:00:08. > :00:14.A breakthrough in researching Alzheimer's.
:00:15. > :00:17.Scientists in Bath find a crucial link between sugar
:00:18. > :00:22.The mother of Christopher Halliwell's last victim fears
:00:23. > :00:25.he may have killed others, as police say they need more time
:00:26. > :00:48.Scientists at Bath University may have found a link between
:00:49. > :00:53.Now it's well-known that high blood sugar can lead to diabetes,
:00:54. > :00:56.but what hasn't been clear is why diabetes patients have an increased
:00:57. > :01:01.risk of developing Alzheimer's until now.
:01:02. > :01:04.This dementia activity club run by the Bristol charity Alive
:01:05. > :01:11.That's because more and more people are being diagnosed with brain
:01:12. > :01:20.can double a person's risk of developing dementia
:01:21. > :01:41.but we still don't really understand how the two conditions are linked.
:01:42. > :01:44.But these researchers have found a vital clue.
:01:45. > :01:47.They've identified a specic effect of high blood glucose
:01:48. > :01:49.on an enzyme in the brains of people with Alzheimers.
:01:50. > :01:51.Scientists compared samples taken from people who have died
:01:52. > :01:55.They've developed a test using flourescent light to look
:01:56. > :01:57.for abnormal proteins in the brain that have been damaged by glucose,
:01:58. > :02:08.An important function of the protein is insulin, showing there is a clear
:02:09. > :02:10.link between the immune system, glucose regulation and Alzheimer's.
:02:11. > :02:14.are now going to investigate if they can detect these
:02:15. > :02:21.telltale signs in blood for an early diagnosis.
:02:22. > :02:27.We think it could have power in identifying those at risk with what
:02:28. > :02:31.we call a mod fable risk factor. High glucose, we could do something
:02:32. > :02:37.about that, so if we can use this as a simple blood test to identify
:02:38. > :02:42.those at risk, we could then use to it validate potential interventions
:02:43. > :02:44.to reduce high glucose, such as dietary changes, lifestyle changes.
:02:45. > :02:46.The search for answers prevent alzheimemrs
:02:47. > :02:51.In the last 10 years, the number of adults in the world
:02:52. > :02:54.living with the disease has jumped from almost 26 million to more
:02:55. > :02:58.But this latest scientific advance shows another
:02:59. > :03:00.possible reason to avoid too much sugar.
:03:01. > :03:07.Earlier I spoke to Dr Tim Shakespeare from
:03:08. > :03:10.the Alzheimer's Society, and asked him what he made
:03:11. > :03:25.We knew there was a link between dementia and diabetes but we didn't
:03:26. > :03:29.know why. This study is helpful, it gives us a clue as to what the link
:03:30. > :03:32.might be, telling us about the biological mechanisms that might
:03:33. > :03:36.cause that link and that means we might be able to find ways to have
:03:37. > :03:40.an effect on it. We might be able to help people with diabetes manage
:03:41. > :03:46.their risk of dementia better in future. How significant is this
:03:47. > :03:50.breakthrough? It's a really important finding because it means
:03:51. > :03:54.that we can now start to look at exactly what that link is and how we
:03:55. > :04:00.can have effects on it in the future. That might mean that people
:04:01. > :04:03.with diabetes don't have such an increased risk with dementia in the
:04:04. > :04:07.future which is valuable to those living with diabetes at the moment.
:04:08. > :04:11.You mentioned the word future a few times so it's not immediately
:04:12. > :04:17.translatable to people who do have Alzheimer's at the moment? This
:04:18. > :04:20.study isn't something that we can immediately translate to benefit
:04:21. > :04:23.people with diabetes right now. But it's really important because it
:04:24. > :04:28.does lay the ground work for some future research that will help us to
:04:29. > :04:33.understand these links and might have benefits for people as time
:04:34. > :04:36.goes on. Where are we now in terms of tackling Alzheimer's? The state
:04:37. > :04:40.of Alzheimer's research at the moment is better than ever. We have
:04:41. > :04:45.made a lot of progress in previous years in understanding the causes of
:04:46. > :04:48.the disease but we still don't know precisely what the causes are. We
:04:49. > :04:53.have had treatments recently that have tried to prevent the symptoms
:04:54. > :04:58.from getting worse but they haven't been successful. We need a lot more
:04:59. > :05:01.progress and tests of different kinds of treatments in order the
:05:02. > :05:02.make the breakthrough treatments that people with dementia really
:05:03. > :05:06.need. Thank you very much. Police in Swindon are tonight
:05:07. > :05:09.investigating the death of a woman who was involved in a collision
:05:10. > :05:12.with a road sweeper. It happened outside
:05:13. > :05:14.Arkells Brewery on Beechcroft Road Officers say she was 32,
:05:15. > :05:21.from North Swindon and on going She died at the scene and her next
:05:22. > :05:35.of kin have been informed. The Secretary of State
:05:36. > :05:37.for Local Government came West today The mother of Christopher
:05:38. > :05:56.Halliwell's final victim thinks it's almost inevitable there are more yet
:05:57. > :05:59.to be discovered. She was speaking as the police
:06:00. > :06:02.announced they'll need more time to continue their forensic search
:06:03. > :06:04.of his former home in Swindon. Halliwell is already serving a whole
:06:05. > :06:07.life sentence for the murders of Becky Godden and Sian
:06:08. > :06:08.O'Callaghan. The police search at the back
:06:09. > :06:15.of these Swindon houses. The former home of double murderer
:06:16. > :06:20.Christopher Halliwell. Forensic teams taking away wheelie
:06:21. > :06:24.bins full of the soil Elaine Pickford's daughter Sian
:06:25. > :06:38.was halliwells second victim. The question now -
:06:39. > :06:52.are there others lying The pathological liar sub. He would
:06:53. > :06:59.have slipped from every day life and then whatever his trigger was, he'd
:07:00. > :07:02.then be capable to go out and do what he's done to, not only Sian,
:07:03. > :07:04.but Becky and possibly others. Becky Godden was Halliwell's first
:07:05. > :07:06.victim, killed in 2003. But did Halliwell offend
:07:07. > :07:11.in the years before Today police said the search
:07:12. > :07:26.here would now go on into next week. Initially this was expected to last
:07:27. > :07:30.five days. Work at the site will pause for the weekend on Friday and
:07:31. > :07:32.we'll reconvene to commence searching once again on Monday next
:07:33. > :07:34.week. Halliwell is currently serving
:07:35. > :07:36.a whole life sentnece. Sian's mother has studied the killer
:07:37. > :07:53.and believes it's likely Given his nature and history and his
:07:54. > :07:55.unnatural urges, sexually, I think he wouldn't have been able to have
:07:56. > :07:57.contained those for eight years. Halliwell appeared to try to make
:07:58. > :08:00.a plea bargain during interviews If I confess he said,
:08:01. > :08:07.will that stop everything else? Police say they are digging
:08:08. > :08:10.here in intelligence they've received but so far haven't said
:08:11. > :08:19.what, if anything, they've found. An education trust in south
:08:20. > :08:22.Gloucestershire is considering shortening the school day because it
:08:23. > :08:25.says it's reached crisis The Olympus Trust which runs
:08:26. > :08:29.seven schools including Abbeywood and Bradley Stoke,
:08:30. > :08:31.has written to parents Next year the two secondaries
:08:32. > :08:36.will have to make savings There were long delays on the M4
:08:37. > :08:46.in Wiltshire earlier after it closed The driver wasn't injured but both
:08:47. > :08:50.sides of the motorway were shut near Chippenham because of heat
:08:51. > :08:53.and thick smoke. And in Bristol there were more
:08:54. > :08:55.delays near the M32 after storm Doris caused a man to be hit
:08:56. > :08:58.by a lump concrete. Eyewitnesses say it
:08:59. > :09:08.fell from a building. Today in the west we saw
:09:09. > :09:10.winds of over 60mph. This our reporter Scott Ellis
:09:11. > :09:19.there being battered And in nearby Clevedon,
:09:20. > :09:23.planks were pulled off parts The view across the Cheddar
:09:24. > :09:29.reservoir looked more This is where I leave
:09:30. > :09:51.you and hand you over to Ian Thank you very much. Good evening.
:09:52. > :09:54.67mph was the top gusts recorded by Met Office observation stations at
:09:55. > :09:58.least across the West Country. That was in Somerset. Let me take you
:09:59. > :10:02.through the forecast for tomorrow. We won't reach wind speeds anything
:10:03. > :10:06.like that, you will be glad to hear. A different day, chalk and cheese
:10:07. > :10:10.compared with today with notably lighter winds and a good deal of
:10:11. > :10:13.fine and dry weather after what will be a noticeably chilly start.
:10:14. > :10:20.Already the temperatures are dropping away to give a marked wind
:10:21. > :10:28.chill while we still retain a windy picture.
:10:29. > :10:33.Despite being fairly cold in the morning, it will be dry and sunny
:10:34. > :10:37.later. Towards the afternoon, more cloud
:10:38. > :10:42.starting to develop but still a bright, pleasant enough afternoon as
:10:43. > :10:49.we head further into the evening, with the cloud thickening up, giving
:10:50. > :10:52.sprinkles of rain in some areas. Up until the evening period, a good
:10:53. > :10:59.chance everywhere will have seen a dry day. Temperatures down on today.
:11:00. > :11:01.For Saturday, it will turn into another windy day, somewhat milder,
:11:02. > :11:17.Good evening. It was quite a day for some of us. We get these sort of
:11:18. > :11:19.storms every couple of years also. Difficult to give an exact number,
:11:20. > :11:20.but it