16/02/2016 BBC News at Ten

David Cameron continues his frantic diplomacy, today in Brussels trying

Just two days to go before the crucial summit and he's told

there are still tough negotiations ahead.

But back home, a speech by Prince William is interpreted

by some as support to keep the UK within the EU.

In an increasingly turbulent world, our ability to unite in common

action with other nations is essential.

The palace though says Prince William's comments were not

Also tonight: A new cancer treatment that's showing unprecedented success

in trials - appearing to make the cancer vanish.

Growing international pressure on Russia as Moscow is forced

to deny again it bombed hospitals in Syria.

I'll be explaining how scientific understanding of mental health

illness is being advanced by these - miniature human brains being grown

And the joke's on George Clooney in the Coen Brothers' latest film -

Later on BBC London: A man goes on trial accused of planning

to attack British or American military personnel in the UK.

And captured on camera - can Nasa technology help cut

David Cameron has completed a day of frantic diplomacy in Brussels

trying to muster support for his EU reform proposals before the meeting

on Thursday at which he hopes European leaders will approve them.

Here a speech given by Prince William at the Foreign Office

has been interpreted by campaigners as a signal

he supports their call to keep Britain in the EU.

Kensington Palace deny he was doing any such thing.

Our political editor Laura Kuenssberg reports

on the Prime Minister's efforts in Brussels - and those

The Foreign Office is as grand as a palace, so Prince William might

Kensington Palace denies it, but just as the Government

prepares its fight to stay in the EU, was the Duke taking sides?

In an increasingly turbulent world, our ability to unite in common

action with other nations is essential.

Right now, the big questions with which you wrestle,

in the UN, Nato, the Middle East and elsewhere are predicated

on your commitment to working in partnership with others.

Whatever William meant, for the Prime Minister "technical

He'll most likely get other leaders to agree to a new relationship,

but after that and after you've voted in a referendum,

probably in June, the European Parliament gets its say.

Its leader made plain that MEPs could block Britain's changes.

No government can go to a parliament and say -

this is our proposal, can you give a guarantee

But the main groups in Brussels do believe

For those who want to leave the EU, the threat of wrecking the deal

If we vote to remain and then we find the European Parliament have

scuppered it, well then actually the British people have been sold

And if it feels like the Prime Minister is making

a last-minute dash, that's because he is,

still trying to secure support to cut child benefit for EU

migrants, to delay paying tax credit to EU workers, too.

Persuading Europe's power players the UK is entitled

But for all the nerves at home, the expectation is the deal

For weeks there's not been talk of much else in this place.

The backwards and forwards between Westminster and Brussels has

dominated what the Government's been doing, but before long this decision

comes to all of us and it's coming soon to a town near you.

We hope for better world, for a better country for ourselves.

On winter nights, in pub back rooms, campaigners are starting to gather.

In Surrey, for some like the Woodhouses',

leaving the EU is about controlling who lives here.

Now, if I had to take up arms at my age, at 72,

to protect my country, I would do it and give my life for it.

And, for you, this choice is as serious as that?

We want doctors, we want nurses, we want people with skills.

We need them, there's no doubt about that, but we don't

I'm going to be taking time off work and I'm going to be campaigning

night and day because this is a unique opportunity.

A very different crowd in East London, for staying in,

What is it that makes you care enough to come here on a week

day night, after work, on a cold winter's evening?

I think it's hard to be, sort of, passionate

about being pro-European, but I think that it's something that

I think we could easily sleepwalk out of the EU.

It is really important, it's also part of my identity.

I think people like us, who are trade unionists,

need to make sure that we engage in the debate because otherwise it's

going to be pro-business Tories fighting little England

As the big day in Brussels approaches, the campaigns

If the deal's done, you'll vote within months to stay or leave

Let's speak to our Europe Editor Katya Adler in Brussels.

David Cameron yet again doing the rounds, this time where you are in

Brussels, does it look like he will succeed? Well, Fiona, here in EU

headquarters, it is very rarely described as a hotbed of excitement

and drama, but there is a real air of tension tonight. To be or not to

be, tweeted the European Council president when he published David

Cameron's draft reform proposals a couple of weeks ago, and that is the

burning question now. Can the Prime Minister get his reforms passed

when the countries of Central and Eastern Europe are still wrangling

over the details of cutting EU migrant benefits, and France is

growling in the face of safeguards for eurozone legislation. Every

single country has to sign up for this deal and that means every

single EU leader has the potential to scupper it. That said, after

hours of the gauche Asians probably a fudge will be merged. France will

probably crowed that it stopped Britain getting a veto over eurozone

legislation, even though David Cameron never actually asked for

one. He knows whatever the deal he gets here in Brussels, it will be

dismissed by the critics at home. If he does get a deal this week, it

will enable him to call a referendum as early as June. His strategy will

be if he can claim to tackle the issue of migration, he can win over

the voters he needs. Thank you. Scientists in America believe

they may have found a potentially They've managed to retrain cells

in the body's own immune system In a trial, more than 90%

of terminally-ill patients with blood cancers went

into complete remission. This is the body's natural

defence mechanism at work, an immune cell attacking

and neutrualising a cancer cell, but when that doesn't function

properly intervention's needed. This new study shows that specially

engineered immune cells, injected back into the patient,

can suppress a type of blood cancer. The study was published

in the United States and British researchers, working in this field,

say it offers exciting potential We know the immune system

is incredibly powerful, we know we can harness cells

from the immune system, engineer them and give

them back to patients. These effects are not just for a few

weeks or a couple of months, they're long-lasting

effects over many months So we think the enormous power

of the immune system in these kind of settings is there to be

harnessed, actually. This is how the new therapy worked,

a blood sample was taken from the patient and immune cells

were separated out and removed. Each one was modified

and transformed into a targeted immune cell to seek out

and destroy cancer cells. The cells were then grown

in a laboratory and stored. Later they were returned

to the patient's bloodstream where they were ready to detect

and then attack the cancer cells. The patients helped by the therapy

had all undergone other forms of treatment which had failed,

including chemotherapy and radiotherapy, but cancer experts

say more extensive trials These results are quite exciting,

but it's important to know this These still early steps

towards making this treatment George knows all about the struggle

with leukaemia, a type He was diagnosed in 2005,

was treated and got better. The cancer returned

and he had another successful The latest trial won't necessarily

help him, but he says its success is heartening for everyone

with the cancer. Any kind of research that might lead

to another option for people with cancers is

definitely good news. I try not to get too

excited about it because, as with all these trials,

it's in the early stages. There's some caution as only a small

number of patients were involved, but there's agreement that this

study is an important development International pressure is mounting

on Russia after claims that it has The Turkish foreign ministry blames

Russia for missile attacks on several hospitals and schools

in Syria yesterday In another development,

the United Nations says Syria has agreed to let convoys take aid

to people trapped in Here's our diplomatic

correspondent Bridget Kendall. What looks like a Russian fighter

jet in the skies over northern Syria and then this. Suspected cluster

bombs. Imagine being in one of those buildings, north of the city of

Aleppo yesterday. And this is the sort of damage being caused,

according to footage supplied by Syrian opposition activists. These

strikes are being widely blamed on Syrian and Russian forces. And after

yesterday's direct hits on hospital Sunday school where they are still

looking for victims, the chorus of outrage is growing. Tonight,

Britain's Defence Secretary added his voice, to those who say it could

amount to a war crime. If these reports are true, then these amount

to war crimes. These are crimes against the civilian population, a

breach of the law of armed conflict, in breach of all international

humanitarian law. Russia needs to be held to account for what it is now

doing, bombing innocent civilians, it is an abomination. The Syrian

army with its Russian and Iranian battlers insist their advance into

northern Syria is to liberate areas from terrorists. Today, Russia

angrily denied suspicions that its air strikes had hit hospitals,

implying this was a propaganda ploy. TRANSLATION: Reports in the Western

media about supposedly Russian air strikes on victims in the media have

grown like a snowball. It started with one hospital in the province of

Idlib in the morning. By the end of the day, a risen to five hospitals

and then schools. There is no excuse for targeting

innocent civilians of course, but the battlefield around Aleppo is

complicated. Not only moderate rebels backed by the west are being

attacked, more extreme fighters linked to Al-Qaeda and designated

terror group by the United Nations, which is why Russia and Syria as

they are bombing the just targets. What's more, also attacking rebel

positions in northern Syria are the Syrian Kurds, keen to extend their

enclaves coloured green. The Kurds were working with the Americans

against so-called Islamic State or ices controlling the territory in

red. Now they are using the Syrian and Russian push for their own ends,

alarming Turkey which sees any Kurdish advanced near the border as

a security threat. But at least one fragile ray of hope today from

Damascus. They pledged secured by the UN special envoy that food aid

May be let into some besieged areas tomorrow.

Let's take a brief look at some of the day's other news stories.

German investigators say human error was probably to blame for the

11 people died and 80 were injured in the head-on collision

An area controller whom it's alleged sent a wrong signal to the

two trains is likely to be charged with involuntary manslaughter.

The trial has begun of a Luton man charged with planning terror attacks

on British and American military personnel at air bases

Junead Khan, who's 25, is also accused with his uncle,

Shazib Khan, of planning to travel to Syria

Inflation has risen very slightly to its highest level for a year,

0.2% to 0.3% as measured by the Consumer Prices Index.

The cost of fuel falling less quickly than before

The figure is still well below the Bank of England's target of 2%.

The Metropolitan Police Commissioner,

Sir Bernard Hogan-Howe, has met Lord Brittan's widow and apologised

in person about Scotland Yard's handling of its investigation

into an allegation of rape against the former Home Secretary.

Officers questioned Lord Brittan and he died in January last year

without knowing the outcome of the inquiry.

Our home affairs correspondent Tom Symonds is at New Scotland Yard.

The Commissioner phrased his apology very carefully.

His force has been under extreme pressure about its investigation

into some past sexual abuse cases. He appeared intent on not offering

an unreserved apology. Lady Brittan, we're told, was more interested in

explanations than apologies. They emerged from this meeting with

different impressions of what was said.

In Lord Brittan's final years, he was accused

He was questioned and, after he died, his home

Today, his wife received a face-to-face apology.

The family described it as a "full apology" which was accepted.

But on BBC Radio London, Sir Bernard Hogan-Howe described it

I confirm the apology that we made, two months ago now, was an apology

for not telling her at an earlier stage about the fact that

Lord Brittan, who by that stage unfortunately had died,

was not to be prosecuted in the future, and there was no

This all results from claims on an investigative website that

Lord Brittan raped a woman, known as Jane, in 1967.

She reported it to the police four years ago.

But the claim proved difficult to fully corroborate.

And, in August 2013, the Crown Prosecution Service

advised there was insufficient evidence to continue

But the Met interviewed Lord Brittan in May 2014,

and then spent months trying to get prosecutors to review the case,

during which, in January 2015, Lord Brittan died.

The inquiry finally came to an end on April 2015.

But the Met failed to tell Lord Brittan's family until October,

and it's for this the force has apologised.

But Scotland Yard's made no apology for its other big investigation.

Operation Midland is hunting for evidence of a paedophile

His family has asked for answers to a further 30 questions.

However cordial, today's meeting is unlikely to silence critics

Reputations have been damaged by a clumsy, ham-fisted

Metropolitan Police investigation, presided over by a Commissioner

who seems totally incapable of understanding how revolted

the public are by what we now know has happened.

The Met insists, in Lord Brittan's case and others, it's trying

to balance the requirements of justice with the need for fairness.

With a hostile media constantly watching.

Our understanding of the human brain is undergoing a revolution,

according to some of the world's top neuroscientists.

Advances in genetics and brain imaging are enabling researchers

to discover more about mental illness, opening up

the possibilities for new treatments.

Our medical correspondent, Fergus Walsh, has been investigating

It is a privilege to be able to examine this,

the right hemisphere of a human brain, one of hundreds of brains

donated in the UK for medical research every year.

This delicate structure is responsible for thought,

memory, language, emotion, consciousness - the very things

Yet despite all our scientific knowledge, there is still a huge

amount yet to discover about how the brain works and why

But the brain is beginning to give up its secrets.

Advances in biology mean many genes implicated in mental illness have

been identified and new scanning techniques are creating something

extraordinary - a complete map of the brain's intricate

These coloured lines represent bundles of nerve fibres linking

different parts of the brain through a number of highly connected hubs.

There are bits of the brain that you can talk of as being hubs

in the brain in the same way that Heathrow is a hub

Researchers have found that people with schizophrenia tend to have

fewer hubs, so their brain networks are less well-connected

Where the excitement is building at the moment is linking the network

diagrams that we can get out of imaging to what we're learning

If we can bring those two things together,

then we may be able to understand more clearly

what are the mechanisms, the genetic mechanisms,

that drive network development to go off on a somewhat different path

And if we can understand mechanisms, then we can design new treatments.

As well as deciphering the brain's network of connections,

scientists are also learning more about its earliest stages

of development, by growing miniature brains.

Known as organoids, here they are in the hands

of the scientist who invented the technique, incubating

in a Medical Research Council lab in Cambridge.

These tiny balls of tissue mimic what the early foetal brain

Each was grown from a single cell donated by a patient.

In those with mental illness, their mini brains can help explore

We can actually then compare the organoids to the patient and see

if we can see some of the features of the disorder and try

to understand what caused those features.

I think it's a really huge step towards some hopefully really

amazing breakthroughs in what has been a desert

Mental health disorders have been incredibly lacking in terms

of new medications to treat these really devastating disorders.

So when will this research pay dividends in delivering

In the next five to ten years you can expect two things

One, we'll be able to use neuroscience and genetics to target

treatments better to patients, and this could happen

The second is that, based on the knowledge we have now,

we could actually have new medications, not for an entire

Of course, our mental health is determined by our life

experiences as well as the genes we inherit.

The more we discover about this masterpiece of evolution,

the greater the chance we have of treating it when it goes wrong.

There's plenty more from BBC One's season on mental health.

All the details are on our special website at bbc.co.uk/inthemind.

You can follow us on social media at #inthemind.

There's anger tonight amongst Scottish National Party politicians

trying to finalise the funding for Scotland's new powers agreed

Talks are currently at a stalemate and the Scottish Parliament has set

next Tuesday as a deadline for an agreement.

Our Scotland editor, Sarah Smith, is in Edinburgh for us tonight.

Sarah, the mood of the SNP hasn't been helped by a key minister

in the negotiations going on holiday?

Well, that's right. The SNP are absolutely furious that they are at

a critical point in these negotiations. The Chief Secretary to

the Treasury has gone on holiday to France. They are approaching a

deadline in these talks because if they don't do a deal by the

beginning of next week, the Scottish Parliament say there may not be time

to enact all those new powers Holyrood were promised in the wake

of the 2014 referendum they won't won't be in place for time for the

Scottish elections in May. The Treasury say he is prepared to cut

the holiday short if the Scottish Government make a substantial move

in the negotiations. What they are arguing about is how much they

should cut the block grant that the UK Government gives to the Scottish

Parliament once Holyrood takes control of income taxes in Scotland.

The negotiations do not seem to be going very well. They are not

anywhere close to reaching agreement. If they don't get it done

in time, if they don't get it agreed by the deadline this issue could

really dominate the Scottish elections in May. You'll have the

SNP complaining that Westminster are trying to cheat Scotland out of

billions of pounds in funding. Tory ministers are saying the Scottish

Government are trying to have their cake and each other people's cases

as well. Sarah in Edinburgh, thank you.

In America, former President, George W Bush, has emerged

from self-imposed political hibernation to hit the campaign

trail in his brother's bid to make it to the White House.

His younger sibling, Jeb, is battling to win

the Republican presidential nomination.

The pair appeared together at a rally in South Carolina

as our North America editor, Jon Sopel, assesses

whether the family name will be a help or a hindrance.

Hold on, one second, Mr President, here we go...

This is the lesser spotted George W Bush.

Since leaving office seven years ago, he's assiduously stayed out

But he's back, to help his kid brother.

This is the Bush family engaged in mission, Stop Donald Trump.

Real strength, strength of purpose, comes from integrity and character.

And in my experience, the strongest person usually isn't

Donald Trump has shown nothing but disdain for Jeb Bush

This ferocious debate took place at the weekend.

George Bush made a mistake, we can make mistakes,

I couldn't care less about the insults that Donald Trump

It's blood sport for him, he enjoys it and I'm glad he's

But I am sick and tired of him going after my family.

The World Trade Center came down during your brother's reign.

He's had the gall to go after my mother.

Almost the most striking thing about Jeb's campaign is the logo.

His first name, an exclamation mark and no mention

It's as if he wants to put the maximum distance between himself

and his big brother and his father, President George HW Bush.

But as this lacklustre campaign has faltered,

so the need to rely on the family has grown.

And the great matriarch of the Bush family, Barbara,

First Lady a quarter of a century ago, has also been out and about.

But for the moment, this dynastic family might have to accept that

for this generation, the Bush brand of Republicanism

is going to lose out to a more populist and raucous variety

being offered by the irrepressible Donald Trump.

Football, and a mixed night for Chelsea as they returned

Despite losing to runaway French league leaders Paris Saint Germain,

they scored a valuable away goal ahead of the second leg.

Our correspondent, Katie Gornall, was watching the action.

Two teams, two very different seasons. While Paris St-Germain are

towering over their rivals in France's top division Chelsea's

defence has struggled. Ibrahimovic PSG post one of the big hitters in

world football. One swing of of his boot and they had the lead.

Ibrahimovic has been a long source of goals. This was Mikel's sixth

goal in ten years, a rare sight indeed. It sent PSG into the

second-half in a hurry. Finding the necessary urgency, if not the

necessariy accuracy. Chelsea's defence was proving a significant

obstacle. The arrival of Cavani would overcome that. He reopened an

entertaining contest with one powerful strike. Europe has been a

place of respite for Chelsea this season, now it's another place where

they need to regain control. Katie Gornall, BBC News.

They're the directors behind some of the most memorable movies

From Fargo and the Big Lebowski to No Country For Old Men

and True Grit - the Coen Brothers are famous for working across

a diverse range of film plots and genres.

Now, they're tackling Hollywood - 1950s Hollywood - with a comedy

in which George Clooney plays an incompetent actor

Our arts editor, Will Gompertz, has been talking to the brothers.

Hop, would that it were so simple.

Hail, Caesar is a classic Coen brothers movie,

in so much as it's a stylised, surreal comic tale, undercut

An original sort of idea or the movie, when we first started

thinking about it, was - OK, 24-hours in the life

as a sort of architecture for a movie.

A marriage doesn't have to last forever, but then having a child

without a father would present a public relations problem

The aquatic pictures did very nicely for us.

Josh Brolin is Eddie Mannix, a legendary 1950s Hollywood fixer.

What does it look like and then how do you between you evolve it?

The scripts kind of develop out of essentially just a long

conversation and then the conversation gets more and more

It's like - oh, I don't like that sentence, I don't like that word,

I mean, that's just the nature of movie-making is that it's a...

It's all about collaboration and the good collaborations

are the ones where you always know what's right, where you know

Gather $100,000 and await instructions.

There are so many familiar structural devices we see in Coen

Brothers movies, do you ever worry why about repeating ourselves?

I think it was when we were shooting Fargo, we were out on the street,

shooting the sort of approaching car coming down and I literally turned

to Ethan and said, "haven't we shot this exact same thing before?"

We realise, to a certain extent, you keep reverting to the same shots

Mr Mannix, I know it sounds screwy, but someone's calling

What would happen if one of you said - look, I don't want

Well, we have talked about...

At one point we said, when we've made 10 movies we'll quit.

It gets too alarming thinking about that.

How many you've done and that, in ways you're not even aware of,

You think you're like an old musician, now on the road

because he doesn't know anything else and he's just

Zac Goldsmith, the Tory candidate for London Mayor will be with me.

We'll talk about housing, Europe and how an Etonian

millionaire can ever understand the lives of ordinary Londoners.

Join me now on BBC Two, 11.00pm in Scotland.

Here, on BBC One, it's time for the news where you are.