:00:00. > :00:00.It's being hailed as a big step forward in the fight
:00:00. > :00:16.?50 million for a new research help in Cambridge. 4000 new homes in
:00:17. > :00:21.Corby, but concerns about the scale of the development. And winter is
:00:22. > :00:23.not finished with that yet. Try me later for a look at the weather
:00:24. > :00:31.ahead. It's being hailed as a big step
:00:32. > :00:34.forward in the fight The University of Cambridge has been
:00:35. > :00:38.chosen as one of five hubs around Britain seeking new ways
:00:39. > :00:40.to diagnose, treat Together, they'll form
:00:41. > :00:44.a Dementia Research Institute thanks to ?250 million
:00:45. > :00:48.of public money. That is another one of my mother
:00:49. > :00:56.with my two cousins. Ian became his mother's carer,
:00:57. > :00:59.Jean, who died aged 85, My mum, she sat in
:01:00. > :01:07.the room, and said, And then, at the time,
:01:08. > :01:12.you thought, crikey, You know, she hadn't
:01:13. > :01:17.got a clue who I was. It's only going to be
:01:18. > :01:19.on the increase. There's estimated 850,000 people in
:01:20. > :01:23.this country who have It's only going to get worse over
:01:24. > :01:28.the next ten, 15 years. These are the new labs,
:01:29. > :01:30.let me show you. At the moment, they're in a state
:01:31. > :01:34.of sort of basic refurb. Now at Cambridge
:01:35. > :01:35.biomedical campus, The site chosen among five
:01:36. > :01:41.in the country My lab works on understanding
:01:42. > :01:44.the basic mechanisms of dementia and finding
:01:45. > :01:46.new treatments. We are making very
:01:47. > :01:48.good progress there. We bring in chemists and,
:01:49. > :01:51.biophysicists, the very best of Cambridge, using state-of-the-art
:01:52. > :01:55.techniques, we are really going to be able to use everything that
:01:56. > :01:58.Cambridge has and its sort of spectrum of excellence
:01:59. > :02:02.and just focus on dementia. And on top of that, we are going
:02:03. > :02:05.to recruit scientists from around the world and we're looking
:02:06. > :02:07.for absolute excellence, world leading scientists
:02:08. > :02:09.to come and join us. On the left, another,
:02:10. > :02:14.shrunk in size after the death The red areas, proteins that have
:02:15. > :02:18.malfunctioned, Teams here working on treatments,
:02:19. > :02:24.the new centre looking more into the causes, one day,
:02:25. > :02:29.they hope to find a cure. The overall Institute's
:02:30. > :02:32.mission is to understand the causes and particularly
:02:33. > :02:35.at the earliest stages, when you are most likely to be able
:02:36. > :02:37.to help people. We're getting about
:02:38. > :02:39.13 million initially, but there is projected
:02:40. > :02:41.more investment. It's to bring in great new
:02:42. > :02:44.scientist, the world's leading and the best, to come
:02:45. > :02:47.and tackle dementia. Ian has seen the devastating
:02:48. > :02:50.effect of dementia. No family should go
:02:51. > :02:52.through what has went through, Any advances in
:02:53. > :03:01.research are welcomed. The charity Alzheimer's Research UK,
:03:02. > :03:03.based in Cambridge, Its Chief Scientific Officer,
:03:04. > :03:08.Dr David Reynolds, I asked him how significant
:03:09. > :03:15.the new hubs were. It's really important because it
:03:16. > :03:18.starts to move the pledge of the previous Government
:03:19. > :03:21.and David Cameron for a global action plan
:03:22. > :03:25.for dementia into reality. And therefore, we can actually start
:03:26. > :03:28.to do that research, get that understanding and bring
:03:29. > :03:32.those medicines to patients. What are you actually hoping will be
:03:33. > :03:36.achieved with these the hubs? Are we talking about
:03:37. > :03:38.better prevention, Most of the research that
:03:39. > :03:43.will happen in the Dementia Research
:03:44. > :03:45.Institute will be understanding the basic mechanisms
:03:46. > :03:47.at the cellular level, so what causes brain cells
:03:48. > :03:51.to die in these diseases. From that, you can
:03:52. > :03:54.lead on to ways to prevent the disease and also treat
:03:55. > :03:58.the disease with medicines. Are you concerned at
:03:59. > :04:00.all about the impact that Brexit might have,
:04:01. > :04:02.given that we don't know yet how movement
:04:03. > :04:04.of people and work permits and that sort of thing
:04:05. > :04:07.might pan out in future? It's really important that dementia
:04:08. > :04:09.remains a priority for the Government after the
:04:10. > :04:13.election, and Brexit may well be something
:04:14. > :04:16.that could have an impact, and we are certainly very
:04:17. > :04:20.concerned about that and are advocating that funding
:04:21. > :04:23.for research, dementia, particularly for us, obviously,
:04:24. > :04:26.is maintained through that. But we don't know what Brexit
:04:27. > :04:29.will mean for research anywhere in the UK at
:04:30. > :04:33.the moment, unfortunately. Of course, we do have a general
:04:34. > :04:36.election coming up. What sort of messages
:04:37. > :04:39.are you hoping to you from the main parties about
:04:40. > :04:41.funding in the future? We are really hoping
:04:42. > :04:44.that the main parties and, ultimately, whoever wins is
:04:45. > :04:47.committed to biomedical research for dementia and more broadly,
:04:48. > :04:51.because this country has a fantastic science base that helps
:04:52. > :04:55.to understand diseases and bring medicines
:04:56. > :04:57.to patients and it is important we don't lose
:04:58. > :04:58.that And how much does this
:04:59. > :05:03.sort of investment help establish Cambridge as a real
:05:04. > :05:06.global scientific centre? Cambridge, as you know,
:05:07. > :05:08.already has a world-leading university, and it is because of
:05:09. > :05:11.those world-leading scientists that Cambridge has been selected
:05:12. > :05:14.as one of the centres. And Cambridge will feed
:05:15. > :05:17.into the rest of the work of the Dementia Research Institute
:05:18. > :05:20.to tackle those big unknown questions that up till now we have
:05:21. > :05:23.struggled to get good answers to, and hopefully the DRI
:05:24. > :05:28.will help crack that. And it feels likea subject we're
:05:29. > :05:31.talking about a lot more these days, Because people understand and are
:05:32. > :05:37.aware of the impact of dementia, either on themselves
:05:38. > :05:40.or their friends and family, it helps get
:05:41. > :05:45.people engaged where they might participate in research,
:05:46. > :05:47.for example, and it helps also to bring in funding
:05:48. > :05:53.to solve the problems. Dr David Reynolds from Alzheimers
:05:54. > :05:58.Research UK speaking earlier. An investigation is underway
:05:59. > :06:02.in Luton after a suspected shooting. Police say there were called
:06:03. > :06:05.at around 3:30pm this afternoon to Whipperley Ring,
:06:06. > :06:08.where a man had been injured. An air ambulance took the man
:06:09. > :06:11.to hospital for treatment. Witnesses are being asked
:06:12. > :06:15.to contact police on 101. Plans have been submitted for a huge
:06:16. > :06:17.extension The project on land
:06:18. > :06:22.to the west of the town would involve more
:06:23. > :06:25.than 4,000 new homes. If approved, it'll also include
:06:26. > :06:28.a secondary and two primary schools, and two local centres with shops
:06:29. > :06:31.and other facilities. There'll be employment opportunities
:06:32. > :06:34.for more than 3,000 people. But residents in neighbouring
:06:35. > :06:39.Rushden say the scheme's too big. If we are not careful,
:06:40. > :06:42.a lot of the local towns Kettering is expanding in this
:06:43. > :06:54.direction, with a warehouse development over there, Corby
:06:55. > :06:56.is expanding in this direction, Desborough is expanding in this
:06:57. > :06:57.direction, or they hope to, so where
:06:58. > :07:02.does it all end? Now to the latest in our profiles
:07:03. > :07:04.of the mayoral candidates He's promised to create a "modular
:07:05. > :07:09.homes" factory in the Fens, building up to 20 homes
:07:10. > :07:12.a day, if he wins. Businessman Peter Dawe is one
:07:13. > :07:15.of seven hopefuls for the job of the county's first devolved
:07:16. > :07:18.mayor, with increased powers over Mousumi Bakshi put Peter Dawe
:07:19. > :07:33.in the mayoral hot-seat. Why should people vote
:07:34. > :07:41.for Peter Dawe, what sets you apart I can see a very big picture,
:07:42. > :07:48.I can see that there are solutions to a lot of the problems
:07:49. > :07:52.in Cambridge, housing and transport, that actually don't need more
:07:53. > :07:57.money than is available. Do you have a big idea,
:07:58. > :08:00.one big vision that you would I believe that we can go
:08:01. > :08:08.to micro cars, In our urban environment, we've got
:08:09. > :08:12.to look at 21st-century solutions. Can you tell us how much money has
:08:13. > :08:15.been put aside Tell us one thing that people
:08:16. > :08:28.might not know about you. I was brought up in a council house,
:08:29. > :08:32.son of a newsagent and I went out delivering newspapers
:08:33. > :08:35.for the family at an early age. I'm coming in with several
:08:36. > :08:41.visions about how to transform local government
:08:42. > :08:46.in Cambridgeshire. I believe that councils
:08:47. > :08:50.have completely lost the plot is bring 21st-century solutions into
:08:51. > :08:57.it. And I can't see how the party
:08:58. > :09:03.political system has got the ability Where is your favourite
:09:04. > :09:09.place to go in Cambridge? I live just outside
:09:10. > :09:13.Ely, I have the most And a sunset, where it's honeyed
:09:14. > :09:20.in the morning, We'll be back with updates
:09:21. > :09:42.during BBC Breakfast from 6:00am. Hello, turning much colder this
:09:43. > :09:47.week. We have had this cold front pushing south, it had cleared now,
:09:48. > :09:51.but behind it, colder but drier air coming down from the Arctic. So
:09:52. > :09:55.clear skies tonight, cold wind blowing, but under this clear skies,
:09:56. > :09:59.temperatures will drop further sharply. Some wintry skies but for
:10:00. > :10:05.most it's right. Around freezing out in the countryside, Frost tonight,
:10:06. > :10:10.damaging for some gardeners. Introduced it, some sunshine, bit of
:10:11. > :10:15.a cold wind blowing, dry from most of the morning but some showers.
:10:16. > :10:19.This could be heavy, somehow, sweet, thunder as well. Temperatures up to
:10:20. > :10:24.nine or ten, but in the wind it will feel colder than that. On Wednesday,
:10:25. > :10:29.more scattered showers, some heavy with some hail mixed in as well.
:10:30. > :10:32.Thursday, warm front drifting down from the north, head of it, still
:10:33. > :10:40.dry. It will bring some cite the warmer air for the end of the week.
:10:41. > :10:46.A slightly frosty Bob Wright start to the morning. Friday, a lot of dry
:10:47. > :10:50.weather, some sunshine around, but hit and miss. Temperatures by this
:10:51. > :10:55.stage looking back-up. As with the ahead into the weekend, Saturday
:10:56. > :11:00.looking dry but for Sunday and Monday some brain, especially on
:11:01. > :11:02.Sunday, maybe every risk for bank audit Monday.
:11:03. > :11:06.some rain. More with the national forecast now.
:11:07. > :11:12.Good evening. It's been turning colder from the north so far today.
:11:13. > :11:15.It's been cold enough for significant snow in northern
:11:16. > :11:19.Scotland. This was mid afternoon. More recently it's been blowing
:11:20. > :11:24.around over the tops of the mountains. Snow in April not
:11:25. > :11:28.necessarily unusual but it's usually unwelcome. The colder air coming in
:11:29. > :11:31.behind the front which clears towards the near continent, opening
:11:32. > :11:36.the floodgates to this Coldstream of air all the way from the Arctic.
:11:37. > :11:40.That cold air increasingly cold air will spread its way across all parts
:11:41. > :11:44.tonight and will be with us tomorrow and Wednesday as well. A cold night
:11:45. > :11:47.ahead of us. A widespread frost developing and further wintry
:11:48. > :11:52.showers. Most in Scotland and the north-east of England too. Cold
:11:53. > :11:55.winds as well. Maybe a few wintry showers in Northern Ireland and
:11:56. > :12:00.Wales, maybe the odd few into the Midlands. Clear skies, windy and
:12:01. > :12:01.cold. Major towns and cities not far from