ali, That is what is wrong with people
:09:24. > :09:31.today, they don't do that. Particularly poignant have been
:09:32. > :09:35.the words of Michael J Fox, who suffers from the same disease
:09:36. > :09:38.that affected Muhammad Ali Before I was diagnosed
:09:39. > :09:44.with Parkinson's, I admired him, and I admired his athleticism,
:09:45. > :09:48.his poise, his class, his style, his stoicism,
:09:49. > :09:53.his belief in what he felt was right and his willingness
:09:54. > :09:55.to accept the consequences His doctor says in the final
:09:56. > :10:02.year before his death, Muhammad Ali had been
:10:03. > :10:05.having a tough time. That will be a distressing thought
:10:06. > :10:08.for many around the world who remember the man in his pomp,
:10:09. > :10:14.all power and elegance and grace. Aleem Maqbool, BBC News,
:10:15. > :10:19.in Louisville, Kentucky. Muhammad Ali's life - and death -
:10:20. > :10:22.has a particular significance He grew up at a time of racial
:10:23. > :10:27.segregation and was later despised by some for his refusal
:10:28. > :10:30.to fight in Vietnam. The civil rights activist
:10:31. > :10:34.the Reverend Al Sharpton has told the BBC that Ali's journey to become
:10:35. > :10:36.global hero symbolises Nick Bryant has been speaking
:10:37. > :10:43.to him, and reports from America's most famous
:10:44. > :10:44.black neighbourhood - In black churches in Harlem today,
:10:45. > :10:54.praise and prayer for America's Once such a polarising
:10:55. > :11:02.figure, now the recipient That rare thing in modern-day
:11:03. > :11:08.America, a unifying figure. He filled us with the audacity
:11:09. > :11:11.to say we could float like The audacity to believe
:11:12. > :11:22.we could accomplish great things. At a time when black Americans
:11:23. > :11:27.were made to feel powerless, He tells a story about not
:11:28. > :11:34.being served in a restaurant Wrapped himself in the American flag
:11:35. > :11:45.and they would not serve him. Membership of the Nation Of Islam
:11:46. > :11:57.and his friendship with black radicals like Malcolm X put him
:11:58. > :11:59.at odds with the mainstream civil rights movement,
:12:00. > :12:02.but he was still the dominant figure He inspired modern-day leaders
:12:03. > :12:11.like his friend, the Here is a man that was despised
:12:12. > :12:15.because he stood up He went from being despised
:12:16. > :12:20.to being a global hero, He symbolises to us that
:12:21. > :12:26.if you struggle and remain true to the cause,
:12:27. > :12:28.you will be vindicated. Whenever Ali toured Harlem,
:12:29. > :12:37.his magnetism meant he was mobbed. Today, the famed Apollo Theatre
:12:38. > :12:40.put his name up in lights and T-shirts went on sale adorned
:12:41. > :12:58.with Ali iconography. PZ take the lead backer deified
:12:59. > :13:03.figure. To visit the churches was to be reminded that I am the greatest
:13:04. > :13:09.was not just his famous boast, but also an affirmation of black pride.
:13:10. > :13:11.Iraqi forces say they have secured the southern edge of Fallujah
:13:12. > :13:14.as part of an operation to recapture the city from so called
:13:15. > :13:18.Fallujah is one of the last strongholds of IS in Iraq -
:13:19. > :13:21.and has been under the militants' control for more than two years.
:13:22. > :13:23.They also hold Iraq's second largest city,
:13:24. > :13:28.Police investigating the murder of a pensioner from Suffolk
:13:29. > :13:31.and the disappearance of his wife have arrested a man in Leicester.
:13:32. > :13:34.A body believed to be that of Peter Stuart, who was 75,
:13:35. > :13:38.was found close to his home near Diss on Friday night.
:13:39. > :13:42.His wife, Sylvia, was last seen over a week ago.
:13:43. > :13:44.A woman's been killed in a shark attack off
:13:45. > :13:49.It's the second fatal attack in the area in less than a week.
:13:50. > :13:53.The 60-year-old woman was diving about a mile off Perth with a man
:13:54. > :13:59.Scientists in the United States are trying to grow human
:14:00. > :14:03.The research uses a pioneering technique known as gene editing,
:14:04. > :14:06.which enables DNA to be altered simply and quickly.
:14:07. > :14:08.Some experts believe animals could provide the answer
:14:09. > :14:15.Our medical correspondent Fergus Walsh has this
:14:16. > :14:24.You are watching two species being mixed.
:14:25. > :14:29.Human stem cells are being injected into a one-day old pig embryo.
:14:30. > :14:32.You can see them travelling down the tube.
:14:33. > :14:34.This biologist in California is trying to grow a human
:14:35. > :14:42.Our hope is that this pig embryo will develop normally,
:14:43. > :14:49.but the pancreas will be made up almost exclusively of human cells.
:14:50. > :14:51.So then that pancreas could be compatible with a patient
:14:52. > :14:58.The technique is known as gene editing.
:14:59. > :15:00.It uses molecular scissors to delete the DNA instructions in the pig
:15:01. > :15:08.The ambition is the human cells will fill the void and grow
:15:09. > :15:15.The same technique might enable other organs to be
:15:16. > :15:22.The BBC's Panorama was allowed to film the sows that
:15:23. > :15:28.were pregnant with human-pig embryos known as chimeras.
:15:29. > :15:32.If human stem cells were taken from a patient, the transplant
:15:33. > :15:36.organs could be tissue matched, reducing the risk of rejection.
:15:37. > :15:40.This research raises profound ethical concerns,
:15:41. > :15:41.crucially, just how human are the piglets
:15:42. > :15:49.It's such a sensitive area that the chimeric embryos will not
:15:50. > :15:53.be permitted to go to term, but be removed for tissue analysis
:15:54. > :15:56.after 28 days gestation, when they are about a centimetre
:15:57. > :16:02.Crucially, they will check whether the pig's developing brain
:16:03. > :16:08.Another pioneer in this field told me this question
:16:09. > :16:16.With every organ that we try to make, the kidney, liver or lung,
:16:17. > :16:24.we will look at what is happening in the brain.
:16:25. > :16:27.And if we find that it is too humanlike, we won't let those
:16:28. > :16:31.But organisations campaigning for an end to factory farming
:16:32. > :16:33.are dismayed by the thought of organ farms.
:16:34. > :16:36.I'm nervous about opening up a new source of animal suffering.
:16:37. > :16:40.Let's first get many more people to donate organs.
:16:41. > :16:42.If there is still a shortage, we could consider using pigs,
:16:43. > :16:46.but on the basis that we eat less meat, so that there is no overall
:16:47. > :16:52.increase in the number of pigs being used for human purposes.
:16:53. > :16:55.7,000 people in the UK are on the transplant waiting list
:16:56. > :17:01.and hundreds die each year before a donor can be found.
:17:02. > :17:03.But patient trials involving gene edited pig organs
:17:04. > :17:12.And you can see more about this on Panorama tomorrow night
:17:13. > :17:18.With all the sport, here's Karthi Gnanasegaram
:17:19. > :17:25.World number two Andy Murray admitted that he's very disappointed
:17:26. > :17:29.after losing today's French Open final to Novak Djokovic but feels
:17:30. > :17:33.he played some of his best clay court tennis during the tournament.
:17:34. > :17:36.Instead of Murray making history today, it was Djokovic,
:17:37. > :17:39.who has become only the third man to hold all four Grand Slam
:17:40. > :17:56.So, would a gloomy Sunday in Paris prove another date with destiny?
:17:57. > :17:59.More than 80 years after a British man last Here, the Andy Murray fan
:18:00. > :18:06.club were hoping once again for history. The only problem was, so
:18:07. > :18:10.was his opponent. His nemesis, Novak Djokovic, aiming for a full set of
:18:11. > :18:17.grand slams. With that pressure weighing on him, it was Murray that
:18:18. > :18:23.roared out of the box. That is Murray at his best. Djokovic looked
:18:24. > :18:27.rattled. After one line call, he lost his composure and duly lost the
:18:28. > :18:32.first set, Murray seemingly in control. But not for long. At last,
:18:33. > :18:37.Djokovic stirred, and in what style, as he raced to the second set. The
:18:38. > :18:43.world number one was now playing like it and, as Murray's form faded,
:18:44. > :18:50.Djokovic's hit dizzying heights. He reeled off the next two sets and his
:18:51. > :18:55.reward was sporting greatness. The last gap on his CV had been finally
:18:56. > :18:58.and a gloriously filled, while Murray could only rue what might
:18:59. > :19:04.have been. I didn't serve particularly well. That can be a
:19:05. > :19:08.factor against one of the best returners. I am sure there were a
:19:09. > :19:13.few other things I could have done a bit better. But he definitely raised
:19:14. > :19:18.his game as well and deserved to win. Disappointment for Murray and
:19:19. > :19:22.his fans, but they know they have witnessed something very special
:19:23. > :19:30.indeed, from a now who now rules his sport like few others. Not since Rod
:19:31. > :19:33.Labour in 1969 has one man held all four micrograms slams. For this
:19:34. > :19:37.seemingly unstoppable player, a quite unforgettable day.
:19:38. > :19:41.Wales have been defeated by Sweden in their one and only warm up match
:19:42. > :19:43.before the European Championship starts on Friday.
:19:44. > :19:45.Sweden were 3-0 winners over Wales in Stockholm.
:19:46. > :19:49.Emil Forsberg scored their first goal just before half time.
:19:50. > :19:53.Even a second half appearance by Gareth Balecouldn't inspire Wales
:19:54. > :19:56.to score while their defence let in two goals after the break.
:19:57. > :19:58.Their first game in the European Championship
:19:59. > :20:04.Great Britain's Becky Downie has won a gold medal
:20:05. > :20:06.in the uneven bars discipline at the European Gymnastics
:20:07. > :20:14.Downie was crowned European Champion for the second time in her
:20:15. > :20:17.Her younger sister, Ellie, claimed two silver medals
:20:18. > :20:20.on the vault and floor on the final day of the competition.
:20:21. > :20:22.Great Britain's women have won four medals in total
:20:23. > :20:26.Athletics, and with exactly two months to go until the Rio Olympics
:20:27. > :20:30.begin, double Olympic and world champion Mo Farah has broken the 34
:20:31. > :20:32.year old British three thousand metres record
:20:33. > :20:38.Farrah is now the national record holder at 1500 metres,
:20:39. > :20:43.2 miles, 3000, 5000 and 10000 metres.
:20:44. > :20:46.But the Olympic long jump champion Greg Rutherford finished in fifth
:20:47. > :20:49.place in Birmingham today as his unbeaten run in 2016 came
:20:50. > :20:56.That is all from the BBC Sport Centre.
:20:57. > :21:03.On this day in 1975, Britain was voting in the first
:21:04. > :21:05.European referendum, on membership of what was then the
:21:06. > :21:13.Our world affairs editor, John Simpson, reported on that
:21:14. > :21:18.referendum and looks now at how the campaigns then and now compare.
:21:19. > :21:25.Sometimes, 41 years on, it feels awfully like Groundhog Day.
:21:26. > :21:28.The same passionate certainty from some people, the same
:21:29. > :21:35.Many of the same arguments, too - though some of the issues
:21:36. > :21:47.Immigration barely surfaced as an issue in 1975.
:21:48. > :21:51.41,000 more people left Britain than came to it that year.
:21:52. > :22:00.We've been in the common market now for two and a half years.
:22:01. > :22:05.We had the three-day week only a year before.
:22:06. > :22:11.Europe was far richer and more successful.
:22:12. > :22:15.At the time, Lord Hannay was a senior diplomat who played
:22:16. > :22:20.an important part renegotiating Britain's new terms of membership.
:22:21. > :22:22.I would, myself, say that the differences are even more
:22:23. > :22:28.For example, I think the whole tone of politics has got a bit
:22:29. > :22:33.There seems to be pretty well no boundaries beyond which you cannot
:22:34. > :22:42.It's become far too much like Have I Got News For You.
:22:43. > :22:48.It's true, people still trusted politics and politicians then.
:22:49. > :22:53.1975 seems like today turned upside down.
:22:54. > :22:57.It was the Labour Party which was bitterly divided over Europe.
:22:58. > :23:00.That is why Harold Wilson, as Labour Prime Minister,
:23:01. > :23:06.The Tories were enthusiastically in favour of staying in Europe,
:23:07. > :23:12.including Margaret Thatcher, their brand-new leader.
:23:13. > :23:16.41 years on, the tone of the debate seems a lot more bitter now,
:23:17. > :23:21.a lot nastier and more personal than it did back in 1975.
:23:22. > :23:24.Partly, of course, because of the way politics
:23:25. > :23:28.But it's also because of the way the press is now reporting
:23:29. > :23:36.This is typical of how the newspapers represented the campaign.
:23:37. > :23:40.Dr Robert Saunders is an historian of the '75 referendum.
:23:41. > :23:43.In those days, only two lone newspapers -
:23:44. > :23:45.the communist Morning Star and The Spectator -
:23:46. > :23:52.Newspapers like The Sun, The Express, the Daily Mail,
:23:53. > :23:54.which today are, to varying degrees, Eurosceptic, in 1975,
:23:55. > :24:00.all of those newspapers campaigned enthusiastically to stay in.
:24:01. > :24:04.So, given that this is a period in which newspaper readership
:24:05. > :24:07.in Britain was extremely high, I think that the message coming
:24:08. > :24:10.from the media was very much on one side of the argument.
:24:11. > :24:13.In 1975, the fact that the press and the main political parties
:24:14. > :24:16.were all in favour of Europe helped to ensure a massive
:24:17. > :24:25.Today, the outcome is a lot less clear.
:24:26. > :24:37.What does seem clear is that referendums rarely sort
:24:38. > :24:40.That's all from me, stay with us on BBC One -