:00:00. > :00:00.Welcome to BBC Points West with Alex Lovell and David Garmston.
:00:07. > :00:12.The extraordinary research into Alzheimer's.
:00:13. > :00:15.We're in the lab with the very hungry caterpillars helping
:00:16. > :00:20.scientists find the link between sugar and dementia.
:00:21. > :00:28.We feed them sugar rich diets, and their proteins in their blood become
:00:29. > :00:30.damaged. We'll have the latest
:00:31. > :00:37.from the professor in charge. A council writes to a resident
:00:38. > :00:44.to take away her tax reduction The football star who may
:00:45. > :00:52.lose his licence yet again. And happy days for the village
:00:53. > :00:55.which has just received Finding the cause of dementia is one
:00:56. > :01:09.of the most pressing challenges in medical science,
:01:10. > :01:12.and in Bath they could be on to something thanks
:01:13. > :01:16.to the humble caterpillar. They're feeding the creatures
:01:17. > :01:19.with the sort of diet they and most of us enjoy,
:01:20. > :01:22.sugar, and seeing Our health correspondent
:01:23. > :01:30.Matthew Hill reports. This is the newest weapon
:01:31. > :01:34.in the fight against Alzheimer's. For some time, scientists have known
:01:35. > :01:37.that how much sugar we eat So they've enlisted the help
:01:38. > :01:41.of one of the greediest creatures on the planet -
:01:42. > :01:43.this very hungry caterpillar. This is kind of almost
:01:44. > :01:52.the end of the cycle... The clue's in its Latin name -
:01:53. > :01:54.manduca sexta which We are studying these
:01:55. > :01:57.because we are interested in the damage that sugars cause
:01:58. > :02:02.to proteins in the diet. In the colony, we hold
:02:03. > :02:07.all of the stages of the life cycle. So it goes through all the stages
:02:08. > :02:10.but it is the caterpillar stage It's been known for some time that
:02:11. > :02:17.people with Type 2 diabetes are far It's thought that's because glucose
:02:18. > :02:24.forms a harmful by-product in their blood, which makes it
:02:25. > :02:28.harder to kill the abnormal proteins known as plaques and tangels,
:02:29. > :02:31.which form in the brain. The same team of scientists in Bath
:02:32. > :02:34.have already developed a technique using a flourescent light
:02:35. > :02:36.to discover the tell-tale It's called glycation where sugar
:02:37. > :02:42.attaches to proteins Scientists think a substance found
:02:43. > :02:49.in berries and chocolate, called flavinoids, may
:02:50. > :02:53.reduce this glycation. So they are adding these flavenoids
:02:54. > :02:56.to the caterpillar diet to see It's an interesting model system
:02:57. > :03:04.that we're using to test the effects of high sugar on biological
:03:05. > :03:07.function, which we hope will give us a way of testing a mechanism that
:03:08. > :03:10.can be used to screen drugs and interventions to reduce this
:03:11. > :03:13.glycation that we are seeing Yes, these caterpillars like eating
:03:14. > :03:23.sugar, so we can mimic that high-sugar environment
:03:24. > :03:25.that we see in humans. This is the only place in Europe
:03:26. > :03:31.to culture these caterpillars. They evenually transform
:03:32. > :03:33.into a moth, and these pests can One essential ingredient
:03:34. > :03:41.for horn worms is tobacco. They need the smell of it in order
:03:42. > :03:44.to breed and lay eggs. That is why the university
:03:45. > :03:46.have a special licence This research project
:03:47. > :03:52.could take years. But if this greedy caterpillar can
:03:53. > :03:55.shed light on how diet could reduce the chances of Alzheimer's,
:03:56. > :03:57.then we may well have Professor Jean Van Den Elsen is from
:03:58. > :04:06.the university research team. Now, you've not brought any
:04:07. > :04:22.of the hungry caterpillars with you. They need to be contained because
:04:23. > :04:26.they are a pest. Not that we grow any tobacco in this country but they
:04:27. > :04:29.eat potatoes, tomatoes and chilli Peppers.
:04:30. > :04:33.And your fingers? They were having a bite. For people
:04:34. > :04:38.at home, they are thinking this. I can see a headline reading:
:04:39. > :04:48."Berries and chocolate It is the gist of the story but a
:04:49. > :04:55.bit more complicated. We feed them high levels of glucose,
:04:56. > :05:00.we make them diabetic, then we can see similar to what happens in
:05:01. > :05:04.diabetes, we see damage to the proteins in their blood. We are
:05:05. > :05:10.trying to find these molecules and stop that from happening. There is
:05:11. > :05:16.evidence that. Potentially any molecules in coffee, tea, berries
:05:17. > :05:18.and chocolate, red wine, could stop this from happening.
:05:19. > :05:23.The flavonoids we were hearing about.
:05:24. > :05:31.In theory, eating too much sugar could give you diabetes, we know it
:05:32. > :05:34.can, type two. Eating chocolate or drinking red wine might actually
:05:35. > :05:38.prevent it or reverse it? We have to take the sugar out of the
:05:39. > :05:44.chocolate. There is always a catch. There is a
:05:45. > :05:50.clear link between sugar and diabetes, diabetes and Alzheimer's.
:05:51. > :05:55.How sure are you? Population studies have shown people suffering from
:05:56. > :06:00.uncontrolled diabetes type two actually can have a high risk to
:06:01. > :06:05.develop Alzheimer's disease. This can affect everybody whether
:06:06. > :06:13.they are worried about their own health or somebody in there found me
:06:14. > :06:17.-- family. People will look at headlines and think we on our way?
:06:18. > :06:22.How exciting do you feel this research could be?
:06:23. > :06:26.It is a great model system to test these compounds and we really
:06:27. > :06:31.hopeful find something, to use a combination of these southern noise
:06:32. > :06:38.from coffee, tea, chocolate or red wine, to make the right clock tile
:06:39. > :06:42.to stop sugar damage. Sugar seems to be number one enemy,
:06:43. > :06:47.is it a fad or is there real evidence?
:06:48. > :06:51.There is real evidence. Evidence in the lab has shown people suffering
:06:52. > :06:56.from Alzheimer's disease have a changed sugar damaged pattern in
:06:57. > :07:02.their brains, it is clearly linked to high sugar levels in their
:07:03. > :07:06.bloods. So, that is really good evidence.
:07:07. > :07:09.And the caterpillars you take care of them?
:07:10. > :07:14.We look after them. They don't live long enough to
:07:15. > :07:16.develop Alzheimer's disease. Thank you for coming in. Incredible.
:07:17. > :07:19.Thank you. Rail services in the west are likely
:07:20. > :07:22.to remain disrupted for the next two days after a freight train
:07:23. > :07:24.derailed in Somerset. Replacement buses are covering
:07:25. > :07:27.the line between Westbury All local services and journeys
:07:28. > :07:32.from the west to London that use that particular stretch
:07:33. > :07:33.of track are affected. Network Rail is helping
:07:34. > :07:36.with the investigation to find out A new line of inquiry
:07:37. > :07:45.in the Sally Ann John murder case in Wiltshire has come from last
:07:46. > :07:47.night's Crimewatch appeal. On the programme, detectives
:07:48. > :07:49.revealed that a postcard existed, supposedly sent by her
:07:50. > :07:51.after she disappeared The handwriting didn't match
:07:52. > :07:58.Sally Ann's and police believed it They had eight calls, one of
:07:59. > :08:16.which was potentially significant. It will send three weeks before she
:08:17. > :08:24.went missing. We strongly believe it was sent to mislead the league -- to
:08:25. > :08:28.mislead the police. We believe the person who wrote that card was
:08:29. > :08:31.coerced or misled into writing that or the person responsible for her
:08:32. > :08:35.murder. We will never give up for the sake
:08:36. > :08:40.of the family. We keep reviewing our lines of
:08:41. > :08:42.inquiring, identifying new lines. We are hopeful we will get the
:08:43. > :08:45.breakthrough we require. There's a reward of ?25,000
:08:46. > :08:47.for information that leads to a conviction,
:08:48. > :08:48.or the discovery Bristol City's star striker
:08:49. > :08:56.Tammy Abraham could lose his driving On the pitch, the 19-year-old's
:08:57. > :08:59.delighted fans with his But off it, he faces a court summons
:09:00. > :09:07.following an accident close to the club's training ground,
:09:08. > :09:12.as Andrew Plant reports. On loan to Bristol City
:09:13. > :09:14.from Chelsea, Tammy Abraham has already had a big impact
:09:15. > :09:17.on the club, scoring The last of those in a 4-0 home win
:09:18. > :09:26.against Huddersfield on Friday. Quite a day for the 19-year-old,
:09:27. > :09:29.earlier that day pictured with his instructor,
:09:30. > :09:30.after success too He later sent him a signed
:09:31. > :09:38.shirt to say thank you. But it wasn't the first
:09:39. > :09:40.time he had passed. His previous licence had been
:09:41. > :09:42.revoked, under rules that prevent new drivers from racking up more
:09:43. > :09:45.than six points in Now it seems his second full licence
:09:46. > :09:49.could also be under threat. At the end of January,
:09:50. > :09:53.Tammy Abraham was leaving training at the club's facilities here,
:09:54. > :09:55.just outside Bristol, when his car He has since been issued
:09:56. > :10:00.with a summons to attend court and faces allegations of driving
:10:01. > :10:05.without a licence or endurance. It means that Tammy Abraham will
:10:06. > :10:10.need to go to court voluntarily, But those offences can
:10:11. > :10:16.carry penalty points. So if he is ever found guilty
:10:17. > :10:19.of them, he could lose that Andrew Plant, BBC
:10:20. > :10:22.Points West, Bristol. You're watching Points West
:10:23. > :10:29.with David and Alex. The first day of spring but it feels
:10:30. > :10:33.like it. Still to come on this
:10:34. > :10:36.evening's programme. A gritty new movie
:10:37. > :10:41.set in Gloucester. The makers will be with us
:10:42. > :10:45.shortly to explain why And find out what happened
:10:46. > :10:52.when we took a monk to meet A grieving son has branded
:10:53. > :10:59.South Gloucestershire Council "insensitive" after receiving
:11:00. > :11:01.a letter about his mother's The letter was addressed to his mum
:11:02. > :11:09.informing her that she would no longer get a reduction
:11:10. > :11:12.as she'd "passed away." He got in touch with us,
:11:13. > :11:15.as he wants to prevent other families from being treated
:11:16. > :11:17.in the same way. Ada Davies, a much-loved
:11:18. > :11:22.mother and wife. Described at her funeral as someone
:11:23. > :11:25.who didn't mince her words. She died aged 95 on
:11:26. > :11:31.the 27th of February. It's been a difficult time
:11:32. > :11:34.for those closest to her. A time, her son says,
:11:35. > :11:37.made worse on receiving this It was addressed to his mum
:11:38. > :11:44.despite the fact that it explained that her council tax reduction
:11:45. > :11:47.was being cancelled It even invited her to "make
:11:48. > :11:51.a new claim" for a reduction, or to "contact" the office
:11:52. > :11:54.for more information. Another letter has since asked her
:11:55. > :11:57.to pay her council tax We are thinking about our mother
:11:58. > :12:10.all the time then you get letters addressed to her stating she is dead
:12:11. > :12:14.but as if she is alive They can't claim
:12:15. > :12:16.because she has passed. Some other members of the family
:12:17. > :12:35.are quite disgusted with it. If the reason for the reduction is
:12:36. > :12:40.death, don't print, or don't send. To add something like
:12:41. > :12:47.that to their system. If it was a family much more
:12:48. > :12:50.distressed by the death, it could have a major
:12:51. > :12:53.impact on them. Mrs Davies's council tax
:12:54. > :12:55.account has now been closed Christopher's family now hope to put
:12:56. > :13:00.the experience behind them, and to focus on grieving
:13:01. > :13:02.for their mother. A Cheltenham man has been sentenced
:13:03. > :13:10.to almost 25 years in prison after pleading guilty
:13:11. > :13:12.to murdering a teenager. 17-year-old Camran Green
:13:13. > :13:14.was stabbed last October. Steven Sharpe admitted
:13:15. > :13:17.the killing and also Our home affairs correspondent
:13:18. > :13:28.Charlotte Callen reports. 17 years old and under the care
:13:29. > :13:31.of social services, Camran Green Despite having a care team,
:13:32. > :13:42.he was able to travel by train from Birmingham
:13:43. > :13:45.to Cheltenham at weekends. Customers ordered drugs
:13:46. > :13:48.over the phone from him, That's how he met this man,
:13:49. > :13:58.Steven Sharpe, who let him stay On the 2nd of October last year,
:13:59. > :14:03.Sharpe tried to rob Camran He stabbed him with this 14-inch
:14:04. > :14:09.knife, described as a Rambo Police say more young vulnerable
:14:10. > :14:17.people are getting caught up in drug I think it is an indication of
:14:18. > :14:26.the world we live in where lots of communications are by mobile phones
:14:27. > :14:29.and people want things instantly. That's what we're seeing
:14:30. > :14:31.here in the drugs His mum wants to warn young people
:14:32. > :14:37.not to carry knives. She's also upset her son wasn't
:14:38. > :14:41.better looked after. You know, they should have found out
:14:42. > :14:45.where he was going, who he was with, you know, all that
:14:46. > :14:49.a mother would do. These care workers should
:14:50. > :14:51.see him as their child. So I am quite disappointed
:14:52. > :14:53.and annoyed they didn't The judge here today said the murky
:14:54. > :15:03.world of drugs had taken yet another Steven Sharpe was given a life
:15:04. > :15:08.sentence, he will serve at Charlotte Callen, BBC
:15:09. > :15:15.Points West, in Bristol. A new film set in Gloucester
:15:16. > :15:17.will receive its premiere It's the work of two brothers-in-law
:15:18. > :15:21.who were so moved by the number of high-profile stabbings,
:15:22. > :15:23.that they felt the need to show on screen how
:15:24. > :15:27.knife crime ruins lives. And we're pleased to say
:15:28. > :15:30.they've joined us in Let us look at the trailer so we
:15:31. > :16:10.know what we are talking about. MUSIC it gives us an idea but we
:16:11. > :16:17.don't see the story. What can we expect? It is a social
:16:18. > :16:20.responsive film that tackles knife crime, domestic violence, it gives
:16:21. > :16:26.an insight into peer pressure that make decisions and a better
:16:27. > :16:32.understanding. We tag line it as a socially
:16:33. > :16:37.conscious from about how knife crime destroys lives.
:16:38. > :16:41.Have you been able to work out from making the film by young people feel
:16:42. > :16:46.the need to carry a knife? We have done a lot of community
:16:47. > :16:49.conversations with charities that work with young people. There are so
:16:50. > :16:58.many reasons, for protection, through fear. We decided to create
:16:59. > :17:02.this form to tackle those issues. You are showing the consequences. It
:17:03. > :17:06.is big and tough to carry a knife. You have seen what it is like, the
:17:07. > :17:11.repercussions that they couldn't expect.
:17:12. > :17:18.That is right. It is analysing things close to home creating a form
:17:19. > :17:23.that will expand on the knowledge. Where will this film go now? We are
:17:24. > :17:29.hoping to launch it at Gloucester Guildhall on Friday in May. And get
:17:30. > :17:33.national distribution so more people can see the film.
:17:34. > :17:39.Knife crime is a national issue. It is so relevant, talked about day. We
:17:40. > :17:43.were talking about it in Gloucester. Have you had any input from the
:17:44. > :17:49.families of the people that have been affected by this. I'm thinking
:17:50. > :17:57.about Hollie Gazzard and her family. We had a word with Nick, he revealed
:17:58. > :18:00.his heart. And we spoke to a local charity dealing with young people on
:18:01. > :18:06.a regular basis, they gave us insight.
:18:07. > :18:11.You decided to make a film but, as you know, that is an extremely
:18:12. > :18:16.difficult thing to do, to make a watchable film with a message is
:18:17. > :18:21.very hard. What expense have you had before this?
:18:22. > :18:25.Is it a first attempt? We worked on stuff tween us, short films. We
:18:26. > :18:30.decided to make something that was socially responsive, and get into
:18:31. > :18:41.the in-depth reasons. We had an insight of Benjamin
:18:42. > :18:45.Woodward who came on board, and Thomas Sellick Newton, a 23-year-old
:18:46. > :18:50.university lecturer. Have you enjoyed the process?
:18:51. > :18:57.As well as educational, it is entertaining as well.
:18:58. > :18:59.Otherwise it won't engage in the right way.
:19:00. > :19:05.Good luck with it. We look forward to seeing it.
:19:06. > :19:11.Nice to meet you. Now we all dream of what we might do
:19:12. > :19:14.if we were suddenly left But imagine what it would be
:19:15. > :19:18.like if your whole village Well, that's what's happened
:19:19. > :19:22.to the people living in the west They're now having to decide
:19:23. > :19:30.between them how to spend what's being described
:19:31. > :19:33.as a "jaw-dropping legacy." Our Somerset correspondent
:19:34. > :19:40.Clinton Rogers reports. As recreation grounds go,
:19:41. > :19:55.it is already pretty impressive. Now imagine you have nearly
:19:56. > :19:58.three-quarters of a million Something amazing
:19:59. > :20:09.for the kids, maybe. Probably build a swimming
:20:10. > :20:11.pool or something. Because 1,200 letters have been
:20:12. > :20:23.delivered to people living in the area asking for ideas of how
:20:24. > :20:26.to spend the money left to them You know one of the more intriguing
:20:27. > :20:34.things about this story is that very We've not met anyone
:20:35. > :20:37.who knew her well. All we know is that she was in her
:20:38. > :20:43.late 90s when she died in December, and apparently she had
:20:44. > :20:54.no surviving children. And so the bulk of her estate
:20:55. > :20:54.was left to the recreation And can you just imagine
:20:55. > :21:00.the surprise of those in charge when they were told there
:21:01. > :21:03.was a legacy for them. When he came to see me and told me
:21:04. > :21:09.what the amount would be, ?700,000, possibly a little more,
:21:10. > :21:13.it was just jaw-dropping. It'll be several months yet before
:21:14. > :21:15.a final decision is made. Porlock is about to get one
:21:16. > :21:19.of the best recreation Clinton Rogers, BBC
:21:20. > :21:28.Points West, Porlock. It is quite remarkable. A lovely
:21:29. > :21:32.place. A brand new copy of a Georgian
:21:33. > :21:35.recipe book has just been published which sheds new light
:21:36. > :21:38.on what was being cooked It chronicled the day-to-day life
:21:39. > :21:43.at an historic home and was later moved to an abbey in Somerset
:21:44. > :21:46.where monks rediscovered it. We sent Liz Beacon for a taster
:21:47. > :21:49.to see if the recipes In the archives of Downside Abbey
:21:50. > :22:00.there are all sorts of treasures. From 11th century church
:22:01. > :22:02.documents to relics collected But the discovery of a Georgian
:22:03. > :22:10.cookbook has been rather special. There's some recipes
:22:11. > :22:12.for rice pudding. Some chicken, even more
:22:13. > :22:24.adventurous recipes, things with pigs' feet and calves'
:22:25. > :22:27.heads that perhaps we wouldn't have nowadays but are really
:22:28. > :22:29.interesting recipes to have. What is surprising is some
:22:30. > :22:32.of the ingredients mentioned As Father Christopher told me,
:22:33. > :22:41.there are examples of the exotic Bristol was the gateway into England
:22:42. > :22:45.and indeed out of England And so things like sugar coming
:22:46. > :22:53.from the West Indies, and spices coming from the Far East,
:22:54. > :22:56.and this house seems to have taken full advantage of that
:22:57. > :22:58.because there are ingredients The Georgian chicken
:22:59. > :23:10.curry has caught my eye, so I am taking a monk to meet
:23:11. > :23:15.a Michelin-starred chef. What surprised me about this
:23:16. > :23:17.recipe in the 18th century It made reference to three
:23:18. > :23:23.teaspoons of curry powder. What struck me about that was,
:23:24. > :23:25.I was thinking, what is Obviously we have curry powder
:23:26. > :23:30.now that we use but we have It was interesting back then
:23:31. > :23:33.they had these curry Curry powder, stock, onions,
:23:34. > :23:41.chicken and thicken with rice flour. Chef Josh Eggleton is following
:23:42. > :23:49.the recipe word for word. More basic than he's used
:23:50. > :23:53.to but with surprising results. It is our recipe but somebody else
:23:54. > :23:58.is cooking so I have to be So, an eight out of ten
:23:59. > :24:10.from Father Christopher. But for simplicity, flavour
:24:11. > :24:12.and being ahead of its time, Looks delicious. Quite slimming I
:24:13. > :24:28.expect. I might have some of that. Now, just before we go
:24:29. > :24:30.to the weather, today All across the country,
:24:31. > :24:34.people are wearing brightly-coloured socks to raise awareness
:24:35. > :24:37.of the condition. Well, you may remember this little
:24:38. > :24:41.boy here on the left. His name's Seb White and a few weeks
:24:42. > :24:44.ago he and his mum were guests Well, today, Seb, and all his
:24:45. > :24:49.friends, wore their coloured socks to school in Bath,
:24:50. > :25:01.and they certainly look Today I forgot. Tomorrow, I will
:25:02. > :25:02.wear bright socks. And me.
:25:03. > :25:16.It is actually a comparatively chilly field to things as we are
:25:17. > :25:21.under what is the first shower to come across here with great timing.
:25:22. > :25:25.For many of you in the sunny spells today it has been decent. But
:25:26. > :25:31.different where you are under the showers, some have been heavy. Over
:25:32. > :25:37.the next 24 hours, the main story will take shape tonight in the form
:25:38. > :25:41.of a band of heavy rain. First light tomorrow, that ball straddles the
:25:42. > :25:46.West Country, particularly to the east, then rotating itself away so
:25:47. > :25:56.the afternoon will brighten up, punctuated by showers, with light
:25:57. > :26:00.winds and any sunny spells will make it a sunny affair.
:26:01. > :26:03.You see that front is developing to the South West peninsular tonight
:26:04. > :26:08.and straddling tomorrow morning. It arcs its way over the Midlands
:26:09. > :26:13.followed by a regime of sunny spells and showers which will fade away as
:26:14. > :26:16.we head through tomorrow evening. At the moment, there is still a
:26:17. > :26:22.number of showers across the West Country, some quite potent, some
:26:23. > :26:27.hailstorms embedded. They will die away but watch how that band of rain
:26:28. > :26:33.develops through the second half of the night, some wintry spells over
:26:34. > :26:41.Exmoor with wet snow and other spots as well. Temperatures tonight fairly
:26:42. > :26:46.chilly, 1-4 C, some spots getting close to freezing, like Exmoor.
:26:47. > :27:16.Tomorrow, some uncertainty, that band will linger during the morning.
:27:17. > :27:16.From Bristol eastwards, drifting out From Bristol
:27:17. > :27:17.a brighter story in the afternoon. towards the north to be replaced by
:27:18. > :27:17.a brighter story in the afternoon. Some showers in the afternoon could
:27:18. > :27:18.be heavy, the winds and slow-moving. Temperatures
:27:19. > :27:19.of year. If you are in the sunshine, of year. If you are in the sunshine,
:27:20. > :27:20.it should be a decent story. That will be dictated by the position of
:27:21. > :27:25.the showers. Thursday, a notably chilly day with
:27:26. > :27:29.a north-easterly wind, seminar on Friday but it will improve at the
:27:30. > :27:34.weekend. Thank you. A fashion tip, if you are
:27:35. > :27:41.wearing thick socks, make sure you have some nice sandals with them.
:27:42. > :27:47.Lovely! You know how to dress! Do it tomorrow! Recipes on our
:27:48. > :27:49.Facebook page to recreate that curry. Goodbye.