:00:00. > :00:00.reports a water leak in his helmet. China says it is planning a space
:00:00. > :00:19.mission to the dark side of the moon.
:00:20. > :00:25.A clinical trial of a new drug in France has left one person
:00:26. > :00:30.brain-dead and another five in hospital in a very serious
:00:31. > :00:32.condition. The painkiller was being tested in a government approved
:00:33. > :00:37.laboratory in the north-west of France and given to 90 people. The
:00:38. > :00:43.study has been halted and all volunteers recalled. There were
:00:44. > :00:47.earlier reports that the drug was a cannabis -based painkiller but that
:00:48. > :00:49.has been denied by the French health ministry, the chief neuroscientist
:00:50. > :00:58.says there is no known antidote to the experimental drug ring tested.
:00:59. > :01:03.It is the worst incident of this kind to ever hit a clinical
:01:04. > :01:07.Six men were first given the drug eight days ago at a respected
:01:08. > :01:11.On Sunday one of the group began to develop alarming symptoms.
:01:12. > :01:15.The other five had similar reactions but to differing degrees.
:01:16. > :01:18.The doctor treating them said that because the drug was experimental
:01:19. > :01:21.it was impossible to give a clear prognosis.
:01:22. > :01:24.Four of the five other patients have neurological problems of differing
:01:25. > :01:32.One has no symptoms but is being carefully watched
:01:33. > :01:34.because of what happened to the other patients who took
:01:35. > :01:40.Among these four patients there are three who are already
:01:41. > :01:42.in a condition that is sufficiently serious to cause us to fear
:01:43. > :01:46.a handicap, which could be irreversible, even
:01:47. > :01:52.The French Health Minister went to Rennes to offer support
:01:53. > :01:56.and promised an exhaustive investigation into what went wrong.
:01:57. > :02:00.She met the five patients who are conscious.
:02:01. > :02:05.I want to tell you that I was overwhelmed by their distress.
:02:06. > :02:13.Because they have been in hospital for several days together.
:02:14. > :02:15.They know each other, because they were together
:02:16. > :02:24.And now their lives have been brutally turned upside down.
:02:25. > :02:26.Every year hundreds of thousands of people around the world are paid
:02:27. > :02:32.to take part in clinical drugs tests but the trials are rigorously
:02:33. > :02:35.controlled and only extremely rarely are there incidents of this nature.
:02:36. > :02:43.Here the drug being tested was a reliever based on molecules
:02:44. > :02:48.Here the drug being tested was a pain reliever based
:02:49. > :02:50.on molecules found in cannabis.
:02:51. > :02:53.90 others have already been given the drug and showed no reaction
:02:54. > :02:55.so investigators will want to know if there was a problem
:02:56. > :02:58.with the latest batch of the drug or if the wrong
:02:59. > :03:12.Our medical correspondent looked into the trial in more detail.
:03:13. > :03:19.All six were part of a clinical trial which actually began in July
:03:20. > :03:22.last year. 90 healthy volunteers were given this experimental drug
:03:23. > :03:28.which works on pain and mood receptors in the brain. They were
:03:29. > :03:35.gradually given escalating doses, what they call a phase one safety
:03:36. > :03:38.trial. Until today there had been no apparent serious side-effects. Last
:03:39. > :03:46.week the six men were given the highest dose so far. Three days
:03:47. > :03:51.later one was rushed into hospital with a catastrophic brain injury.
:03:52. > :03:56.Others then followed. That first man is brain-dead, it is just a question
:03:57. > :04:01.of time until the life is switched off. Three others may have a
:04:02. > :04:05.responsible brain damage. And the doctors you saw, they are
:04:06. > :04:13.struggling, because they don't know quite how to treat this. So it is
:04:14. > :04:17.important to stress, this trial has been going on for six months, but
:04:18. > :04:22.there is always a risk with these safety trials but at some point
:04:23. > :04:27.there would be a side-effect. But it does seem a very unusual
:04:28. > :04:33.story, a rare thing to happen? It is a rare thing. They are are
:04:34. > :04:40.very tight procedures across Europe, tightened considerably after a
:04:41. > :04:45.scandal years ago in London when six men, again, became seriously ill,
:04:46. > :04:49.but in that case, within minutes of receiving an intravenous drug. And
:04:50. > :04:55.that was the first time it had been given to man, so you can see, it is
:04:56. > :04:59.quite different here. We all rely on volunteers who come forward, they
:05:00. > :05:04.would have been paid for this, but they come forward to test these
:05:05. > :05:10.drugs, and without them we would not have new medication.
:05:11. > :05:21.Gunmen have reportedly attacked a hotel in the capital of Burkina
:05:22. > :05:32.Faso, were eyewitnesses say two bombs went off outside a hotel in,
:05:33. > :05:37.gunfire was then exchanged between the men and security forces at the
:05:38. > :05:38.scene, there is no indication yet casualties, we will bring you more
:05:39. > :05:47.on the story as we get it. Stock markets in the USA have fallen
:05:48. > :05:57.sharply following the kinds earlier in Europe and Asia -- declines. Our
:05:58. > :06:08.correspondent is in New York. What is the latest you can tell us?
:06:09. > :06:14.The Dow recovered slightly, in the end, down 2.93%, so recovering a
:06:15. > :06:23.little bit from the low of over 500 point it lost earlier in the day.
:06:24. > :06:26.The SMP 500 town 2.6% at close, recovering a little bit following
:06:27. > :06:31.those we saw in August, the last time the markets really had those of
:06:32. > :06:36.the concern from China and the slowdown of the summer. What we are
:06:37. > :06:47.seeing is that investors are still fleeing US equities. We are seeing
:06:48. > :06:52.them go to safer investments like bonds and gold, we saw the
:06:53. > :06:58.nervousness, one analyst said the market was still a slave to oil,
:06:59. > :07:02.prices this week hitting $30 a barrel, causing jitters on Wall
:07:03. > :07:05.Street, and we are also seeing, because of concern about a Chinese
:07:06. > :07:11.slowdown and the Chinese stock market taking a beating today, about
:07:12. > :07:16.entering into a bear market, 20% down from their highs, and that
:07:17. > :07:20.rattled investors. To top it all we got really ugly economic data
:07:21. > :07:25.raising concerns about the strength of the US economy in the fourth
:07:26. > :07:29.quarter, retail sales are down, consumers are not spending as much
:07:30. > :07:32.as we thought, industrial output is down. So plenty of talk on Wall
:07:33. > :07:36.Street about whether this is the bottom or whether stocks will keep
:07:37. > :07:46.tumbling, but certainly the knees at the moment with all of this bad
:07:47. > :07:48.news. -- certainly unease. A spacewalk to repair the
:07:49. > :07:54.International Space Station has ended early after an astronaut
:07:55. > :07:59.reported water in his helmet. Both astronaut on the walk returned to
:08:00. > :08:00.the station safely, it had been the first spacewalk by an astronaut
:08:01. > :08:14.representing the UK. A moment of history as Tim Peake
:08:15. > :08:17.prepares to walk outside, weightless, but jammed
:08:18. > :08:21.into a bulky spacesuit, he needs his colleagues
:08:22. > :08:26.to guide him into the airlock. We hear him go through his final
:08:27. > :08:33.checks. It was dark when he emerged,
:08:34. > :08:43.a tiny figure against It is really cool to see
:08:44. > :08:47.the Union Jack outside, it has explored all over the world
:08:48. > :08:50.and now it has explored space. Hand by hand he and a fellow
:08:51. > :08:59.astronaut inched along outside. Filmed by his American colleagues
:09:00. > :09:05.he is perched at the very edge of the station to perform
:09:06. > :09:10.a key repair job. Look how hard it is
:09:11. > :09:13.managing tools in space. This is the view from his camera,
:09:14. > :09:16.everything is weightless and wants Stepping outside the International
:09:17. > :09:25.Space Station is always risky. But spacewalks are essential
:09:26. > :09:29.to build and fix things. The astronauts emerge
:09:30. > :09:32.through an airlock here. If we take a closer look we can see
:09:33. > :09:36.how they had to make their way about 60 metres to a place called
:09:37. > :09:42.a sequential shunt unit, part of the power supply
:09:43. > :09:45.connecting solar panels. Their suits have 14 layers
:09:46. > :09:54.of material to give protection from the vacuum of space
:09:55. > :09:58.and temperatures ranging from -100 Backpacks supply power
:09:59. > :10:07.and water for life support. In case they drift away,
:10:08. > :10:10.small thruster jets can manoeuvre The main task was to fix the power
:10:11. > :10:17.unit, they had to get it done within 31 minutes,
:10:18. > :10:20.because that is how long night lasts on the station,
:10:21. > :10:22.and if the sunlight hit the solar We know it is a small amount
:10:23. > :10:37.of water, is there any way to check the temperature, I don't know
:10:38. > :10:44.if there's a way to move around, or to drink it and note
:10:45. > :10:59.what the taste...? It is three inches above my head.
:11:00. > :11:02.Let me see if I can make it mobile...
:11:03. > :11:07.The astronauts were ordered back into the airlock.
:11:08. > :11:10.There was no alarm, but it was a reminder of the dangers
:11:11. > :11:20.You guys did a great job, thank you.
:11:21. > :11:25.China is planning a mission to the dark side of the mine, which has
:11:26. > :11:30.never been explored. An expert on their space programme told me why
:11:31. > :11:36.there's so much fascination with the dark side the moon.
:11:37. > :11:41.Because it is on the far side of a move which are never really rotates
:11:42. > :11:46.we have never put our eyes on it. We have seen photographs of it, and the
:11:47. > :11:50.like, but nobody has even landed there, even robotically, on the far
:11:51. > :11:55.side. So China will break new ground, literally, in terms of
:11:56. > :12:00.landing a new probe on the dark side of the moon, and taking samples,
:12:01. > :12:05.which is the plan. And then try to figure out what the difference is,
:12:06. > :12:11.apart from it being a shade darker? Exactly. There is some evidence
:12:12. > :12:17.based on photographs that the far side may perhaps have undergone some
:12:18. > :12:20.different effects. That the material rising to the surface may be
:12:21. > :12:25.slightly different from the part of the moon which we can see. And
:12:26. > :12:31.therefore it has always been something which many scientists had
:12:32. > :12:34.hoped to do, and there, take some samples, do chemical and other
:12:35. > :12:39.tests, to see if there is any difference.
:12:40. > :12:44.We can show our viewers some of the pictures. The first is from 1959, a
:12:45. > :12:53.soggy spacecraft. You can imagine how exciting that was -- a Soviet
:12:54. > :12:57.spacecraft. The pictures are still impressive, even 55 years later. It
:12:58. > :13:06.began to show a little bit of the surface. It did though move on. We
:13:07. > :13:12.got a clearer, better picture, just back in July. That was when Nasa
:13:13. > :13:16.decided to have a satellite which was able to take these pictures.
:13:17. > :13:21.When you looked at them, what were you thinking?
:13:22. > :13:25.I was thinking that there has been such a long time since we last went
:13:26. > :13:30.to the moon and despite the fact it is our nearest celestial neighbour
:13:31. > :13:34.we still know relatively limited amounts about it. So when I heard
:13:35. > :13:37.the news that the Chinese were interested in doing this more than
:13:38. > :13:43.anything else it was a feeling of, about time.
:13:44. > :13:49.Still to come: a BBC investigation has found that Turkish authorities
:13:50. > :13:54.have detained and deported Syrians back to Syria. Turkey denies the
:13:55. > :13:59.charge. They one of operation Desert Storm
:14:00. > :14:03.to force Iraq out of Kuwait has seen the most intense air attacks since
:14:04. > :14:08.World War II... Tobacco is one of America's oldest
:14:09. > :14:15.and biggest industries but it is nervous of a report which may make
:14:16. > :14:19.people want to stop smoking. There is no evidence of street
:14:20. > :14:24.unaffected, large parts of the city crashed into one another, this woman
:14:25. > :14:30.said she was given no advice or help by authorities and stood outside the
:14:31. > :14:35.ruins of her business... Tens of thousands of South African
:14:36. > :14:44.black children have taken advantage of new laws and enrolled at formerly
:14:45. > :14:50.white schools. When there was news of the death
:14:51. > :14:53.today the management debated whether to cancel the performance but Agatha
:14:54. > :15:02.Christie would have been the last person to want such a thing...
:15:03. > :15:07.The latest headlines: a clinical drugs trial in France has left one
:15:08. > :15:11.person brain dead and three others facing a reversible rain damage. The
:15:12. > :15:17.French health minister said the drug was given to 90 volunteers.
:15:18. > :15:26.Explosions and gunfire have been heard in the capital of Burkina
:15:27. > :15:29.Faso, the AFP news agency reported a car on fire in front of a hotel
:15:30. > :15:36.regularly used by United Nations staff and Westerners.
:15:37. > :15:40.And now the sport. We start with cricket and a century from Joe Root
:15:41. > :15:44.helped England to stay in contention in the third test against South
:15:45. > :15:53.Africa. The home team were bowled out early on that date two but had
:15:54. > :16:03.England warbling. A great partnership between Joe Root and Ben
:16:04. > :16:07.Stokes got them back into the match. Obviously very pleased at the
:16:08. > :16:11.moment. You will need to ask me at the end of the game for the true
:16:12. > :16:15.reflection on it, but more than anything it is now about going on,
:16:16. > :16:20.making a really big score, getting a substantial lead for the second
:16:21. > :16:29.innings, and putting them back on the pressure.
:16:30. > :16:37.Mohammed Amir was found guilty of deliberately delivering no-balls in
:16:38. > :16:40.2010 but today returned in Auckland. His reintegration into the team came
:16:41. > :16:57.with objections from some team-mates and he was booed by some supporters.
:16:58. > :17:05.Pakistan won as New Zealand failed 16 runs short of the 155 they needed
:17:06. > :17:11.from 20 overs. Chelsea manager Guus Hiddink says
:17:12. > :17:15.the team are still facing a relegation battle despite improved
:17:16. > :17:19.form. They are six games unbeaten under the Dutchman but he says they
:17:20. > :17:23.could be in trouble if they lose forthcoming games against Everton
:17:24. > :17:28.and Arsenal. We all like to look forward to the
:17:29. > :17:35.top of the table, but don't be unrealistic, you are six points off
:17:36. > :17:43.the line. Off relegation. That is also a fact. So we have do work hard
:17:44. > :17:51.and be very concentrated, and gather our points, to step up.
:17:52. > :17:54.Serena Williams and Novak Djokovic are favourites to win the Australian
:17:55. > :17:59.open in Melbourne next week. Our tennis correspondent is the and has
:18:00. > :18:03.been talking us through the draw for the first major tournament of the
:18:04. > :18:07.year. It is a difficult start for Serena
:18:08. > :18:15.Williams, Milla George a very dangerous opponent. Given the state
:18:16. > :18:19.of Serena William's knees, pulling out of two and earlier in the year,
:18:20. > :18:25.and not having played a competitive match since temper, a very tough
:18:26. > :18:29.start indeed. In the men's competition, Novak Djokovic with a
:18:30. > :18:33.first round match against a very talented opponent, it will get tough
:18:34. > :18:37.for him in the second week. The dangerous Japanese player has
:18:38. > :18:43.potential quarterfinal opponent, and also in the same half of the draw as
:18:44. > :18:51.Roger Federer. They would meet in the semifinals. It is the champion
:18:52. > :18:56.of two years ago, Stan Wawrinki, who has the toughest draw of the men,
:18:57. > :19:00.needing to go past Rafa Nadal, Andy Murray, and Novak Djokovic, to win
:19:01. > :19:05.the title again. The greatest match in Masters
:19:06. > :19:09.snooker history is what BBC commentators called the wing for
:19:10. > :19:15.Judd Trump against Neil Robertson at Alexandra Palace. Both scored six
:19:16. > :19:20.centuries into live in frames. Robertson was 2-1 down but levelled
:19:21. > :19:28.the match with the highest break of the two and so far at 139. Trump hit
:19:29. > :19:33.back with a break of 140. An incredible standard in the match, as
:19:34. > :19:37.Robertson levelled at 5-5, Judd Trump raised his game someone they
:19:38. > :19:47.decided to book a game in the semifinals. -- some more in the
:19:48. > :19:52.decider. The European Union has committed to
:19:53. > :19:56.giving 3 billion euros to Turkey to manage migrants crossing from Syria
:19:57. > :19:58.into the country and in turn, reduce the numbers heading through the
:19:59. > :20:03.European Union. But a BBC investigation found Turkish
:20:04. > :20:08.authorities had detained and deported Syrians back to Syria,
:20:09. > :20:15.making international humanitarian law, banning governments sending
:20:16. > :20:21.people back to war zones. -- breaking international law.
:20:22. > :20:27.For some refugees the road to Europe and in Turkey. We heard reports of
:20:28. > :20:30.the breaking of international law by deporting Syrians back to a conflict
:20:31. > :20:36.zone. Those deemed troublesome were detained. We went to meet one.
:20:37. > :20:42.Journalist are not allowed to film here so we recorded undercover. We
:20:43. > :20:47.had met on the Greek border months ago and stayed in touch. I had been
:20:48. > :20:53.hit by Turkish police. They could me bad.
:20:54. > :20:59.This, he says, shows his mistreatment by guards. For more
:21:00. > :21:03.privacy we went inside to talk. He has been held for weeks with no
:21:04. > :21:09.charge. What happened to all the others?
:21:10. > :21:15.Deported to Syria. Did they want to go back?
:21:16. > :21:21.I am sure they did not. Definitely sure. They were running from Syria.
:21:22. > :21:27.If they try to send you back, what would you do?
:21:28. > :21:32.I don't know. He was amongst those who refused to leave a border town
:21:33. > :21:36.in September. They were rounded up by police and taken to a camp. The
:21:37. > :21:40.authorities would not inform us of their final destination. Inmates
:21:41. > :21:46.already there shouted for help, saying they had been injured. Three
:21:47. > :21:49.months and we tracked down one of the group who says they were
:21:50. > :22:03.deported to Syria. He had since made it back to southern Turkey.
:22:04. > :22:10.They forced us to sign, and a ride on it, I want to be sent back to
:22:11. > :22:16.Syria. -- to write on it. They ask you to sign a paper saying
:22:17. > :22:21.you were voluntarily going back? They said if you don't send it we
:22:22. > :22:28.will send you to a... A detention centre in Turkey?
:22:29. > :22:33.Yes, I did not want to go back to Syria, many of us feel afraid.
:22:34. > :22:38.Once they crossed the border many say they were arrested by armed
:22:39. > :22:41.groups and in some cases imprisoned. Over 2 million Syrians are already
:22:42. > :22:45.in Turkey, the government is under pressure to keep them here, they
:22:46. > :22:49.will receive 3 billion euros from the European Union, but it is
:22:50. > :22:55.contingent on improving conditions for refugees here in Turkey, not on
:22:56. > :22:58.sending them back to an act of war zone, contravening international
:22:59. > :23:02.Germanic Terry law. Amnesty International says they
:23:03. > :23:06.believe hundreds were possibly deported to Syria where their lives
:23:07. > :23:10.are in danger. The European Union needs to wake up
:23:11. > :23:14.to the fact that on its own borders international law is being broken on
:23:15. > :23:20.a regular basis. It needs to wake up to the fact that it has a gatekeeper
:23:21. > :23:23.in Turkey violating the rights of refugees in detaining them secretly,
:23:24. > :23:28.arbitrarily, and returning them to Syria.
:23:29. > :23:28.The Turkish government refused and interview but issued this
:23:29. > :23:47.statement... Covert detention, deportation to a
:23:48. > :23:51.war zone, the charges are serious. A country that has warmly welcomed so
:23:52. > :23:59.many Syrians now accused of illegal acts.
:24:00. > :24:07.A reminder of our breaking news, gunmen have reportedly attacked a
:24:08. > :24:12.hotel in the capital of Burkina Faso in West Africa, eyewitnesses said
:24:13. > :24:17.car bombs went off outside a hotel, men stormed the hotel, used by UN
:24:18. > :24:22.staff and Westerners, gunfire was then exchanged between the men and
:24:23. > :24:27.the security forces at the scene, there is not yet any indication of
:24:28. > :24:30.casualties. Before we go, US lottery officials have confirmed that a
:24:31. > :24:37.Tennessee couple has one of the three winning tickets for the $1.6
:24:38. > :24:40.billion jackpot. John and Lisa Robinson have been announced as the
:24:41. > :24:47.couple. The other winning tickets were sold in California and also in
:24:48. > :24:52.Melbourne beach, Florida. That is all from the programme. Coming up
:24:53. > :25:07.next, the weather where you are. From me and the team, goodbye.
:25:08. > :25:17.Good evening. Some unusual weather to start this look around the world.
:25:18. > :25:18.We have had our first hurricane of the season. A hurricane in