:00:11. > :00:24.On the killing of a vulnerable teenager.
:00:25. > :00:29.His mum is now warning others about the danger of knives.
:00:30. > :00:33.As much as you think it's going to protect you, it's not.
:00:34. > :00:40.How this creature could help in the fight against Alzheimer's.
:00:41. > :00:47.And heavy rain developing later tonight particularly across western
:00:48. > :00:48.areas where there could be snow as well. Details later in the
:00:49. > :00:49.programme. A serious case review is going to be
:00:50. > :00:55.carried out after the killing A local man has admitted murdering
:00:56. > :00:59.17-year-old Camran Green and now Camran had been under local
:01:00. > :01:03.authority care and an investigation has begun into how he became
:01:04. > :01:06.involved with a criminal gang. Our Home Affairs Correspondent
:01:07. > :01:11.Charlotte Callen reports. 17 years old and under the care
:01:12. > :01:15.of social services, Camran Green He'd fallen in with a gang
:01:16. > :01:23.and he was dealing drugs. Despite having a care team,
:01:24. > :01:25.he was able to travel by train from Birmingham
:01:26. > :01:29.to Cheltenham at weekends. Customers ordered drugs
:01:30. > :01:31.over the phone from him, That's how he met this man,
:01:32. > :01:37.Steven Sharpe, who let him stay On the 2nd of October last year,
:01:38. > :01:45.Sharpe tried to rob Camran He stabbed him with this 14-inch
:01:46. > :01:52.knife, described as a Rambo Police say more young
:01:53. > :02:00.vulnerable people are getting I think it is an indication
:02:01. > :02:05.of the world we live in where lots of communications
:02:06. > :02:10.are by mobile phones and people That's what we're seeing
:02:11. > :02:16.here in the drugs market. His mum wants to warn young people
:02:17. > :02:18.not to carry knives. She's also upset her son wasn't
:02:19. > :02:23.better looked after. You know, they should have found
:02:24. > :02:25.out where he was going, who he was with, you know,
:02:26. > :02:30.all that a mother would do. His care workers should
:02:31. > :02:35.see him as their child. So I am quite disappointed
:02:36. > :02:38.and annoyed they didn't Dudley City Council,
:02:39. > :02:42.who were responsible for Camran's care, say this is a tragic case
:02:43. > :02:54.and our fault with the family. -- and our thoughts are with the
:02:55. > :02:58.family. They say it is now the subject
:02:59. > :03:00.of a serious case review. The judge here today said the murky
:03:01. > :03:03.world of drugs had taken Steven Sharpe was given
:03:04. > :03:06.a life sentence. He will serve at least
:03:07. > :03:10.24-and-a-half years in prison. A man has branded South
:03:11. > :03:12.Gloucestershire Council "insensitive" after his mother
:03:13. > :03:14.received a letter about her council The letter was written
:03:15. > :03:18.to Ada Davies, who died in February, informing her that she would no
:03:19. > :03:21.longer get a reduction It even invited her to make
:03:22. > :03:26.a new claim for a reduction. The authority has apologised for
:03:27. > :03:33.the automatically generated letter. This is the manduca sexta and it
:03:34. > :03:36.loves to eat and scientists in Bath hope it could help
:03:37. > :03:40.in the fight against dementia. They'll be feeding caterpillars
:03:41. > :03:42.a sugary diet to see Our Health Correspondent Matthew
:03:43. > :03:47.Hill has had exclusive access This is the newest weapon
:03:48. > :03:54.in the fight against Alzheimer's. For some time, scientists have known
:03:55. > :03:57.that how much sugar we eat So they've enlisted the help
:03:58. > :04:02.of one of the greediest creatures on the planet -
:04:03. > :04:06.this very hungry caterpillar. This is kind of almost
:04:07. > :04:09.the end of the cycle... The clue's in its Latin name -
:04:10. > :04:13.manduca sexta which means We are studying these
:04:14. > :04:18.because we are interested in the damage that sugars cause
:04:19. > :04:22.to proteins in the diet. In the colony, we hold
:04:23. > :04:27.all of the stages of the life cycle. So it goes through all the stages
:04:28. > :04:30.but it is the caterpillar stage It's been known for some time that
:04:31. > :04:38.people with Type 2 diabetes are far It's thought that's because glucose
:04:39. > :04:43.forms a harmful by-product in their blood, which makes it
:04:44. > :04:48.harder to kill the abnormal proteins known as plaques and tangels,
:04:49. > :04:52.which form in the brain. The same team of scientists in Bath
:04:53. > :04:55.have already developed a technique using a fluorescent light
:04:56. > :04:58.to discover the tell-tale It's called glycation -
:04:59. > :05:04.where sugar attaches to proteins Scientists think a substance found
:05:05. > :05:10.in berries and chocolate, called flavonoids, may
:05:11. > :05:15.reduce this glycation. So they are adding these flavonoids
:05:16. > :05:17.to the caterpillar diet to see It's an interesting model system
:05:18. > :05:24.that we're using to test the effects of high sugar on biological
:05:25. > :05:28.function, which we hope will give us a way of testing a mechanism that
:05:29. > :05:32.can be used to screen drugs and interventions to reduce this
:05:33. > :05:35.glycation that we are seeing Yes, these caterpillars like eating
:05:36. > :05:42.sugar, so we can mimic that high-sugar environment that
:05:43. > :05:46.you see in humans. This is the only place in Europe
:05:47. > :05:52.to culture these caterpillars. They evenually transform
:05:53. > :05:54.into a moth, and these pests can One essential ingredient
:05:55. > :06:02.for horn worms is tobacco. They need the smell of it in order
:06:03. > :06:07.to breed and lay eggs. That is why the university
:06:08. > :06:09.have a special licence This research project
:06:10. > :06:12.could take years. But if this greedy caterpillar can
:06:13. > :06:15.shed light on how diet could reduce the chances of Alzheimer's,
:06:16. > :06:18.then we may well have Earlier, I spoke to Dr Rosa Sancho,
:06:19. > :06:26.the Head of Research She told me she welcomed any
:06:27. > :06:33.research into the disease. Dementia is caused
:06:34. > :06:35.by a mix of factors, And by environmental,
:06:36. > :06:41.I mean our lifestyle, So it is not the first time
:06:42. > :06:49.that sugar is linked However, I would say that rather
:06:50. > :06:55.than the one food group, the best evidence supports that
:06:56. > :07:01.people should have a balanced and healthy diet in general,
:07:02. > :07:04.not just pay attention to one You mentioned a balanced
:07:05. > :07:11.and healthy diet as regards How far have you got to finding out
:07:12. > :07:18.what can prevent it? Well, the best evidence
:07:19. > :07:22.supports vascular health. So, really what is good for your
:07:23. > :07:25.heart is good for your brain. The best evidence says
:07:26. > :07:29.that we should exercise, we should keep our cholesterol
:07:30. > :07:33.and blood pressure in check, not smoking and, as this
:07:34. > :07:38.study has alluded to, There is also some evidence behind
:07:39. > :07:44.keeping socially and mentally active as a way to prevent the development
:07:45. > :07:49.of Alzheimer's disease. Where are we currently in finding
:07:50. > :07:53.a cure for Alzheimer's? Do you think we will see
:07:54. > :07:55.that in our generation? We have had more funding for
:07:56. > :08:02.research then we have had before. We have a lot of political backing
:08:03. > :08:08.in the last few years and we have seen the start of more
:08:09. > :08:11.and more clinical trials. So we hope that yes,
:08:12. > :08:14.in our generation, It's really important
:08:15. > :08:18.because at the moment, people do not have access
:08:19. > :08:21.to effective treatments. And research like this and any other
:08:22. > :08:25.research is very important to further our understanding
:08:26. > :08:29.of what causes it and how we can A generous legacy has been
:08:30. > :08:40.left to people who live in the West Somerset
:08:41. > :08:43.village of Porlock. Susan Taylor left ?700,000
:08:44. > :08:46.to improve the village 1,200 letters have now been
:08:47. > :08:51.delivered to people living in the area asking for ideas on how
:08:52. > :08:58.to spend the money. It's such a big amount
:08:59. > :09:00.of money and... -- something amazing for the kids,
:09:01. > :09:16.maybe? Probably build a swimming
:09:17. > :09:17.pool or something? A decision on how to spend
:09:18. > :09:22.the village's inheritance will made Forest Green Rovers have gone top
:09:23. > :09:27.of the National League tonight Christian Doidge scored in the final
:09:28. > :09:30.minute to beat Solihull Moors 2-1. The victory puts Forest Green
:09:31. > :09:41.three points clear. That's it from us tonight. More news
:09:42. > :09:48.on your local station and online. Good night and here is the forecast.
:09:49. > :09:54.A chilly wind started to develop. Let me take you through the
:09:55. > :09:59.forecasts as we head through to tomorrow. A band of rain developing
:10:00. > :10:03.across western areas. That will take shape through the course of the
:10:04. > :10:07.night. There is a question mark as to how far east that will be by
:10:08. > :10:12.first light. It will rotate north-east with giving heavy rain
:10:13. > :10:19.and snow in places. And the rest of tomorrow will brighten up. Through
:10:20. > :10:23.the afternoon. Temperatures tonight dropping towards freezing in some
:10:24. > :10:28.upland spots. The rain is across western part of Somerset at the
:10:29. > :10:33.moment. Some of that good fall as snow, it could penetrate down to
:10:34. > :10:38.about 100 metres or 200 metres elevation and lying at 200 metres
:10:39. > :10:47.plus. There could be patches elsewhere. There is uncertainty
:10:48. > :10:52.about the position of where it is tomorrow morning. That rain will go
:10:53. > :10:57.north eastwards. Then in the afternoon, it will start to brighten
:10:58. > :11:02.up. Some quite slow-moving, heavy showers in that part of the day.
:11:03. > :11:10.Temperatures below average. It will feel decent where you
:11:11. > :11:18.Heavy rain, snow and ice are all in the forecast once again. It was
:11:19. > :11:19.quite a wintry scene today, especially in Scotland. Some very