:00:00. > :00:08.Donald Trump and Hillary Clinton, prepare for possibly the most
:00:09. > :00:13.acrimonious Presidential debate in television history.
:00:14. > :00:16.The candidates face off, amid lurid allegations from both camps,
:00:17. > :00:26.Mr Trump says he'll be fight back, despite senior Republicans
:00:27. > :00:35.urging him to quit, over past lewd and sexist comments.
:00:36. > :00:37.Saudi Arabia says it will investigate the airstrike
:00:38. > :00:45.on a funeral ceremony in Yemen, that killed more than 140 people.
:00:46. > :00:47.Scientists says it's a potential "game changer" in cancer treatment,
:00:48. > :00:54.And, a bad start for Lewis Hamilton in Japan badly hits his hopes
:00:55. > :01:20.In the race for the White House, Donald Trump and Hillary Clinton
:01:21. > :01:22.are making final preparations for a televised debate tonight,
:01:23. > :01:25.amid lurid allegations from both campaigns, over the treatment
:01:26. > :01:29.of women.Several senior members of the Republican Party,
:01:30. > :01:33.have urged Mr Trump to stand down as candidate, after being heard
:01:34. > :01:37.on tape making lewd remarks about women in 2005.
:01:38. > :01:40.But he says he won't quit, and is threatening to raise
:01:41. > :01:42.questions about Bill Clinton's sexual history in tonight's
:01:43. > :01:54.Here's our Washington Correspondent, Laura Bicker.
:01:55. > :01:57.Donald Trump's supporters are as defiant as the man himself.
:01:58. > :01:59.As they gathered for this brief glimpse outside Trump Towers,
:02:00. > :02:02.it was clear he is still the choice to be president.
:02:03. > :02:15.As ever, Mr Trump used Twitter to reinforce that message.
:02:16. > :02:19.The media and establishment want me out of the race a badly, he wrote.
:02:20. > :02:22.I will never drop out of the race, I will never let my supporters down.
:02:23. > :02:25.In a later Twitter storm, he tried to turn the tables
:02:26. > :02:30.on the Clinton campaign and published this, a link
:02:31. > :02:33.to an interview of a woman who made an historic rape allegation
:02:34. > :02:42.Clinton's spokesman denied this 17 years ago and the accusation has
:02:43. > :02:52.16 Republican senators have withdrawn support for the party's
:02:53. > :02:58.handed it since the video was published full peers heard bragging
:02:59. > :03:02.about kissing and groping women. You can do anything. Just hours before
:03:03. > :03:07.the debate can his campaign team is trying to show some contrition. He
:03:08. > :03:12.is ashamed of himself and embarrassed. He is the father of two
:03:13. > :03:18.daughters and he has eight grandchildren. I think three of them
:03:19. > :03:23.are girls. He wouldn't want them to hear that all see that and some of
:03:24. > :03:28.them have now. Donald Trump has always proved to be a polarising
:03:29. > :03:33.figure and his sexual boasts not putting off all his voters.
:03:34. > :03:37.Everybody has flaws and things they do that are inappropriate. That
:03:38. > :03:43.doesn't mean he can't be president. I compared JFK, Bill Clinton in the
:03:44. > :03:48.past and they have loved women. Women are attracted to power.
:03:49. > :03:50.It won't just be Donald Trump facing
:03:51. > :03:53.Hillary Clinton might be asked about her e-mails or her husband's
:03:54. > :03:56.past but never has the pressure being greater than on Donald Trump
:03:57. > :03:59.and if he fails this test it could be a fatal
:04:00. > :04:03.Our North America Editor Jon Sopel is in St Louis, where that
:04:04. > :04:15.One wonders how low this debate could go tonight. If the Donald
:04:16. > :04:20.Trump tweets are anything to go by, very low. I think it will be quite
:04:21. > :04:24.shocking. I think there will be a huge amount of mud being slang. The
:04:25. > :04:29.strategy from Donald Trump is, you might not think much of me but Bill
:04:30. > :04:32.Clinton is even worse. It is very unclear from the polls were people
:04:33. > :04:36.are that concerned about what happened with Bill Clinton. It's a
:04:37. > :04:41.long time ago and he is not running for president. What we have also
:04:42. > :04:48.seen today as senior Republicans running for the hills. They were due
:04:49. > :04:50.to appear on morning shows and many have pulled out, not wanting to
:04:51. > :04:54.support Donald Trump. Donald Trump has tweeted saying, they are being
:04:55. > :04:59.called self-righteous hypocrites. What we have seen is a yawning chasm
:05:00. > :05:04.between the Republican leadership and the grassroots, many of whom we
:05:05. > :05:08.heard in that report saying they still support Donald Trump.
:05:09. > :05:12.Increasingly, unless something dramatically changes, you will see
:05:13. > :05:16.Donald Trump virtually campaigning as an independent from the rest of
:05:17. > :05:20.the Republican party. This party is in turmoil.
:05:21. > :05:22.And you can watch the debate between Donald Trump
:05:23. > :05:24.and Hillary Clinton live overnight here on BBC One, and
:05:25. > :05:32.The UN says more than 140 people have been killed,
:05:33. > :05:35.in an air strike on a funeral ceremony in Yemen.
:05:36. > :05:38.Saudi Arabia described the attack in the capital Sanaa,
:05:39. > :05:43.as a "regrettable event" and said it would investigate A Saudi-led
:05:44. > :05:46.coalition of Arab countries has been engaged in air strikes in Yemen
:05:47. > :06:04.Dense black smoke billows from what was a funeral hole, packed with
:06:05. > :06:12.civilians. -- Hall. Some survivors can be glimpsed trying to escape
:06:13. > :06:18.from the wreckage. Then this. A second strike on the wounded. This
:06:19. > :06:27.amateur video appears to show how the funeral of one man became the
:06:28. > :06:30.slaughter of many. Here the aftermath of the carnage and the
:06:31. > :06:40.rush to find the wounded and the dead. Minutes earlier they had been
:06:41. > :06:45.mourning the father of a Huthi rebel official. We came here after the
:06:46. > :06:49.first hit happened. While we are trying to help the survivors and get
:06:50. > :06:54.the people out, the second hit happened. It created a massacre. The
:06:55. > :07:00.Foreign Office said the images from the scene were shocking and Defence
:07:01. > :07:03.Secretary Michael Fallon said, if civilians were deliberately
:07:04. > :07:09.targeted, Britain would review its criteria for selling arms to Saudi
:07:10. > :07:15.Arabia. The conflict in Yemen escalated in September 2014 when the
:07:16. > :07:24.Huthi rebels, allied with Iran, seized control of the capital,
:07:25. > :07:33.Sanaa. In March 2015 the Saudis began a campaign of air strikes
:07:34. > :07:38.against the Huthis. 4000 civilians have been killed since then. Saudi
:07:39. > :07:42.Arabia has promised to investigate the latest strike, having initially
:07:43. > :07:48.denied involvement. It says its troops have clear
:07:49. > :07:53.instructions not to bomb populated areas. The White House has begun an
:07:54. > :07:54.immediate review of its support for the Saudi coalition, which has
:07:55. > :07:58.already been cut back. The Government has ruled out forcing
:07:59. > :08:01.British firms, to reveal how many Ministers say the data
:08:02. > :08:04.will still be collected, but not made public.The proposal,
:08:05. > :08:11.unveiled at the Conservative Party Conference, was criticised
:08:12. > :08:12.by business groups. Our Political Correspondent Carole
:08:13. > :08:21.Walker has the latest. Tackling immigration was a key theme
:08:22. > :08:26.at the Home Secretary's beach to the party conference. She seized the
:08:27. > :08:29.headlines with new measures, including a consultation on tighter
:08:30. > :08:34.rules for companies who recruit from abroad. I want us to look again at
:08:35. > :08:38.whether our immigration system provides the right incentives for
:08:39. > :08:43.businesses to invest in British workers. The briefing said the
:08:44. > :08:47.consultation would consider the impact on the local labour force of
:08:48. > :08:51.their foreign recruitment and require employers to be clear about
:08:52. > :08:55.the proportion of their workforce which is international. This
:08:56. > :09:01.morning, ministers denied they had been naming and shaming businesses.
:09:02. > :09:04.We're not going to ask companies to list, the name or identify foreign
:09:05. > :09:09.workers. The position is that companies already have, when in
:09:10. > :09:13.gauge some are from outside the European Union, they already have to
:09:14. > :09:16.go through what is called the resident labour market test and
:09:17. > :09:21.advertise the position in Britain for 28 days and demonstrate there
:09:22. > :09:27.has been no other British applicant. We are looking at whether that is
:09:28. > :09:31.just box ticking. Government says there has been a misunderstanding a
:09:32. > :09:40.U-turn. The Home Office says there was never any attempt to publish
:09:41. > :09:43.this information. A brewing boss was one of those who had lined up to
:09:44. > :09:48.criticise the Government and questioned why it had not explain
:09:49. > :09:55.its plans soon, given the outcry at the original announcement. It is not
:09:56. > :10:00.about a hard or soft Brexit, it is about whether this will be open or
:10:01. > :10:03.closed. Saying we will have to name or lift foreign workers is sending
:10:04. > :10:09.out the wrong signals to a country that has been built on being an open
:10:10. > :10:12.economy. The Government is still committed to getting net immigration
:10:13. > :10:16.down to the tens of thousands but their hasty rethink on foreign
:10:17. > :10:19.workers underlined how difficult it is to get the policy right.
:10:20. > :10:22.A new cancer treatment is being described as a potentially
:10:23. > :10:23.revolutionary,after promising results in the treatment
:10:24. > :10:35.Patients who took nivolumab, survived longer than those
:10:36. > :10:39.And a separate study has found that combining the drug with another
:10:40. > :10:42.immuno-therapy drug, shrank four out of ten kidney tumours.
:10:43. > :10:43.Here's our Medical Correspondent Fergus Walsh.
:10:44. > :10:45.Last year, Peter Waite from Hertfordshire was told he had
:10:46. > :10:48.terminal kidney cancer, which had spread to his lungs.
:10:49. > :10:51.He went on a trial and instead of chemotherapy received
:10:52. > :10:54.a combination of two immunotherapy drugs,
:10:55. > :11:01.The drugs shrank his tumours and he suffered few side-effects.
:11:02. > :11:04.He's not cured, but feels very fortunate.
:11:05. > :11:06.Nobody really knows what's in the future,
:11:07. > :11:09.but I can't be any worse off, because I have got something now
:11:10. > :11:16.Immunotherapy drugs work by unmasking cancer cells hiding
:11:17. > :11:23.in the body and priming the immune system to destroy them.
:11:24. > :11:26.Early data from a study of 94 patients with advanced kidney cancer
:11:27. > :11:30.showed using immunotherapy drugs in combination significantly reduced
:11:31. > :11:34.the size of tumours in 40% of patients, compared to 5%
:11:35. > :11:42.But although promising, immunotherapy is not
:11:43. > :11:48.There is no one single magic bullet cure that will work for every type
:11:49. > :11:51.of cancer or for every person, so immunotherapy will work for some
:11:52. > :11:56.patients and, unfortunately, will not work for other patients.
:11:57. > :11:59.What we need is more research to help us figure out who are those
:12:00. > :12:03.patients who will best benefit from it and should be given it,
:12:04. > :12:05.but equally, who may not and what is the other alternative
:12:06. > :12:09.In another trial of more than 350 patients with advanced head and neck
:12:10. > :12:15.cancer, 56% treated with nivolumab were alive after one year, compared
:12:16. > :12:24.The team at the Institute of Cancer Research,
:12:25. > :12:26.and Royal Marsden Hospital, which led the trial,
:12:27. > :12:31.said it was a potential game changer for this difficult to treat cancer.
:12:32. > :12:38.With the day's sport, here's Olly Foster at the BBC Sport Centre.
:12:39. > :12:41.Lewis Hamilton has slipped further behind in Formula One
:12:42. > :12:46.The reigning champion finished third at the Japanese Grand Prix
:12:47. > :12:48.as his teamate Nico Rosberg won the race to stretch
:12:49. > :12:54.Even if Hamilton wins the remaining races this season it may not be
:12:55. > :13:07.Lewis Hamilton could barely hide his disappointment that his title
:13:08. > :13:12.appears to have slipped out of his hands. After victory in Japan, Nico
:13:13. > :13:17.Rosberg only appears that a Japanese to finish second to take the crown
:13:18. > :13:20.for the Hamilton's is slipped away at the start he has struggled to
:13:21. > :13:25.make good getaways all season but would never have imagined he would
:13:26. > :13:30.have won as bad as those as he dropped from second to eighth. The
:13:31. > :13:35.soothing words appeared to helpful. He jumped two places during the
:13:36. > :13:39.opening round of pit stops. In one breathtaking lap, he passed another
:13:40. > :13:44.three castles and he got the best of Sebastian Vettel after his final pit
:13:45. > :13:48.stop and pushed the limits to catch Max Verstappen for the second place
:13:49. > :13:55.was beyond him and, by the looks of things, so is the title. Rosberg's
:13:56. > :13:58.ninth win of the season got Mercedes the constructors championship. A
:13:59. > :14:10.3-point lead over Hamilton is surely a knockout blow.
:14:11. > :14:12.We didn't get the British double we had been
:14:13. > :14:16.final but Andy Murray is the new China Open Champion.
:14:17. > :14:19.He beat Grigor Dimitrov in straight sets for his 5th singles title
:14:20. > :14:22.of the year and the 40th of his career.
:14:23. > :14:25.He can still knock Novak Djokovic off the top of the world rankings
:14:26. > :14:30.Konta's run to the final in Beijing has seen her reach the world top 10.
:14:31. > :14:33.But she was out-classed by the third seed Agneska Radwanska and lost
:14:34. > :14:37.series against England after victory in Dhaka.
:14:38. > :14:46.They had set England 239 for victory and despite some big
:14:47. > :14:48.shots from Adil Rashid and Jake Ball late on,
:14:49. > :14:51.The deciding match is in Chittagong on Wednesday.
:14:52. > :14:54.Wales are playing Georgia in a World Cup qualifier in Cardiff
:14:55. > :15:02.Gareth Bale with his third goal of the campaign.
:15:03. > :15:10.This month marks the 50th anniversary of the Aberfan Disaster.
:15:11. > :15:13.116 children and 28 adults died when a mountain of colliery waste
:15:14. > :15:15.collapsed, and the slurry engulfed the village school.
:15:16. > :15:17.A special concert has been held in commemoration
:15:18. > :15:19.at the Millennium Centre in Cardiff, and our correspondent
:15:20. > :15:34.A Welsh song that has become part of the Aberfan story.
:15:35. > :15:37.Myfanwy was sung by rescuers as they fought to find the children
:15:38. > :15:42.Performed by opera star Bryn Terfel as part of a new choral work
:15:43. > :15:48.116 children and 28 adults were killed when an avalanche
:15:49. > :15:56.of coal waste crashed into classrooms and homes.
:15:57. > :16:09.The concert included poetry and this reading from actor Michael Sheen.
:16:10. > :16:12.One of the most poignant moments came when the names of those
:16:13. > :16:21.Cantata Memoria for the children was composed by Sir Karl Jenkins,
:16:22. > :16:24.who was a young music student when the tragedy happened.
:16:25. > :16:27.Perhaps some will be upset, particularly by the early
:16:28. > :16:33.part, where the names are intoned, for example.
:16:34. > :16:36.But I'd like them to know that it's done with the utmost
:16:37. > :16:41.From darkness, the work moves towards hope and survival.
:16:42. > :16:44.Among those watching were bereaved parents and survivors,
:16:45. > :16:49.including three teachers, who were in the school 50 years ago.
:16:50. > :16:54.Once the names came up, that caught my throat.
:16:55. > :16:57.That really upset us because we could see the faces.
:16:58. > :16:59.Once the names came up, we could see the children's faces.
:17:00. > :17:04.I thought the music was really, really wonderful.
:17:05. > :17:07.Something that everybody will remember and they'll
:17:08. > :17:29.And you can see that concert in full on S4C this evening at 7:30pm.
:17:30. > :17:30.I'll be back with the late news at Ten, but now on BBC1 it's time