30/11/2012 Newsnight


30/11/2012

Will common medical procedures become too dangerous as superbugs learn to resist antibiotics? Is UKIP really about to be Britain's 3rd party?


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Tonight, imagine a world in which diseases you thought were curable

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suddenly cannot be cured, treatable infections become untreatable, and

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cancer therapy and surgery leads to new dangers.

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That is the medical nightmare of a new breed of superbug, resistant to

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antibiotics, and threatening to overturn some of the best hopes of

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modern medicine. 21st century medicine, the hip replacements and

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cancer chemotherapy, they won't be possible, because patients will be

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succumbing to infxs that were treatable. We will hear whether our

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doctors need to cut down drastically on the prescription of

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antibiotics. Labour holds on to three parliamentary seats, and UKIP

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does well, and claims to be the nation's third party. Is any of

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that credible. From the celebrations last night,

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you would think coming second of the new coming first. But remember,

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UKIP haven't yet got one MP. We will ask if they are really

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keeping David Cameron awake at Good evening. Some of the miracles

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of modern medicine are in danger. We come to take for granted

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treatments for cancer and hip replacements, the stuff of dreams a

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few decades ago. Many of these advances depend on antibiotic,

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which have been used to fight infection since the 1940s. Many of

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them are losing their effectiveness. At a rate that is both alarming and

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irreversible. -- irreversible. That is from Britain's Chief Medical

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Officer. We have talked to the teams at the frontline in the fight

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against drug-resistant bacteria, or superbugs. And just as scientists

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thought they were gaining the upper hand, a new threat is emerging, and

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this next wave could be what the Chief Medical Officer describes as

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one of the greatest threats to modern health.

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At the frontline, in the battle between man and miebcob, each new

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anti--- microbe, each new anti- biotic we create has an army of

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resistance. Antibiotics underpins all areas of 21st century medicine.

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If we allow them to proliferate, we undermine all those advances.

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Bacteria that constantly evolve are evading our best weapons. One year

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your house is a mile away from the cliff age, with coastal erosion,

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come back ten years later, and the cliff edge is only 100 yards away.

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That is the position we are now in with antibiotic resistance.

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arrival of antibiotics in the 1940s, revolutionised healthcare, until

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bacteria began to fight back. Now, doctors and scientists are warning

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that ever-evolving, resistant strains, are putting modern

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medicine at risk. For antibiotic- resistant organisms you might have

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heard of, like MRSA, doctors and scientists have been making

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headation, there is a new group of bacteria gaining ground now. It is

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a fresh challenge, and there is a lot at stake. Nick Brown has to

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deal with the reality of resistant bacteria every day on the hospital

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ward. Often it is as simple as keeping patients apart. Hospitals

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are continuously bombarded by the introduction of antibiotic

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resistant bacteria from patients transferred from other hospitals

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and overseas, therefore, we have to take precautions to segregate the

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patients from others, and take infection control precautions to

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prevent the organisms spreading. At her Birmingham lab,

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microbiologists, Laura Piddock, is trying to understand resistance, to

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see if there might be better ways to counter it. She says bacteria

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become resistant in a process that is a form of revolution, where the

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fittest bacteria survive. The ones that can withstand antibiotics, and

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the more we use antibiotics, the more we unwittingly encourage those

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resistant bacteria to thrive. So what is it about these bacteria,

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that makes them resistant? We can boil it down really into two wave,

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first of all, they can share small pieces of DNA and transfer in

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bacteria population. That might allow them to produce an enzyme to

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chew up the drug. The bacteria has the genetic material to overcome

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the drug, and produces the mechanism of resistance. There are

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two main groups of bacteria called ground-positive and ground-negative.

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It is the second group causing concern to microbiologists. Ground-

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negative bacteria have a double- cell ball w biological pump

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inbetween. In ground-negative bacteria here, this is the joud

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site of the cell and this is the inside. They have these two

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barriers, which ground-positive bacteria doesn't have. They are

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very clever, they have a three-part system that works like a vacuum

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cleaner. Any drug that gets in, immediately just pumps it straight

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out. This built-in pump means ground-negative bacteria can spit

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out our best antibiotics, making it harder to design one that will

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destroy them. There are six resistant bacteria that worry

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microbiologists most. Two are ground-positive, all of the rest

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are ground-negative. The one that is demanding attention right now is

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Klebsiella. Klebsiella is seen in renal infections. It has resisted

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antibiotics and we have had to return to the reserves, carbopenins,

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2% of Klebsiella are resistant to carbopenin antibiotics, it has shot

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up in parts of Europe and the US. You only have to go to southern

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Europe to see what can happen. As early as 2008, there were problems

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in Greece. 40% of Klebsiella resistant to cabopenin. Watch Italy

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n2008 it is between 1-5%, no worse than our present problems. But come

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forward to 2010, and already Italy is up to 17%. And come now to the

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most recent data, Italy is now up to 30%. It is vital that we in the

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UK avoid going down this trajectory. If we lose cabopenins, against

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bacteria like Klebsiella, we are forced to use what are really

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rather poor, toxic, not very God antibiotics, we are down to the

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bottom of the barrel. It is a potentially lethal

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infection that is resistant to treatment...$$NEWLINE It is the

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most vulnerable patients who are at risk. MRSA, for example, the drug-

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resistant ground-positive bacteria, is harmless to the many healthy

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people who carry it, but not the weak. When it was found in the

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special care baby unit at Addenbrooks last year, the hospital

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turned to the latest in genetic technology for help. A few miles

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from the hospital, in the Cambridgeshire countryside, is the

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world-famous Sanger institute. started 15 years ago, references

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bacteria. Scientists here helped decode our DNA blueprint, in the

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human genome project. Now they are using a similar approach to

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identify and track the most threatening of bacteria. Two things

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may be going on in the hospital, the strains may be brought in

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independently or transmission in the hospital. Current typing

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techniques find it difficult to differentiate strains at high level.

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The genome sequencing we are trying to use here, allow very fine

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discrimination of strains. This approach will work with any

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bacterium, we have shown it working with MRSA, it will almost certainly

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allow the hospital to differentiate outbreaks of Klebsiella from

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independent introductions of Klebsiella, and knowing there has

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been an outbreak and transmission is key to any intervention to

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prevent transmission. How important might these new

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sequencing technologies be where it really matters? There is potential

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for the new gene sequencing technologies to enable us to better

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understand the epidemiology of the spread of ground-negative

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antibiotic resistance. Therefore, we would be able to target our

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isolation facilities, and the infection control precaution that

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is we use to prevent further spread within the hospital environment.

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But, it will be years before we can contain every outbreak quickly. So

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the warning now is that we must stop resistant strains reaching

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patients in the first place, to avoid the unthinkable.

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For -- For those who get an infection by a ground-negative

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bacterium, it will be increasingly difficult to treat it. We will see

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the day where we have untreatable infections. In some wards in the UK

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it has already happened F we don't sort out, these wonderful medical

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advances we take for granted, the hip replacements and cancer chemo

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therapy, they won't be possible, because patients will succumb to

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infections that were previously treatable. Unusually, Professor

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Piddock and other specialists like her, are campaigning to persuade

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Governments and industry to do more to preserve current antibiotics and

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find new ones. Their concern that we overuse these drugs, most

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recently, by buying them via the Internet.

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It is not like other types of medicine. If I have a headache, I

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would take a tablet for my headache. If I take an antibiotic, all of the

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bacteria in my body are exposed to that antibiotics, I would be

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selecting drug-resistant strains and sharing them. I may not need an

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antibiotic. We are saying use them sparingly and preserve their use

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for as long as possible until we get new drugs.

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Bacteria breed quickly and in situation that can surprise the

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experts. No-one can say for sure what the next big resistant threat

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will be. Only that there will be more. And that we may not always be

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confident that our antibiotics will work.

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Professor Alan Johnson is a consultant clinical scientist at

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the Health Protection Agency in England and an expert in resistant

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antibiotics. How serious is this? We have a large number of bacteria

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can cause infections and a range of antibiotics. The extent of the

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problem depends on which range of those you are looking at. At one

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end of the spectrum we have some strains of bacteria causing

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infections that are becoming virtually untreatable already, at

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the other end of the spectrum we have some strains of bacteria that

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cause infections that remain readily treatable. We have some

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time, but there are lots of parts to the puzzle. How important is it

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for doctors to say to us as patients, you really don't need

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antibiotic, I won't give them to you, even though hur whinge ago

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bit? The key issue in the report, is cannotitybiotics are unlike

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other drugs used in medicine, the more you use them, the less

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effective they become. The key part of the strategy at the moment,

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because of the lack of new drugs in development, is to make sure that

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the drugs we currently have, and are active at the moment, remain so

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for the future. And doctors play a part in that? In order to do this

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we need to cut back on unnecessary and inappropriate prescribing.

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speaking as a patients, must of us think these are wonder drugs, we

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think they cure a lot of things. My demand to a doctor would be please

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give it to me? We know that is one of the problems, there is good

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evidence from studies that doctors, unfortunately, do prescribe

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inappropriately, because of the pressure put on them by patients,

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who have a high expectation of getting a drug. One of the key

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things at the moment is attempts to try to educate patients. That

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antibiotics are not harmless, as we thought. If you take an antibiotic

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unnecessarily, you get what we know as collateral damage, you end up

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possibly colonising superbugs. Educating doctors about that.

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Indeed. You can get them on the internet, before I came in, I

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checked, it is easy to get a whole range of antibiotics? That is an

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appalling development. It goes totally counter to global efforts

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to optimise and reduce prescribing as much as possible. If they are

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made freely. Another thing to be aware of, what you buy over the

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Internet is sometimes counter fit drugs. You are not only use theing

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the drugs inappropriately d counterfeit drugs, you are not only

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using the drugs inappropriately. They will tend to promote

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resistance if the does aj isn't what you think -- does aj isn't

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what you think it is. -- dosage isn't what you think it is.

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The message isn't getting through? There are initiatives to redress

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this. In terms of doctors' education, because of the advances

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in modern medicine, if you are a trainee doctor, the sheer amount of

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knowledge that you have to accumulate during your training is

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vast. There is a problem that at the moment, in terms of the medical

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curriculum, the amount of time that trainee doctors have lectures on

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infection, let alone the use of antibiotics, it is a tiny part of

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the medical curriculum, and colleagues, I know who are

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interested in education, say that has to change, there needs to be

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more much focus on how to use antibiotics properly.

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Thank you very much. Now, there is nothing unusual about

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Governments taking a beating in by- elections half way through a

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parliament, nor is there anything unusual about an opposition holding

:14:57.:15:04.

three safe seats, as Labour did yesterday. But, the UK Independence

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Party say recent elections amounts to sea change in British politics.

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UKIP, they claim, and not the Liberal Democrats, are the third

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party. They claim to be going on in future elections to possibly

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reshape things. We report on whether any of this is

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justifiable or political dreaming. The morning after the night before

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in Rotherham, sees normal life continue apace, and it is business

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as usual in affairs of state too. The local Labour Party retained the

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constituency last night in a by- election, comfortably, but beneath

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the surface, basking in winter sun, quite some disturbance was caused.

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Last night it wasn't the winning that counted, but the coming second

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that seemed to matter. In the European elections, in cities like

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Hull, we came first, in the local elections last year in Sheffield,

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we got more votes than the Conservatives. We have just

:16:07.:16:10.

performed creditably well in the Police Commissioner elections. The

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general election, two-and-a-half years ago, UKIP scored 3% of the

:16:15.:16:18.

vote, the last opinion poll put us on 11% nationally you are looking

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at a very different party, and a confident party.

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Add to that, last night's positions, in Rotherham UKIP secured 21.79% of

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the vote. Its highest showing in a Westminster by-election, elsewhere,

:16:31.:16:36.

in the two other by-elections of Middlesborough and Croydon t came

:16:36.:16:41.

in second and third respectively. This triplicate of positions for a

:16:41.:16:44.

party, once teased by the Prime Minister, appeared sweeter than

:16:44.:16:48.

winning. For the celebrations last night by UKIP, you would think that

:16:48.:16:52.

coming second in a by-election is the new coming first. Remember,

:16:52.:16:55.

UKIP doesn't yet have its own MP at Westminster. That goes to the heart

:16:56.:17:00.

of the strategic questions being asked, if not by the party itself,

:17:00.:17:05.

then being asked about the party. Why are they not digging deep in

:17:05.:17:09.

one constituency, trying to get the MP, instead of the mini-explosions

:17:09.:17:13.

they are letting go off around the country. I think they are not

:17:13.:17:20.

inclined to go for the MP, why should they bother, a -- as it

:17:20.:17:24.

stands they are scrambling the signal of UK politics. At the

:17:24.:17:28.

beginning of this year they started to overtake the Liberal Democrats

:17:28.:17:32.

as the third part. The Liberal Democrats have done well as a

:17:32.:17:37.

protest vote sometimes. Now they are in Government they are not the

:17:37.:17:40.

natural receiving of protest votes, and that is what we have seen in

:17:40.:17:44.

Rotherham. Does it mean they are wiped out because they came eighth?

:17:45.:17:51.

No, but it does show they are squeezed. What drove up UKIP's vote,

:17:51.:17:57.

two issues repelled loyalists from Labour. Who did you vote for?

:17:57.:18:04.

Why? Because what is on the Labour council, old-time Labour voter,

:18:04.:18:07.

disillusioned with them. Denis MacShane with the scam he pulled on

:18:07.:18:15.

everybody, and also with, what I heard about the foster carers.

:18:15.:18:18.

That one-time Labour loyalist confirmed UKIP is not just a

:18:19.:18:23.

problem for the Conservative Party. A larger proportion of UKIP

:18:23.:18:26.

supporters in 2010 would go Tory, but there are Labour-inclined

:18:26.:18:30.

voters too. If you drill into UKIP's numbers, there is something

:18:30.:18:34.

else going on. When we look back at the data of people who say they

:18:34.:18:37.

support UKIP, what is interesting about them, is yes, they are

:18:37.:18:40.

interested in Europe, they are as interested in immigration and race.

:18:40.:18:44.

Where as one person in five in Britain says that immigration is

:18:44.:18:49.

the key issue, problem, facing the country, amongst UKIP voters, in

:18:49.:18:55.

our recent analysis, the figure is 49%. We have stumbled across the

:18:56.:18:59.

well named new Labour MP for Rotherham, Sarah Champion, she will

:18:59.:19:02.

probably keep the seat at the next election, this place a Labour

:19:02.:19:05.

stronghold. But, as we have seen this morning, she and her party

:19:05.:19:08.

will have a lot to do on immigration.

:19:08.:19:12.

According to the office of national statistics, last year, Rotherham

:19:12.:19:17.

was home to 237,000 British inhabitants, and 15,000 non-British.

:19:17.:19:20.

These figures are clearly blunt, and may not reflect the actual

:19:20.:19:25.

community. But on the ground, there did appear to be some of the anti-

:19:25.:19:28.

immigrant feeling driving UKIP's surge, diagnosed by the pollsters.

:19:28.:19:34.

We had been at Eastwood, two life- long Labour loyalists, took us to a

:19:34.:19:38.

car park, where they say the children of eastern European

:19:38.:19:42.

immigrants gather nightly and Iraqously, our pair had organised

:19:42.:19:49.

to resist them -- racausly, our pair had organised to resist them.

:19:49.:19:53.

Do you equate how upset you are in your community and the by-election?

:19:53.:19:57.

A lot of people have decided to vote for someone else definitely.

:19:57.:20:01.

You were a Labour voter? Yes. it a difficult decision? Yes, I

:20:01.:20:05.

have voted for somebody else this time, definitely. I didn't vote

:20:05.:20:15.
:20:15.:20:17.

UKIP, I stuck to being a Labour voter. But I think the voters of

:20:17.:20:21.

Rotherham have sent a message in the result that came through. Help

:20:21.:20:26.

us out, do something for us. You know, let's help each other to

:20:26.:20:32.

improve the area. They discuss how they vote with their friends Saber,

:20:32.:20:36.

the secretary of the local mosque. Why didn't you go for UKIP? If it

:20:37.:20:41.

was the same MP I wouldn't have voted, I would have gone for UKIP.

:20:41.:20:44.

Would you have voted UKIP? possibly would have, because their

:20:45.:20:48.

policy applies to myself as well, therefore, I have to be careful

:20:48.:20:52.

when I'm voting. Anecdotes on the ground aside, it

:20:52.:20:55.

was Labour that did well yesterday. The two parties in Government are

:20:55.:20:59.

spinning last night's result as mid-term blues, more blue than

:20:59.:21:03.

usual in the chill weather of November. But all minds in

:21:03.:21:06.

Government are turned to next Wednesday's big economic statement

:21:06.:21:12.

of intent. In the knowledge that, at root, the prospect of a triple-

:21:12.:21:17.

dip recession, caused last night's triple-boost for UKIP. With me is

:21:18.:21:23.

the editor of the Spectator, and Steve Richards from the Independent.

:21:23.:21:31.

We hear from Jeremy Batten an MP for London from UKIP. Well done for

:21:31.:21:35.

not winning anything, 70 piers of the people didn't vote, you are not

:21:35.:21:38.

the third force in British politics? We have been doing this

:21:38.:21:43.

for 20 years now. It has been a slow progress, because we are up

:21:43.:21:46.

against the first pass the post electoral system, that is very

:21:46.:21:52.

difficult to breakthrough in. We have 100 years of entrenched

:21:52.:21:54.

tribunal voting we are trying to make -- tribal voting we are trying

:21:54.:22:00.

to break down. You did well in 2009, European elections, came second,

:22:00.:22:04.

2010, no Westminster seats. Which Westminster seat are you within a

:22:04.:22:10.

sniff of winning? We would give away our strategy if I tell you

:22:10.:22:14.

that. We will fight as many seat as we K we are look to go do the whole

:22:14.:22:18.

of the 645 we will be targeting seats as well. Deciding which ones

:22:18.:22:22.

to put the most effort into. many will you win? I can't make

:22:22.:22:27.

those kind of predictions, I don't know. I have never underrated how

:22:27.:22:30.

difficult it is. The reason we are doing so well, is because we have a

:22:30.:22:35.

flavour of that from your intervoos, is because we actually rep --

:22:35.:22:39.

interviews, is because we represent the centre of British opinion. The

:22:39.:22:42.

old parties don't actually appeal to what the ordinary voters want.

:22:42.:22:47.

They were talking pretty much about local issues, the kids causing a

:22:47.:22:50.

row, talking about what is going on in Rotherham council, and a

:22:50.:22:56.

disgraced local MP. Not the kinds of things that are your policies?

:22:56.:22:59.

Some maeings the Government -- so many of the things the Government

:22:59.:23:04.

wants to do they can't, because our laws are made in the European Union.

:23:04.:23:07.

Controlling immigration, we can't control it, because the EU sets the

:23:07.:23:12.

laws. Is there any chance of you forming an electoral pact with the

:23:12.:23:14.

Conservative Party, or even undermining them, given that,

:23:15.:23:20.

actually, even if everybody voted UKIP last time, it wouldn't have

:23:20.:23:25.

helped them a great deal? It is the myth that we only take Conservative

:23:25.:23:28.

votes. We have always taken Labour votes, if you look at the figures

:23:28.:23:33.

back 20 years, to 1994, the first elections we took part in, we do as

:23:33.:23:37.

well in Labour as Conservative seats. Would you do pact with the

:23:37.:23:40.

Tories, given the current leadership, you know what David

:23:40.:23:50.

Cameron said about you four years ago, "fruitcakes and loonies"?

:23:50.:23:54.

got endorsed by Peter Mandelson last year -- week. I wouldn't say

:23:54.:23:59.

endorsement. What about a pact? don't know what the pact is. If the

:23:59.:24:03.

Tories want that they can announce it. It would kill you off? They

:24:03.:24:06.

could announce the policy that they have decided to withdraw from the

:24:06.:24:09.

European Union. I don't see what the pact is supposed to deliver for

:24:09.:24:14.

us or them. We fight because we know, clear and simply, what we

:24:14.:24:17.

believe in and what we want. If they want to try to undermine us,

:24:17.:24:23.

all they have to do is say they will withdraw from the EU or offer

:24:23.:24:29.

a referendum. How big a problems is UKIP for David Cameron, or is the

:24:29.:24:32.

problem an historical problem for the Conservative Party about

:24:32.:24:37.

Europe? The problem is a third of the public only want to stay in

:24:37.:24:40.

Europe now. There is no issue in British politics where there is a

:24:40.:24:43.

bigger gulf between the public opinion and the mainstream

:24:43.:24:49.

Westminster opinion. What UKIP will do, by consistently getting 10% of

:24:49.:24:54.

the vote, it will remind the parties they are out of line.

:24:54.:24:57.

much more than that? It is still more than the Liberal Democrats.

:24:57.:25:00.

Isn't that the big story, the Lib Dems are nowhere, what is happening

:25:00.:25:03.

to them is exactly what happens to parties in coalitions from Ireland

:25:03.:25:11.

through to Germany. The smaller parties lose out. No question. One

:25:11.:25:15.

of the things by-elections do is fuel a sense of doubt and security

:25:15.:25:21.

within a party. The specific events, the specific seats, soon fade. But

:25:21.:25:27.

that kind of fear of potential electoral oblivion, will shape, to

:25:27.:25:31.

some extent, the way they calculate and think. They seem robust in this

:25:31.:25:35.

election. Even after coming eighth. But coming eighth will be traumatic,

:25:35.:25:39.

especially to MPs who are worried about keeping their seats at the

:25:39.:25:41.

next election. It will play a part in the thinking over the next few

:25:41.:25:46.

months and years. Talking about the thinking, the big story this week

:25:46.:25:50.

presumably will be the Autumn Statement and what the Chancellor

:25:50.:25:58.

will do, for all of us. It looks a pretty grim 2013. Yes, and 2014, 15,

:25:58.:26:01.

16. They will come out with a forecast. The fact is there is not

:26:01.:26:06.

much growth in the economy now. Nor is three predicted to be. What

:26:06.:26:09.

George Osborne hoped to be a recovery in time for the next

:26:09.:26:13.

election, will be belt-tightening and austerity for the foreseeable

:26:13.:26:17.

future. He will have to come to terms with the fact that telling

:26:17.:26:22.

the public that, after having served them cuts in the last

:26:22.:26:26.

election but there will be in the next election too. That won't go

:26:26.:26:30.

down well. It is not a great vote- winner. The one thing he can do is

:26:30.:26:33.

say Labour's best hope is to talk down the economy, that nothing

:26:33.:26:36.

turns up? I don't think that is a very effective argument when people

:26:36.:26:42.

are feeling down about the economy. They will feel more down after

:26:42.:26:46.

Wednesday? What he will do, he has already said it, he wrote an

:26:46.:26:49.

article about following lessons from the Obama campaign, he will

:26:49.:26:53.

try to blame what has happened, again, on the Labour Government.

:26:53.:26:57.

And the recent past. Rather than his attempts to address the

:26:57.:27:01.

situation. So far, that has had some impact on Labour's ability to

:27:01.:27:06.

get its message across, it hasn't helped him at all electorally, or,

:27:06.:27:11.

as we were talking about earlier, the Lib Dems who pursue the same

:27:11.:27:16.

message, that it isn't their fault. What women see this week is

:27:16.:27:19.

incredibly important, in terms of the dynamics of the Government and

:27:19.:27:21.

the future of the parliament T won't change the debate, it is

:27:21.:27:25.

already framed. It will be bleak, they were argue it is worth it, and

:27:25.:27:29.

make it far bleaker than it need be, we are already at that point.

:27:29.:27:34.

terms of options, tax rises, more austerity, and more cuts, the

:27:34.:27:37.

deepest cuts haven't happened? There is another option he could

:27:37.:27:41.

take, which he won't, I suspect, is to come up with a radical pro--

:27:41.:27:45.

growth package. What he has done is not enough, cuts are not enough,

:27:45.:27:48.

austerity not enough to get the economy moving. We have seen other

:27:48.:27:52.

countries abroad do deficit finance tax cuts. Swede just did a major

:27:52.:27:56.

one in the last budget. That is new thinking and it is working. I don't

:27:56.:27:58.

think politically the Conservatives are there yet. I think they believe

:27:58.:28:02.

they are stuck in a groove of relatively bleak economic activity.

:28:02.:28:07.

The only question is, who gets the blame for this, and they are hoping

:28:07.:28:11.

that Labour still hasn't got the credibility to blame the

:28:11.:28:14.

Conservatives probably. That is the battle, that is what most people

:28:14.:28:18.

talk about, and just saying get out of Europe would solve everything

:28:18.:28:22.

isn't playing? More and more people are realising that you can't

:28:22.:28:24.

actually address the problems inside the European Union. Look at

:28:24.:28:29.

the countries outside the European Union, Norway, Switzerland, Canada,

:28:29.:28:34.

Austrailia they all have higher living standards. So has Germany.

:28:34.:28:37.

That is held back by the European Union. If we left the European

:28:37.:28:42.

Union we would get our own destiny back, we could be a more prosperous

:28:42.:28:46.

country, a freer country, we could control the big issues people care

:28:46.:28:50.

about. Our message is going home to people f you want to address those

:28:50.:28:53.

issues, there is no point in voting for the old parties. If I may say,

:28:53.:29:01.

the Lib Dems are now becoming irrelevant in that they are no

:29:01.:29:07.

longer the party of protest. much like the politics of the 70s,

:29:07.:29:12.

economic gloom in or out. Close decisions. If we made the right

:29:12.:29:16.

decision in 1975 we wouldn't have these problems.

:29:16.:29:19.

On I'm joined by Bennett Miller, Hadley Freeman and Christina

:29:19.:29:26.

Patterson, for the latest baseball film, this one starring Amy Adams

:29:26.:29:32.

and Clint Eastwood. Valentino sweeps in with show-stopping frocks.

:29:32.:29:38.

Spike Lee has made a film pulling Michael Jackson back up on to a

:29:38.:29:43.

president das tell as a musical genius. And a grandfather who

:29:43.:29:46.

modelled his granddaughter's clothes, that is love.

:29:46.:29:56.
:29:56.:30:21.

There is flash photography coming up, leaving you with Freddie

:30:21.:30:27.

Will common medical procedures become too dangerous as superbugs learn to resist antibiotics? Is UKIP really about to be Britain's 3rd party?


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