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The pioneering genetic research giving new hope to a chronically ill
What we did find out was that you have 3.2 billion
letters in your DNA, and for me to have what I have,
And this is where the breakthrough was made, a research laboratory
The team here are engaged in a project that's pushing
Jailed for three years, the cyclist who killed a pedestrian
after an argument about riding a bike on the pavement.
We'll tell you about a storytelling cottage industry that's now
And a haunting commemoration of World War I.
The scrap metal soldier forged in Dorset
A pioneering genetic test developed by doctors in Southampton has
pinpointed a rare immune deficiency in a ten-year-old Dorset boy.
Matthew Knight has suffered from one infection after another
The success of the test has made it possible
to boost his immunity and help him fight off future illnesses.
The team responsible believe their work could benefit
many more people, paving the way for a routine genetic test for all
Matthew has got no problem with Lego. It's the building blocks in
his DNA that have caught him grief. What we did find out was that you
have 3.2 billion letters in your DNA and for me to have what I have, I
have four missing. Just four, which is, wow. Matthew had been in and out
of hospital with infections since she was three months old. Endless
tests and blood tests and x-rays and scanned and everything. It was a
long haul, waiting and finding out exactly how he was going to be
treated because they did not know what to do with it. Then the family
was invited to take part in a medical trial. This is where the
breakthrough was made, research laboratory at Southampton Hospital.
The team are engaged in a project which is pushing the boundaries of
medical science. They have developed a test that can go deeper than any
time before it our genetic make up and pinpoint precisely because of a
range of rare diseases. Some have compared this to manned landing on
the moon. We are moving into a reality of delivering tests that we
would not have thought possible 15 years ago, into clinical care and in
Matthew's case, within three weeks, we were able to turn around a result
and give the family information that had been previously elusive. All of
the data in the lab comes into a sequence. This machine tells us what
the genetic code of an individual is and there we determine where the
illness arrives from. He is now getting the right treatment to boost
his immune system. I feel like I am sitting in now, now I feel like I am
covered, I fit in a bit more. You can get out and enjoy yourself.
Similar tests are being developed to detect the causes of common cancers.
It is thought they could be routine in the NHS within a few years.
A cyclist has been jailed for just under three and a half years
after admitting he killed a pedestrian last September
after an argument about riding a bike on the pavement.
69-year-old Roy Galvin, from Alverstoke in Hampshire,
was pushed over, hitting his head on the road.
Duncan Snelgrove from Gosport pleaded guilty to his manslaughter.
Roy Galvin was an aircraft engineer in the Royal Navy for 24 years.
Receiving Falklands War and good conduct medals.
Retirement was said to have given him a new lease of life,
but it was ended suddenly on a street in Gosport.
It was early evening in September when Roy Galvin and his wife Deborah
were coming along here on their way home from a nearby pub.
Deborah Galvin was in a motorised wheelchair.
Ahead of them were a group of people including two men on bikes.
One of the bicycles was obstructing the footpath, and it
Mrs Galvin said Snelgrove was full of rage, and without warning
had raised both arms and pushed her husband in the chest.
Mr Galvin fell backwards into the road and received
Snelgrove pleaded guilty to manslaughter.
Today the court heard he has 17 previous convictions,
His barrister said Snelgrove was deeply remorseful.
Outside, a police officer read a statement on behalf
I've had my husband and soul mate taken from me far too early.
The terror of the incident of Bury Road is still with me
and is pretty much on my mind for every minute of every day.
I just can't seem to get out of my head.
Snelgrove was imprisoned for three years and four months.
It was an appropriate sentence, I thought, for this incident.
Comment on this incident was, it was just such an unnecessary use
of violence at that time on a Sunday afternoon in Bury Road, and such
I suppose it demonstrates the fact that even small amounts
of violence can end up in these outrageous tragic consequences.
A Berkshire council has been heavily criticised after a vulnerable woman
with dementia lost a third of her body weight while
The woman weighed less than six and a half stone at the end
of her three year long council-funded stay at Murdoch House
The Borough council has been ordered to pay compensation
Nikki Mitchell is in our Reading studio.
What were the consequences of this lady losing so much weight?
The woman was severely malnourished by the time she left the care home.
She simply hadn't been eating enough food to get the nutrients
And we're talking about a very vulnerable woman.
An elderly woman with dementia, who'd had a stroke and had
When she was moved into Murdoch House Care Home in Wokingham
in 2010 she weighed a healthy nine and a half stone.
But by the time she left three years later, she weighed less
Her family complained to Wokingham Borough Council and it
transpired that while the council had funded her care, they'd failed
The local government and social care ombudsman says it's one of the worst
The council failed to properly monitor the quality of care
and they are responsible for the quality of that care.
Even though the failures rest with the care home ultimately.
So the message we want to send out today is that the councils have
to recognise that they must monitor the quality of care,
they must review the needs of the people in these placements
and make sure those needs are being met.
And I'm afraid that didn't happen in this case.
How were things allowed to go so badly wrong? The council accepts it
failed in this case. This lady's name vanished from a computer
system. We changed from one
computer system to another, and unfortunately in the transfer,
we lost the name of that individual. And whereas normally, they would get
at least an annual review, that became unsighted to us
and we can't do anything We know that that led
to an unfortunate outcome So I'm happy to say that we've
corrected all of that and massively So the Borough Council
is going to have to pay ?4,000 in compensation to the lady
concerned, and her family. The company which runs
Murdoch House Care Home meanwhile has also apologised
for any failings. But it says the ombudsman's report
did not reflect the substantial weight loss the patient suffered
while in hospital, and that the home did take steps to fortify her diet
with additional cream and butter. An MP's stepped into the row
about a controversial bus lane camera near the QA
hospital in Portsmouth. Penny Mordaunt, Conservative MP
for Portsmouth North has asked the council to rethink how it
operates the camera after more than 3,500 people were fined
in just five months. The camera was installed in July
and within the first 11 weeks, fines totalling nearly
?124,000 were issued. Between October and December fines
totalled another ?87,000. It's a camera that's been called
a cash cow and unfair. It was meant to deter nonhospital
users from using the bus lane as a short cut,
but because you cannot see the sign clearly,
it's actually penalising hospital If you approach this
junction from the north or the south car park,
then the signing here is obscured so people don't actually noticed
there's a bus lane as you turn left And as you go through there,
there's a camera, which would then Andrew is one of more than 3500
drivers who have been caught. He received the fine only two days
after his terminally Although the council has
since let him off the ticket, on compassionate grounds,
he says the system is unfair. I think it's immoral
that they do that. People here are coming
here for treatment or to take relatives, or visit relatives,
and it's quite immoral that people Where you've got cameras in the city
that are creating very, very high levels of fines,
that should be reviewed And in this instance, clearly,
those who have been fined had suggested that the signage could be
improved, and I think that's probably the sensible thing
for the council to do. Motoring experts say the issue
in Portsmouth is not unique. In Preston recently,
a bus lane was actually switched off after two weeks of a camera looking
at a bus lane and catching people. And the reason they stopped
that was that they realised that there were, that the signage
it wasn't adequate. So they decided that they would stop
putting fines in place, they would reassess the site,
and look at the signage And that's what we'd
like Portsmouth to do. Portsmouth City Council says
that the current signs do comply However it does recognise there have
been a large number of fines issued so it's now speaking to the hospital
trust to see if any additional signs or road markings on the approach
to the bus lane can be put in place. A motorway service station
in Hampshire which was engulfed by a large fire
has partially re-opened. The southbound Fleet Services
on the M3 was closed last month. The blaze started in a restaurant
and spread to other buildings. Operators Welcome Break have
reopened some of the facilities including the forecourt and toilets
with access restored to the northbound service station
across the footbridge. Don't go away because Tony's
here with all the sport in a few minutes' time,
and Alexis will tell us if last Last night was the coldest night of
the season. Tonight will not be as cold but still pretty chilly. I will
have the forecast for you shortly. It's the argument at the heart
of the year-long dispute that has wrecked services for hundreds
of thousands of commuters. Plans to run driver only
trains between Horsham and Bognor Regis are safe,
according to the Chief He's carried out months of research
into Southern Railway's plan for drivers to operate train doors
on the route, instead of conductors. The rail unions which are striking
over this issue dismissed the report Our transport correspondent
Paul Clifton is at Does this report prove
the unions are wrong? Sally, there have been many reports
into the safety of driver controlled operation. Everyone, without
exception, has concluded that it is safe. So what makes today's report
different? It was carried out on Southern Railways on the exact route
through West Sussex that the system is being extended across. It has
been carried out by the most senior safety expert in the industry, a man
who is widely respected. Driver only operation can be
operated safely in compliance with the law on Southern Railways
and we have told Aslef The safety inspector ran tests on
the Horsham to Bognor Regis route. They looked at the union claims that
cameras on trains were unsafe in poor light and at night-time.
Deficiencies were found at some stations, so Southern is more
lights. The inspectors looked at whether cameras can see small
children adequately. They also looked at leaving the door cameras
running as the train starts to move. This offers clear safety benefits
compared to using a guard, they say. But the drivers union is pressing
ahead with next week's strike. It says the two sides are on different
planets. The reality is that there has been
no real move to address the fundamental issues that
are at the heart of the deal. It is about the imposition of
a system and breaking of agrrements And if everything is done
by imposition in the future, then the reaction is always
going to be the same. What other reaction do you get
from anybody in any other walk of life if they're forced
to do things? But every safety report, every
statistic I have ever read, on driver door operation, says it is
safe. But the RMT union called today's report a total whitewash,
which proved the safety authority is no longer fit for purpose. The union
even said there was no longer any independent safety regulation of
Britain's row ways. So, sadly, the two sides are not in any mood for
compromise. Portsmouth port will lose
about a third of its cruise ship trade after a holiday company went
out of business. All Leisure holidays went
into administration yesterday, affecting Swan Hellenic
and Voyages of Discovery. The City Council, which owns
the port, says the expected loss will be less than 1%
of the ?15 million generated Two friends, working in a converted
shed in rural Berkshire, producing audiobooks
for blind people. They're still doing that,
but the initial idea has morphed They're now producing
recordings of stories that, thanks to the internet,
are reaching people If you're sitting comfortably, Allen
Sinclair has the story for you. He slipped his finger to the tail
section of the blueprint. In the back would be
another smaller... Creating audio books is a lot more
involved than simply recording Can we actually have
that heaving sigh? You need a soundproof studio,
the kit, vocal talent, and an ability to judge pace,
passion and pitch in a performance. We don't want that,
that's the wrong one. Then a way to get the
finished work out there. You'll agree this is
certainly interesting. Matt is almost totally blind and set
up Living Audio as a social Initially to produce recordings
of fan fiction featuring He even got JK Rowling's
blessing, because it was They were released, really,
to benefit blind and print disabled people, and they've
been very popular. And many, many blind and dyslexic
people and people with other various disabilities that prevent them
from reading have come back and said, you know,
these are absolutely amazing. That led the friends to seek out
collaborations with other, It was very much working with books
that wouldn't normally be Even when we do commercial books,
we're producing audio to the best quality that we can do,
knowing that blind, print disabled, anybody that can't hold a print book
or read it comfortably, will have the best
production we can produce. The UK spent ?12 million
on digital downloads in 2015. The business is still finding
its feet but audio books recorded here in Berkshire are now
being downloaded daily Excellent work. On to sport, Tony is
here, cricket in a moment and think of the summer.
Still frost on the ground but let's talk about winter first.
Southampton say captain Jose Fonte has asked to leave the club.
The 33-year-old has been in a contractual impasse
with St Mary's officials for several months.
Southampton say he turned down a pay rise in the summer
but the Portuguese defender, who is the only survivor
from their time in League One, wants a longer term deal.
Saints Executive Director Les Reed says the club are yet
The question of another year, we haven't rejected that.
He has turned down the opportunity to increase his salary,
and he's turned down the opportunity to get another permanent
That interview is in full on the BBC sport website.
Meanwhile Portsmouth could close the gap to just a point
on the promotion places in League Two tonight.
They're at the leaders Doncaster, you can hear it live
on BBC Radio Solent and we'll have the goals at 10.30pm.
Some big news from Hampshire cricket today, and a signing
which has sent shock waves through South African cricket too.
Fast bowler Kyle Abbott has turned his back on his international
career to sign a four year deal at the Ageas Bowl ending
his Test match career, amid controversy back home.
He'll become the latest player to use a freedom
of movement law, known in sport as the Kolpak agreement.
Abbott himself revealed he was joining Hampshire
after South Africa's test victory over Sir Lanka in Cape
For Kyle Abbott, a huge life decision.
I'd like to take this opportunity to announce that I have signed
It has been one of the hardest decisions I have had to make.
But at the end of the day it is the right decision for me.
Abbott will play as a non-overseas player under the Kolpak agreement.
South African citizens have the same freedom of movement as EU citizens,
but it means the end of his international
It has been a few evenings where I have gone to sleep thinking,
But I have always woken up the next morning knowing
I have had a great run with Cricket South Africa,
I have no regrets at all, I have been involved
And I'm incredibly grateful for that.
And I just feel it's a time in my life where I have
The 29 year old signed a four-year contract.
He's a well considered man, and he's decided this is the right
And we're obviously the club that he's chosen to come
to and we're delighted that he's on board with us.
Abbott's move is emulated fellow South African Rilee Rossouw,
a batsman and another Kolpak player, who's agreed three-year deal.
Meanwhile Hampshire all-rounder Liam Dawson arrives in India tonight
to play in England's one-day international series.
The one-day cricket we've played, in the last sort of two years,
So hopefully can continue that in the next in India.
Dawson will be in the squad for three one-day internationals
Another step towards becoming a regular in the national setup.
Gold medal winning diver Chris Mears from Reading,
says he's angry that his coach has quit to join the Australian team.
Ady Hinchliffe is moving to Australia to become lead
Mears says Hinchliffe should have been offered a full time
British Diving says it began discussions but timescales didn't
It's led to frustration and anger from the winning pair
Ady has taken me from a boy with a lot of dreams to a man able
It is a massive shame from the bottom of my heart to say
He has his reasons for why he's leading, and I think to be honest,
he's been forced to leave, which is a shame, for what he's done
The three time Olympic rowing champion Pete Reed has announced
that he will bid to compete in the 2020 Games.
The Caversham based rower has returned to the gym this week
and will be aiming to match Sir Matthew Pinsent's haul of four
Reed will be 39 come Games time and faces four years
of gruelling training, including rowing more
I made sure I had a good break, I had a lot to do in that time
off after the Olympics, and you can see we are back
at Caversham now, this is not Rio de Janeiro,
I haven't got a suntan, I feel, to be quite honest,
And this is day three of training for me, I'm already aches
But yeah, a big decision and definitely the right one
It is a gruelling schedule. 25,000 miles on the water! You can hear
more on the BBC Berkshire site. Next year marks the centenary
of the end of the first world war and to mark a significant milestone,
a monumental sculpture has Made as a tribute to all those
Tommies who lost their lives, it is a six metre high soldier
forged out of scrap metal. Clinton Rogers has had
a preview of a work He is a monument to bravery, but
also recycling. At the Dorset Forge where he was created, they pieced
together pretty much everything they could get their hands on. From car
parks to spammers. -- parts of cars to spammers, changed to garden
forks, and the result is impassive. Only when you stand next to the --
impressive. Only when you stand next to the sculptured EU get a true
sense of scale, it is 5.8 is tall and weighs one and a half tonnes and
took three and a half months to build. It is called The Haunting and
it has been made for a local man who wants to remain anonymous. It is a
commission for a local author who came to us and ask if he could build
a ghostly figure of a First World War soldier. This is what we have
ended up with an I think it fits the bill spot-on. It is going to be
featured in the book, at the moment that is as much as I can say. As it
stands proudly waiting for delivery, the sculpture is certainly
attracting admiring glances from passers-by. I think it is just
incredible. The more you look at it, you see so many little bits that he
missed and it's absolutely wonderful -- that you missed and it is a
wonderful tribute, beautiful. Though younger admirers are not sure who it
is. What do you call him? The DFG? He might be! He is a giant and
friendly, and I think that depends on which side you are on. The
Haunting will go on public show, but when and where that will be for now
remains a mystery. That is magnificent, I hope we get
an opportunity to see it. Onto the weather, very cold. I had the
thermals on walking the dog this morning. My hands were white 30
seconds after stepping outside the front door. The temperatures in a
minute, but here are some pictures. It was the coldest night of the
season last night, with temperatures plunging down to minus eight
Celsius, -7 at Bournemouth Airport and freezing us elsewhere across the
region. It will not be as cold tonight but chilly temperatures for
the widespread frost and freezing fog patches. The fog will develop
through the second part of the night. Temperatures in towns and
cities down 2-3 C, but in the countryside, we could get to minus
five. Slightly more cloud arriving in western areas during the second
part of the night. The fog will clear around 11am and once it does,
sunny spells. Sussex and Surrey holding onto the sunshine but Al
where the cloud will increase, turning the sunshine hazy. The odd
spot of frames in northern and western areas. Temperatures -- the
odd spot of rain. Temperatures will not be as low as today. Feeling my
-- milder tomorrow, and a band of rain will be coming through tomorrow
night. The odd moderate to heavy burst in there. Temperatures will
fall away tomorrow night to milder 47 Celsius, maybe some mist patches
to start the weekend. The weekend as a whole -- 4-7 C. The weekend as a
whole will be milder. High pressure will be building but there will be
cloud associated with it. The odd spot of drizzle cannot be ruled out
over the weekend, more likely Saturday. Temperatures will reach
high of ten to 11 Celsius. The outlook, a frost tomorrow in some
places, a bright start to the day but cloud increasing and rain
arriving by dusk and into the evening. Over the weekend, mainly
dry but fairly cloudy. Tomorrow we are looking ahead to the
FA Cup? Yes, Reading at Old Trafford. That is it from us, good
night. We're looking for someone
who can sing, someone who can move. Someone who can keep an audience
on the edge of their seat. Something like this
could change my life. When you're born to perform,
Let It Shine... Magical new drama...
The Worst Witch. Shall we? Absolutely.
..DI Goodman... It's been lovely, our little holiday
romance. ..is back on the case.