:00:00. > :00:15.For the fifth year in a row, a North East health trust
:00:16. > :00:18.has been named the most active in clinical research.
:00:19. > :00:21.Finding the treatments that can save, or transform, our livds.
:00:22. > :00:24.Hundreds of people across the North East Cumbria volunteer
:00:25. > :00:29.People like Pascal Johnston, from Sunderland.
:00:30. > :00:33.He suffers from Muscular Dystrophy, but is helping Newcastle Hospital's
:00:34. > :00:38.It's one of around 500 clinical trials being run
:00:39. > :00:44.by the Trust this year alone, as Jim Knight reports.
:00:45. > :00:47.14-year-old Pascal suffers from muscular dystrophy, a genetic,
:00:48. > :00:54.life-limiting condition that over time will slowly weaken his muscles.
:00:55. > :00:56.When he heard that there was the possibility of being part
:00:57. > :01:01.of a trial, a pioneering pidce of clinical research that one day
:01:02. > :01:03.may help find a cure, Pascal talked it over with his mum
:01:04. > :01:06.and decided he wanted to do anything he could to help.
:01:07. > :01:10.I wasn't too sure what would happen if I had this new drug put hnto me.
:01:11. > :01:27...more about it, so I kind of just thought, well,
:01:28. > :01:34.Pascal's trialling a new colpound which is designed to work
:01:35. > :01:38.like a genetic patch over the missing bits of his DNA.
:01:39. > :01:42.It means he has to come into the RVI every week for an infusion
:01:43. > :01:47.and the research teams are constantly monitoring his progress.
:01:48. > :01:52.Even if at the end of the trial they don't find a cure, at least
:01:53. > :01:57.what they will find is they need to go in a different directhon.
:01:58. > :02:01.Never think of it as being negative.
:02:02. > :02:08.The clinicians and research teams know that without people like Pascal
:02:09. > :02:11.being prepared to put their body on the line like this,
:02:12. > :02:13.new drugs and treatment just wouldn't be found.
:02:14. > :02:16.There are drugs that are often quite expensive.
:02:17. > :02:19.And therefore we need to demonstrate that it has an impact
:02:20. > :02:27.That is the only way to do it, in a systematic way, to be sure that
:02:28. > :02:30.what we are administering is the right thing to do.
:02:31. > :02:37.Medical research can often `ppear to move incredibly slowly.
:02:38. > :02:40.But, over time, the breakthroughs do eventually come.
:02:41. > :02:44.Maybe in the years ahead, thousands of fellow
:02:45. > :02:47.muscular dystrophy sufferers all over the world may one day owe
:02:48. > :02:57.a huge debt of gratitude to one boy from Sunderland.
:02:58. > :02:59.It's been one of the region's longest running sagas.
:03:00. > :03:02.Hundreds of town centre strdets were earmarked for demolition -
:03:03. > :03:08.And that left the Gresham area of Middlesbrough in limbo.
:03:09. > :03:10.Now another plan has been unveiled to regenerate the area.
:03:11. > :03:20.Creating a ready-made film set was never the plan.
:03:21. > :03:23.This is Middlesbrough, the boarded-up streets the backdrop
:03:24. > :03:28.for a riot scene in the TV series George Gently.
:03:29. > :03:33.The semi-derelict landscape was ideal for the film makers.
:03:34. > :03:37.Three years on, much of the area still stands.
:03:38. > :03:41.There was no money to pay for demolition work.
:03:42. > :03:46.There have been talks with the University who have already
:03:47. > :03:50.invested ?250 million in the campus and are interdsted
:03:51. > :03:53.and I think they're talking to developers.
:03:54. > :03:57.Getting a master plan together to get the land together
:03:58. > :04:00.There is progress, but here it has been painfully slow.
:04:01. > :04:03.Middlesbrough Council wanted to knock down 1,500 houses here
:04:04. > :04:07.ten years ago, then came thd recession and the financial crash
:04:08. > :04:12.Eight years after that, only a couple of hundred
:04:13. > :04:20.Teesside University's ambition for more student housing
:04:21. > :04:29.There are ideas about improvement, but it has either
:04:30. > :04:33.not happened or just been slow, because this is not good.
:04:34. > :04:38.I welcome the idea of it being built.
:04:39. > :04:40.I think they were built as good stock
:04:41. > :04:42.and they could be renovated and restored and reused.
:04:43. > :04:47.And they will have better architectural merit than
:04:48. > :04:55.A future at last perhaps for a place once so derelict it was homd
:04:56. > :05:06.It is always quite eerie down here, because you have got
:05:07. > :05:10.so many empty houses across many different streets.
:05:11. > :05:13.Over time, in fact, it has got better as they have gradually
:05:14. > :05:17.If it is to be a student village, it does make sense,
:05:18. > :05:21.as the university is only half a mile or so away.
:05:22. > :05:24.This is still sometime in the future.
:05:25. > :05:26.Middlesbrough Council meets to discuss the next step
:05:27. > :05:38.It's emerged that North Cumbria's two main hospitals lost the medical
:05:39. > :05:44.records of patients more th`n 7 0 times in a four-year period.
:05:45. > :05:48.As a result, 53 patients at the Cumberland Infirmary in Carlisle,
:05:49. > :05:50.and the West Cumberland Hospital in Whitehaven,
:05:51. > :05:53.have had procedures delayed since 2013.
:05:54. > :05:56.But the trust which runs the hospitals says the notes
:05:57. > :05:58.were mislaid during a major modernisation programme,
:05:59. > :06:03.which will lead to an improved service as a whole.
:06:04. > :06:05.Two men have appeared before magistrates in Scarborough,
:06:06. > :06:08.after a 50-year-old man was found dead in the town last Thursday.
:06:09. > :06:11.Richard Walker was discovered in his flat in Princess Strdet.
:06:12. > :06:15.42-year-old Clifford Honeym`n and 39-year-old Andrew Stevenson -
:06:16. > :06:19.both of no fixed address - are accused of his killing.
:06:20. > :06:22.One of the world's richest women is to provide money
:06:23. > :06:24.for the massive potash mine that's expected to be built
:06:25. > :06:27.in the North York Moors National Park.
:06:28. > :06:30.The Australian billionaire Gina Rinehart has said she will put
:06:31. > :06:34.about ?250 million into Sirius Minerals.
:06:35. > :06:38.That's the company behind the mine, which would be near Whitby.
:06:39. > :06:40.The final part of the development was given planning approval
:06:41. > :06:47.in June, with mining expected to begin in 2021.
:06:48. > :06:51.The host towns of next year's Tour de Yorkshire have been unvehled
:06:52. > :06:54.Scarborough is included for the third year running
:06:55. > :06:56.and Harrogate will feature for the first time.
:06:57. > :06:59.Last year's race was enormously successful -
:07:00. > :07:02.it's hoped 2017's will be even bigger.
:07:03. > :07:15.Yorkshire's well and truly on the global cycling map.
:07:16. > :07:18.It started with the hosting of the first stage
:07:19. > :07:23.which led to the creation of the Tour De Yorkshire.
:07:24. > :07:25.Harrogate, a host town of the grand depart
:07:26. > :07:29.will feature in the race for the first time next year.
:07:30. > :07:32.It seems that Harrogate is becoming synonymous
:07:33. > :07:34.with bicycle racing, and that has kept going
:07:35. > :07:37.since the Grand Depart, and I think that
:07:38. > :07:40.the Tour de Yorkshire coming to us either for a start or finish
:07:41. > :07:44.We will fill our hotels and guesthouses, we will make sure
:07:45. > :07:48.that our economy is driven by the Tour de Yorkshire.
:07:49. > :07:50.Harrogate's also hoping to play a major role
:07:51. > :07:52.in another major cycling event in Yorkshire.
:07:53. > :07:59.that the county would host the UCI Road World Championships in 201 .
:08:00. > :08:02.We have said all along, we want to be one of the cycling
:08:03. > :08:04.capitals of the world, and Yorkshire has firmly
:08:05. > :08:08.got its identity clearly stated as a big, big cycling place.
:08:09. > :08:11.Harrogate has got all of the ingredients to play a big
:08:12. > :08:15.role in the World Championships and I think, if they were able to do
:08:16. > :08:18.Meanwhile, Scarborough's also been named as a host town
:08:19. > :08:21.for a start or finish event of the Tour de Yorkshire
:08:22. > :08:25.In 2015, 1.5 million roadside spectators
:08:26. > :08:30.But this year there were two million,
:08:31. > :08:33.and the local economy was boosted by around ?60 million.
:08:34. > :08:35.People have started to plan their holidays around it
:08:36. > :08:39.so we are really excited about it again.
:08:40. > :08:46.Next year's Tour De Yorkshire takes place at the end of April.
:08:47. > :08:48.The other host towns are Bridlington, Tadcaster
:08:49. > :08:57.The exact route will be unveiled in December.
:08:58. > :08:59.In tonight's football, Newcastle are safely through
:09:00. > :09:06.after a 6-0 victory over Preston North End.
:09:07. > :09:12.Preston played most of the game with ten men.
:09:13. > :09:14.See those goals in Look North tomorrow.
:09:15. > :09:18.Gateshead came from behind to earn a point at Guiseley.
:09:19. > :09:20.But York are nine games without a League win now,
:09:21. > :09:26.A lot of half term holiday families are looking
:09:27. > :09:37.I think we can do milder, btt not necessarily sunshine in next couple
:09:38. > :09:39.of days. I will start graphics of days. I will start graphhcs
:09:40. > :09:42.again. Tomorrow will turn milder, of days. I will start graphics
:09:43. > :09:42.again. Tomorrow will turn mhlder, as again. Tomorrow will turn mhlder, as
:09:43. > :09:48.I say. They will come from a I say. They will come from a
:09:49. > :09:54.westerly direction, bringing milder air. We will not have quite so much
:09:55. > :09:58.sunshine as today. As we go through this evening and overnight, the
:09:59. > :10:04.cloud. To spilling from the West. We will see some patchy mist and fog,
:10:05. > :10:05.and perhaps some drizzle in Cumbria by tomorrow morning. Temperatures
:10:06. > :10:10.by tomorrow morning. Temper`tures will be milder than last night,
:10:11. > :10:13.dropping to seven or 8 degrdes. First thing tomorrow morning, there
:10:14. > :10:17.will be a lot of cloud around and some of that drizzly rain, but we
:10:18. > :10:18.will see some sunny spells throughout the afternoon. We
:10:19. > :10:18.will see some sunny spells throughout the afternoon. Wd have a
:10:19. > :10:22.throughout the afternoon. We have a weather front sinking southwards
:10:23. > :10:25.which will bring more in the way of cloud and further outbreaks of rain.
:10:26. > :10:32.A breezy day from the West, and temperatures up to 13 or 14 degrees.
:10:33. > :10:35.Even 15 where we get the sunshine. Into Thursday, we do see a similar
:10:36. > :10:40.picture. We have winds coming from the West, it will bring in a fair
:10:41. > :10:46.amount of cloud again with some spots of rain. We will see some
:10:47. > :10:48.sunshine once again as well. Thursday's temperatures simhlar to
:10:49. > :10:51.Thursday's temperatures similar to today's, 13 or 14 degrees Cdlsius.
:10:52. > :10:55.today's, 13 or 14 degrees Celsius. Towards the weekend, it is ` similar
:10:56. > :11:01.picture, but high pressure is in picture, but high pressure is in
:11:02. > :11:02.charge so we lose the strong winds. I will hand
:11:03. > :11:03.week, it's set to be fine and settled and on the mild side. Nick
:11:04. > :11:12.now has all the national weather. Hello. Autumn is the season of
:11:13. > :11:15.change, most noticeably with those autumn colours on display today in
:11:16. > :11:19.Buckinghamshire, as photographed by one of our weather watchers. Always
:11:20. > :11:21.helps when there is blue sky above. Our weather is always changing
:11:22. > :11:25.regardless of the season. One of those changes is taking place, we
:11:26. > :11:29.are losing last week's Easterly winds and now a westerly wind. That
:11:30. > :11:34.means it's turning milder by day and night but it does mean the return of
:11:35. > :11:39.Atlantic weather fronts, especially to north-western parts of the UK.
:11:40. > :11:42.The reason, high pressure in Germany and low pressure Iceland. Here is
:11:43. > :11:45.the first of those weather fronts for Scotland and Northern Ireland
:11:46. > :11:49.through the night, the first part of tomorrow. There isn't a huge amount
:11:50. > :11:52.of rain associated with this. Could see rain over the hills of northern
:11:53. > :11:56.England and Wales as the night goes on. The odd shower clipping Sussex
:11:57. > :12:00.and Kent. A lot of dry weather for England and Wales. It's mild here,
:12:01. > :12:04.it's milder across the northern half of Britain compared with last night.
:12:05. > :12:06.But the further south you are the closer to that area of high
:12:07. > :12:07.pressure, and we