21/03/2017 Points West


21/03/2017

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Welcome to BBC Points West with Alex Lovell and David Garmston.

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The extraordinary research into Alzheimer's.

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We're in the lab with the very hungry caterpillars helping

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scientists find the link between sugar and dementia.

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We feed them sugar rich diets, and their proteins in their blood become

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damaged. We'll have the latest

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from the professor in charge. A council writes to a resident

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to take away her tax reduction The football star who may

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lose his licence yet again. And happy days for the village

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which has just received Finding the cause of dementia is one

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of the most pressing challenges in medical science,

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and in Bath they could be on to something thanks

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to the humble caterpillar. They're feeding the creatures

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with the sort of diet they and most of us enjoy,

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sugar, and seeing Our health correspondent

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Matthew Hill reports. This is the newest weapon

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in the fight against Alzheimer's. For some time, scientists have known

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that how much sugar we eat So they've enlisted the help

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of one of the greediest creatures on the planet -

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this very hungry caterpillar. This is kind of almost

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the end of the cycle... The clue's in its Latin name -

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manduca sexta which We are studying these

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because we are interested in the damage that sugars cause

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to proteins in the diet. In the colony, we hold

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all of the stages of the life cycle. So it goes through all the stages

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but it is the caterpillar stage It's been known for some time that

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people with Type 2 diabetes are far It's thought that's because glucose

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forms a harmful by-product in their blood, which makes it

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harder to kill the abnormal proteins known as plaques and tangels,

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which form in the brain. The same team of scientists in Bath

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have already developed a technique using a flourescent light

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to discover the tell-tale It's called glycation where sugar

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attaches to proteins Scientists think a substance found

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in berries and chocolate, called flavinoids, may

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reduce this glycation. So they are adding these flavenoids

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to the caterpillar diet to see It's an interesting model system

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that we're using to test the effects of high sugar on biological

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function, which we hope will give us a way of testing a mechanism that

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can be used to screen drugs and interventions to reduce this

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glycation that we are seeing Yes, these caterpillars like eating

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sugar, so we can mimic that high-sugar environment

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that we see in humans. This is the only place in Europe

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to culture these caterpillars. They evenually transform

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into a moth, and these pests can One essential ingredient

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for horn worms is tobacco. They need the smell of it in order

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to breed and lay eggs. That is why the university

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have a special licence This research project

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could take years. But if this greedy caterpillar can

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shed light on how diet could reduce the chances of Alzheimer's,

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then we may well have Professor Jean Van Den Elsen is from

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the university research team. Now, you've not brought any

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of the hungry caterpillars with you. They need to be contained because

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they are a pest. Not that we grow any tobacco in this country but they

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eat potatoes, tomatoes and chilli Peppers.

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And your fingers? They were having a bite. For people

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at home, they are thinking this. I can see a headline reading:

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"Berries and chocolate It is the gist of the story but a

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bit more complicated. We feed them high levels of glucose,

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we make them diabetic, then we can see similar to what happens in

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diabetes, we see damage to the proteins in their blood. We are

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trying to find these molecules and stop that from happening. There is

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evidence that. Potentially any molecules in coffee, tea, berries

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and chocolate, red wine, could stop this from happening.

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The flavonoids we were hearing about.

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In theory, eating too much sugar could give you diabetes, we know it

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can, type two. Eating chocolate or drinking red wine might actually

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prevent it or reverse it? We have to take the sugar out of the

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chocolate. There is always a catch. There is a

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clear link between sugar and diabetes, diabetes and Alzheimer's.

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How sure are you? Population studies have shown people suffering from

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uncontrolled diabetes type two actually can have a high risk to

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develop Alzheimer's disease. This can affect everybody whether

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they are worried about their own health or somebody in there found me

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-- family. People will look at headlines and think we on our way?

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How exciting do you feel this research could be?

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It is a great model system to test these compounds and we really

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hopeful find something, to use a combination of these southern noise

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from coffee, tea, chocolate or red wine, to make the right clock tile

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to stop sugar damage. Sugar seems to be number one enemy,

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is it a fad or is there real evidence?

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There is real evidence. Evidence in the lab has shown people suffering

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from Alzheimer's disease have a changed sugar damaged pattern in

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their brains, it is clearly linked to high sugar levels in their

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bloods. So, that is really good evidence.

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And the caterpillars you take care of them?

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We look after them. They don't live long enough to

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develop Alzheimer's disease. Thank you for coming in. Incredible.

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Thank you. Rail services in the west are likely

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to remain disrupted for the next two days after a freight train

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derailed in Somerset. Replacement buses are covering

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the line between Westbury All local services and journeys

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from the west to London that use that particular stretch

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of track are affected. Network Rail is helping

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with the investigation to find out A new line of inquiry

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in the Sally Ann John murder case in Wiltshire has come from last

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night's Crimewatch appeal. On the programme, detectives

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revealed that a postcard existed, supposedly sent by her

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after she disappeared The handwriting didn't match

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Sally Ann's and police believed it They had eight calls, one of

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which was potentially significant. It will send three weeks before she

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went missing. We strongly believe it was sent to mislead the league -- to

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mislead the police. We believe the person who wrote that card was

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coerced or misled into writing that or the person responsible for her

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murder. We will never give up for the sake

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of the family. We keep reviewing our lines of

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inquiring, identifying new lines. We are hopeful we will get the

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breakthrough we require. There's a reward of ?25,000

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for information that leads to a conviction,

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or the discovery Bristol City's star striker

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Tammy Abraham could lose his driving On the pitch, the 19-year-old's

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delighted fans with his But off it, he faces a court summons

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following an accident close to the club's training ground,

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as Andrew Plant reports. On loan to Bristol City

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from Chelsea, Tammy Abraham has already had a big impact

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on the club, scoring The last of those in a 4-0 home win

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against Huddersfield on Friday. Quite a day for the 19-year-old,

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earlier that day pictured with his instructor,

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after success too He later sent him a signed

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shirt to say thank you. But it wasn't the first

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time he had passed. His previous licence had been

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revoked, under rules that prevent new drivers from racking up more

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than six points in Now it seems his second full licence

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could also be under threat. At the end of January,

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Tammy Abraham was leaving training at the club's facilities here,

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just outside Bristol, when his car He has since been issued

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with a summons to attend court and faces allegations of driving

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without a licence or endurance. It means that Tammy Abraham will

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need to go to court voluntarily, But those offences can

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carry penalty points. So if he is ever found guilty

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of them, he could lose that Andrew Plant, BBC

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Points West, Bristol. You're watching Points West

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with David and Alex. The first day of spring but it feels

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like it. Still to come on this

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evening's programme. A gritty new movie

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set in Gloucester. The makers will be with us

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shortly to explain why And find out what happened

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when we took a monk to meet A grieving son has branded

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South Gloucestershire Council "insensitive" after receiving

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a letter about his mother's The letter was addressed to his mum

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informing her that she would no longer get a reduction

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as she'd "passed away." He got in touch with us,

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as he wants to prevent other families from being treated

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in the same way. Ada Davies, a much-loved

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mother and wife. Described at her funeral as someone

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who didn't mince her words. She died aged 95 on

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the 27th of February. It's been a difficult time

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for those closest to her. A time, her son says,

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made worse on receiving this It was addressed to his mum

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despite the fact that it explained that her council tax reduction

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was being cancelled It even invited her to "make

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a new claim" for a reduction, or to "contact" the office

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for more information. Another letter has since asked her

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to pay her council tax We are thinking about our mother

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all the time then you get letters addressed to her stating she is dead

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but as if she is alive They can't claim

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because she has passed. Some other members of the family

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are quite disgusted with it. If the reason for the reduction is

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death, don't print, or don't send. To add something like

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that to their system. If it was a family much more

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distressed by the death, it could have a major

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impact on them. Mrs Davies's council tax

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account has now been closed Christopher's family now hope to put

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the experience behind them, and to focus on grieving

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for their mother. A Cheltenham man has been sentenced

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to almost 25 years in prison after pleading guilty

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to murdering a teenager. 17-year-old Camran Green

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was stabbed last October. Steven Sharpe admitted

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the killing and also Our home affairs correspondent

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Charlotte Callen reports. 17 years old and under the care

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of social services, Camran Green Despite having a care team,

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he was able to travel by train from Birmingham

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to Cheltenham at weekends. Customers ordered drugs

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over the phone from him, That's how he met this man,

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Steven Sharpe, who let him stay On the 2nd of October last year,

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Sharpe tried to rob Camran He stabbed him with this 14-inch

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knife, described as a Rambo Police say more young vulnerable

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people are getting caught up in drug I think it is an indication of

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the world we live in where lots of communications are by mobile phones

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and people want things instantly. That's what we're seeing

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here in the drugs His mum wants to warn young people

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not to carry knives. She's also upset her son wasn't

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better looked after. You know, they should have found out

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where he was going, who he was with, you know, all that

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a mother would do. These care workers should

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see him as their child. So I am quite disappointed

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and annoyed they didn't The judge here today said the murky

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world of drugs had taken yet another Steven Sharpe was given a life

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sentence, he will serve at Charlotte Callen, BBC

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Points West, in Bristol. A new film set in Gloucester

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will receive its premiere It's the work of two brothers-in-law

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who were so moved by the number of high-profile stabbings,

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that they felt the need to show on screen how

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knife crime ruins lives. And we're pleased to say

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they've joined us in Let us look at the trailer so we

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know what we are talking about. MUSIC it gives us an idea but we

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don't see the story. What can we expect? It is a social

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responsive film that tackles knife crime, domestic violence, it gives

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an insight into peer pressure that make decisions and a better

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understanding. We tag line it as a socially

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conscious from about how knife crime destroys lives.

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Have you been able to work out from making the film by young people feel

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the need to carry a knife? We have done a lot of community

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conversations with charities that work with young people. There are so

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many reasons, for protection, through fear. We decided to create

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this form to tackle those issues. You are showing the consequences. It

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is big and tough to carry a knife. You have seen what it is like, the

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repercussions that they couldn't expect.

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That is right. It is analysing things close to home creating a form

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that will expand on the knowledge. Where will this film go now? We are

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hoping to launch it at Gloucester Guildhall on Friday in May. And get

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national distribution so more people can see the film.

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Knife crime is a national issue. It is so relevant, talked about day. We

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were talking about it in Gloucester. Have you had any input from the

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families of the people that have been affected by this. I'm thinking

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about Hollie Gazzard and her family. We had a word with Nick, he revealed

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his heart. And we spoke to a local charity dealing with young people on

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a regular basis, they gave us insight.

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You decided to make a film but, as you know, that is an extremely

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difficult thing to do, to make a watchable film with a message is

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very hard. What expense have you had before this?

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Is it a first attempt? We worked on stuff tween us, short films. We

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decided to make something that was socially responsive, and get into

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the in-depth reasons. We had an insight of Benjamin

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Woodward who came on board, and Thomas Sellick Newton, a 23-year-old

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university lecturer. Have you enjoyed the process?

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As well as educational, it is entertaining as well.

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Otherwise it won't engage in the right way.

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Good luck with it. We look forward to seeing it.

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Nice to meet you. Now we all dream of what we might do

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if we were suddenly left But imagine what it would be

:19:12.:19:14.

like if your whole village Well, that's what's happened

:19:15.:19:18.

to the people living in the west They're now having to decide

:19:19.:19:22.

between them how to spend what's being described

:19:23.:19:30.

as a "jaw-dropping legacy." Our Somerset correspondent

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Clinton Rogers reports. As recreation grounds go,

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it is already pretty impressive. Now imagine you have nearly

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three-quarters of a million Something amazing

:19:56.:19:58.

for the kids, maybe. Probably build a swimming

:19:59.:20:09.

pool or something. Because 1,200 letters have been

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delivered to people living in the area asking for ideas of how

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to spend the money left to them You know one of the more intriguing

:20:24.:20:26.

things about this story is that very We've not met anyone

:20:27.:20:34.

who knew her well. All we know is that she was in her

:20:35.:20:37.

late 90s when she died in December, and apparently she had

:20:38.:20:43.

no surviving children. And so the bulk of her estate

:20:44.:20:54.

was left to the recreation And can you just imagine

:20:55.:20:54.

the surprise of those in charge when they were told there

:20:55.:21:00.

was a legacy for them. When he came to see me and told me

:21:01.:21:03.

what the amount would be, ?700,000, possibly a little more,

:21:04.:21:09.

it was just jaw-dropping. It'll be several months yet before

:21:10.:21:13.

a final decision is made. Porlock is about to get one

:21:14.:21:15.

of the best recreation Clinton Rogers, BBC

:21:16.:21:19.

Points West, Porlock. It is quite remarkable. A lovely

:21:20.:21:28.

place. A brand new copy of a Georgian

:21:29.:21:32.

recipe book has just been published which sheds new light

:21:33.:21:35.

on what was being cooked It chronicled the day-to-day life

:21:36.:21:38.

at an historic home and was later moved to an abbey in Somerset

:21:39.:21:43.

where monks rediscovered it. We sent Liz Beacon for a taster

:21:44.:21:46.

to see if the recipes In the archives of Downside Abbey

:21:47.:21:49.

there are all sorts of treasures. From 11th century church

:21:50.:22:00.

documents to relics collected But the discovery of a Georgian

:22:01.:22:02.

cookbook has been rather special. There's some recipes

:22:03.:22:10.

for rice pudding. Some chicken, even more

:22:11.:22:12.

adventurous recipes, things with pigs' feet and calves'

:22:13.:22:24.

heads that perhaps we wouldn't have nowadays but are really

:22:25.:22:27.

interesting recipes to have. What is surprising is some

:22:28.:22:29.

of the ingredients mentioned As Father Christopher told me,

:22:30.:22:32.

there are examples of the exotic Bristol was the gateway into England

:22:33.:22:41.

and indeed out of England And so things like sugar coming

:22:42.:22:45.

from the West Indies, and spices coming from the Far East,

:22:46.:22:53.

and this house seems to have taken full advantage of that

:22:54.:22:56.

because there are ingredients The Georgian chicken

:22:57.:22:58.

curry has caught my eye, so I am taking a monk to meet

:22:59.:23:10.

a Michelin-starred chef. What surprised me about this

:23:11.:23:15.

recipe in the 18th century It made reference to three

:23:16.:23:17.

teaspoons of curry powder. What struck me about that was,

:23:18.:23:23.

I was thinking, what is Obviously we have curry powder

:23:24.:23:25.

now that we use but we have It was interesting back then

:23:26.:23:30.

they had these curry Curry powder, stock, onions,

:23:31.:23:33.

chicken and thicken with rice flour. Chef Josh Eggleton is following

:23:34.:23:41.

the recipe word for word. More basic than he's used

:23:42.:23:49.

to but with surprising results. It is our recipe but somebody else

:23:50.:23:53.

is cooking so I have to be So, an eight out of ten

:23:54.:23:58.

from Father Christopher. But for simplicity, flavour

:23:59.:24:10.

and being ahead of its time, Looks delicious. Quite slimming I

:24:11.:24:12.

expect. I might have some of that. Now, just before we go

:24:13.:24:28.

to the weather, today All across the country,

:24:29.:24:30.

people are wearing brightly-coloured socks to raise awareness

:24:31.:24:34.

of the condition. Well, you may remember this little

:24:35.:24:37.

boy here on the left. His name's Seb White and a few weeks

:24:38.:24:41.

ago he and his mum were guests Well, today, Seb, and all his

:24:42.:24:44.

friends, wore their coloured socks to school in Bath,

:24:45.:24:49.

and they certainly look Today I forgot. Tomorrow, I will

:24:50.:25:01.

wear bright socks. And me.

:25:02.:25:02.

It is actually a comparatively chilly field to things as we are

:25:03.:25:16.

under what is the first shower to come across here with great timing.

:25:17.:25:21.

For many of you in the sunny spells today it has been decent. But

:25:22.:25:25.

different where you are under the showers, some have been heavy. Over

:25:26.:25:31.

the next 24 hours, the main story will take shape tonight in the form

:25:32.:25:37.

of a band of heavy rain. First light tomorrow, that ball straddles the

:25:38.:25:41.

West Country, particularly to the east, then rotating itself away so

:25:42.:25:46.

the afternoon will brighten up, punctuated by showers, with light

:25:47.:25:56.

winds and any sunny spells will make it a sunny affair.

:25:57.:26:00.

You see that front is developing to the South West peninsular tonight

:26:01.:26:03.

and straddling tomorrow morning. It arcs its way over the Midlands

:26:04.:26:08.

followed by a regime of sunny spells and showers which will fade away as

:26:09.:26:13.

we head through tomorrow evening. At the moment, there is still a

:26:14.:26:16.

number of showers across the West Country, some quite potent, some

:26:17.:26:22.

hailstorms embedded. They will die away but watch how that band of rain

:26:23.:26:27.

develops through the second half of the night, some wintry spells over

:26:28.:26:33.

Exmoor with wet snow and other spots as well. Temperatures tonight fairly

:26:34.:26:41.

chilly, 1-4 C, some spots getting close to freezing, like Exmoor.

:26:42.:26:46.

Tomorrow, some uncertainty, that band will linger during the morning.

:26:47.:27:16.

From Bristol eastwards, drifting out From Bristol

:27:17.:27:16.

a brighter story in the afternoon. towards the north to be replaced by

:27:17.:27:17.

a brighter story in the afternoon. Some showers in the afternoon could

:27:18.:27:17.

be heavy, the winds and slow-moving. Temperatures

:27:18.:27:18.

of year. If you are in the sunshine, of year. If you are in the sunshine,

:27:19.:27:19.

it should be a decent story. That will be dictated by the position of

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the showers. Thursday, a notably chilly day with

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a north-easterly wind, seminar on Friday but it will improve at the

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weekend. Thank you. A fashion tip, if you are

:27:30.:27:34.

wearing thick socks, make sure you have some nice sandals with them.

:27:35.:27:41.

Lovely! You know how to dress! Do it tomorrow! Recipes on our

:27:42.:27:47.

Facebook page to recreate that curry. Goodbye.

:27:48.:27:49.

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