:00:00. > :00:00.In Look East tonight, the biggest pharmaceuticals hub in Europe.
:00:00. > :00:07.Why AstraZeneca is committed to Cambridge despite
:00:08. > :00:12.Jail for a teenage hacker from Hertfordshire.
:00:13. > :00:16.We ask how he did it and how he got caught.
:00:17. > :00:19.And the risk of a frost tonight with further wintry showers.
:00:20. > :00:33.One of the biggest investments in our region's booming science
:00:34. > :00:35.industry moved a step closer today with the topping out
:00:36. > :00:38.of AstraZeneca's new headquarters in Cambridge.
:00:39. > :00:41.2,000 staff will work there, developing a new generation
:00:42. > :00:45.of life-saving drugs and forging closer ties with the wider
:00:46. > :00:52.There is so much building going on in Cambridge,
:00:53. > :00:56.it's starting to be called CraneBridge.
:00:57. > :01:00.And at the biomedical campus today, it was easy to see why.
:01:01. > :01:02.AstraZeneca topped out its new research centre
:01:03. > :01:08.The concrete frame having been completed, the roof and glass
:01:09. > :01:14.padding will now be installed on the ?500 million building.
:01:15. > :01:16.Right now, we are over 2000 people in over eight
:01:17. > :01:18.sites around Cambridge, so we are very well integrated
:01:19. > :01:22.The plans are to start moving those 2000 people
:01:23. > :01:27.into our fantastic new building, hopefully at the end of 2018.
:01:28. > :01:30.The building will feature open laboratories and glass walls,
:01:31. > :01:33.reflecting the company's collaborative approach.
:01:34. > :01:39.It's already working with scientific neighbours to develop new drugs.
:01:40. > :01:41.It works because we are the scientists, we are the academic
:01:42. > :01:44.clinicians that developed the drugs in the clinic.
:01:45. > :01:47.But we are not the ones making the drugs, and making drugs that
:01:48. > :01:52.So these partnerships, like this one with AstraZeneca,
:01:53. > :01:55.are essential for the progress of cancer medicine.
:01:56. > :01:58.This region has the biggest cluster of drugs firms in Europe,
:01:59. > :02:01.which is why Astra decided to close its old research base in
:02:02. > :02:08.But the scientists inside the posh new building will be under
:02:09. > :02:13.Three years ago, AstraZeneca fought off a takeover bid
:02:14. > :02:19.To have an independent future, Astra needs to dream up
:02:20. > :02:24.new blockbuster drugs in areas such as cancer and respiratory
:02:25. > :02:34.The boss will be keeping a close eye on his scientists.
:02:35. > :02:36.They are here to discover new medicines, that's
:02:37. > :02:40.That's why we are so excited, being surrounded by the LMB,
:02:41. > :02:48.the laboratory of medical biology, the Cancer Research Centre,
:02:49. > :02:50.the University, the Eden Brooke Hospital -
:02:51. > :02:53.The referendum result made no difference to Astra's determination
:02:54. > :03:00.Whether it's successful will be a big test of whether the drugs
:03:01. > :03:08.AstraZenica employs scientists from around the world, so how
:03:09. > :03:13.Earlier, I asked Dr Andy Williams, Vice President of the Cambridge
:03:14. > :03:15.operation, if he's concerned about restrictions on free movement
:03:16. > :03:30.At the moment, we have not seen much effect. The draw of Cambridge is
:03:31. > :03:34.very great, and that is what we see here in the Cambridge area. I do not
:03:35. > :03:38.see any reason why that will not be the case moving forward but we also
:03:39. > :03:42.need to think about our local community and how we bring more
:03:43. > :03:47.people to deliver the benefits of growth in Cambridge. We would like
:03:48. > :03:51.to see a higher skilled local population, improved transport limps
:03:52. > :03:56.from the wider region into Cambridge, so everybody gets the
:03:57. > :04:00.benefit. We have skills from the local community, Europe and the
:04:01. > :04:05.world. How many local jobs will there be? It is hard to say but we
:04:06. > :04:12.found many people and the local area so I would put the number into the
:04:13. > :04:16.hundreds. Within the support services, catering, cleaning, or
:04:17. > :04:20.those jobs which are not seen as directly involved with science, most
:04:21. > :04:24.of not all will be taken by local people. We know that banks and
:04:25. > :04:29.multinationals can relocate at the drop of a hat, so how do we know you
:04:30. > :04:34.are fully committed to a long-term future in Cambridge? It is a huge
:04:35. > :04:40.building. The reality is, we have a huge investment here in Cambridge.
:04:41. > :04:44.The draw of Cambridge are the people already here, the university, the
:04:45. > :04:50.companies around the advocate general culture. It is a great place
:04:51. > :04:54.to be an great place to relocate. A lot of good science, generosity,
:04:55. > :04:59.collaboration, and it is those key collaborations which will keep a
:05:00. > :05:04.safe as long as I can think. Science and economics aside, what will
:05:05. > :05:10.actually be done in the building behind you that will change people's
:05:11. > :05:13.lives? There will be personalised medicines, medicines given the
:05:14. > :05:16.smaller population but have a better chance of working, and will
:05:17. > :05:18.transform the lives of the patients who take them.
:05:19. > :05:21.A man from Hertfordshire has been sentenced to two years in a young
:05:22. > :05:23.offenders institution after pleading guilty to charges
:05:24. > :05:26.As a teenager, Adam Mudd created a computer programme that
:05:27. > :05:28.brought down major networks around the world.
:05:29. > :05:30.It was police effort in this region that stopped him.
:05:31. > :05:35.Our reporter, Waseem Mirza, has been following the case.
:05:36. > :05:38.Well, Clare, this is a story about a 16-year-old
:05:39. > :05:41.from Hertfordshrie who facilitated hacking on an industrial scale.
:05:42. > :05:45.Adam Mudd was 16 when he created a tool in his bedroom which,
:05:46. > :05:48.after successful test attacks, was then sold on the internet
:05:49. > :05:56.In all, this digital weapon was used more than 1.7 million times.
:05:57. > :06:03.One of the victims was the University of Cambridge.
:06:04. > :06:13.The regional crime unit in the Eastern region is the biggest crime
:06:14. > :06:19.unit outside London. We have heavily invested in working with all of the
:06:20. > :06:22.seven forces that we represent and also with the other regional units
:06:23. > :06:26.and the National Crime Agency so we can make a real difference.
:06:27. > :06:29.The Old Bailey heard Mudd made over a third of a million pounds in just
:06:30. > :06:32.18 months by posing as a rent-a-hack in this way.
:06:33. > :06:35.The judge said his offences had caused great and last damage,
:06:36. > :06:38.and what will shock a lot of people is that he was just 17 years
:06:39. > :06:42.Experts say, every day, computer use can be a gateway
:06:43. > :06:54.The is a lot of science that may be an indicator of someone involved in
:06:55. > :06:57.cybercrime that there is an escalation through low-level
:06:58. > :07:01.activities through the more serious offending, and we can see gaming
:07:02. > :07:04.being as a training ground for some of those.
:07:05. > :07:07.Police in our region believe they're closing the net on the web's most
:07:08. > :07:09.serious criminals and making clear that, when hackers cause such
:07:10. > :07:13.widespread damage to businesses, they will face time in prison.
:07:14. > :07:16.The private hire firm Addison Lee is to create 250
:07:17. > :07:21.The taxi company is relocating its call centre to Hampton -
:07:22. > :07:25.The city council welcomed the move, saying low business rates
:07:26. > :07:28.and cheaper officer space were making the city
:07:29. > :07:33.Next to the race to be the first mayor of Cambridgeshire.
:07:34. > :07:36.The new role comes with new powers over housing, transport and growth
:07:37. > :07:41.The Green Party candidate is a disability rights campaigner
:07:42. > :07:45.Our political reporter, Mousumi Bakshi, put Julie Howell
:07:46. > :07:53.I'm Julie Howell, I'm standing for the Green party and we object
:07:54. > :07:56.to the creation of a new post of Mayor, but as this has
:07:57. > :07:58.been forced upon us, as a mayor, I will be
:07:59. > :08:04.Houses, yes, transport, yes, but communities that really work.
:08:05. > :08:08.What's your one big policy area that you will concentrate
:08:09. > :08:14.My first policy area is transport because I really do want to break up
:08:15. > :08:19.I will not be spending money on new roads, for example.
:08:20. > :08:21.I know that many people are calling for new roads,
:08:22. > :08:26.Let's find out what the real issue is here.
:08:27. > :08:29.Because I think that many people will commute using the train once
:08:30. > :08:32.they realise that you can actually work while you travel.
:08:33. > :08:36.What sets you apart from the rest of the candidates?
:08:37. > :08:38.Apart from being female - all the other candidates
:08:39. > :08:44.What sets me apart is they tend to be at county council level,
:08:45. > :08:47.That means I'm so much closer to residents.
:08:48. > :08:49.Can you tell us something unusual, something that people
:08:50. > :08:54.People may not know that I have multiple sclerosis,
:08:55. > :09:00.You may be expecting us all to be politicians with many decades
:09:01. > :09:06.I only entered politics as a politician a year ago, actually.
:09:07. > :09:08.The rest of the time I have been a disability rights
:09:09. > :09:13.Can you tell us how much money has been set aside under
:09:14. > :09:17.the devolution deal for affordable housing in Cambridge?
:09:18. > :09:21.A portion of the money that has been set aside for the devolution deal
:09:22. > :09:25.The reason for that is because we have got a very
:09:26. > :09:28.You may be the mayor for Cambridgeshire,
:09:29. > :09:30.what's your favourite place in Cambridgeshire?
:09:31. > :09:34.You know, I go around Cambridgeshire, I go to Cambridge,
:09:35. > :09:37.but my heart is not in Cambridge, my heart is in Peterborough.
:09:38. > :09:41.Lovely to visit these other places, spent a day in Ely the other day
:09:42. > :09:44.and I love it, it's beautiful, but my heart - my heart
:09:45. > :09:49.Cycling fans are in for a treat this summer as the Tour of Britain
:09:50. > :09:52.Stage six of the mens' race runs between Newmarket
:09:53. > :09:55.And before that, on 7th June, the womens' event starts
:09:56. > :09:58.in Northamptonshire with a stage from Daventry to Kettering.
:09:59. > :10:00.And that's the late news from Look East.
:10:01. > :10:05.We'll leave you with the weather from Alex Dolan.
:10:06. > :10:11.The wintry flavour to our weather will continue for the next couple of
:10:12. > :10:16.days. We have got wintry showers affecting the region. Some of them
:10:17. > :10:20.are heavy, the possibility of hail, sleet and snow. Also temperatures
:10:21. > :10:24.getting down below freezing in some parts of the region. That will mean
:10:25. > :10:29.a widespread frost and the risk of icy patches first thing tomorrow. A
:10:30. > :10:33.brisk northerly wind about will be a feature of our weather tomorrow.
:10:34. > :10:37.Similar weather conditions. This weather feature is close by. We are
:10:38. > :10:41.likely to see sunshine at times. It will feel bitterly cold with that
:10:42. > :10:46.northerly wind and further scattered showers. Any could be heavy with
:10:47. > :10:54.hail or sleet mixed in. It will feel colder now wind. Temperatures around
:10:55. > :10:58.nine Celsius. As the day goes on, those showers are expected to become
:10:59. > :11:03.more isolated and a very cold night follows. After a frosty start to
:11:04. > :11:13.Thursday, Good evening. Another cold night
:11:14. > :11:18.lies ahead after what was a chilly day for swathes of the UK. This is
:11:19. > :11:19.the Highlands of Scotland. 25th of April and lying