02/05/2016 BBC News at Six

New research gives a near-complete picture of

and could lead to fresh methods of treatment.

The US Secretary of State insists any peace deal in Syria must include

the besieged city of Aleppo, the focus of recent intense fighting.

And Government plans to reform tipping, to see more money

Scientists say they have a near-perfect picture

of the genetic mutations that cause breast cancer.

The study, in the journal Nature, has been described as

a hugely significant moment in cancer research.

It's hoped the analysis could help unlock new ways of treating

Here's our Health Correspondent, Dominic Hughes.

Enjoying a spot of Bank Holiday Monday gardening, Vanessa Babbage

But Vanessa has fought a long, arduous battle

After extensive surgery, chemo and radiotherapy, she

knows how devastating the disease and its treatment can be.

It's actually worse than the cancer itself,

because you are constantly ill, so they do try to help you to

minimise the side-effects by giving you other drugs to help the nausea

and things like that, so the treatment is very, very harsh.

Scanners like this one are used to detect and monitor cancerous tumours

once they've already developed, but to understand the underlying

causes of cancer, scientists have had to go much deeper,

to the level of DNA, to try and work out what happens

An international team of scientists, led by the Sanger Institute

in Cambridge, examined all 3 billion letters in the genetic code of every

What they've found has transformed the understanding of what happens

Getting a comprehensive collection of information, including the

mutations that are causing cancer, tells us something about why that

cancer is going wrong, why that cell is turning

into a cancerous cell, and if you can understand that,

you can understand the causes of the cancer, and then you can

This opens up the possibility of much greater individualised

treatments for cancer, targeting each of the mutations.

That's already happening with some treatments, like the drug

Herceptin, but experts believe this could be a big step forward.

What this study might achieve is finding

better treatments, matching them better to women.

By understanding the causes that underline the biology

of different types of the disease, we might be able to match better

treatments and offer them things that are more likely to work for

Back at home, Vanessa Babbage is moving on with her life after

cancer, and she is optimistic that science is starting to make real

headway in the fight against the disease.

It gives people hope, because when people are affected

by someone that they love and they have breast cancer,

they hope for a better future for other women that are going to be

This research has transformed the understanding of cancer,

and offers the tantalising prospect it could prevent the disease

In talks in Geneva to try to save the ceasefire in Syria,

the US Secretary of State John Kerry said foreign powers were "getting

There's been a two-month pause in hostilities in the country,

but the last ten days have seen an upsurge of violence.

Mr Kerry said a renewed ceasefire must include

the besieged city of Aleppo, where more than 250 civilians

Our correspondent Barbara Plett-Usher has been travelling

War has returned to Syria's largest city after two

The air strikes on a hospital last week thrust the carnage

back into the spotlight, but hundreds of civilians have

been killed in the past ten days of fighting.

The Syrian military says it is targeting jihadists,

But the lines between such groups and other rebels in Aleppo

If the cease-fire breaks down here, it may crumble across the country.

The crisis triggered emergency meetings in Geneva,

the city that's been hosting Syrian peace talks.

America's top diplomat came here to try to salvage the truce.

We are engaged in an effort with all of the members

of the international Syrian Support Group,

and with Russia particularly, in an effort to restore that

cessation of hostilities in those places where it has been most

There is no excuse for not finding, again, a reinvigorating

and reinstalling and re-implementing what has been the only strong

message the Syrian people have heard from all of us.

Mr Kerry is urging Moscow to push its Syrian ally to stop

But the most he announced he was a joint agreement agreement

to strengthen the monitoring and implementation of the truce.

So they are wrestling with a formula to bring quiet back to Aleppo.

Are there will be intensive talks involving the Russians

Mr Kerry said there should soon be greater clarity about the details of

But the bigger question is whether Damascus

and Moscow are serious about the UN path to peace,

or whether they are using it to make military gains on the ground.

Barbara Plett-Usher, BBC News, Geneva.

A 36-year-old man has been shot dead during an operation

Officers were called to a property near Maidstone last night,

The pre-planned operation was connected to the suspected

murder of Roy Blackman, who was beaten to death

during a burglary at his home last month.

The Independent Police Complaints Commission is now investigating.

A 21-year-old man has appeared in court accused of planning

The government is considering new laws on what happens

The proposals include plans for a customer code that would make

tipping more transparent and ensure that all tips do go

It follows major criticism of some restaurants for failing

to pass the money on, as our business correspondent,

Unlike some other national restaurant chains,

Gourmet Burger Kitchen doesn't apply an automatic service charge,

nor does it deduct any administration fees from tips.

If the Government has its way, that will be the norm.

I think it is only fair that if a customer leaves a tip

with the intention of it being given to the staff member,

Now, the Business Secretary, Sajid Javid, is proposing that

gratuities are passed on in full to service staff.

At the same time, he wants restaurants to make it much clearer

And he is proposing a new code, but says he will pass legislation

if companies continue to withhold tips from staff.

It's got to go to the people that you intend it to go to.

It also has to be voluntary for good service.

That is what everyone wants to see and that is why

But some critics say tipping has had its day.

I think it is time that we scrapped all forms of service charges

and tipping and simply increased waiters' salaries to make

The British public feel very uncomfortable when it comes

to tipping, they don't know where the money is going to.

It is also bizarre, in the 21st century,

that we have this weird servile relationship with waiters.

The general public are less sure about that.

I would like to think it is going to the waiters

and waitresses and the cooks and that it is shared

equally, but I'm not sure whether it is or not.

Everyone who gets tips, it just gets split at the end of the day.

I don't think that's fair because I might work

The restaurant business is very competitive and margins

But if restaurateurs are forced to hand over part or all

of the tips their staff get, it may drive some of them

Ultimately, it's the dining public who will decide whether and how much

An Australian computer scientist has ended years of speculation,

saying he is the creator of the controversial

Dr Craig Wright, who lives in London,

showed the BBC evidence that he launched the currency

Dr Wright is believed to hold hundreds of millions of dollars

of bitcoins, which are a virtual currency

transferred via the internet, and which can be exchanged

This exclusive report from our technology correspondent

In an office in London, a mystery that has been an intranet

obsession for seven years is about to be solved.

So you are going to show me that Satoshi Nakamoto is you?

If that is true then Dr Craig Wright is the reason there is a new

Bitcoin is a currency invented on the Internet and

designed to operate outside the control

Its value and its reputation has been

widely used by criminals has been the world spends.

It was back in 2008 that someone calling themselves Satoshi Nakamoto

published a paper on the Internet describing a plan for Bitcoins. It

was the following year that he introduced the software allowing the

currency to take shape. Ever since, Satoshi Nakamoto 's Mac precise

identity has been a mystery. Last year there was a speculation about

Craig White, a Dutch Craig Wright, an Australian scientist. Now he he

has confirmed that he is Satoshi Nakamoto. Some people will believe

and some people won't. I don't really care. The evidence published

by Dr Wright to prove that he is Satoshi Nakamoto 's been met with

some scepticism, but at a Bitcoin conference in New York today, a

leading figure said he was convinced. I met with him in London.

He fits the kind of person that I was interacting with back in 2010.

And he provided some cryptographic proof. It was a private key from the

very first Bitcoin. Craig Wright will not reveal how rich Bitcoin has

made him, that says he doesn't want to be a figurehead for the currency.

I don't want money, I don't want fame or adoration. I just want to be

left alone. I'm going to come in front of the camera once, and I will

never ever be on the camera ever again. If he is to be believed, he

is a modern day Midas, the man who conjured new money out of thin air.

It is a remarkable achievement, but having emerged from the shadows,

Craig Wright, or Satoshi Nakamoto wants to disappear once more.

This Thursday, voters across most of England and Wales will be able go

to the polls to elect their Police and Crime Commissioners.

PCCs were introduced in 2012, with the aim of making police forces

accountable and more responsive to public needs.

But voting then suggested widespread apathy for the new role.

Our home editor Mark Easton reports from the campaign trail

32 million people get the chance to vote for their Police and Crime

Commissioner in England and Wales on Thursday.

Here in Northamptonshire, three candidates are up for

I want to maintain front line policing.

The first thing I'll do is reduce the cost

of the office of Police and Crime Commissioner.

Local people should help decide where police resources

The idea behind PCCs is the elected commissioner would be

impartial, setting police priorities for all the people, whatever their

But there are concerns that candidates should

Of the 188 PCC candidates across England and

Turn-out last time was a miserable 15%, a little higher in

But hopes that the public would start to

embrace this new elected official with the power

to hire and fire the Chief Constable, well let's say this

election could be seen as a referendum on the PCC idea.

To be honest, I don't really know what's going on.

Do you think people are excited about it?

I don't think they are excited about it at all.

Their previous PCC, Tory Adam Simmonds, is standing

Praised by the Home Secretary for helping cut crime, he was

criticised locally for increasing his office budget while the police

I spent 30 years in business from a technology point

of view, so I want to see body-worn video

cameras, the latest technology - that will make the difference.

We have lost over 105 police officers in

Northamptonshire since 2010 and at the same time

crime has doubled over the past two years, so we need a better

We have seen over the years that the established political

parties have failed to address the problems of

Ukip is the party to change that, and so am I.

Turnout is likely to be higher this time than last

because in many places PCC elections coincide

But whatever the local situation, there seems there is

plenty of scope for increasing public enthusiasm.

Mark Easton, BBC News, Northamptonshire.

And finally, Leicester City didn't quite manage it yesterday,

but tonight there's another opportunity for them to clinch

If Spurs fail to beat Chelsea this evening, Leicester will

Andy Swiss is in Leicester, where fans are gathering

in pubs around the city to watch the match.

Yes, welcome to the local hero pub, just a stone's throw from

Leicester's Stadium. Among the fans who will be watching the TV rather

nervously tonight is lifelong Leicester supporter Lee job. Thank

you for joining us. If Tottenham don't win, Leicester are champions.

How confident are you that? It's got to happen tonight, surely. If you'd

asked me two days ago, I would have wanted it to happen at Old Trafford

yesterday. Let's just get it on and enjoy the rest of the week, and

party on to next week. I don't want to go to Chelsea needing points.

Let's get it out the way and enjoy Champions League. No one has

mentioned that because everyone is so wrapped up in the potential title

win. What a story, the Champions League, the whole Leicester story

itself... The whole city is either anxious or buzzing. Everyone has

different feelings about the situation. Let's get it out the way,

take it to Everton and a massive party at the weekend. What would it

mean to you to see your beloved Leicester be crowned champions? I

don't know if there is a word for it. It needs to be added to the

dictionary! I know it is positive, and a million times better than

great. It should be a nervous nights a Leicester fans, but could be a

very special one. There's more throughout the evening

on the BBC News Channel. Now on BBC One, it's time

for the news where you are.