07/05/2016 Click - Short Edition

course, for most of history, genetics was unknown territory. This

is the world Society of medicine in central London. And this institution

has been at the forefront of demoting innovation and the sharing

of information through the medical community. And in 2003, a community

received an explosion of information. The human gene project

was declared complete. And this knowledge paves the way for a far

deeper understanding of which genes cause which diseases. These days,

the talk is all about personalised medicine. But how useful is this

genetic information at the moment? After meeting a leading geneticist

in San Francisco, our reporter decided to embark on her own genetic

discovery journey. If you could unlock all of the secrets of your

health, how long you will live, what diseases right risk of developing,

would you? Stand to profit in a department is hoping that this day

will one day be a reality. It is studying 100 healthy people and

sequencing their DNA to see if they can predict when they will get sick

before they do. Leading the research is this professor. I'm always

keeping my devices very well charged. Here's a 1-man tracking

machine and along with sequencing his Geno, he wears nine different

devices every day to monitor his health outputs, including three

smart watchers and the radiation monitor. I have it continual glucose

monitor that sits just on top of my skin that continuously measures my

glucose levels. The Professor, it is already been a success of sorts. He

found he had a genetic predisposition to type 2 diabetes,

despite showing no typical signs of the condition. My gin and predicted

a number of risks, one of which was type 2 diabetes. As we doing all of

these medicines analyses, we discovered that my sugar which have

been running on perfectly fine actually shot through the roof, and

basically to the poor grass asked as fighters diabetic. The professor

keeps track of his Geno and to this personalised system. It looks

complex, but it is showing changes happening in his gingers everyday.

The outside affects my gene representation of my gin, and all

the different changes I have relative to the inner line here.

Inspired by Professor Snider, I signed up for 23 and May. Is one of

the better-known and cheap services that offers you insights to your

genes. Rather than looking at your whole Geno, it looks of the ones

that are significant. Civilly send a sample and you're left with this. Is

to getting back 3 billion bits of info, I received 100. These included

risk factors for indicators of Alzheimer's disease and are very

name breast cancer syndrome. The roles of 41 genetic variants that

produced different things from lactose intolerance to eye colour. I

was lucky to find out I didn't have anything significant to report. In

fact, the most interesting thing I found out with sales likely lactose

intolerant. I've changed my diet accordingly and that his made a

difference to my life. This small discovery increase my appetite for

more results. After reading forums, I discovered a site. It says it can

unlock more data for only $5. So I went for it. And rather wished I

hadn't. In ten minutes I was flooded with information on 20,000 Geno and.

These are marked as non- said, good and bad. And whatever this is?

Instead of nothing to report I seem to have hundreds of bad genes and

knows that a high risk of developing type 2 diabetes and various cancer.

Put my results to a clinical geneticists. I'm absolutely baffled

by the information that is in this report. You find any of this

information useful to me. As a clinical genesis would be looking at

your risk of disease, I would say there is nothing in here that we

would find clinically actionable in terms of setting up screening or

modifying your lifestyle. It may tell you something about where you

are and that spectrum of normality. Adam explained that the percentages

that scared me actually showed that these genes were fairly common in

the general population. It is also just one genetic aspect out of 3

billion molecules and make up your Geno and and that single molecule is

not going to change that much. What you think my GP would say to me if I

brought them this? I think your GP was struggle to find anything in

here that they would find useful in managing your health. And more

comrades of insight into our genes may come from the NHS's 100,000 GM

project. Participants include people with rare diseases and their family.

The NHS wants us to form the base for a genomic medical service,

potentially offering new and more effective treatments and diagnoses.

And while it may be many years before we can access useful

information about her Geno 's cheaply on a smartphone, a future

when a greater role in the healthcare seems increasingly

possible. Will that was Jennifer, and this is Tony Young who was the

leader of innovation at the NHS, but you're also a surgeon. That is

correct. What do you make of giving a load of raw genetic data to the

public to read through. Because she seemed quite freaked out when she

read that. I can understand that and there are more and more of these

offerings coming from the private sector around doing some element of

your genomic screening and when you have that data, what do you do with

the? What sense can you make of the? And the explicit she had was one of

very confusion and there is an enormous mass of data. It is not

just the public who is confused, many clinicians as well don't know

what to do with large swathes of data coming out. And that is one of

the reasons in 2012, our Prime Minister launched 100,000 GM

project, which was a world first because it was a larger scale effort

the country had undertaken to that point to screen 100,000 whole Geno

and throw population to look at both cancer risk and rare genetic

disorders, so we at the NHS could say, the results of confusing data

but actually, we're going to take a major first step in a. Not relying

on a commercial company to give you some advice on the risk of diabetes

or our son is that may or may not be relevant. We learn very recently

that Google is using the deep mine project to analyse health data from

the NHS patients. The programme that you mentioned with a deep mind is

all around acute kidney injury. So patients are going to hospital and

have an altered blood test or a Syrian correction, but the early

stages of that. And you are still very well and your kidneys are very

well, but I can deteriorate over time. But you're waiting for a human

to look at that blood test result, and the whole point of using a

machine learning and artificial intelligence is that can we use is

to actually pick that up much earlier to prevent that person

getting kidney damage and renal failure. The data is there we're

just not using it. So we can deliver safer and better care. I think it is

really exciting. Over 47 million people in the world are suffering

from dementia and an ageing population means that that figure is

only likely to increase. So I've been looking at the technology

hoping to better the lives of those with the condition. This week, see

hero launches, a game designed to appeal to gamers but beneath the

surface is real science. While you may in think of the main feature

being memory loss, or the early things to be affected is actually

spatial awareness. So after collecting data about how healthy

minded players navigate the game and comparing that to how someone with

dementia plays, at benchmark can be created to both diagnose and assess

progression. Just two minutes spent on the app will generate the same

amount of data is five hours in a research lab. The design of the game

was built from the perspective of a scientist and what data they needed

to understand how people navigate in 3-D space. We should provide not

only a standardised measure of quantifying cells condition, and

also the condition to do several only. The key with this research is

understanding what goes wrong with spatial navigation and orientation.

To having understood that with this experiment in this big set of data,

we're armed to go on and do new research tell people working with

drug trials through example and to investigate particular drugs and how

they will have a good idea as to how people navigate. The boy was now a

man. The hope is that now in a crowded market of smartphone games,

the Apple appeal to enough people to make this mission possible. Bring

them back to his beloved see hero. That was Lara. And that is if the

shortcut of click this week. GOTO I play if you like to see the

full-length version. Jonas Twitter throughout the week. They differ

watching, see you soon.