:00:07. > :00:11.New research gives a near-complete picture of
:00:12. > :00:17.and could lead to fresh methods of treatment.
:00:18. > :00:20.The US Secretary of State insists any peace deal in Syria must include
:00:21. > :00:26.the besieged city of Aleppo, the focus of recent intense fighting.
:00:27. > :00:29.And Government plans to reform tipping, to see more money
:00:30. > :00:54.Scientists say they have a near-perfect picture
:00:55. > :00:57.of the genetic mutations that cause breast cancer.
:00:58. > :00:59.The study, in the journal Nature, has been described as
:01:00. > :01:02.a hugely significant moment in cancer research.
:01:03. > :01:05.It's hoped the analysis could help unlock new ways of treating
:01:06. > :01:12.Here's our Health Correspondent, Dominic Hughes.
:01:13. > :01:15.Enjoying a spot of Bank Holiday Monday gardening, Vanessa Babbage
:01:16. > :01:20.But Vanessa has fought a long, arduous battle
:01:21. > :01:25.After extensive surgery, chemo and radiotherapy, she
:01:26. > :01:29.knows how devastating the disease and its treatment can be.
:01:30. > :01:34.It's actually worse than the cancer itself,
:01:35. > :01:40.because you are constantly ill, so they do try to help you to
:01:41. > :01:47.minimise the side-effects by giving you other drugs to help the nausea
:01:48. > :01:50.and things like that, so the treatment is very, very harsh.
:01:51. > :01:54.Scanners like this one are used to detect and monitor cancerous tumours
:01:55. > :02:01.once they've already developed, but to understand the underlying
:02:02. > :02:03.causes of cancer, scientists have had to go much deeper,
:02:04. > :02:06.to the level of DNA, to try and work out what happens
:02:07. > :02:11.An international team of scientists, led by the Sanger Institute
:02:12. > :02:15.in Cambridge, examined all 3 billion letters in the genetic code of every
:02:16. > :02:23.What they've found has transformed the understanding of what happens
:02:24. > :02:30.Getting a comprehensive collection of information, including the
:02:31. > :02:34.mutations that are causing cancer, tells us something about why that
:02:35. > :02:38.cancer is going wrong, why that cell is turning
:02:39. > :02:40.into a cancerous cell, and if you can understand that,
:02:41. > :02:44.you can understand the causes of the cancer, and then you can
:02:45. > :02:50.This opens up the possibility of much greater individualised
:02:51. > :02:53.treatments for cancer, targeting each of the mutations.
:02:54. > :02:57.That's already happening with some treatments, like the drug
:02:58. > :02:59.Herceptin, but experts believe this could be a big step forward.
:03:00. > :03:01.What this study might achieve is finding
:03:02. > :03:12.better treatments, matching them better to women.
:03:13. > :03:13.By understanding the causes that underline the biology
:03:14. > :03:16.of different types of the disease, we might be able to match better
:03:17. > :03:19.treatments and offer them things that are more likely to work for
:03:20. > :03:23.Back at home, Vanessa Babbage is moving on with her life after
:03:24. > :03:26.cancer, and she is optimistic that science is starting to make real
:03:27. > :03:28.headway in the fight against the disease.
:03:29. > :03:30.It gives people hope, because when people are affected
:03:31. > :03:32.by someone that they love and they have breast cancer,
:03:33. > :03:36.they hope for a better future for other women that are going to be
:03:37. > :03:42.This research has transformed the understanding of cancer,
:03:43. > :03:45.and offers the tantalising prospect it could prevent the disease
:03:46. > :03:54.In talks in Geneva to try to save the ceasefire in Syria,
:03:55. > :03:58.the US Secretary of State John Kerry said foreign powers were "getting
:03:59. > :04:03.There's been a two-month pause in hostilities in the country,
:04:04. > :04:06.but the last ten days have seen an upsurge of violence.
:04:07. > :04:09.Mr Kerry said a renewed ceasefire must include
:04:10. > :04:11.the besieged city of Aleppo, where more than 250 civilians
:04:12. > :04:18.Our correspondent Barbara Plett-Usher has been travelling
:04:19. > :04:25.War has returned to Syria's largest city after two
:04:26. > :04:32.The air strikes on a hospital last week thrust the carnage
:04:33. > :04:34.back into the spotlight, but hundreds of civilians have
:04:35. > :04:38.been killed in the past ten days of fighting.
:04:39. > :04:40.The Syrian military says it is targeting jihadists,
:04:41. > :04:45.But the lines between such groups and other rebels in Aleppo
:04:46. > :04:54.If the cease-fire breaks down here, it may crumble across the country.
:04:55. > :04:56.The crisis triggered emergency meetings in Geneva,
:04:57. > :04:58.the city that's been hosting Syrian peace talks.
:04:59. > :05:03.America's top diplomat came here to try to salvage the truce.
:05:04. > :05:09.We are engaged in an effort with all of the members
:05:10. > :05:13.of the international Syrian Support Group,
:05:14. > :05:19.and with Russia particularly, in an effort to restore that
:05:20. > :05:25.cessation of hostilities in those places where it has been most
:05:26. > :05:33.There is no excuse for not finding, again, a reinvigorating
:05:34. > :05:38.and reinstalling and re-implementing what has been the only strong
:05:39. > :05:41.message the Syrian people have heard from all of us.
:05:42. > :05:46.Mr Kerry is urging Moscow to push its Syrian ally to stop
:05:47. > :05:53.But the most he announced he was a joint agreement agreement
:05:54. > :05:55.to strengthen the monitoring and implementation of the truce.
:05:56. > :05:58.So they are wrestling with a formula to bring quiet back to Aleppo.
:05:59. > :06:01.Are there will be intensive talks involving the Russians
:06:02. > :06:07.Mr Kerry said there should soon be greater clarity about the details of
:06:08. > :06:11.But the bigger question is whether Damascus
:06:12. > :06:14.and Moscow are serious about the UN path to peace,
:06:15. > :06:17.or whether they are using it to make military gains on the ground.
:06:18. > :06:21.Barbara Plett-Usher, BBC News, Geneva.
:06:22. > :06:24.A 36-year-old man has been shot dead during an operation
:06:25. > :06:28.Officers were called to a property near Maidstone last night,
:06:29. > :06:33.The pre-planned operation was connected to the suspected
:06:34. > :06:35.murder of Roy Blackman, who was beaten to death
:06:36. > :06:38.during a burglary at his home last month.
:06:39. > :06:42.The Independent Police Complaints Commission is now investigating.
:06:43. > :06:46.A 21-year-old man has appeared in court accused of planning
:06:47. > :06:48.The government is considering new laws on what happens
:06:49. > :06:52.The proposals include plans for a customer code that would make
:06:53. > :06:54.tipping more transparent and ensure that all tips do go
:06:55. > :06:57.It follows major criticism of some restaurants for failing
:06:58. > :06:59.to pass the money on, as our business correspondent,
:07:00. > :07:05.Unlike some other national restaurant chains,
:07:06. > :07:08.Gourmet Burger Kitchen doesn't apply an automatic service charge,
:07:09. > :07:12.nor does it deduct any administration fees from tips.
:07:13. > :07:16.If the Government has its way, that will be the norm.
:07:17. > :07:19.I think it is only fair that if a customer leaves a tip
:07:20. > :07:22.with the intention of it being given to the staff member,
:07:23. > :07:25.Now, the Business Secretary, Sajid Javid, is proposing that
:07:26. > :07:28.gratuities are passed on in full to service staff.
:07:29. > :07:31.At the same time, he wants restaurants to make it much clearer
:07:32. > :07:37.And he is proposing a new code, but says he will pass legislation
:07:38. > :07:40.if companies continue to withhold tips from staff.
:07:41. > :07:44.It's got to go to the people that you intend it to go to.
:07:45. > :07:48.It also has to be voluntary for good service.
:07:49. > :07:50.That is what everyone wants to see and that is why
:07:51. > :07:55.But some critics say tipping has had its day.
:07:56. > :07:59.I think it is time that we scrapped all forms of service charges
:08:00. > :08:02.and tipping and simply increased waiters' salaries to make
:08:03. > :08:06.The British public feel very uncomfortable when it comes
:08:07. > :08:09.to tipping, they don't know where the money is going to.
:08:10. > :08:11.It is also bizarre, in the 21st century,
:08:12. > :08:14.that we have this weird servile relationship with waiters.
:08:15. > :08:17.The general public are less sure about that.
:08:18. > :08:20.I would like to think it is going to the waiters
:08:21. > :08:22.and waitresses and the cooks and that it is shared
:08:23. > :08:24.equally, but I'm not sure whether it is or not.
:08:25. > :08:28.Everyone who gets tips, it just gets split at the end of the day.
:08:29. > :08:30.I don't think that's fair because I might work
:08:31. > :08:33.The restaurant business is very competitive and margins
:08:34. > :08:38.But if restaurateurs are forced to hand over part or all
:08:39. > :08:40.of the tips their staff get, it may drive some of them
:08:41. > :08:46.Ultimately, it's the dining public who will decide whether and how much
:08:47. > :08:56.An Australian computer scientist has ended years of speculation,
:08:57. > :08:59.saying he is the creator of the controversial
:09:00. > :09:05.Dr Craig Wright, who lives in London,
:09:06. > :09:07.showed the BBC evidence that he launched the currency
:09:08. > :09:11.Dr Wright is believed to hold hundreds of millions of dollars
:09:12. > :09:13.of bitcoins, which are a virtual currency
:09:14. > :09:16.transferred via the internet, and which can be exchanged
:09:17. > :09:20.This exclusive report from our technology correspondent
:09:21. > :09:29.In an office in London, a mystery that has been an intranet
:09:30. > :09:31.obsession for seven years is about to be solved.
:09:32. > :09:37.So you are going to show me that Satoshi Nakamoto is you?
:09:38. > :09:44.If that is true then Dr Craig Wright is the reason there is a new
:09:45. > :09:48.Bitcoin is a currency invented on the Internet and
:09:49. > :09:50.designed to operate outside the control
:09:51. > :09:55.Its value and its reputation has been
:09:56. > :10:00.widely used by criminals has been the world spends.
:10:01. > :10:15.It was back in 2008 that someone calling themselves Satoshi Nakamoto
:10:16. > :10:20.published a paper on the Internet describing a plan for Bitcoins. It
:10:21. > :10:24.was the following year that he introduced the software allowing the
:10:25. > :10:29.currency to take shape. Ever since, Satoshi Nakamoto 's Mac precise
:10:30. > :10:35.identity has been a mystery. Last year there was a speculation about
:10:36. > :10:38.Craig White, a Dutch Craig Wright, an Australian scientist. Now he he
:10:39. > :10:45.has confirmed that he is Satoshi Nakamoto. Some people will believe
:10:46. > :10:49.and some people won't. I don't really care. The evidence published
:10:50. > :10:54.by Dr Wright to prove that he is Satoshi Nakamoto 's been met with
:10:55. > :10:58.some scepticism, but at a Bitcoin conference in New York today, a
:10:59. > :11:03.leading figure said he was convinced. I met with him in London.
:11:04. > :11:09.He fits the kind of person that I was interacting with back in 2010.
:11:10. > :11:15.And he provided some cryptographic proof. It was a private key from the
:11:16. > :11:18.very first Bitcoin. Craig Wright will not reveal how rich Bitcoin has
:11:19. > :11:23.made him, that says he doesn't want to be a figurehead for the currency.
:11:24. > :11:29.I don't want money, I don't want fame or adoration. I just want to be
:11:30. > :11:34.left alone. I'm going to come in front of the camera once, and I will
:11:35. > :11:39.never ever be on the camera ever again. If he is to be believed, he
:11:40. > :11:45.is a modern day Midas, the man who conjured new money out of thin air.
:11:46. > :11:48.It is a remarkable achievement, but having emerged from the shadows,
:11:49. > :11:53.Craig Wright, or Satoshi Nakamoto wants to disappear once more.
:11:54. > :11:56.This Thursday, voters across most of England and Wales will be able go
:11:57. > :11:58.to the polls to elect their Police and Crime Commissioners.
:11:59. > :12:01.PCCs were introduced in 2012, with the aim of making police forces
:12:02. > :12:02.accountable and more responsive to public needs.
:12:03. > :12:07.But voting then suggested widespread apathy for the new role.
:12:08. > :12:09.Our home editor Mark Easton reports from the campaign trail
:12:10. > :12:15.32 million people get the chance to vote for their Police and Crime
:12:16. > :12:17.Commissioner in England and Wales on Thursday.
:12:18. > :12:19.Here in Northamptonshire, three candidates are up for
:12:20. > :12:26.I want to maintain front line policing.
:12:27. > :12:29.The first thing I'll do is reduce the cost
:12:30. > :12:31.of the office of Police and Crime Commissioner.
:12:32. > :12:35.Local people should help decide where police resources
:12:36. > :12:39.The idea behind PCCs is the elected commissioner would be
:12:40. > :12:43.impartial, setting police priorities for all the people, whatever their
:12:44. > :12:51.But there are concerns that candidates should
:12:52. > :12:55.Of the 188 PCC candidates across England and
:12:56. > :13:07.Turn-out last time was a miserable 15%, a little higher in
:13:08. > :13:12.But hopes that the public would start to
:13:13. > :13:16.embrace this new elected official with the power
:13:17. > :13:19.to hire and fire the Chief Constable, well let's say this
:13:20. > :13:22.election could be seen as a referendum on the PCC idea.
:13:23. > :13:34.To be honest, I don't really know what's going on.
:13:35. > :13:35.Do you think people are excited about it?
:13:36. > :13:39.I don't think they are excited about it at all.
:13:40. > :13:46.Their previous PCC, Tory Adam Simmonds, is standing
:13:47. > :13:50.Praised by the Home Secretary for helping cut crime, he was
:13:51. > :13:52.criticised locally for increasing his office budget while the police
:13:53. > :14:03.I spent 30 years in business from a technology point
:14:04. > :14:06.of view, so I want to see body-worn video
:14:07. > :14:09.cameras, the latest technology - that will make the difference.
:14:10. > :14:11.We have lost over 105 police officers in
:14:12. > :14:14.Northamptonshire since 2010 and at the same time
:14:15. > :14:18.crime has doubled over the past two years, so we need a better
:14:19. > :14:23.We have seen over the years that the established political
:14:24. > :14:26.parties have failed to address the problems of
:14:27. > :14:32.Ukip is the party to change that, and so am I.
:14:33. > :14:36.Turnout is likely to be higher this time than last
:14:37. > :14:38.because in many places PCC elections coincide
:14:39. > :14:42.But whatever the local situation, there seems there is
:14:43. > :14:44.plenty of scope for increasing public enthusiasm.
:14:45. > :14:49.Mark Easton, BBC News, Northamptonshire.
:14:50. > :14:51.And finally, Leicester City didn't quite manage it yesterday,
:14:52. > :14:54.but tonight there's another opportunity for them to clinch
:14:55. > :14:58.If Spurs fail to beat Chelsea this evening, Leicester will
:14:59. > :15:02.Andy Swiss is in Leicester, where fans are gathering
:15:03. > :15:10.in pubs around the city to watch the match.
:15:11. > :15:18.Yes, welcome to the local hero pub, just a stone's throw from
:15:19. > :15:23.Leicester's Stadium. Among the fans who will be watching the TV rather
:15:24. > :15:29.nervously tonight is lifelong Leicester supporter Lee job. Thank
:15:30. > :15:34.you for joining us. If Tottenham don't win, Leicester are champions.
:15:35. > :15:38.How confident are you that? It's got to happen tonight, surely. If you'd
:15:39. > :15:43.asked me two days ago, I would have wanted it to happen at Old Trafford
:15:44. > :15:48.yesterday. Let's just get it on and enjoy the rest of the week, and
:15:49. > :15:52.party on to next week. I don't want to go to Chelsea needing points.
:15:53. > :15:55.Let's get it out the way and enjoy Champions League. No one has
:15:56. > :16:00.mentioned that because everyone is so wrapped up in the potential title
:16:01. > :16:06.win. What a story, the Champions League, the whole Leicester story
:16:07. > :16:09.itself... The whole city is either anxious or buzzing. Everyone has
:16:10. > :16:17.different feelings about the situation. Let's get it out the way,
:16:18. > :16:20.take it to Everton and a massive party at the weekend. What would it
:16:21. > :16:23.mean to you to see your beloved Leicester be crowned champions? I
:16:24. > :16:28.don't know if there is a word for it. It needs to be added to the
:16:29. > :16:32.dictionary! I know it is positive, and a million times better than
:16:33. > :16:35.great. It should be a nervous nights a Leicester fans, but could be a
:16:36. > :16:38.very special one. There's more throughout the evening
:16:39. > :16:40.on the BBC News Channel. Now on BBC One, it's time
:16:41. > :16:44.for the news where you are.