Kirsty Wark: The Menopause and Me


Kirsty Wark: The Menopause and Me

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Transcript


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On my 11th birthday, I went with some other girls to see a film.

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This was...you'd go to the pictures on your birthday,

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you were very grown-up. We went to see She,

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the Hammer film based on the H Rider Haggard book and I had read the

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H Rider Haggard books,

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and this is She, Aisha, looking for the elixir of life,

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finding it, going back into the fire a second time to take the man she

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loves with her.

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And she starts to age and she starts to crumble and she starts to turn to

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dust and it's absolutely terrifying, and it was probably my first real

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connection with old age.

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Bizarrely, in my head, ever since then, I thought,

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this is what the menopause is all about,

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this is getting really, really, old, this is turning to dust.

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It's nonsense, of course, and I have always associated it with this film.

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Every woman goes through the menopause and yet there is something

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about the word itself that has these negative connotations

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of ageing and atrophy which, in our youth obsessed culture,

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can be debilitating for women and even

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embarrassing, and yet we are all living longer and working longer and

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menopause is a feature of midlife.

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It's the start of a new chapter.

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So why the persistent taboo?

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It really is time for a change.

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I'm setting out to discover what the menopause actually is.

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I've never talked about vaginas so much in all my life

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since taking this on.

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I spoke to Joan Collins once and she said menopause is a myth.

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Find out the reality for some women.

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Then I would get hot spells and they would disappear and I would wonder

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what is happening to me?

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I was 14 and it was diagnosed at 16.

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I'd be making sandwiches with a knife in my hand and I would have to

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put the knife down and just walk away.

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Look at what we can do to help ourselves deal with the effects.

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I noticed the difference in my symptoms within a week.

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Then the hot flushes started and that was horrific.

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It was a bit more like adolescent sex, a lot of fun, really.

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Yeah.

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I meet scientists at the cutting edge of controversial research which

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could potentially reverse the menopause.

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I will look for any evidence of follicles and eggs being formed.

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And I'm curious to find out how older women have been portrayed over the

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centuries and the way that has shaped our modern attitudes to age and the menopause.

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In her award-winning book Hot Flushes, Cold Science

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historian Louise Foxcroft examined how society has treated older women through the millennia.

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Take us back to the Greeks, what was the menopause judged as then?

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First of all, I would say it was not really judged at all because women

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post menopause were just not interesting and, in fact,

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what happened to them, they became much more masculine.

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The female, she is pathological, she is deformed,

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she's a sort of mutilated male, in fact,

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and that is where the interest lies in her

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and her pathology and her reproductive system.

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Did the Greeks demonise then, women, post-menopause?

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No, they did not demonise them, but they didn't do anything with them.

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It's just not interesting.

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It's the gateway to death. That's the end of them.

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-They're finished.

-The Victorians have the idea that there is a link

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between the womb and the brain.

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That is an ancient idea.

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That goes back to the early modern period and before that where the womb

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is sort of a disreputable and wild organ that runs around the body and

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distributes blood. Of course blood is a bad idea.

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They thought at one point that the blood stayed in the body after

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menopause and then causes cancers and other degenerative illnesses.

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We had hoped that negative attitudes towards older women and the menopause

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might have changed over the last century,

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however, even if we don't talk about it much, we do laugh at it

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and the menopause has always provided fertile fodder for comedy.

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It's like a big tide of jam coming towards us

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but jam made out of old women.

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I've got a bad feeling about this.

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-I think we'd better get back in the house.

-Go away. I don't want to catch the menopause.

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'And sometimes it even requires a man to take on woman's trouble.'

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I wouldn't tell another living soul this, of course.

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I'm approaching the change.

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Approaching the change?

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From which direction?

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The menopause, like most things in life, has its funny side.

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But sometimes, it just doesn't feel like a laughing matter.

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Despite the majority of women experiencing this transition between the ages of 45 and 55,

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we are still shockingly uninformed about what the menopause actually is

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and, more importantly, how to deal with it.

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We are headed towards Dumfries.

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Actually, funnily enough, I was born in Dumfries,

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which was instant, unlike the menopause, which we are going to talk about,

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which is anything but instant.

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It goes on for a very long time sometimes.

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It happens to all women so therefore why do we know so little about it

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and why are women so reluctant to do anything to alleviate the symptoms?

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These symptoms can be alleviated now, myself included.

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I haven't done enough to alleviate the symptoms so I am on a quest to

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find out more.

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I am here to see one woman who knows more about the menopause than most.

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Doctor Heather Currie chairs the British Menopause Society,

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which provides health care professionals with information and guidance.

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So it's normal process that our bodies go through.

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Sadly, our ovaries are only designed to last a certain number of years.

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We produce egg cells on average up until the late 40s, early 50s

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and by the age of 51, on average,

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women are stopping having periods and the reason they stop periods is

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because we run out of egg cells,

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but the complicated thing is we now live for many years beyond that.

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So when our ovaries are not working,

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the key hormone that we stop producing is oestrogen.

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Rather than it being just about periods stopping and flushing,

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it is around the consequences of the lack of oestrogen.

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There are lots of taboos about gynaecology in general

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and the menopause affects every single woman.

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So we really, really need to talk about it more.

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There are many aspects of the menopause

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that women can be embarrassed to talk about in public.

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I thought it would be interesting to see if I could encourage them to open up on radio.

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You're listing to Kaye Adams on BBC Radio Scotland

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here with you until 12.

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Coming up, we will be talking the menopause with Kirsty Wark,

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and we would love to hear from you. How was it for you?

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Maybe you're still going through it. Did you consult your GP,

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your family, your friends, your work colleagues? Do give us a call.

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We are also joined by Doctor Fiona Kennan,

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but we would love to hear from you this morning.

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Kirsty, can I ask how was it for you?

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Not great, really. Absolutely.

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Not great. Medically induced,

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hysterectomy at 47, everything whipped out,

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HRT for three years and then came the big boom scare.

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And suddenly HRT was taboo

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and I came off HRT and actually my symptoms have not really gone away in the last ten years.

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-What about you?

-I don't seem to have been affected.

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-I know that I annoy people.

-You're not annoying me at all.

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Virtually 100% will experience some symptoms, Kaye.

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You're wonderful, you and my mother.

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I do stick my leg out of the bed at night.

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Hot, hot flushes.

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I think that is a symptom, Kaye.

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Even if it is only one leg.

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-Only one leg.

-The menopause would affect your urogenital system,

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so you might get dryness down below, problems passing urine,

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discomfort during intercourse, loss of libido.

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People don't want to talk about that stuff with their doctors.

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I want to hear from women about how detrimental that is to their lives.

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What you want to hear from people,

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you get what you want because we've got lots of them.

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Let's speak to Nan. Good morning, Nan.

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-'Good morning.'

-How are you this morning?

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'I'm OK.

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'I've had a horrible, horrible night with hot flushes.'

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-Oh.

-'Yes.'

-Does it affect you every night, Nan?

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'Every single night.

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'What I would like to ask is, I am 78, am I too old to go back on HRT?'

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You may also want to consider other options,

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non-hormonal options which can be helpful in some cases to control hot

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flushes and which we sometimes use for ladies who are not so suitable for HRT.

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Just a wee second, we talk about going through the menopause

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as if it is a discrete period of time.

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You have been experiencing menopausal symptoms for more than 30 years.

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'Yes, I have.'

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The average figures are that ladies will go through the menopause symptoms

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in about four years, but the range,

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we would normally quote a range of up to about 12 years.

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Actually, we have Margaret on the line who I think is in a similar boat.

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Margaret, just for people who are not at this stage of your life,

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when you say sweats, it doesn't always sound that dramatic.

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'It is terrible. I'd throw the covers back, get out of bed,

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'cool myself down, onto the tiles in the bathroom,

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'walk about there and cool down and then back to bed, and then up again.'

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Aside from all the other symptoms,

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the sleep disruption associated with that is huge.

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'Sleep disruption's a big problem.'

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Coming up to five to 12.

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Time is against us.

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We are talking about the menopause, let's speak to Angus.

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Good morning.

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'Good morning, Kaye. I saw my mother when she was going through all of this.

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'I did not understand it, I was about 11. She was so depressed, etc,

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'and at one stage they were thinking of committing her

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'into an asylum or something like that. The doctor

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'said "Right, we will give your wife pills, if it doesn't work,

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'we will have her committed,"

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'and Father said, "Over my dead body." '

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That was really, an overwhelming response,

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I have to say, and it was very immediate

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which is interesting.

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As soon as you were on,

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somebody is saying to me, really busy on this, really busy on this,

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and actually we quickly took a decision to dump what we had planned

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for the last half-hour of the show.

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You kind of know that you have touched a nerve when that happens.

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Sharing experiences honestly and bravely

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is a very powerful thing to do.

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And it can help others to know that they are not alone.

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Especially if they feel they are having to battle to be heard,

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even by their GP.

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I was 46 when I started to see my periods have got less.

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And I feel that I am going through the early stages of the menopause

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and his words were, "You're far too young."

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The menopause does not happen until you're 52.

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Just like that. 52, on maybe the 3rd of January.

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-Great.

-A few months down the line I noticed other things like low mood,

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feeling very depressed at times.

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Tearful, emotional for no reason at all.

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So I went back to him again and I sat with him and I said to him,

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"Look, I know I'm going through something. Something is happening to me."

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"Maybe it's just a bit of depression, you're having."

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I said, "No, I know fine it's not a bit of depression I'm having.

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"That's not causing hot sweats," and I said, "If you do a blood test

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"and if it comes back, we'll take it from there."

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He said, "I'll do the blood test but I still think that...

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"..you're not going to be, it's not going to show anything."

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What happened?

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So I went back and he said, "There it is written down in black and white,

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"likely to be perimenopausal," and I breathed a sigh of relief.

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I think lots of people identify with Caroline's story.

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I think lots of women will feel I have just got to manage it,

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because their GPs have been unsympathetic.

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I think there are lots of GPs that are sympathetic, but I think for many

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women, they don't get the answer they want first time and don't feel

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confident about getting an answer the second time.

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So it is a kind of suffer in silence.

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We are all aware of the many pressures GPs and the wider NHS face these days.

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In 2015, the National Institute for Health and Care Excellence, or NICE,

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published its guidelines designed to clarify the confusion

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about both diagnosis and management of the menopause.

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Professor Mary Ann Lumsden is an internationally renowned expert on

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the menopause. She chaired the specialist group which developed the guideline

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by re-evaluating all the existing evidence.

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What we wanted to get across is that menopause can cause problems for a

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lot of women. That help is readily available for them,

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should they want it and that every woman needs to be treated as an

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individual, because everybody's circumstances are different.

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There are lesser known and surprising symptoms.

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It is not just hot flushes and mood swings.

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Zarina has been dealing with joint pain for more than a year.

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I didn't think it was anything to do with menopause.

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I thought it was because I was hitting 50,

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and I'm just getting old, so I'm getting these aches and pains in my joints.

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I need to get more fitter.

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There were other things that were going on as well.

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I was having really bad dizzy spells.

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I was getting really bad headaches, very bad severe headaches.

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What do the pains actually feel like?

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It was like shooting pains, in my ankle or my knees,

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either get a pain that would shoot down my leg

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and then you would have an ache that would last for days.

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So, you've had all these different things,

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you've had joint pains, and night sweats.

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-Yes.

-And you go up to the loo in the night?

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Yes. And then you get thirsty because you're sweating in the night and you

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drink water and then you drink water and you need to get up to go to the

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toilet, but most of the time now, after every two hours, I get up.

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You've got two options, you put up with the night sweats, the dizziness,

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the joint pain,

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going to the loo in the middle of the night or you maybe seek some help

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for it, and it might alleviate some of your symptoms.

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-What are you likely to do?

-What I would want to do,

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is make my life better and have a better quality of life.

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But, the way I am, I would probably just ignore it and just think,

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it's going to get better and I think part of me thinks,

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it is a passing phase that the menopause is something that will be here

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for a little while and then you go back to normal.

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I know that's not the case, but in my head,

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I'm probably still in denial.

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The most common treatment for menopausal symptoms

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is hormone replacement therapy, HRT,

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which helps replace the oestrogen lost

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when our ovaries stop producing eggs.

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It can be taken via patches or as a gel or tablets.

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But it's been hard to work out if it's wise to take HRT.

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This is due to the confusion ignited by the publication of the

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women's health initiative study in America back in 2002.

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The study cast serious doubts on the safety of HRT.

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So, 2002, HRT study cancelled over cancer and stroke fears, The Guardian,

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HRT risk to breast cancer in the Mail,

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HRT does more harm than good, 2002.

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2008, new cancer fear for women taking HRT and then HRT is safe for

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millions of women.

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Again the Express, two Express stories.

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New menopause guide says one million women can benefit from HRT.

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This is why it is all so confusing.

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I was using HRT tablets for three years after my hysterectomy

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but stopped suddenly, like so many women, because of this scare.

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In 2002 the result of the women's health initiative study came out and

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those suggested that being on HRT hugely increased your risk of breast

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cancer and at the time it seemed like being on HRT even for a short period.

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So at that time people just stopped taking their HRT because of this

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risk. Lots of them without any discussion with a medical professional,

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they literally stopped, cold turkey and after that people stopped coming

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to ask for HRT from the doctors

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and GPs became less and less familiar with

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prescribing it and also got caught up in the safety issues around it so

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were probably less likely to suggest it to their patients.

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-So it's a kind of vicious circle.

-Yes.

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Subsequent research suggested that the analysis of the data was

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flawed and that the findings were overstated.

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But these more positive reappraisals received nothing like the same

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publicity as the original scare.

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More up-to-date research has attempted to offer clarification of the risks involved.

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The current understanding is that if women take oestrogen only,

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which is taken if a woman has had the womb removed,

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had a hysterectomy,

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there seems to be very little increased risk of being diagnosed

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with breast cancer.

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If women take HRT which is oestrogen and progestogen,

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the other hormone, progestogen, is added in to protect the lining of the womb for more

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than five years after the age of 50,

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there is a possibility that there is an increased risk of being diagnosed

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with breast cancer. The other thing we have to clearly remember,

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which is a really important fact,

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is that there is no evidence that HRT causes breast cells to turn into

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cancer. It may be that it is promoting something that is already there and

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the other really important fact is that being overweight or drinking two

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or more units of alcohol a day are actually really important risk factors

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for breast cancer,

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and particularly being overweight is a far greater risk factor than taking HRT.

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The feeling now is that for women who are having menopausal symptoms,

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for most women, the benefits of HRT outweigh the risks.

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And it is the most effective treatment that we have for controlling symptoms.

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Janice has been taking HRT for almost ten years.

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She began to experience menopausal symptoms when she was just 39.

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I had this flush and I could feel it and my sister turned round and said

0:19:530:19:57

to me, "Are you OK? You've gone awfully red."

0:19:570:20:00

And I thought, thank God!

0:20:000:20:01

It is actually noticeable.

0:20:010:20:04

I didn't just imagine this.

0:20:040:20:05

So, I went back to my GP just after,

0:20:050:20:08

well, it was actually my nurse and I said to her,

0:20:080:20:11

"Could you do the test for me, just to put my mind at rest?"

0:20:110:20:15

And she put it through and she said she'd get back to me in a couple of

0:20:150:20:19

weeks' time. She phoned me two days later and said,

0:20:190:20:21

"You were absolutely right."

0:20:210:20:23

She says, "Your hormone balances are all over the place."

0:20:230:20:26

So, after that I started dealing with a female GP.

0:20:260:20:30

She offered me the chance to go on HRT but then, you know,

0:20:300:20:35

talked about the risks that were involved,

0:20:350:20:37

like the breast cancer risks and suchlike.

0:20:370:20:40

But also about the risk at my age of osteoporosis.

0:20:400:20:44

And we didn't really have much of a history in our house,

0:20:440:20:48

in our family for breast cancer.

0:20:480:20:51

So for me the osteoporosis thing was more of a sort of...

0:20:510:20:56

because my mum has arthritis and I have known people with osteoporosis

0:20:560:21:01

and thought, "Oh, that's horrible."

0:21:010:21:03

So, talking about that made me more inclined to go with the HRT option

0:21:030:21:08

and they put me on patches.

0:21:080:21:09

And so I started on them and it was great.

0:21:090:21:12

How quickly did things change once you got a patch on?

0:21:120:21:15

I noticed a difference in my symptoms almost within a week.

0:21:150:21:19

The sweat, the night hot flushes weren't nearly as bad.

0:21:190:21:24

They still came,

0:21:240:21:26

but they were so much more bearable. Sometimes you barely even noticed them.

0:21:260:21:30

Janice's concerns about osteoporosis are certainly well founded.

0:21:320:21:37

It's a condition that weakens bones,

0:21:370:21:39

making them fragile and more likely to break.

0:21:390:21:42

Reaching menopause at a younger age means your body is losing the oestrogen

0:21:420:21:46

vital for bone health even sooner than usual.

0:21:460:21:49

Many of us are a generation who've watched our mothers experience the

0:21:500:21:57

effects of osteoporosis with multiple fractures often,

0:21:570:22:01

and decreased mobility, loss of confidence.

0:22:010:22:05

It's an awful disease and it is extremely common,

0:22:050:22:10

particularly in women.

0:22:100:22:13

And so some people would like to prevent osteoporosis.

0:22:130:22:18

It doesn't totally prevent fractures,

0:22:180:22:21

but it certainly can go some way in doing so.

0:22:210:22:25

HRT decreases the likelihood of a fracture.

0:22:250:22:28

It's a beautiful sunny morning and I'm on my way to have a bone density scan. A Dexa scan.

0:22:370:22:43

And the reason I'm having it is that it's definitely the case

0:22:440:22:50

that bone density is a pretty critical issue for a lot of women

0:22:500:22:54

going through the menopause,

0:22:540:22:56

and osteoporosis is a pretty horrible disease.

0:22:560:22:59

I am not expecting to find problems with my bone density

0:23:010:23:05

because it's not in the family. I'm reasonably fit and healthy, but you never know!

0:23:050:23:09

Dr Adamson, nice to see you.

0:23:210:23:22

We're going to use this calculation tool just to calculate your

0:23:280:23:31

probability of a fracture and then that will help us to guide us as to

0:23:310:23:34

whether you need a Dexa scan or not.

0:23:340:23:36

You can see the first thing that we need to just pop in is your age.

0:23:360:23:39

-61.

-OK.

0:23:390:23:41

And then you're female.

0:23:410:23:42

No previous fractures.

0:23:420:23:45

-Parent fractured a hip?

-No.

0:23:450:23:46

-You don't smoke?

-No.

0:23:460:23:47

And alcohol.

0:23:470:23:48

So the question here is three or more units a day?

0:23:480:23:51

So that would be 21 units a week.

0:23:510:23:53

Pretty sure most times I'm under that,

0:23:530:23:56

but there could be the odd party time where I'm over that.

0:23:560:23:59

Of course. So we calculate it both ways because I think it's quite

0:23:590:24:02

interesting to see the difference that that makes.

0:24:020:24:05

So if we do it without and then we calculate,

0:24:050:24:09

you can see that your fracture risk there is 6.7% over ten years.

0:24:090:24:14

And just to see that visually, you can see there.

0:24:140:24:17

So, I'm in green, just.

0:24:170:24:19

Just in the green.

0:24:190:24:21

And then if we change that and say, yes on the alcohol,

0:24:210:24:25

that takes us up to a risk of 8.3% over ten years,

0:24:250:24:29

and you can see that that's

0:24:300:24:31

just enough to push you into the category where

0:24:310:24:34

we would measure your bone mineral density.

0:24:340:24:36

-So, actually, lifestyle is really important.

-Really, really important.

0:24:360:24:39

Yes. Alcohol intake is very important.

0:24:390:24:41

-And if you were a smoker then that would have pushed you even further into that category.

-OK.

0:24:410:24:46

OK, so we'll just get you to come over and lie up on your back on the table.

0:24:470:24:50

Just shuffle down the bed an inch there. That's lovely. And just rest back.

0:24:540:24:58

So, we're going to start off by taking a picture of your left hip.

0:25:000:25:03

We use this as an average across the population.

0:25:030:25:06

So we do the left hip on every one and the lumbar spine.

0:25:060:25:09

OK, so that's just ready for the first scan.

0:25:090:25:12

I'll just pop this hand just on to your tummy.

0:25:120:25:15

Just nice and still there.

0:25:150:25:16

It has recently been estimated that by the age of 70,

0:25:180:25:22

half of all women will have had a fracture related to osteoporosis.

0:25:220:25:27

So, what we're going to do now is position your knees on top of this pad.

0:25:270:25:32

Just there. How is that for you?

0:25:320:25:33

-Fine.

-OK.

0:25:330:25:35

No instructions for you, just to lie nice and still.

0:25:350:25:38

Not even pressing my back into the table?

0:25:380:25:39

No. Just relaxing normally.

0:25:390:25:41

Osteoporosis can be treated and bone strength increased in a variety of

0:25:440:25:49

ways. But because it can lead to such devastating consequences,

0:25:490:25:53

it should always be addressed.

0:25:530:25:55

Fantastic! That's us all finished.

0:25:590:26:01

-Hi.

-Hi, Kirsty.

0:26:030:26:04

-How was that?

-Straightforward.

0:26:040:26:07

Good! Good! Are you a bit anxious to see the results?

0:26:070:26:09

I'm keen. I really am keen.

0:26:090:26:11

OK, so we'll start with the spine.

0:26:110:26:12

-Yes.

-OK.

0:26:120:26:15

Bottom line here, total T-score is minus 0.7.

0:26:150:26:20

That's normal. A T-score down to minus 1 is normal.

0:26:200:26:23

A little bit of a different story at the hip though.

0:26:230:26:26

-OK.

-Nothing to worry about desperately,

0:26:270:26:30

but just below minus one.

0:26:300:26:33

So minus 1.1.

0:26:330:26:34

So, classification of that would be osteopenia.

0:26:340:26:38

Right, so it's pre-osteoporosis.

0:26:380:26:40

-Wow!

-Just a little bit thin at the hip.

0:26:400:26:42

Minus one down to 2.5 is osteopenia.

0:26:420:26:45

And below minus 2.5 is osteoporosis.

0:26:450:26:48

So, what does that mean in terms of what I have to do about it?

0:26:480:26:55

So, we would just recommend lifestyle management.

0:26:550:26:57

Lifestyle changes.

0:26:570:26:58

So the kind of things we talked about earlier,

0:26:580:27:00

keeping your alcohol intake down.

0:27:000:27:02

You don't smoke.

0:27:020:27:03

Sensible, healthy diet.

0:27:040:27:06

Making sure you get a decent amount of calcium in your diet.

0:27:060:27:08

-Yeah.

-Yeah.

-And in terms of alcohol, it should be south of 14 units.

0:27:080:27:14

South of 14 units, where possible.

0:27:140:27:15

Yeah.

0:27:150:27:17

Good. Well, I better get a grip on that.

0:27:170:27:20

OK.

0:27:200:27:21

Well, that was a bit of a surprise.

0:27:250:27:27

I was quite shocked, actually.

0:27:270:27:31

But, you know, it could be a lot worse

0:27:310:27:33

and I can do something about it.

0:27:330:27:35

I'm now beginning to wonder if coming off HRT so suddenly all these years ago was a mistake.

0:27:380:27:44

If I had kept taking it would my bone density have been better?

0:27:440:27:47

So is it too late for me to start taking it again?

0:27:480:27:51

It's not ideal to have that gap, but we can't turn the clock back,

0:27:520:27:56

so what we have to do is look at the safest way of taking HRT and

0:27:560:28:01

certainly start with a low dose and you'd give consideration as to the

0:28:010:28:05

route, whether it was tablet or a patch.

0:28:050:28:07

But, yes, I feel sorry for a lot of women who,

0:28:070:28:11

you know, this has been often described as ten years wasted,

0:28:110:28:15

but HRT is definitely still an option.

0:28:150:28:17

There's obviously been an impact on my bone health and I'm going to have

0:28:220:28:25

to be extra vigilant for the rest of my life.

0:28:250:28:27

It certainly wasn't something I was thinking about in my 30s.

0:28:290:28:33

So, let's look at this.

0:28:330:28:34

Back when she was in her 30s,

0:28:340:28:36

Jennifer Saunders was writing about the funny side of the menopause.

0:28:360:28:40

-Did you go to the hospital?

-Yes.

0:28:400:28:42

And to the gynaecologist.

0:28:420:28:44

I hate gynaecologists,

0:28:440:28:45

a man who can look you in the vagina but never in the eye!

0:28:450:28:47

Used that line about four times!

0:28:500:28:52

Patsy's got osteoporosis.

0:28:540:28:56

She has the lowest bone density on record.

0:28:590:29:01

Cheers! Well done, darling!

0:29:010:29:03

She is just gristle clinging on to bone powder.

0:29:050:29:09

This is what happens when you have the menopause.

0:29:090:29:11

-No!

-No!

-You will learn about this and you will take control because

0:29:110:29:17

frankly, if you don't...

0:29:170:29:20

See you learn about this and take control.

0:29:200:29:21

Certainly was a precedent.

0:29:210:29:23

Oh! This is bad!

0:29:250:29:26

BONES CRACK

0:29:300:29:31

Oh!

0:29:310:29:32

-Is that my leg?

-It's my leg.

0:29:340:29:38

Split!

0:29:380:29:39

Oh, God!

0:29:440:29:46

When you look at that now!

0:29:460:29:47

I know!

0:29:470:29:48

Oh, my God! Little did I know it was all going to happen.

0:29:500:29:53

When you were writing this episode,

0:29:540:29:57

this was specifically about the menopause.

0:29:570:29:59

Yes. I wonder why I did that?

0:29:590:30:01

I think I did it because I thought it would be funny if Patsy had osteoporosis.

0:30:010:30:06

We liked it when she had a breast check,

0:30:060:30:07

so I thought anything gynaecological with Patsy is really funny.

0:30:070:30:10

And we don't know how old she is,

0:30:100:30:12

so I thought she won't have any bones in it, so it's a funny thing.

0:30:120:30:16

Yours was a particular kind of menopause.

0:30:160:30:19

-What happened?

-I was, I got breast cancer and so I wasn't menopausal,

0:30:190:30:26

I was still having periods,

0:30:260:30:29

but the second year of chemotherapy all your periods stop

0:30:290:30:34

and so you're sort of plunged into it, but because you're so full of

0:30:340:30:39

chemicals, you really have no idea.

0:30:390:30:41

It's like the tiniest thing.

0:30:410:30:43

Compared to everything else that's happening.

0:30:430:30:46

By the time you've got over the chemicals and you're on Tamoxifen,

0:30:460:30:50

which gets rid of all your oestrogen, you can't tell the difference.

0:30:500:30:55

You don't know what's coming out of chemo and what's menopause and it

0:30:550:30:59

wasn't until, I think about a year after,

0:30:590:31:03

that I started to feel like, oh, this doesn't feel right.

0:31:030:31:06

This feels different and it changes everything.

0:31:060:31:08

It changes your metabolism, your energy levels, your skin, your hair.

0:31:080:31:14

Everything. I mean it was quite astonishing.

0:31:140:31:17

-So, how did you deal with it?

-I don't know.

0:31:170:31:19

I drank. No!

0:31:200:31:21

I had a large glass of champagne!

0:31:220:31:24

And got on with it. I think you just get on with it.

0:31:260:31:29

What are your symptoms now?

0:31:290:31:30

I mean I still have, my main symptoms are night sweats and bad sleep pattern.

0:31:300:31:36

I've always had a very good sleep, I'm very good at sleeping.

0:31:360:31:38

-Lucky you!

-Yes, I'm very good at sleeping, but the

0:31:380:31:42

first time I had a hot sweat it did take me by surprise.

0:31:420:31:46

I kept going, "What's that?

0:31:460:31:48

"What am I sitting on? What am I sitting on?"

0:31:480:31:51

I kept thinking... It felt like I was sitting on a radiator.

0:31:510:31:54

Sitting on a radiator.

0:31:540:31:56

I was looking around the room going, "Is everyone else?

0:31:560:31:58

"No, they are not hot like me."

0:31:580:32:00

Do you actually feel different post menopausal as to who you were before?

0:32:000:32:04

Is that tied up in the breast cancer as well?

0:32:040:32:06

No, I don't really think about the breast cancer.

0:32:070:32:09

But I think, yeah,

0:32:110:32:13

I think it happens and all the things I used to make jokes about are so true.

0:32:130:32:19

You know, just your place in the world and how you feel about yourself.

0:32:190:32:23

Your general feeling of sexiness and libido and, and,

0:32:240:32:30

it's an indefinable something that you don't have any more.

0:32:300:32:34

But for me, I feel completely able to do what I want to do.

0:32:360:32:40

Some of the physical changes of the menopause can massively affect a

0:32:440:32:47

woman's self-esteem. Like Jennifer,

0:32:470:32:50

Isabel experienced what is termed medical menopause,

0:32:500:32:54

'that is when a woman is catapulted into menopause unnaturally

0:32:540:32:58

'because of surgery, like a hysterectomy,

0:32:580:33:01

'or as a result of cancer treatment.

0:33:010:33:03

'Isabel experienced symptoms almost overnight after she had her ovaries removed.'

0:33:030:33:09

Because I didn't feel like me.

0:33:090:33:11

I didn't really feel like me.

0:33:110:33:12

When I was looking in the mirror I had changed so, so much.

0:33:120:33:15

My face had changed, it blew up, everything.

0:33:150:33:19

My skin was really...

0:33:190:33:20

My mum always had amazing skin,

0:33:200:33:23

she always looked younger than what she was and I prided myself in that.

0:33:230:33:26

I then developed a beard as well

0:33:260:33:31

and my husband... That became a joke as well because my husband has got a

0:33:310:33:34

goatee and these hairs stop growing on your legs but they just travel up

0:33:340:33:40

to your chin, so tweezers became my best friend.

0:33:400:33:43

Do you think there is a problem talking about the menopause?

0:33:430:33:45

Yes, I think so.

0:33:450:33:47

I think in one way it's you're facing the fact that you are no longer

0:33:470:33:53

a young woman. As we say. So you've got that to get over as well, that this is now...

0:33:530:34:01

You're not going back the way,

0:34:010:34:04

there's no change, as much as I didn't want to have any more children,

0:34:040:34:07

it's gone. All that's gone, you're into a new phase of your life but...

0:34:070:34:11

-And I think...

-But the point is you're not old.

0:34:110:34:15

You're young, middle-aged.

0:34:150:34:17

But it made me feel old.

0:34:170:34:21

For some women like Isabel,

0:34:210:34:23

the menopause can really shake their confidence but it doesn't need to

0:34:230:34:27

feel like the beginning of the end.

0:34:270:34:29

No matter what we look like on the outside,

0:34:300:34:32

inside our bodies are inevitably ageing

0:34:320:34:36

but there are many ways to deal with that.

0:34:360:34:39

We know that being low on oestrogen also affects our bone health and our

0:34:400:34:43

heart health and for these reasons, so HRT is part of the option,

0:34:430:34:49

one of the options, if we need to take treatment for

0:34:490:34:52

menopausal effects but

0:34:520:34:54

also diet and lifestyle changes are really important as well.

0:34:540:34:57

So not only are the symptoms important,

0:34:570:35:00

but that should also lead to a discussion

0:35:000:35:03

around what can I do to improve my health later on?

0:35:030:35:06

Now, some people turn their noses up at herbal remedies or

0:35:090:35:15

different kind of, almost talismanic things.

0:35:150:35:18

But I'm going to meet Karen.

0:35:200:35:22

The thing about Karen is that she swears by her lady magnet and

0:35:220:35:30

what we're going to do is we're going to see how that works for her,

0:35:300:35:33

what difference it's made to her life.

0:35:330:35:35

For Karen, and women like her who have a family history of ovarian or

0:35:380:35:42

breast cancer, taking HRT does have slightly increased risks of

0:35:420:35:47

breast cancer, so Karen felt it was not a safe option

0:35:470:35:50

and she had to consider alternatives.

0:35:500:35:53

So I looked at my diet,

0:35:550:35:57

I looked at my exercise regime,

0:35:570:35:58

which was kind of non-existent at that time,

0:35:580:36:01

and I thought I've been a runner before, I can do this again.

0:36:010:36:04

That's been a big part of your, as it were, rejuvenation.

0:36:040:36:07

It has been an absolute huge part of my rejuvenation.

0:36:070:36:11

And then I thought, right OK, the exercise thing is there,

0:36:110:36:14

now I need to adjust my eating.

0:36:140:36:16

My eating habits were just a bit appalling, really.

0:36:160:36:19

Then the hot flushes started.

0:36:190:36:21

I thought, what's this? I was like, what?

0:36:210:36:24

People had told me about this and you just have to whip all your

0:36:240:36:27

clothes off and then it doesn't matter where you are,

0:36:270:36:30

Marks & Spencer's or anywhere, you'd be like...

0:36:300:36:32

And people will be looking and you going, "Oh, dear."

0:36:320:36:36

Well, I was having up to about 85 hot flushes a day and night

0:36:360:36:39

in a 24-hour period. I've ignored this a wee bit.

0:36:390:36:42

No, I'll do it, it's my job.

0:36:420:36:44

And so I heard about this magnet and I thought, right, OK.

0:36:440:36:49

People wear magnets for arthritis and rheumatism,

0:36:490:36:53

and it works on the same principle as that.

0:36:530:36:56

I think it's a balancing thing.

0:36:560:36:58

So how long did it take to stop the hot flushes?

0:36:580:36:59

It took me about eight weeks.

0:36:590:37:01

-But you persevered?

-For me to notice a difference and the difference

0:37:010:37:07

that it's made to my life, I probably have maybe four,

0:37:070:37:11

five hot flushes a day now.

0:37:110:37:13

I'd still say four or five is quite a lot actually, but obviously compared to 80.

0:37:130:37:17

Compared to 80 it's not.

0:37:170:37:18

And you think it's definitely the magnet and not a progression of your

0:37:180:37:23

-menopause?

-It could be a progression of my menopause.

0:37:230:37:26

-It doesn't matter because it works for you.

-It doesn't matter because it works for me.

0:37:260:37:29

So it could all be psychosomatic but it works for me.

0:37:290:37:34

-Can I just see the magnet?

-Yes, of course.

0:37:340:37:36

That's the magnet now. How does it...?

0:37:380:37:42

It's two bits. Two pieces to it.

0:37:420:37:44

-Right.

-And that it goes inside, up against...

-Yes.

0:37:460:37:49

-Your pubic bone there.

-And the other bit goes on the front of your knickers and keeps it firm.

0:37:490:37:54

-And that's 24 hours a day?

-24 hours a day.

0:37:540:37:57

Magnet therapy is just one option for dealing with the menopause.

0:38:010:38:04

Although there is no comprehensive medical research to back up the

0:38:060:38:09

effectiveness of alternative therapies,

0:38:090:38:12

the idea of a placebo which works on the mind rather than the body has been proven.

0:38:120:38:18

Placebo work brilliantly for everything.

0:38:190:38:21

And you need quite an effective treatment to be better than

0:38:210:38:25

placebos, so I never say to a woman something won't work.

0:38:250:38:29

-Never say that because you know that in a certain proportion of cases it will.

-Why?

0:38:290:38:34

I suspect it's because of neuronal pathways.

0:38:350:38:41

The control of hot flushing is in the brain

0:38:410:38:44

and it's an alteration in the perception of temperature,

0:38:440:38:48

heat and cold.

0:38:480:38:50

So you react very quickly to changes in temperature postmenopausally in a

0:38:500:38:54

way you don't premenopausally, due to the absence of oestrogen,

0:38:540:38:59

and I wonder if somehow the placebo, if you like,

0:38:590:39:05

relaxes somebody.

0:39:050:39:07

They feel differently and this impacts on the way the brain is working.

0:39:070:39:11

It's quite possible.

0:39:110:39:13

This connection between mind and body can have a massive impact on our lives.

0:39:140:39:19

One of the effects of the menopause is the mood swing or indeed low

0:39:190:39:24

mood, as I've heard it described.

0:39:240:39:26

And that can be incredibly upsetting and debilitating for women

0:39:260:39:31

experiencing that, but just as upsetting and debilitating for

0:39:310:39:34

relationships, be it with your partner or indeed with your family when,

0:39:340:39:39

all of a sudden, out of nowhere

0:39:390:39:41

a rage comes on.

0:39:410:39:42

Women are, historically and traditionally,

0:39:450:39:49

have been thought of as unstable, volatile, uncontrollable.

0:39:490:39:55

What happens is that they are supposed to, post-menopause, do good deeds,

0:39:550:40:00

do charity, to become serene, to get by on just the love of their families

0:40:000:40:07

and the love of society.

0:40:070:40:09

Generally keep quiet, not rock the boat,

0:40:090:40:12

vanish. Just disappear and if you don't do that

0:40:120:40:15

then you're troublesome and

0:40:150:40:17

then you can be diagnosed with immoral insanity or hysteria.

0:40:170:40:20

Hysteria was a very big thing, only dying out in the early 20th century.

0:40:200:40:24

The cliche of the older woman as mad, bad and dangerous to know

0:40:250:40:29

is the comedy gift that just keeps on giving.

0:40:290:40:33

-Dougal!

-Hello.

0:40:390:40:41

But uncontrollable rage is no joke.

0:40:430:40:47

For Jackie, it's been horrendous.

0:40:470:40:50

She was prescribed antidepressants for six months

0:40:500:40:53

to try to help her cope

0:40:530:40:54

but she didn't feel that was the best way for her.

0:40:540:40:57

She's been trying to manage the effects of her menopause without

0:40:570:41:01

medication for more than a year.

0:41:010:41:03

It's like having an out of body experience where I'm watching and

0:41:040:41:10

listening to myself ranting like a lunatic.

0:41:100:41:13

Completely nuts and what I'm saying is irrational

0:41:140:41:18

and the logical side of my brain is saying, "Shut up, you are being stupid," and I can't.

0:41:180:41:24

So did you direct the attack at anybody in particular?

0:41:250:41:29

My husband got it every time.

0:41:290:41:30

And sometimes he'll poke fun at me a wee bit just to make me laugh

0:41:320:41:38

and he actually said to me, he says, "It's not the menopause,

0:41:380:41:41

"I've got another phrase for it," and I said, "What is it?"

0:41:410:41:44

Me - No - Pause. He says, because see when you start,

0:41:450:41:50

you don't know when to shut up.

0:41:500:41:52

Full-on. You know,

0:41:550:41:57

all those years ago women were locked up in lunatic asylums for it

0:41:570:42:01

and I'm thinking, "Yep, that would probably be me."

0:42:010:42:05

If that was a century ago, that would have probably been me.

0:42:050:42:07

What, losing the temper, losing the rag, going into a rage?

0:42:070:42:11

Absolute rage.

0:42:110:42:12

And I've been making sandwiches with a knife in my hand and I've had to

0:42:140:42:17

put the knife down and just walk away.

0:42:170:42:19

How do you calm yourself down?

0:42:210:42:24

Well, I was taught some breathing techniques.

0:42:250:42:29

So I close my eyes, imagine this light round me,

0:42:290:42:34

slow down my breathing and imagine either running water...

0:42:340:42:38

I'm either at the side of a river or on the shore

0:42:380:42:42

and then as my breathing slows down,

0:42:420:42:45

I then lie down on the bed and carry that through for the next 10-15 minutes.

0:42:450:42:51

Just concentrating on breathing slowly,

0:42:510:42:55

deeply, in and out.

0:42:550:42:57

Finding practical ways to cope with the symptoms of the menopause can be

0:42:590:43:03

an uphill struggle.

0:43:030:43:04

'Three teas? I invited some of the women I met in the course of making this film for afternoon tea.

0:43:050:43:12

'And the chance to get a bit more information and support from Ruth Devlin,

0:43:130:43:17

'who runs workshops for small groups of women.

0:43:170:43:21

'She's also the Scottish ambassador for the British Menopause Society.'

0:43:210:43:25

So do you take us through,

0:43:250:43:27

do you now take us through different treatments for what happens?

0:43:270:43:29

Yes, I will go through different treatments.

0:43:290:43:31

-Great.

-You'll have heard of vaginal atrophy being bandied around.

0:43:310:43:34

Well, that just means that basically everything is thinning and wasting

0:43:340:43:38

away down below. I've never talked about vaginas so much in all my life

0:43:380:43:42

since taking this on.

0:43:420:43:44

Very easily treatable.

0:43:440:43:46

You can have the moisturising lubricants or you can have vaginal

0:43:460:43:51

oestrogen. That is the safest way to take HRT.

0:43:510:43:55

It is a tiny, tiny, tiny amount of oestrogen.

0:43:550:43:58

It's extremely safe and it's also not systemic because it's localised,

0:43:580:44:02

so it's not being processed through your liver,

0:44:020:44:04

so it's the safest way that you can have it.

0:44:040:44:08

You get something like this tiny little tablet in the end there which you

0:44:080:44:11

insert. You can start off, if you've got bad symptoms,

0:44:110:44:14

you can start off having it daily and then reduce it down

0:44:140:44:17

to twice a week and then you might find

0:44:170:44:19

that you just need it once a week.

0:44:190:44:21

If you take oestrogen like that,

0:44:210:44:22

that is a general good or is it too small a dose?

0:44:220:44:24

The vaginal oestrogen is only treating your vaginal atrophy.

0:44:240:44:29

-That isn't treating any of the other symptoms.

-OK.

0:44:290:44:31

-If you want to go...

-This poor woman's having a hot flush.

0:44:310:44:34

It always happens at the most inopportune times. Sorry.

0:44:340:44:38

-Would you like some water?

-I've got some here, it's OK.

0:44:380:44:41

That one came from your head down. Explain to me what's happening.

0:44:430:44:48

Right, it starts here.

0:44:480:44:50

And as much as you try and put it off,

0:44:510:44:53

you can't and I was getting hotter and hotter and hotter and I thought,

0:44:530:44:56

typical. This always happens to me at the most inopportune times.

0:44:560:45:00

-Can happen anywhere, can't it?

-Yes.

-It doesn't matter, you just proved it.

0:45:000:45:04

CBT, cognitive behavioural therapy has definitely been proven

0:45:040:45:09

to help with all your psychological symptoms,

0:45:090:45:11

but also now you can train yourself to help manage your hot flushes

0:45:110:45:16

and your night sweats as well.

0:45:160:45:18

I don't get many hot flushes but sometimes they come on if I'm stressed

0:45:180:45:22

with something or a train journey being late or about to miss a flight

0:45:220:45:26

or something. That tends to bring them on.

0:45:260:45:28

Sometimes they'll come on in the middle of a meeting at work

0:45:280:45:32

and it's usually a meeting where you're predominantly surrounded by men.

0:45:320:45:35

You should just be able to take a little fan.

0:45:350:45:38

A rather lovely fan and fan yourself.

0:45:380:45:40

That would be wonderful.

0:45:400:45:42

It's one thing for women to talk to each other but symptoms that can

0:45:500:45:54

affect a couple's physical relationship are often really tricky to tackle.

0:45:540:46:00

Artists Minty and Nick have been together for almost 30 years.

0:46:000:46:04

We don't have children and that's through choice.

0:46:070:46:09

So for me, in a way,

0:46:090:46:11

going through menopause isn't tied up with reproduction.

0:46:110:46:14

When you were going through the menopause, what symptoms did you have?

0:46:150:46:20

The big one was vaginal dryness and soreness

0:46:200:46:24

and how that affected having vaginal sex,

0:46:240:46:29

and that was a bit of a shock.

0:46:290:46:30

Yeah, and was that gradual or did you, when you went through menopause,

0:46:300:46:34

-was that quite quick?

-It was quite quick actually.

0:46:340:46:37

It was really quite quick.

0:46:370:46:39

It seemed to go from being completely fine

0:46:390:46:42

and everything in the garden was rosy, then, ooh, what's going on?

0:46:420:46:47

This is actually sore, this is not...

0:46:470:46:49

This is not comfortable.

0:46:490:46:51

So what did you do about that?

0:46:510:46:53

-Initially...

-Initially, I suppose you kind of, you know,

0:46:550:46:59

take a little bit of advice and suss out things that might help.

0:46:590:47:03

-But that wasn't really...

-It didn't really seem to make enough difference

0:47:050:47:11

and the kind of faffing around with tubes of lube and stuff like that.

0:47:110:47:18

Yeah, it was odd to find it not straightforward.

0:47:180:47:21

-Yes.

-But, I mean,

0:47:210:47:23

it wasn't that difficult to start going, OK,

0:47:230:47:29

how do we enjoy having sex but in a different way, or whatever?

0:47:290:47:34

So without penetration, that's the key thing?

0:47:340:47:37

-Yeah, without that.

-Wasn't going to work.

0:47:370:47:40

I mean, we often sort of talk about it as a bit more like adolescent sex,

0:47:400:47:43

really, which a lot of fun, really.

0:47:430:47:45

-Yeah.

-Yep.

0:47:450:47:47

And it's kind of, you know, it's a funny thing.

0:47:490:47:53

Then you go, actually,

0:47:530:47:54

but we think about sex as being just about vaginal penetrative sex and

0:47:540:48:00

actually it's lots of things.

0:48:000:48:01

But clearly,

0:48:010:48:02

I mean it's wonderful because you have a relationship where you can

0:48:020:48:05

talk about this stuff and you can deal with it together.

0:48:050:48:08

Yeah, I think... There was a bit where I felt like...

0:48:080:48:12

I was letting you down, I think.

0:48:120:48:14

We don't always talk about everything immediately, it maybe took a week,

0:48:140:48:18

a month or so, before...

0:48:180:48:19

Or you said, I'm not sure which of us said, actually, you know,

0:48:190:48:24

if this is just painful, let's just stop trying to do this and it's OK.

0:48:240:48:29

I mean, there's other options.

0:48:290:48:31

Nick and Minty were just so honest and giving and reassuring about the

0:48:350:48:39

impact it's had on their relationship and how they've dealt with it.

0:48:390:48:43

And it must be like that for lots of people.

0:48:430:48:45

We tend to think of the menopause as something that usually happens to

0:48:540:48:57

women in their 50s,

0:48:570:48:59

but going through a natural menopause before the age of 45 is not uncommon

0:48:590:49:05

and a tiny proportion of women will experience it at a very young age.

0:49:050:49:09

It's a devastating diagnosis to be told.

0:49:110:49:14

We've had lots of young women who'd been told, it can't be menopause,

0:49:140:49:17

you're too young, but actually we are encouraging

0:49:170:49:19

that investigations are carried out. So there is the fertility aspect,

0:49:190:49:24

which is hugely important and, as I said, absolutely devastating,

0:49:240:49:27

but there are also then these extra number of years of potentially being

0:49:270:49:31

low on hormones.

0:49:310:49:32

'Dealing with the health implications of the menopause

0:49:350:49:37

'when you're extremely young is a lot to bear.

0:49:370:49:41

'When it happened to Heather, she was still at school.'

0:49:410:49:44

I was very young when I went through menopause.

0:49:450:49:48

It was termed as premature ovarian failure.

0:49:490:49:52

I was 14 and it was diagnosed at 16.

0:49:520:49:55

And in those two years do you remember what life was like?

0:49:550:49:58

When I was 13 I started to miss periods, so we went to the GP who had said,

0:49:580:50:04

"You're still young, they're just settling down."

0:50:040:50:07

So we just kind of forgot about it and, actually,

0:50:070:50:09

I was quite pleased that they weren't there

0:50:090:50:10

because they'd been so heavy and painful.

0:50:100:50:13

But actually at school that must have been quite interesting

0:50:130:50:15

because your friends were having periods and you weren't,

0:50:150:50:17

so you are able to say, well, actually, I don't feel so bad.

0:50:170:50:20

I don't feel so bad, exactly.

0:50:200:50:21

I was doing my GCSEs,

0:50:210:50:23

quite glad not to have periods but it was at the end of that,

0:50:230:50:26

when I was 16, that we went back to the GP and said, "Look,

0:50:260:50:29

"I think this needs to be looked into the bit further."

0:50:290:50:31

And that's when I was referred to an endocrinologist, who said,

0:50:310:50:35

actually, you're no longer ovulating,

0:50:350:50:37

you've had premature ovarian failure.

0:50:370:50:40

But your mum was perimenopausal at that moment, no?

0:50:400:50:42

She was in her early 40s, hadn't gone through the menopause,

0:50:420:50:46

my grandmother had not long gone through the menopause,

0:50:460:50:50

so it wasn't something that I'd ever really thought about.

0:50:500:50:54

How did you and your mum talk about it?

0:50:540:50:57

I think after we left the hospital there was that initial...aah

0:50:570:51:01

..moment and I had a good cry.

0:51:010:51:03

Always knew that I wanted to be a mum,

0:51:030:51:05

and that was the only thing at first that was sort of sticking with me.

0:51:050:51:08

This is going to be quite difficult to be a mum now.

0:51:080:51:11

So when did you meet your husband?

0:51:110:51:13

When I was 22.

0:51:130:51:15

And he would have known from the beginning?

0:51:150:51:18

Yes. About six weeks in, I knew, very early on,

0:51:180:51:22

that he was the man for me, so I had to test at that point.

0:51:220:51:26

It was a big part, I wouldn't want him down the line saying this is a deal-breaker for me,

0:51:270:51:33

-so...

-And the implications for you in terms of having a family were,

0:51:330:51:36

obviously, huge. But you have taken steps.

0:51:360:51:39

We have tried egg donation and IVF treatment

0:51:390:51:42

and unfortunately it wasn't successful.

0:51:420:51:45

It was quite a painful time.

0:51:470:51:49

It was five years ago and we haven't tried since.

0:51:490:51:51

And there is a part of me that doesn't want to get hurt again.

0:51:510:51:56

At the moment, I'm over the weight limit to get treated,

0:51:570:52:00

so I think a little part of me is thinking, well,

0:52:000:52:04

I can't get the treatment, I can't get hurt again.

0:52:040:52:07

So, there's a little bit that I need to work on with myself to do that.

0:52:070:52:11

But it hasn't dulled my want to have children.

0:52:110:52:14

Entering menopause at such a young age is extremely rare,

0:52:180:52:23

but it can happen in your 20s or 30s and this has a massive effect on the

0:52:230:52:28

chances of having children.

0:52:280:52:29

But in the future, this may not always mean the end of a woman's fertility.

0:52:300:52:35

In Edinburgh, Professor Evelyn Telfer and Dr Marie McLaughlin are

0:52:390:52:43

collaborating with US scientists on ground-breaking research to determine

0:52:430:52:47

the potential of our ovaries.

0:52:470:52:49

The prevailing wisdom has been that woman are born with a finite supply

0:52:510:52:55

of eggs. However, a controversial scientific paper was published

0:52:550:53:00

in 2004 which challenged this thinking.

0:53:000:53:02

The view now is that ever since the work of an American scientist at

0:53:040:53:09

Harvard, he discovered a population of cells

0:53:090:53:12

within the ovary that had the potential to form new eggs later in life

0:53:120:53:18

and that was the work of John Tilly.

0:53:180:53:20

And this really met the scientific community with surprise and...

0:53:200:53:27

-Scepticism.

-Scepticism, and I was one of the sceptics.

0:53:270:53:30

I was really incredibly sceptical.

0:53:300:53:33

He came to our lab.

0:53:330:53:34

He brought the cells and we then saw what these cells were capable of,

0:53:340:53:39

and we then thought, well, you know, there is something in this.

0:53:390:53:44

The game changer was the cells that had the potential to form eggs.

0:53:440:53:49

Now, that's different from them forming eggs throughout life.

0:53:490:53:53

So, they may well be sitting there, dormant,

0:53:530:53:57

but if they're given the opportunity of the correct environment they may

0:53:570:54:02

well form new eggs.

0:54:020:54:03

So, we then decided we're going to look to see if we can isolate them.

0:54:040:54:09

These are cells that we have taken, we've taken a piece of human tissue,

0:54:110:54:15

cut into very, very tiny pieces.

0:54:150:54:17

We've dissociated using enzymes and filtered that,

0:54:170:54:20

so essentially we have a single cell suspension.

0:54:200:54:24

We've then used an anti-body to try and tease out the cells that have

0:54:240:54:29

-the important molecular markers.

-Potential?

-Yes, that's right.

0:54:290:54:32

The gem cells and then we've gotten these back and sorted them out and

0:54:320:54:37

then grown them to a point where we think we can see cells that look

0:54:370:54:41

as if they're developing into eggs.

0:54:410:54:43

And to them we would then inject them into small pieces of tissue and

0:54:430:54:46

watch and wait and see what happens.

0:54:460:54:50

At this stage, we see our researchers finding out more about the ovary.

0:54:500:54:54

We see it more in terms of say, alleviating infertility

0:54:540:55:01

for, particularly young girls, who lose their eggs

0:55:010:55:05

very early and that may well be through a genetic disorder,

0:55:050:55:09

or chemotherapy.

0:55:090:55:10

But I think we really need to get more,

0:55:100:55:13

a greater understanding of how the ovary actually works,

0:55:130:55:18

and then we can, you know, understand the process of menopause

0:55:180:55:23

and how we view the ovary as well.

0:55:230:55:26

The work that Professor Telfer and her team is doing is potentially

0:55:280:55:33

transformative for all women who are, for whatever reason, infertile.

0:55:330:55:37

But it's got something else going for it,

0:55:370:55:39

it also means that the way we view the menopause may well be different

0:55:390:55:43

because it may not be the end of a woman's child-bearing years

0:55:430:55:46

and if that is the case, what is the impact that will have

0:55:460:55:50

on the way we look at ageing?

0:55:500:55:52

In years past, women have often been written off after a certain age,

0:55:540:55:58

when work and child rearing are at an end.

0:55:580:56:01

But in the early 21st century,

0:56:010:56:03

when the average life expectancy for women is now 81,

0:56:030:56:07

how can we best approach this next stage?

0:56:070:56:11

I don't think many people have thought through that women will live

0:56:110:56:15

probably a third of their life post-menopausally...

0:56:150:56:18

..and so need to be absolutely at their best in terms of feeling well.

0:56:200:56:26

The key thing I think is let's talk.

0:56:270:56:30

Let's just talk menopause, so it is going to happen to all of us, so,

0:56:300:56:34

it's a normal event, but we need to tackle it and be proactive about it.

0:56:340:56:39

So, post menopause, women are still strong and vital,

0:56:430:56:48

creative and capable.

0:56:480:56:51

We are not in retreat.

0:56:510:56:52

Instead of fearing this stage of life,

0:56:540:56:57

the years after the menopause should be a positive, liberating time.

0:56:570:57:03

I don't feel any less intelligent

0:57:040:57:06

and, in fact, I think I'm probably more confident.

0:57:060:57:10

I think I set out more positively about things because I don't,

0:57:110:57:18

I don't know... I don't ever,

0:57:180:57:20

like if I go into a meeting or anything,

0:57:200:57:22

there's not that element of, oh, I wonder if I look all right? I don't have any of that any more.

0:57:220:57:28

I feel much more positive and confident about my own abilities for things.

0:57:280:57:33

In the making of this programme, I have met such lovely women,

0:57:350:57:38

willingly sharing our stories with us and some of these stories are very

0:57:380:57:42

different, all because they don't want other women to feel alone or to

0:57:420:57:45

suffer in silence. Of course,

0:57:450:57:48

some women will sail through the menopause and there'll always be women

0:57:480:57:51

who put up with whatever the menopause throws at them.

0:57:510:57:54

But we don't have to do that.

0:57:540:57:56

Things are changing.

0:57:560:57:57

I had no idea the extent and variety of symptoms, so, of course,

0:57:570:58:02

women should have individualised care.

0:58:020:58:04

And I certainly learned I need to take better care of myself,

0:58:040:58:07

to do even more exercise, watch my alcohol intake,

0:58:070:58:10

take vitamin D and now I may revisit taking HRT.

0:58:100:58:15

The menopause, the 21st century, shouldn't be a curse.

0:58:150:58:20

It should be about stepping forward to embrace the next stage in our lives,

0:58:200:58:23

not letting it hold us back, and in order to do that,

0:58:230:58:26

we have to learn to be good to ourselves.

0:58:260:58:29

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