:00:13. > :00:16.tonight, the Cambridge conndction. Why scientists here will be at the
:00:17. > :00:21.forefront for the fight agahnst dementia. At the scene but not
:00:22. > :00:27.guilty. Two men are cleared of a double murder. We'll be herd later
:00:28. > :00:32.in the programme with the b`ttle to beat black grass, a weed hitting
:00:33. > :00:34.crops. And heading for the hills but he will triumph when it comds to man
:00:35. > :00:42.versus horse? First tonight, the Cambridgd
:00:43. > :00:45.scientists leading the new worldwide the Prime Minister called
:00:46. > :00:52.for a "big, bold, global push" And Cambridge is at the heart
:00:53. > :00:58.of that plan. This is what we're looking `t,
:00:59. > :01:00.new research and development effort centred
:01:01. > :01:03.on the University of Cambridge and on the company Medimmund,
:01:04. > :01:07.based just outside the city. Heading this up will be
:01:08. > :01:11.Alzheimer?s Research UK with Today, the charity announced
:01:12. > :01:17.a ?100 million research campaign. I'll be talking to the chief
:01:18. > :01:20.executive in just a moment. But first,
:01:21. > :01:22.Anna Todd reports on the schentific challenge to combat a disease,
:01:23. > :01:29.which affects around 800,000 of us. But 12 years ago she started
:01:30. > :01:38.showing signs of dementia. Now aged 82 she is
:01:39. > :01:42.in a nursing home. Her memory, her dignity,
:01:43. > :01:46.all but gone. It makes you feel
:01:47. > :02:06.absolutely terrible. I used to visit every week
:02:07. > :02:10.but now it is about once a lonth. It is my wife who does most
:02:11. > :02:13.of the talking to her This photo shows the brain
:02:14. > :02:19.of a healthy person. This is that of someone with
:02:20. > :02:23.Alzheimer's, shrinking away from the sides of the skull as the dhsease
:02:24. > :02:28.robs the organ of vital nerve cells. At this Cambridge lab they `re
:02:29. > :02:30.moving away from animal experimentation, instead ushng
:02:31. > :02:35.human stem cells to essenti`lly The news of charity funding to
:02:36. > :02:43.the tune of ?100 million will be What the funding allows us to do is
:02:44. > :02:49.to take that work, build on it and work out in far more
:02:50. > :02:52.detail the mechanisms behind the disease, test how different
:02:53. > :02:55.drugs work and then ask... Initially we were all working
:02:56. > :02:58.on the inherited form of the disease and ask how does it
:02:59. > :03:01.relate to the much more comlon But as Alzheimer's tightens
:03:02. > :03:08.its grip worldwide, some sax My father's mother had dementia
:03:09. > :03:18.although she only lived to `bout 82 and it wasn't as extreme as my
:03:19. > :03:24.mother, but she died 50 years ago. You would have thought something
:03:25. > :03:26.might have happened over The brain,
:03:27. > :03:31.our most inaccessible organ. Alzheimer's Research UK describes
:03:32. > :03:36.it as finding fault in the world's The charity admits it faces
:03:37. > :03:46.a massive challenge. Well a short time ago I spoke to
:03:47. > :03:49.Rebecca Wood, who's Chief Executive of Alzheimer's Research UK,
:03:50. > :03:52.and asked how significant today s Actually it is a significant sum
:03:53. > :03:58.of money, and obviously we still need to raise that money so it is
:03:59. > :04:03.a very significant sum in that way. Straightforwardly,
:04:04. > :04:05.2 million of it will go for a stem cell research centre
:04:06. > :04:09.and on top that we have a ndtwork A significant hub for that hs
:04:10. > :04:15.in Cambridge, so they will receive Also we have all of our norlal grant
:04:16. > :04:22.calls and funding bids and Cambridge has always been good at that
:04:23. > :04:26.as a centre of excellence. We heard
:04:27. > :04:29.in Anna's reports talking about the fact that Paul's grandmother
:04:30. > :04:34.died 50 years ago with dementia He is now caring for his mother
:04:35. > :04:38.yet he feels, and I think m`ny other people would agree, that
:04:39. > :04:42.nothing really significant seems to They relieve the symptoms
:04:43. > :04:51.but he is right in some respects, because actually not
:04:52. > :04:53.a lot seems to have happened from Because it is a complex set
:04:54. > :05:02.of diseases. We know a lot more
:05:03. > :05:05.about the disease but actually that hasn't yet started translathng into
:05:06. > :05:09.patient benefit and that is what we Is one of the reasons because,
:05:10. > :05:15.we have this research ethic and more would go into that,
:05:16. > :05:19.but what we need to do is gdt those pharmaceutical companies taking
:05:20. > :05:24.the risk and investing A lot of this ?100 million will be
:05:25. > :05:32.for a set of drug discovery institutes and that will look at how
:05:33. > :05:37.we can get academics to look at the first part of what we need to know
:05:38. > :05:41.about the disease, to get it to a stage where the drug companhes,
:05:42. > :05:45.where people would have Then we would get the drug company
:05:46. > :05:53.to come in and take that molecule, that potential drug and test it
:05:54. > :05:58.in larger numbers of people. When will patients actually feel
:05:59. > :06:01.the benefit? The challenge is by 2025 to have
:06:02. > :06:05.a disease modifying drug. I think we will see something very
:06:06. > :06:09.different over Two men have this afternoon been
:06:10. > :06:16.cleared of a double murder hn Brahim Haji and Ahmed Ahmed had
:06:17. > :06:21.admitted being at the scene of the shooting on the Fishermead dstate
:06:22. > :06:25.but told a Luton jury that they had They were teenage friends who lost
:06:26. > :06:34.their lives in a row about drugs. 19`year`old Mohammed Abdi F`rahand
:06:35. > :06:39.and Amin Ahmed Ismail, who was 8, The prosecution described it
:06:40. > :06:45.as an execution. This is the chilling 999
:06:46. > :06:50.call that alerted police. There is someone laying
:06:51. > :06:52.in the alleyway. The gunmen, Fuad Awale and his
:06:53. > :07:06.accomplice Abulkadir, were convicted But the prosecution alleged others
:07:07. > :07:15.were actively involved, among them Dutch national
:07:16. > :07:20.Brahim Haji and Ahmed Ahmed. Both men admitted being
:07:21. > :07:22.at the scene on the night of the murders but denied any
:07:23. > :07:27.knowledge of the shootings. The jury accepted their version
:07:28. > :07:29.of events and cleared them I think it is very important, both
:07:30. > :07:36.for the interests of justicd that all five people were brought to
:07:37. > :07:40.account, and also for the f`milies involved to be able to hear the
:07:41. > :07:44.words of those two people and have a full understanding
:07:45. > :07:48.of exactly how their two sons came Three years on,
:07:49. > :07:53.justice has finally run its course. For the victims' families though,
:07:54. > :08:03.it could never heal their p`in. Well, it can scarcely have dscaped
:08:04. > :08:05.your attention that in less than half hour therd's
:08:06. > :08:10.a very important football m`tch If England lose to Uruguay, their
:08:11. > :08:14.World Cup hopes are virtually gone. But with thousands of peopld
:08:15. > :08:17.across the region watching the game in pubs and clubs, the emergency
:08:18. > :08:20.services are taking no chances with Let's join Mike Cartwright who's
:08:21. > :08:39.in a Cambridge pub now. In just a matter of minutes we will
:08:40. > :08:45.have kick`off and in this ptb fans are beginning to filing. Thdy are
:08:46. > :08:51.expecting big numbers here. These fans are hoping for an Engl`nd the
:08:52. > :08:53.authorities across the region, what ever the score, are hoping fans
:08:54. > :08:56.behave themselves. On Saturday night, Italy's second
:08:57. > :08:58.goal and defeat for England. Lose again this evening and England
:08:59. > :09:01.are out. The police prepared in this part of
:09:02. > :09:05.the world for any football dvents. We are all working very closely with
:09:06. > :09:08.Bedfordshire and Hertfordshhre and We are going to be in close contact
:09:09. > :09:13.throughout the evening, making sure we can put the resources
:09:14. > :09:16.where they are most needed `nd we The ambulance service, too, say they
:09:17. > :09:22.are planned for tonight's g`me. Extra crews,
:09:23. > :09:25.extra resources in place, they say. Sometimes
:09:26. > :09:28.around these incidents people enjoy themselves at the match, perhaps
:09:29. > :09:33.they take a bit too much alcohol. Sometimes we see increased violent
:09:34. > :09:36.behaviour which results in hnjuries, but we have extra resources
:09:37. > :09:39.on tonight and we are confident we But in our towns and cities are
:09:40. > :09:45.we really expecting trouble? I would say there will be more
:09:46. > :09:48.trouble in town centres and stuff. In Saint Ives in one
:09:49. > :09:54.of the bars with some friends. So you don't think there
:09:55. > :09:58.will be any trouble? I waited till half time
:09:59. > :10:05.until I went to the pub. I didn't want any trouble
:10:06. > :10:08.if they were losing. And now police are warning tomorrow
:10:09. > :10:10.they will be on watch for people who've been drinking
:10:11. > :10:15.during the match. Four pints tonight, they sax,
:10:16. > :10:17.could put you over the limit It depends on what you had to eat,
:10:18. > :10:20.how you're feeling, Make sure if you're driving early,
:10:21. > :10:25.that you have stopped drinkhng Fans will be hoping that
:10:26. > :10:29.England can deliver tonight. The authorities are hoping that
:10:30. > :10:45.whatever the result, It is interesting is speaking to the
:10:46. > :10:49.bar staff after Saturday. They said there was more despondency than
:10:50. > :10:55.trouble. The police will repeat that message. There was no major flash
:10:56. > :10:58.point but nobody wants trouble or expected. The authorities s`y they
:10:59. > :11:01.have enough police and paraledics to deal with it if it flares up
:11:02. > :11:06.anywhere across the region. And news just in, a lawyer
:11:07. > :11:08.representing the Northampton couple extradited to the United St`tes has
:11:09. > :11:11.told the BBC Paul and Sandr` Dunham The couple were flown to Amdrica
:11:12. > :11:18.last month to face 13 counts of Their lawyer says that
:11:19. > :11:23.after a court hearing today they should be released subject to
:11:24. > :11:32.certain conditions. Now it's over to Stewart and Susie
:11:33. > :11:47.for the rest of the programle. Also coming up:
:11:48. > :11:49.After a cooler few days, Aldx will be here with news of the warmer
:11:50. > :11:56.weekend. And take a look at this. Horses
:11:57. > :11:59.racing men, a 23 mile endur`nce test.
:12:00. > :12:02.A research project costing ?3 million is about to start
:12:03. > :12:04.to protect our wheat and barley harvest.
:12:05. > :12:07.It's being threatened by an old enemy.
:12:08. > :12:14.It's been about for years but experts say it has now built up
:12:15. > :12:17.resistance to the chemicals used by farmers.
:12:18. > :12:21.It's a particular threat to wheat and barley taking nutrients
:12:22. > :12:27.John's family has been farmhng in Suffolk since the 1960s.
:12:28. > :12:31.Today it is purely arable, more than 500 acres in all.
:12:32. > :12:36.The industry is so diverse, there is always something that is throwing
:12:37. > :12:44.At the moment, black grass is the main one.
:12:45. > :12:49.He says that in places 50% of the wheat crop could be lost.
:12:50. > :12:53.You couple with that the fact that cereal prices are
:12:54. > :13:03.Certainly we have seen ?50 per tonne come off the price of wheat.
:13:04. > :13:06.You then add in this and it makes it very margin`l.
:13:07. > :13:08.He says that tighter EU regulations have cut
:13:09. > :13:12.by half the chemicals they can use to control it.
:13:13. > :13:15.A limited number means greater resistance.
:13:16. > :13:17.The one thing experts say is that farmers need
:13:18. > :13:21.Last year, this field was ftll of oilseed rape.
:13:22. > :13:25.This year it is wheat and yet it is one of the worst
:13:26. > :13:29.Those in the agricultural industry say it shows that rotation
:13:30. > :13:35.Few experts know more about black grass than Dr Steve Moss.
:13:36. > :13:40.He has been researching it for over 40 years.
:13:41. > :13:44.Fundamentally black grass h`s evolved a resistance to herbicides.
:13:45. > :13:48.In the same process as bactdria have evolved a resistance to anthbiotics,
:13:49. > :13:52.and in addition there are similarities because there `re no
:13:53. > :13:57.new antibiotics, the same being true for herbicides.
:13:58. > :13:59.There are no new herbicide plans of action.
:14:00. > :14:05.Even using the most sophisthcated pinpoint technology,
:14:06. > :14:13.it does feel, he says, like a battle they are losing.
:14:14. > :14:15.Since the recent elections there's been a lot of talk
:14:16. > :14:18.about voters being disillushoned with politics and feeling that
:14:19. > :14:23.Today officials from the Hotses of Parliament held
:14:24. > :14:30.The idea is to show how polhtics at Westminster actually works.
:14:31. > :14:34.Our political correspondent Andrew Sinclair was there.
:14:35. > :14:37.The organisers said they were pleased with the turnout.
:14:38. > :14:40.30 people came along to the meeting in Norwich to ldarn
:14:41. > :14:45.Some were form local charithes, some were teachers,
:14:46. > :14:50.I have just come out of interest to see how much...
:14:51. > :14:57.Do you think Parliament is out of touch, or seen to be?
:14:58. > :15:01.Yes, I think it probably is a little out of touch but pdrhaps
:15:02. > :15:08.Certainly for kids at a high school it is more difficult.
:15:09. > :15:11.So if we can try to help thdm to understand the process more then
:15:12. > :15:14.I hope this is an effective way to do it.
:15:15. > :15:17.This is a new attempt by Parliament to connect to the public.
:15:18. > :15:21.There is real concern that lore and more people appear to bd
:15:22. > :15:26.I think politics really matters and can make a real difference
:15:27. > :15:32.Unless people are engaged ` if they do not bother to vote then
:15:33. > :15:36.I worry that they do not have a right to complain.
:15:37. > :15:39.He should be at Kettering Hospital getting the splinters taken out
:15:40. > :15:44.of his backside for sitting on the fence so long.
:15:45. > :15:48.This was one of the livelier moments in Parliament yesterday,
:15:49. > :15:51.although hardly anyone was there to witness it.
:15:52. > :15:55.A recent survey found that only 51% of people believe Parliament debates
:15:56. > :16:00.Only 23% believe Parliament encourages
:16:01. > :16:09.In 2010, 92% of voters supported the main Westminster parties.
:16:10. > :16:13.Now, according to opinion polls it is just 75%.
:16:14. > :16:19.of growing public disenchantment with parliament.
:16:20. > :16:23.Many of those who voted UKIP this year say they did so
:16:24. > :16:27.because the Westminster parties all seem the same.
:16:28. > :16:29.It is questionable if anybody will have been won round
:16:30. > :16:34.by this event in Norwich today but it is a sign that the establishment
:16:35. > :16:43.recognises there is a probldm and is trying to fight back.
:16:44. > :16:46.Now, have you ever heard of the Man V Horse marathon?
:16:47. > :16:51.But apparently they have bedn running it for the last 30 xears.
:16:52. > :16:55.Only twice has a man or woman ever won.
:16:56. > :16:58.It's become an annual event attracting
:16:59. > :17:02.And this year Norfolk's four`time World Iron Man Champion Chrhssie
:17:03. > :17:04.Wellington was one of the competitors challenghng
:17:05. > :17:16.Around 500 runners, a 23.6 mile endurance race
:17:17. > :17:24.15 minutes later, the race takes a twist.
:17:25. > :17:30.Energy sapping, exciting, and a little eccentric.
:17:31. > :17:33.It started as a bet between two people about whdther
:17:34. > :17:40.Ten years ago, when I ran it, it was the first time that ` man
:17:41. > :17:45.The bet over a pint was herd, the local.
:17:46. > :17:49.The landlord earwigging a debate which
:17:50. > :17:54.suggested that man was equal to any house over mountainous terr`in.
:17:55. > :17:57.It was put to the test 25 years past, unthl they
:17:58. > :18:03.I have travelled the world `nd have never heard of a race like ht.
:18:04. > :18:06.They do scare you slightly when they come up behind yot
:18:07. > :18:12.What could be more special than running in a beautiful placd
:18:13. > :18:20.And trying to beat people on four legs?!
:18:21. > :18:23.The runners, to be clear the humans, havd the
:18:24. > :18:27.Horses are checked by vets three times and withdrawn
:18:28. > :18:32.This year, again, the bonus of four legs rather than two
:18:33. > :18:37.The first man past the post was from Essex.
:18:38. > :18:40.It feels great to win but I don't think I was really expecting
:18:41. > :18:45.When they came past, they went past really quick.
:18:46. > :18:52.I know Hugh, the first person to ever beat the horse.
:18:53. > :18:58.It was not this year but maxbe I will come back
:18:59. > :19:01.Christie was unrivalled in the women's race,
:19:02. > :19:05.as you would expect from thd world's greatest iron man triathletd.
:19:06. > :19:17.But no match for beasts with greater horsepower.
:19:18. > :19:22.Kick off in Brazil is now jtst about eight minutes away.
:19:23. > :19:25.England play Uruguay in a g`me England can't afford to losd.
:19:26. > :19:28.Luis Suarez is back from injury for Uruguay tonight and
:19:29. > :19:30.if anyone knows about how good he is just ask Norwich City fans.
:19:31. > :19:33.The Liverpool striker has scored ten goals in four games
:19:34. > :19:44.Let's go live to Carrow Road and World Cup Mike.
:19:45. > :19:53.Welcome to this restaurant. 150 votes for England fans. Let's show
:19:54. > :19:57.you some Luis Suarez action. We would not be short years yot can
:19:58. > :20:02.look at it at home. A hat`trick In actual fact, he's scored three
:20:03. > :20:04.hat`trick against Norwich Chty and if anybody knows how good hd is it
:20:05. > :20:06.is the Norwich City fans. In a moment we'll talk to former
:20:07. > :20:09.Norwich City striker Darren Huckerby but before that,
:20:10. > :20:23.let's meet some people who `re This is my collection of football
:20:24. > :20:29.shirts. My aim is to elect ` shirt from each of the 209 differdnt FIFA
:20:30. > :20:41.members. Nick and his collection of 1000 football shirts.
:20:42. > :20:48.He started collecting leagud shirts then national teams. 209 cotntries
:20:49. > :20:54.are affiliated to the full. He is missing just nine from the list
:20:55. > :21:00.including Aruba and Mauritania. It is usually the fact they do not play
:21:01. > :21:02.football very often. They h`ve not got a particularly organised
:21:03. > :21:06.football associations or yot try to contact them and they don't get back
:21:07. > :21:12.to you. Remembered John? He is a regular at the pub and is trying to
:21:13. > :21:17.get this flag seen by the c`meras in Brazil. If he does, he gets nine
:21:18. > :21:23.gallons of there from the l`ndlord. He is hoping to be in Sao P`ulo to
:21:24. > :21:28.make the lookout for the fl`g! Also at the game last night were no it
:21:29. > :21:31.fans. In case you were not watching, Chile one 2`0 and Spain went home.
:21:32. > :21:37.What happens if the worst comes to the worst tonight? This doctor is a
:21:38. > :21:41.mental health specialist in Cambridge. He has come up whth tips
:21:42. > :21:47.about how to say stress fred during the World Cup and quite likds
:21:48. > :21:53.tactics also. Sturridge, thdy moved the site. They are expecting a cross
:21:54. > :21:58.but then he moves and saw the ball will be with sterling. That is as
:21:59. > :22:04.clear as mud. Down Centre, heading into the front. No seriouslx, he
:22:05. > :22:12.says what it with others if you can, do not drink to excess and H accept
:22:13. > :22:14.defeat. Acceptance is a big part of mental health and water tell people
:22:15. > :22:27.is remind them of Martin Luther King. We must accept defeat but
:22:28. > :22:33.never lose hope. Come on, England! So remember what Martin Luther King
:22:34. > :22:42.said. Never lose hope. Come on, England! Darren, 48 goals for
:22:43. > :22:47.Norwich City. Out his youth going to make Luis Suarez is their bdst
:22:48. > :22:52.player. There is no wiki can be fit three weeks after `` way he can be
:22:53. > :22:55.fit to three weeks after a knee operation so somebody needs to kick
:22:56. > :22:58.him in the knee. He could bd one of the best players in the world when
:22:59. > :23:02.he is fit but I cannot see how he can be. The headlines:
:23:03. > :23:07.He does not tend to miss, though. We have got some very good plaxers so
:23:08. > :23:14.hopefully everyone will get behind the team and we can produce a
:23:15. > :23:21.result. `` but he does not need many chances, he does not tend to miss.
:23:22. > :23:27.We need to get the all the `ttacking players but we need storage to get
:23:28. > :23:33.another call in. Put them on the back. He is predicting a dr`w. Do
:23:34. > :23:38.not forget to take a photograph of a two during the game. You can either
:23:39. > :23:45.tweeted to me or e`mail it. `` of what you're up to.
:23:46. > :23:48.I thought he was going to sde why Kim again!
:23:49. > :23:55.Now let's take a look at thd weather.
:23:56. > :24:00.Compared to last in, condithons in Sao Paulo looking pretty good.
:24:01. > :24:04.Cloudy and cool. Pretty ide`l conditions for running around on a
:24:05. > :24:08.football pitch. For some of us today, it was cloudy and cool. We
:24:09. > :24:12.have a weak weather front so cloudy conditions first thing this morning
:24:13. > :24:15.but compared to yesterday, the cloud did break up so we saw some
:24:16. > :24:19.brightness and sunshine, particularly across the southern and
:24:20. > :24:23.western half of the region. We ended the day with bright spells `nd
:24:24. > :24:27.sunshine but some errors of cloudy throughout the night. That doesn't
:24:28. > :24:30.mean that when we collect any clear spells the chance of the order mist
:24:31. > :24:36.patch forming and also it could be cool, eight or 9 degrees. Elsewhere,
:24:37. > :24:42.where we keep the cloud, anxthing that we now ten and 12 Celshus. We
:24:43. > :24:48.start tomorrow with a bit of cloud but also some sunshine. `` `nything
:24:49. > :24:52.between 10 Celsius and 12 Cdlsius. Tomorrow we will have a warler day
:24:53. > :24:57.and where we get the sunshine, likely to be more across thd west
:24:58. > :25:00.and south of the region, temperatures of 22 Celsius hn some
:25:01. > :25:04.places. I am afraid the course again suffers a little bit, with `n
:25:05. > :25:08.onshore breeze. That will mdan it is a little bit cooler around the
:25:09. > :25:11.Norfolk home in Suffolk and Essex coastline. As for the afternoon
:25:12. > :25:17.largely fine words on Fridax spells of sunshine. There will be times
:25:18. > :25:19.where it says little bit cloudy This weather pattern contintes. We
:25:20. > :25:25.stick with high pressure out to the West. We started to get a slate
:25:26. > :25:31.north`westerly wind again. Ht cool things down a touch and agahn,
:25:32. > :25:33.particularly the North Norfolk coast, through the weekend ht will
:25:34. > :25:37.stay a little bit cloudy. Btt mainly dry and there will be sunshhne
:25:38. > :25:42.about. Best of that in the south and west of the region. Here is how it
:25:43. > :25:46.shapes up for the weekend. They are in mind, if you live in North
:25:47. > :25:53.Norfolk, those values will be a bit lower. `` bear in mind. A wdek
:25:54. > :25:57.weather front in Fundy may turn the northern part of the region a little
:25:58. > :26:00.bit cloudier. We start next week fairly settled before it becomes
:26:01. > :26:04.changeable. Some bright weather on the way and a barometer check for
:26:05. > :26:10.you tonight. Thank you very much. That is all
:26:11. > :26:11.from ours. Two minutes! Enjoy the football
:26:12. > :26:14.Goodbye.