Browse content similar to 05/10/2011. Check below for episodes and series from the same categories and more!
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I can't believe the brilliant Will Ferrell is on the show tonight. It | :00:09. | :00:13. | |
is good news, isn't it? He is on to talk about his new film, it is | :00:13. | :00:18. | |
about his wife throwing him out and she throws his stuff out tonne to | :00:18. | :00:21. | |
the lawn. I have seen the film. I get the | :00:22. | :00:31. | |
:00:32. | :00:32. | ||
concept. Who is it that we've upset? | :00:32. | :00:42. | |
:00:42. | :00:48. | ||
Oh no! I think we've forgotten So here we are. Hello and welcome | :00:48. | :00:52. | |
to the One Show. We have not been really thrown out | :00:53. | :00:57. | |
by the props man. He doesn't have the power to do that! But we are | :00:57. | :01:02. | |
here to make our guest feel right at home. Ladies and gentlemen, Will | :01:02. | :01:05. | |
Ferrell. APPLAUSE | :01:06. | :01:12. | |
Thank you. Hello, Will. | :01:12. | :01:14. | |
How are you? Come and sit down. | :01:14. | :01:18. | |
Thank you. Thank you for having me. Your dressing room there, it is | :01:18. | :01:23. | |
just a screen, but you were surrounded by glass offices. What | :01:23. | :01:27. | |
was the point of that? It really was ill conceived. | :01:27. | :01:32. | |
Will, your new film is about your wife kicking you out and you set-up | :01:32. | :01:35. | |
home on the lawn. Do you like our effort? I love what you guys have | :01:36. | :01:43. | |
done here. I feel very at home here. I'm getting warmth off this hot | :01:43. | :01:48. | |
plate and this toast! Did you spend nights outside? Did | :01:48. | :01:53. | |
you do the method thing and spend nights... I did not spend nights | :01:53. | :01:58. | |
living on this front lawn even though my character does. I | :01:58. | :02:05. | |
probably should have, but I'm not, you know, I don't really try too | :02:05. | :02:11. | |
hard with my roles in terms of research! I'm a slacker! | :02:11. | :02:15. | |
The home that we shot in front of, they actually lived in it during | :02:15. | :02:18. | |
the night so I don't think they would want me to sleep in the front. | :02:18. | :02:22. | |
No, it would have been weird, but at the end of the film you hold | :02:22. | :02:26. | |
this sale where you sell off your possessions so you were welcome to | :02:26. | :02:31. | |
take anything you see, glitterball, plastic chicken | :02:31. | :02:40. | |
The world's biggest shoes. Are those a 22? They are a size 18. | :02:40. | :02:44. | |
Has anyone claimed the massive carp? | :02:44. | :02:48. | |
That's mine! We will talk about your new film | :02:48. | :02:51. | |
later. We needed a good clear out and a | :02:51. | :02:57. | |
good way to do it is to donate unwanted possessions to charity. | :02:57. | :03:01. | |
The charities encourage it with bags like these through your | :03:01. | :03:03. | |
letterbox, but not all are from genuine charities. | :03:03. | :03:09. | |
The police are cracking down on organised criminals to line their | :03:09. | :03:14. | |
own pockets. Lucy Siegle went to investigate. | :03:14. | :03:18. | |
It is the middle of the night in a Bristol car park and this guy is | :03:18. | :03:22. | |
helping his mate climb into a charity bank to steal clothes. How | :03:22. | :03:27. | |
low can you get? A withdrawal from this bank isn't as easy as it seems | :03:27. | :03:32. | |
and the thief gets stuck inside. He is in there for four hours before | :03:32. | :03:39. | |
emergency services get him out. Many of us are familiar with these. | :03:39. | :03:44. | |
They are charity donation bags, used to collect your old clothes. | :03:44. | :03:48. | |
It sounds a simple system - they recycle your old clobber, turning | :03:48. | :03:52. | |
clothes into profits for charitable causes, but there is one big | :03:52. | :03:59. | |
problem - some of those bags are not genuine. Bogus charity clothes | :03:59. | :04:04. | |
collectors cost charities an estimated �12 million every year. | :04:04. | :04:08. | |
The fraudsters make their money using different methods including | :04:08. | :04:12. | |
stealing genuine charity bags from people's doorsteps and some even | :04:12. | :04:17. | |
print their own fake charity bags or set-up companies that give the | :04:17. | :04:23. | |
impression of being a charity. And today, we are with the police | :04:23. | :04:29. | |
as they take on one of these gangs. Officers from the City of London | :04:29. | :04:32. | |
Police are about to conduct a raid on the warehouse of a gang they | :04:32. | :04:38. | |
believe are operating a fake charity bag scam worth over | :04:38. | :04:43. | |
�100,000 per week. I'm with the officers in one of the | :04:43. | :04:46. | |
vans on our way to the raid. It might seem over the top, there is a | :04:46. | :04:49. | |
lot of officers. There is vans, but the important thing to remember | :04:50. | :04:55. | |
this is a highly lucrative scam and we don't know how this gang will | :04:55. | :04:57. | |
react. Although the police were prepared | :04:57. | :05:03. | |
for the worst, on arrival, the suspects give up without a fight. | :05:03. | :05:07. | |
The scale of this operation is massive. These clothes are sold by | :05:07. | :05:11. | |
the tonne and this fleet of vans leaving here every week means | :05:11. | :05:15. | |
thousands of pounds in lost revenue for the real charities. | :05:15. | :05:21. | |
In total �20,000 in cash was seized during today's operation. It has | :05:21. | :05:25. | |
gone well. We've found our main subjects and they have been | :05:25. | :05:32. | |
arrested. We have found good evidence and we are starting to do | :05:32. | :05:36. | |
our search. We have had nine operations. They are sending vans | :05:36. | :05:39. | |
up to Scotland and Wales. They are nationwide. | :05:39. | :05:42. | |
The police continue to conduct raids throughout the day and in | :05:42. | :05:47. | |
total, four arrests are made. They were later released on bail pending | :05:47. | :05:53. | |
further investigation. The NSPCC is one of many charities | :05:53. | :05:58. | |
affected by gangs like these. Clothing bag theft is a a massive | :05:58. | :06:02. | |
problem for NSPCC, a growing one and one we're desperate to stop. We | :06:02. | :06:06. | |
estimate last year we lost over �130,000 to this unscrupulous crime. | :06:06. | :06:11. | |
There are two easy ways to ensure your clothing bag is legitimate. | :06:11. | :06:14. | |
First, check to make sure it displays the organisation's | :06:14. | :06:19. | |
registered charity number. Second, look for the give | :06:19. | :06:25. | |
worthwhile confidence logo. All charities can do is relied on | :06:25. | :06:29. | |
our continued goodwill and ask us to be vigilant about the types of | :06:29. | :06:36. | |
Louise Richards from the Institute of Fundraising joins us. Is it | :06:36. | :06:41. | |
getting worse? It is, unfortunately. There is a huge demand for good | :06:41. | :06:46. | |
quality second-hand clothes particularly in africk Caa in -- | :06:46. | :06:52. | |
Africa and Eastern Europe and that could be worth �50,000 upwards. | :06:52. | :06:56. | |
Organised criminal gangs are targeting clothing collections and | :06:56. | :07:01. | |
making a lot of money at the expense of charities. | :07:01. | :07:04. | |
Lucy told us to look for the charity number on the bags. What | :07:04. | :07:10. | |
else can help us determine if the bags are legitimate? Apart from the | :07:10. | :07:14. | |
spelling mistakes. There is no land line telephone number for you to | :07:14. | :07:19. | |
ring to see if it is a genuine collection. There are into | :07:19. | :07:24. | |
kitemarks. It doesn't talk about a designated cause. It is vague about | :07:24. | :07:27. | |
what cause it is going to. For people at home, they might not | :07:27. | :07:31. | |
care where it ends up really, as long as it is gone and off their | :07:31. | :07:34. | |
doorstep, does it really matter? does matter. It does matter because | :07:34. | :07:39. | |
this is costing charities a lot of money, between �15 million and �20 | :07:39. | :07:41. | |
million, a conservative estimate is lost to charities every year | :07:41. | :07:45. | |
because of theft and because of fraud. The Institute of | :07:45. | :07:48. | |
Fundraising's website has a lot of information about how you can tell | :07:48. | :07:51. | |
a genuine collection from a bogus one and it is really important | :07:51. | :07:55. | |
because particularly now in these economic times every penny counts | :07:55. | :07:57. | |
for charities so it is really important that people don't get put | :07:57. | :08:01. | |
off by this. That they are aware of the problems that can happen, but | :08:01. | :08:07. | |
that they keep on giving. Well, what about you? You must have | :08:07. | :08:13. | |
loads of jackets in your garage? feel terrible because I have | :08:13. | :08:20. | |
invested in a company that makes fake charity bags! | :08:20. | :08:22. | |
LAUGHTER I think I have been at the centre | :08:22. | :08:25. | |
of this problem! I didn't realise it. I didn't realise it. | :08:25. | :08:33. | |
There is the answer! LAUGHTER | :08:34. | :08:36. | |
His character gets thrown out of the house by his wife. How do you | :08:36. | :08:39. | |
avoid an argument turning into a full blown feud? The people of | :08:39. | :08:42. | |
Birmingham seem to have the answer. A a survey declared them to have | :08:42. | :08:46. | |
the happiest marriages in Britain, but as Carrie Grant and her husband | :08:46. | :08:52. | |
David find out, even they have The the trouble with my husband, | :08:52. | :08:56. | |
that's him, David. That's me. He never let's go of the remote | :08:56. | :09:00. | |
control. If Carrie had the remote control we | :09:00. | :09:06. | |
would be watching wall to wall CSI. And... There is only so many dead | :09:06. | :09:09. | |
bodies I can take! Do you ever argue? | :09:09. | :09:15. | |
Yes. All the time. LAUGHTER | :09:15. | :09:20. | |
We don't argue. When was the last time you had an argument? This | :09:20. | :09:22. | |
morning. What do you argue about when you | :09:22. | :09:28. | |
argue? Everything. He looked through my phone. | :09:28. | :09:31. | |
His driving does wind me up. When you went off and played | :09:31. | :09:40. | |
football and left me with the children. | :09:40. | :09:42. | |
LAUGHTER Don't kiss me in public, please. | :09:42. | :09:47. | |
What's the longest time that you haven't talked to each? Weeks. | :09:47. | :09:51. | |
I could go weeks. I remember I stopped speaking to | :09:51. | :09:58. | |
him for a few days. The word "sorry" isn't in his | :09:58. | :10:02. | |
vocabulary. Why is that? Because he is a man! | :10:02. | :10:07. | |
As you get older, you learn to live with it because what's the use of | :10:07. | :10:14. | |
arguing? I think we agree to disagree. | :10:14. | :10:18. | |
The grass isn't always greener on the other side. I don't know, I | :10:18. | :10:21. | |
never tried the other side so it might be! | :10:21. | :10:26. | |
Do we argue? Occasionally. All the time! | :10:26. | :10:29. | |
Even the people of Birmingham, it seems, have their problems, but we | :10:29. | :10:33. | |
have the solution because we have Will Ferrell, a very quick agony | :10:33. | :10:37. | |
clinic. If you argue with your partner about bad driving, what | :10:37. | :10:42. | |
should you do? Take the car keys away. Give them a bicycle to ride. | :10:42. | :10:47. | |
What if one partner is checking the other person's text messages? | :10:47. | :10:51. | |
would have their hands removed. Simple as that. It is a simple | :10:51. | :10:55. | |
medical procedure. It is not a big deal. | :10:55. | :10:58. | |
Arguing about your husband going to play football without asking. What | :10:58. | :11:02. | |
should you do? That's every man's right to play football whenever | :11:02. | :11:04. | |
they want. There is no argument there. | :11:04. | :11:09. | |
The women have to succumb to that. You and I would not get on, Will. | :11:09. | :11:13. | |
You're right. Now what about your own life? What | :11:13. | :11:18. | |
gets you going? What makes you argue? You know that she is so | :11:18. | :11:23. | |
beautiful and smart that she always wins every argument. Yes. | :11:23. | :11:26. | |
Good answer. Good answer. You are really in the dog house right now, | :11:26. | :11:32. | |
aren't you? I have been in trouble all summer. I'm climbing my way out. | :11:32. | :11:37. | |
You are the peace maker then. Do you solve arguments with your kids? | :11:37. | :11:41. | |
I just, you know, any issues I have with my children, I just shower | :11:41. | :11:49. | |
them with toys. LAUGHTER | :11:49. | :11:52. | |
And candy and in fact they are on a strict diet of candy. | :11:52. | :11:58. | |
They are slighty plump, but they are very happy. So we don't have | :11:58. | :12:01. | |
any issues in our house. You are not there anyway? Yeah and | :12:01. | :12:06. | |
I'm not there. I just check-in 15 minutes a day, I | :12:06. | :12:10. | |
live somewhere else. I live in that city that has all the good | :12:10. | :12:13. | |
marriages. The one we always put on TV. | :12:13. | :12:16. | |
The city we were talking about... Birmingham. | :12:16. | :12:21. | |
Birmingham. In your new film Everything Must Go, | :12:21. | :12:25. | |
it is a full blown argument with the wife. She throws you out and | :12:25. | :12:29. | |
you are living in the garden. Tell us about it. | :12:29. | :12:33. | |
It is a drama about a gentleman who in the course of one day loses his | :12:33. | :12:39. | |
job, his wife leaves him, locks him outside the front of his house, and | :12:39. | :12:43. | |
changes the locks and puts all his personal possessions on the front | :12:43. | :12:48. | |
lawn and he is at a low ebb that he decides to just live there and | :12:48. | :12:50. | |
figure out what he is going to do next. | :12:50. | :12:54. | |
Let's look at you coming to terms with front lawn living. | :12:54. | :12:57. | |
You know the moment that you even thought about having a drink, you | :12:57. | :13:02. | |
should have just called me. Well, let's see. Yesterday, what | :13:02. | :13:07. | |
happened? I got fired from my job. And my wife left me. So somehow | :13:07. | :13:15. | |
calling you slipped my mind. I got it. I got it. | :13:15. | :13:20. | |
They say the dining room is the least utilised room in the house. I | :13:20. | :13:24. | |
think it is the front lawn. It is starting to look good, don't | :13:24. | :13:31. | |
you think? APPLAUSE | :13:31. | :13:34. | |
Will, there are, you know, this is a serious film, as you say, but | :13:34. | :13:37. | |
there are funny moments, but it is a tragedy. This guy's life has hit | :13:37. | :13:40. | |
rock bottom and that's a change for you to play that role? Yeah, it was | :13:40. | :13:44. | |
an interesting and fun challenge. It is outside of my comfort zone of | :13:44. | :13:48. | |
what I'm usually known for doing and that's why I loved it. And it | :13:48. | :13:55. | |
is an excellent cast, Rebecca Hall, Christopher Walker, there is a boy | :13:55. | :13:58. | |
in the in the neighbourhood who is a lost soul himself and we find | :13:58. | :14:02. | |
this friendship that helps both of us kind of find our path. | :14:02. | :14:06. | |
Do you think that every comic at some point wants to be seen in a | :14:06. | :14:13. | |
more serious role? I have no idea what you're talking about! | :14:13. | :14:15. | |
LAUGHTER When you do it, you got to do the | :14:15. | :14:16. | |
face. No, come on. There we are. | :14:17. | :14:20. | |
I mean, I'm not particularly obsessed with that and yet at the | :14:20. | :14:25. | |
same time I think anyone who is creative likes to just mix it up. | :14:25. | :14:27. | |
Yeah, of course. To keep themselves interested and | :14:27. | :14:30. | |
to keep the audience interested, so yeah. | :14:30. | :14:36. | |
You are still funny. I'm still 30%. So funny that you | :14:36. | :14:42. | |
are about to receive the Mark Twain Prize for Humour and that will be | :14:42. | :14:45. | |
accepted in front of other comedians, in fact 300 comedians in | :14:45. | :14:50. | |
the room. Does that make you nervous? No, it is an audience at | :14:50. | :14:54. | |
the Kennedy centre in Washington, so there will only be the people | :14:54. | :14:59. | |
we've invited to talk on my behalf. It is regular civilians. It is a | :14:59. | :15:02. | |
big deal. It is a huge deal and there has | :15:02. | :15:09. | |
only been 14 other recipients, but the list includes Steve Martin and | :15:09. | :15:13. | |
Richard Prior and some giants in American comedy. | :15:13. | :15:15. | |
It is good company. Brilliant. | :15:15. | :15:20. | |
I don't know who Mark Twain is! Well, we asked the same question. | :15:20. | :15:24. | |
He wasn't that funny. Everything Must Go is out on Friday, | :15:24. | :15:34. | |
:15:34. | :15:34. | ||
If I have read one of the most popular pieces of music, I would be | :15:34. | :15:39. | |
pretty happy about it. But not Percy Grainger. He hated the sound | :15:39. | :15:44. | |
of his most famous work. A country garden. Perfect for | :15:44. | :15:48. | |
drifting through in a picturesque fashion. But I am ashamed to say | :15:48. | :15:53. | |
that my producer has committed the ultimate sin. Listen to that. He | :15:54. | :15:58. | |
has put on the soundtrack of an English country garden, what a | :15:58. | :16:03. | |
cliche. It is quintessentially English and painfully conventional. | :16:03. | :16:06. | |
There couldn't be a more predictable tune. The curious thing | :16:07. | :16:13. | |
is, the man who made it famous was anything but conventional. Percy | :16:13. | :16:17. | |
Grainger was a brilliant Australian pianist, who emigrated to Britain | :16:17. | :16:23. | |
in 1901. Gloriously eccentric, he made his own clothes out of towels | :16:23. | :16:27. | |
and would drop between concert halls, leaping over the piano on | :16:27. | :16:33. | |
arrival -- would drop between. His compositions were often | :16:33. | :16:37. | |
experimental and off the -- he built a giant music machine in his | :16:37. | :16:41. | |
living room. He is very interested in the future of modern music but | :16:41. | :16:46. | |
also intrigued by the past. Absolute be. He came over here from | :16:46. | :16:52. | |
Australia, launched into folksong music movement, collected over 500 | :16:52. | :16:55. | |
folksong, some by hand, some by phonograph, and use these to make | :16:56. | :17:00. | |
arrangements for the rest of his life. And this is where the big hit | :17:01. | :17:05. | |
came from, the Headington Quarry Morris Dancers of Oxford. A century | :17:05. | :17:11. | |
ago, they sent -- the accordion player used to play an obscure song | :17:11. | :17:20. | |
called Country Gardens. Bravo! Wonderful stuff. Congratulations, | :17:20. | :17:27. | |
gentlemen, well done. That was magnificent. You are the squire of | :17:27. | :17:30. | |
the Headington Quarry Morris Dancers. And this tune, it is | :17:30. | :17:35. | |
thanks to this actual team of Morris dancers that we know it. How | :17:35. | :17:40. | |
did Percy Grainger get hold of it? As far as we know, he got it from | :17:40. | :17:45. | |
the folksong collector, and he met up with the Headington Quarry | :17:45. | :17:49. | |
dancers in 1899. He wrote down the dunes and Percy Grainger did his | :17:49. | :17:56. | |
famous piano arrangement from that notation of Country Gardens -- Road | :17:56. | :18:02. | |
downer the tunes. And this is William Kimber's concertina? You | :18:02. | :18:08. | |
knew him? I knew him, but he told us at school. Can I shake your | :18:08. | :18:17. | |
hand? It is fantastic. Grainger's piano arrangement of Country | :18:18. | :18:24. | |
Gardens became a massive hit, selling 450,000 copies in one year. | :18:24. | :18:34. | |
:18:34. | :18:59. | ||
Here it is, it performed by local Do you think Percy Grainger would | :18:59. | :19:04. | |
have approved of the setting? much so, it is typical. He said | :19:04. | :19:13. | |
most English country gardens Was he a one-hit wonder? Well, yes. | :19:14. | :19:16. | |
With country gardens. It was the millstone around his neck, because | :19:16. | :19:22. | |
he wanted to know Baghdad to be known by his original country -- he | :19:22. | :19:27. | |
wanted to be known by his original compositions. He would have people | :19:27. | :19:31. | |
saying, give us Country Gardens! Right until the end of his life, | :19:31. | :19:38. | |
and he hated it. Bravo. A brickie - - a Bekele is called for. A bunch | :19:39. | :19:48. | |
:19:49. | :19:51. | ||
of turnips. Grainger would have He was always disappointed that his | :19:52. | :19:56. | |
own music failed to set the world alight. Country Gardens haunted | :19:56. | :20:00. | |
Percy Grainger for the rest of his life. He came to think of the tune | :20:00. | :20:06. | |
as his personal musical albatross. He died in 1961, regarding himself | :20:06. | :20:12. | |
as a failure. And leaving behind 500 original works. Most of which | :20:12. | :20:22. | |
:20:22. | :20:23. | ||
Such a shame. I want to hear some Percy Grainger. We should unearth | :20:23. | :20:29. | |
it. Are you familiar with Morris dancing? Not at all. It is | :20:29. | :20:36. | |
surprising, I know. I know a lot of different things. Every English man | :20:36. | :20:40. | |
every Saturday Morris dances, it is what we do. It is a British form of | :20:40. | :20:44. | |
folk-dancing, but you have done some European folk dancing yourself. | :20:44. | :20:48. | |
It looks slightly like square dancing make some sort of | :20:48. | :20:58. | |
:20:58. | :21:14. | ||
Germanic... It is a bit similar to Look at that. The denial that first | :21:14. | :21:23. | |
time? That was one take. -- bid you nail that. And I really got to slap | :21:23. | :21:30. | |
Matthew Broderick. Did you enjoy the lederhosen? You mentioned every | :21:30. | :21:33. | |
Saturday that the British man does this dance, every Saturday I wear | :21:33. | :21:40. | |
my lederhosen. We have some Morris dancers with you tonight, what did | :21:40. | :21:46. | |
you think of Will Ferrell's effort? I think they are lying! Are you | :21:46. | :21:56. | |
:21:56. | :22:02. | ||
lying? Yes! That is all they say! Marty Jopson has been touring the | :22:02. | :22:05. | |
country's laps to see who inspired the current generation of | :22:05. | :22:15. | |
:22:15. | :22:22. | ||
Award-winning British scientists, Professor Anthony Hollander, leads | :22:22. | :22:27. | |
the cutting-edge field of the tissue engineering. I absolutely | :22:27. | :22:30. | |
believe that it can help us to transform the way we treat the | :22:30. | :22:33. | |
whole range of diseases. Tissue engineering is a revolutionary | :22:33. | :22:39. | |
technique, which involves creating new human tissues and sells like | :22:39. | :22:43. | |
skin and blood vessels. We can make a difference to people's lives. | :22:43. | :22:47. | |
That is why I wanted to do science in the first place. Anthony's | :22:47. | :22:50. | |
passion for science started early. Aged nine, he became fascinated | :22:50. | :22:54. | |
with the idea for fixing people and created a list of tools he needed | :22:54. | :22:58. | |
to do the job. He sent his Mr Blue Peter, asking for, amongst other | :22:58. | :23:04. | |
things, a model of a heart and a diagram of how the body works. | :23:04. | :23:09. | |
got a lovely letter back from Billy Baxter, taking it very seriously, | :23:09. | :23:13. | |
suggesting perhaps my GP might be able to help with some of the | :23:13. | :23:18. | |
equipment. Receiving that reply was important to me, and I think if | :23:18. | :23:23. | |
they hadn't written back, perhaps I wouldn't have pursued my fledgling | :23:23. | :23:29. | |
scientific dreams. Fired with enthusiasm, Anthony went on to | :23:29. | :23:33. | |
study pharmacology. At university, he discovered his science hero, | :23:33. | :23:39. | |
this man, Dr Edward Jenner, the father of vaccination. The first | :23:39. | :23:43. | |
time I came here, to Edward Jenner's House, was when I was a | :23:43. | :23:52. | |
PhD student, in my early 20s. It was 1929. -- 1989. It was in this | :23:52. | :23:58. | |
House that the sides of vaccine and him in his son was born. -- the | :23:58. | :24:01. | |
science of a vaccine and immunisation. He had heard the | :24:01. | :24:05. | |
story that farm staff who developed cowpox would never go on to develop | :24:05. | :24:11. | |
smallpox. Edward Jenner said out to test this theory. He injected | :24:11. | :24:15. | |
cowpox pass into the arm of an 8- year-old boy, James Phipps. After | :24:15. | :24:22. | |
that, Jenna then tried to infect him with pass from a small pox | :24:22. | :24:26. | |
patient, and the boy never developed smallpox. When published, | :24:26. | :24:32. | |
his results were rejected as dangerous and lacking prove. I was | :24:32. | :24:36. | |
very inspired from hearing how Jenna, after this rejection, simply | :24:36. | :24:41. | |
persisted. He tried again and again. And he was right. Over 200 years | :24:41. | :24:47. | |
later, smallpox has been eradicated. Today, every vaccine we used stems | :24:47. | :24:53. | |
from the breakthrough made by Edward Jenner. Anthony holiday's | :24:53. | :24:58. | |
own break through the moment came three years ago. A Spanish woman | :24:58. | :25:02. | |
has become the first person in the world to be given a whole organ, a | :25:02. | :25:06. | |
wind but grown from her own stem cells. Claudia Castillo, a mother- | :25:06. | :25:10. | |
of-two from Spain, had a diseased windpipe which left an able to | :25:10. | :25:14. | |
breathe. A conventional organ transplant ran a high risk of | :25:14. | :25:19. | |
tissue rejection. Thanks to his 20 years of research, Anthony had an | :25:19. | :25:26. | |
alternative solution. The idea we had was to take a donated windpipe, | :25:26. | :25:33. | |
and remove the cells that naturally occur, because we didn't want this | :25:33. | :25:39. | |
windpipe to be rejected by the patient. Claudia Castillo's | :25:39. | :25:42. | |
themselves were used to grow a new wind pipe around the donor | :25:42. | :25:45. | |
structure. Because the new organ was made with their new cells, | :25:45. | :25:52. | |
there was less chance of tissue rejection. This was a medical first. | :25:52. | :25:55. | |
Her away function returned to normal and has stayed absolutely | :25:55. | :26:02. | |
normal ever since. Following the success of her operation, Anthony | :26:02. | :26:07. | |
Holland it plans to use stem cells to repair knee cartilage. He | :26:07. | :26:11. | |
credits Edward Jenner for continuing to inspire him. When I | :26:11. | :26:14. | |
face scepticism about my work, I will often think back to Edward | :26:14. | :26:19. | |
Jenner, and be encouraged just to carry on. Eventually, I know I will | :26:19. | :26:23. | |
get there, and people will understand that this science can | :26:23. | :26:29. | |
really make a difference. Edward Jenner took a random trialled, put | :26:29. | :26:35. | |
cowpox and then smallpox... Can you imagine allowing... Would you allow | :26:35. | :26:39. | |
your child? He walked up to a random trialled, and said, I am | :26:39. | :26:48. | |
going to inject you... More or less. Sign me up right now. All three. | :26:48. | :26:53. | |
All three boys, give them a go, if it is going to help humanity. | :26:53. | :26:56. | |
back to your own childhood, who was your comedy hero when you were a | :26:56. | :27:03. | |
boy? I had a number of comedy heroes. I laughed Dan Ackroyd and | :27:03. | :27:08. | |
Bill Murray and the original Saturday Night Live cast members. | :27:08. | :27:16. | |
Steve Martin is a big idol of mine. We love him on this show. Peter | :27:16. | :27:21. | |
Sellers, I loved his work, the fact he was able to do comedy and drama. | :27:21. | :27:24. | |
When you first got your job on Saturday Night Live, that must have | :27:24. | :27:30. | |
been a big deal for you. Huge. Somewhat surreal. It still is, when | :27:30. | :27:34. | |
I think I was on that show for seven years. It feels like a hazy | :27:34. | :27:38. | |
wonderful dream. Especially having watched that show my entire life. | :27:38. | :27:43. | |
And finally getting to be on it. A dream come true. Isn't it true that | :27:43. | :27:48. | |
you took a briefcase full of fake money, to try to bribe the | :27:48. | :27:51. | |
producers during your audition? thought it would be really funny | :27:51. | :27:57. | |
joke, to stack a pile of fake money on Lorne Michaels' desk and walk | :27:57. | :28:02. | |
out, but I got extremely shy in the interview. And I just held a brief | :28:02. | :28:07. | |
case the whole time. Later I thought, what comedian holds a | :28:08. | :28:12. | |
briefcase with them? I thought I had completely sunk or my chances. | :28:12. | :28:18. | |
But you still got it. In hindsight, he thought it was really funny. | :28:18. | :28:22. | |
Your mum must be terrifically proud of you, she is in the audience | :28:22. | :28:32. | |
:28:32. | :28:37. | ||
tonight. My mum is here. Mum... Are you proud of me? Yes! OK, I wanted | :28:37. | :28:42. | |
to check. Thank you so much. Everything Must Go is out on Friday | :28:42. | :28:47. |