:00:00. > :00:00.Scientists hail a "milestone" in understanding what
:00:00. > :00:10.New research gives a near-complete picture of
:00:11. > :00:15.and could lead to fresh methods of treatment.
:00:16. > :00:18.The US Secretary of State insists any peace deal in Syria must include
:00:19. > :00:24.the besieged city of Aleppo, the focus of recent intense fighting.
:00:25. > :00:27.And Government plans to reform tipping, to see more money
:00:28. > :00:52.Scientists say they have a near-perfect picture
:00:53. > :00:55.of the genetic mutations that cause breast cancer.
:00:56. > :00:57.The study, in the journal Nature, has been described as
:00:58. > :01:00.a hugely significant moment in cancer research.
:01:01. > :01:03.It's hoped the analysis could help unlock new ways of treating
:01:04. > :01:10.Here's our Health Correspondent, Dominic Hughes.
:01:11. > :01:13.Enjoying a spot of Bank Holiday Monday gardening, Vanessa Babbage
:01:14. > :01:18.But Vanessa has fought a long, arduous battle
:01:19. > :01:23.After extensive surgery, chemo and radiotherapy, she
:01:24. > :01:27.knows how devastating the disease and its treatment can be.
:01:28. > :01:32.It's actually worse than the cancer itself,
:01:33. > :01:38.because you are constantly ill, so they do try to help you to
:01:39. > :01:45.minimise the side-effects by giving you other drugs to help the nausea
:01:46. > :01:49.and things like that, so the treatment is very, very harsh.
:01:50. > :01:52.Scanners like this one are used to detect and monitor cancerous tumours
:01:53. > :01:59.once they've already developed, but to understand the underlying
:02:00. > :02:01.causes of cancer, scientists have had to go much deeper,
:02:02. > :02:04.to the level of DNA, to try and work out what happens
:02:05. > :02:09.An international team of scientists, led by the Sanger Institute
:02:10. > :02:14.in Cambridge, examined all 3 billion letters in the genetic code of every
:02:15. > :02:21.What they've found has transformed the understanding of what happens
:02:22. > :02:28.Getting a comprehensive collection of information, including the
:02:29. > :02:32.mutations that are causing cancer, tells us something about why that
:02:33. > :02:36.cancer is going wrong, why that cell is turning
:02:37. > :02:39.into a cancerous cell, and if you can understand that,
:02:40. > :02:42.you can understand the causes of the cancer, and then you can
:02:43. > :02:48.This opens up the possibility of much greater individualised
:02:49. > :02:51.treatments for cancer, targeting each of the mutations.
:02:52. > :02:55.That's already happening with some treatments, like the drug
:02:56. > :02:58.Herceptin, but experts believe this could be a big step forward.
:02:59. > :03:00.What this study might achieve is finding
:03:01. > :03:10.better treatments, matching them better to women.
:03:11. > :03:11.By understanding the causes that underline the biology
:03:12. > :03:14.of different types of the disease, we might be able to match better
:03:15. > :03:17.treatments and offer them things that are more likely to work for
:03:18. > :03:21.Back at home, Vanessa Babbage is moving on with her life after
:03:22. > :03:24.cancer, and she is optimistic that science is starting to make real
:03:25. > :03:26.headway in the fight against the disease.
:03:27. > :03:28.It gives people hope, because when people are affected
:03:29. > :03:30.by someone that they love and they have breast cancer,
:03:31. > :03:34.they hope for a better future for other women that are going to be
:03:35. > :03:40.This research has transformed the understanding of cancer,
:03:41. > :03:44.and offers the tantalising prospect it could prevent the disease
:03:45. > :03:52.In talks in Geneva to try to save the ceasefire in Syria,
:03:53. > :03:56.the US Secretary of State John Kerry said foreign powers were "getting
:03:57. > :04:01.There's been a two-month pause in hostilities in the country,
:04:02. > :04:04.but the last ten days have seen an upsurge of violence.
:04:05. > :04:07.Mr Kerry said a renewed ceasefire must include
:04:08. > :04:10.the besieged city of Aleppo, where more than 250 civilians
:04:11. > :04:16.Our correspondent Barbara Plett-Usher has been travelling
:04:17. > :04:23.War has returned to Syria's largest city after two
:04:24. > :04:30.The air strikes on a hospital last week thrust the carnage
:04:31. > :04:33.back into the spotlight, but hundreds of civilians have
:04:34. > :04:36.been killed in the past ten days of fighting.
:04:37. > :04:38.The Syrian military says it is targeting jihadists,
:04:39. > :04:43.But the lines between such groups and other rebels in Aleppo
:04:44. > :04:52.If the cease-fire breaks down here, it may crumble across the country.
:04:53. > :04:54.The crisis triggered emergency meetings in Geneva,
:04:55. > :04:56.the city that's been hosting Syrian peace talks.
:04:57. > :05:01.America's top diplomat came here to try to salvage the truce.
:05:02. > :05:07.We are engaged in an effort with all of the members
:05:08. > :05:11.of the international Syrian Support Group,
:05:12. > :05:17.and with Russia particularly, in an effort to restore that
:05:18. > :05:23.cessation of hostilities in those places where it has been most
:05:24. > :05:31.There is no excuse for not finding, again, a reinvigorating
:05:32. > :05:36.and reinstalling and re-implementing what has been the only strong
:05:37. > :05:39.message the Syrian people have heard from all of us.
:05:40. > :05:44.Mr Kerry is urging Moscow to push its Syrian ally to stop
:05:45. > :05:51.But the most he announced he was a joint agreement agreement
:05:52. > :05:53.to strengthen the monitoring and implementation of the truce.
:05:54. > :05:56.So they are wrestling with a formula to bring quiet back to Aleppo.
:05:57. > :05:59.Are there will be intensive talks involving the Russians
:06:00. > :06:05.Mr Kerry said there should soon be greater clarity about the details of
:06:06. > :06:10.But the bigger question is whether Damascus
:06:11. > :06:12.and Moscow are serious about the UN path to peace,
:06:13. > :06:15.or whether they are using it to make military gains on the ground.
:06:16. > :06:19.Barbara Plett-Usher, BBC News, Geneva.
:06:20. > :06:22.A 36-year-old man has been shot dead during an operation
:06:23. > :06:26.Officers were called to a property near Maidstone last night,
:06:27. > :06:31.The pre-planned operation was connected to the suspected
:06:32. > :06:34.murder of Roy Blackman, who was beaten to death
:06:35. > :06:36.during a burglary at his home last month.
:06:37. > :06:41.The Independent Police Complaints Commission is now investigating.
:06:42. > :06:44.A 21-year-old man has appeared in court accused of planning
:06:45. > :06:46.The government is considering new laws on what happens
:06:47. > :06:50.The proposals include plans for a customer code that would make
:06:51. > :06:52.tipping more transparent and ensure that all tips do go
:06:53. > :06:55.It follows major criticism of some restaurants for failing
:06:56. > :06:57.to pass the money on, as our business correspondent,
:06:58. > :07:03.Unlike some other national restaurant chains,
:07:04. > :07:07.Gourmet Burger Kitchen doesn't apply an automatic service charge,
:07:08. > :07:11.nor does it deduct any administration fees from tips.
:07:12. > :07:14.If the Government has its way, that will be the norm.
:07:15. > :07:17.I think it is only fair that if a customer leaves a tip
:07:18. > :07:20.with the intention of it being given to the staff member,
:07:21. > :07:23.Now, the Business Secretary, Sajid Javid, is proposing that
:07:24. > :07:26.gratuities are passed on in full to service staff.
:07:27. > :07:29.At the same time, he wants restaurants to make it much clearer
:07:30. > :07:35.And he is proposing a new code, but says he will pass legislation
:07:36. > :07:38.if companies continue to withhold tips from staff.
:07:39. > :07:42.It's got to go to the people that you intend it to go to.
:07:43. > :07:46.It also has to be voluntary for good service.
:07:47. > :07:48.That is what everyone wants to see and that is why
:07:49. > :07:53.But some critics say tipping has had its day.
:07:54. > :07:57.I think it is time that we scrapped all forms of service charges
:07:58. > :08:00.and tipping and simply increased waiters' salaries to make
:08:01. > :08:04.The British public feel very uncomfortable when it comes
:08:05. > :08:07.to tipping, they don't know where the money is going to.
:08:08. > :08:09.It is also bizarre, in the 21st century,
:08:10. > :08:12.that we have this weird servile relationship with waiters.
:08:13. > :08:15.The general public are less sure about that.
:08:16. > :08:18.I would like to think it is going to the waiters
:08:19. > :08:20.and waitresses and the cooks and that it is shared
:08:21. > :08:23.equally, but I'm not sure whether it is or not.
:08:24. > :08:26.Everyone who gets tips, it just gets split at the end of the day.
:08:27. > :08:28.I don't think that's fair because I might work
:08:29. > :08:31.The restaurant business is very competitive and margins
:08:32. > :08:36.But if restaurateurs are forced to hand over part or all
:08:37. > :08:39.of the tips their staff get, it may drive some of them
:08:40. > :08:45.Ultimately, it's the dining public who will decide whether and how much
:08:46. > :08:54.An Australian computer scientist has ended years of speculation,
:08:55. > :08:58.saying he is the creator of the controversial
:08:59. > :09:03.Dr Craig Wright, who lives in London,
:09:04. > :09:05.showed the BBC evidence that he launched the currency
:09:06. > :09:09.Dr Wright is believed to hold hundreds of millions of dollars
:09:10. > :09:12.of bitcoins, which are a virtual currency
:09:13. > :09:14.transferred via the internet, and which can be exchanged
:09:15. > :09:18.This exclusive report from our technology correspondent
:09:19. > :09:27.In an office in London, a mystery that has been an intranet
:09:28. > :09:29.obsession for seven years is about to be solved.
:09:30. > :09:35.So you are going to show me that Satoshi Nakamoto is you?
:09:36. > :09:42.If that is true then Dr Craig Wright is the reason there is a new
:09:43. > :09:47.Bitcoin is a currency invented on the Internet and
:09:48. > :09:48.designed to operate outside the control
:09:49. > :09:53.Its value and its reputation has been
:09:54. > :09:58.widely used by criminals has been the world spends.
:09:59. > :10:14.It was back in 2008 that someone calling themselves Satoshi Nakamoto
:10:15. > :10:19.published a paper on the Internet describing a plan for Bitcoins. It
:10:20. > :10:23.was the following year that he introduced the software allowing the
:10:24. > :10:27.currency to take shape. Ever since, Satoshi Nakamoto 's Mac precise
:10:28. > :10:33.identity has been a mystery. Last year there was a speculation about
:10:34. > :10:36.Craig White, a Dutch Craig Wright, an Australian scientist. Now he he
:10:37. > :10:44.has confirmed that he is Satoshi Nakamoto. Some people will believe
:10:45. > :10:47.and some people won't. I don't really care. The evidence published
:10:48. > :10:52.by Dr Wright to prove that he is Satoshi Nakamoto 's been met with
:10:53. > :10:56.some scepticism, but at a Bitcoin conference in New York today, a
:10:57. > :11:01.leading figure said he was convinced. I met with him in London.
:11:02. > :11:08.He fits the kind of person that I was interacting with back in 2010.
:11:09. > :11:13.And he provided some cryptographic proof. It was a private key from the
:11:14. > :11:17.very first Bitcoin. Craig Wright will not reveal how rich Bitcoin has
:11:18. > :11:22.made him, that says he doesn't want to be a figurehead for the currency.
:11:23. > :11:27.I don't want money, I don't want fame or adoration. I just want to be
:11:28. > :11:32.left alone. I'm going to come in front of the camera once, and I will
:11:33. > :11:37.never ever be on the camera ever again. If he is to be believed, he
:11:38. > :11:43.is a modern day Midas, the man who conjured new money out of thin air.
:11:44. > :11:47.It is a remarkable achievement, but having emerged from the shadows,
:11:48. > :11:51.Craig Wright, or Satoshi Nakamoto wants to disappear once more.
:11:52. > :11:54.This Thursday, voters across most of England and Wales will be able go
:11:55. > :11:56.to the polls to elect their Police and Crime Commissioners.
:11:57. > :11:59.PCCs were introduced in 2012, with the aim of making police forces
:12:00. > :12:01.accountable and more responsive to public needs.
:12:02. > :12:05.But voting then suggested widespread apathy for the new role.
:12:06. > :12:07.Our home editor Mark Easton reports from the campaign trail
:12:08. > :12:13.32 million people get the chance to vote for their Police and Crime
:12:14. > :12:15.Commissioner in England and Wales on Thursday.
:12:16. > :12:17.Here in Northamptonshire, three candidates are up for
:12:18. > :12:24.I want to maintain front line policing.
:12:25. > :12:27.The first thing I'll do is reduce the cost
:12:28. > :12:29.of the office of Police and Crime Commissioner.
:12:30. > :12:34.Local people should help decide where police resources
:12:35. > :12:37.The idea behind PCCs is the elected commissioner would be
:12:38. > :12:41.impartial, setting police priorities for all the people, whatever their
:12:42. > :12:49.But there are concerns that candidates should
:12:50. > :12:52.Of the 188 PCC candidates across England and
:12:53. > :13:05.Turn-out last time was a miserable 15%, a little higher in
:13:06. > :13:10.But hopes that the public would start to
:13:11. > :13:14.embrace this new elected official with the power
:13:15. > :13:17.to hire and fire the Chief Constable, well let's say this
:13:18. > :13:21.election could be seen as a referendum on the PCC idea.
:13:22. > :13:32.To be honest, I don't really know what's going on.
:13:33. > :13:34.Do you think people are excited about it?
:13:35. > :13:37.I don't think they are excited about it at all.
:13:38. > :13:44.Their previous PCC, Tory Adam Simmonds, is standing
:13:45. > :13:48.Praised by the Home Secretary for helping cut crime, he was
:13:49. > :13:50.criticised locally for increasing his office budget while the police
:13:51. > :14:01.I spent 30 years in business from a technology point
:14:02. > :14:04.of view, so I want to see body-worn video
:14:05. > :14:07.cameras, the latest technology - that will make the difference.
:14:08. > :14:09.We have lost over 105 police officers in
:14:10. > :14:13.Northamptonshire since 2010 and at the same time
:14:14. > :14:16.crime has doubled over the past two years, so we need a better
:14:17. > :14:22.We have seen over the years that the established political
:14:23. > :14:24.parties have failed to address the problems of
:14:25. > :14:30.Ukip is the party to change that, and so am I.
:14:31. > :14:34.Turnout is likely to be higher this time than last
:14:35. > :14:36.because in many places PCC elections coincide
:14:37. > :14:41.But whatever the local situation, there seems there is
:14:42. > :14:42.plenty of scope for increasing public enthusiasm.
:14:43. > :14:47.Mark Easton, BBC News, Northamptonshire.
:14:48. > :14:50.And finally, Leicester City didn't quite manage it yesterday,
:14:51. > :14:52.but tonight there's another opportunity for them to clinch
:14:53. > :14:56.If Spurs fail to beat Chelsea this evening, Leicester will
:14:57. > :15:00.Andy Swiss is in Leicester, where fans are gathering
:15:01. > :15:09.in pubs around the city to watch the match.
:15:10. > :15:16.Yes, welcome to the local hero pub, just a stone's throw from
:15:17. > :15:21.Leicester's Stadium. Among the fans who will be watching the TV rather
:15:22. > :15:27.nervously tonight is lifelong Leicester supporter Lee job. Thank
:15:28. > :15:32.you for joining us. If Tottenham don't win, Leicester are champions.
:15:33. > :15:36.How confident are you that? It's got to happen tonight, surely. If you'd
:15:37. > :15:41.asked me two days ago, I would have wanted it to happen at Old Trafford
:15:42. > :15:46.yesterday. Let's just get it on and enjoy the rest of the week, and
:15:47. > :15:50.party on to next week. I don't want to go to Chelsea needing points.
:15:51. > :15:53.Let's get it out the way and enjoy Champions League. No one has
:15:54. > :15:59.mentioned that because everyone is so wrapped up in the potential title
:16:00. > :16:04.win. What a story, the Champions League, the whole Leicester story
:16:05. > :16:07.itself... The whole city is either anxious or buzzing. Everyone has
:16:08. > :16:16.different feelings about the situation. Let's get it out the way,
:16:17. > :16:19.take it to Everton and a massive party at the weekend. What would it
:16:20. > :16:21.mean to you to see your beloved Leicester be crowned champions? I
:16:22. > :16:26.don't know if there is a word for it. It needs to be added to the
:16:27. > :16:31.dictionary! I know it is positive, and a million times better than
:16:32. > :16:34.great. It should be a nervous nights a Leicester fans, but could be a
:16:35. > :16:37.very special one.