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Blists Hill Victorian Town in Shropshire revives the sights, | 0:00:02 | 0:00:05 | |
-sounds and smells of the 19th century. -Morning. | 0:00:05 | 0:00:09 | |
At its heart stands the pharmacy - | 0:00:09 | 0:00:12 | |
a treasure house of potions and remedies from a century and a half ago. | 0:00:12 | 0:00:17 | |
Now, in a unique experiment, historian Ruth Goodman, | 0:00:17 | 0:00:20 | |
Professor of Pharmacy Nick Barber and PhD student Tom Quick | 0:00:20 | 0:00:25 | |
have opened the doors to the Victorian pharmacy, | 0:00:25 | 0:00:27 | |
recreating a High Street institution we take for granted, | 0:00:27 | 0:00:32 | |
but which was once a novel idea. | 0:00:32 | 0:00:34 | |
They've brought the pharmacy to life, | 0:00:34 | 0:00:37 | |
sourcing ingredients, mixing potions and dispensing cures. | 0:00:37 | 0:00:42 | |
But in an age when skin creams contained arsenic and | 0:00:42 | 0:00:45 | |
cold medicines were based on opium, the team are being highly selective. | 0:00:45 | 0:00:51 | |
They're only trying out safe versions of traditional remedies | 0:00:51 | 0:00:54 | |
on carefully selected customers. | 0:00:54 | 0:00:57 | |
The start was like the Wild West - people didn't know what was good and bad. | 0:00:58 | 0:01:02 | |
Try to get a bit of speed up. Oh, there we go! | 0:01:02 | 0:01:04 | |
The pharmacy was something that affected everybody's lives in one way or another. | 0:01:04 | 0:01:09 | |
They're discovering an age of social change | 0:01:09 | 0:01:13 | |
that brought healthcare within the reach of ordinary people for the very first time, | 0:01:13 | 0:01:18 | |
heralding a consumer revolution that reached far beyond medicine | 0:01:18 | 0:01:21 | |
to create the model for the modern High Street chemist as we know it today. | 0:01:21 | 0:01:26 | |
Having followed the evolution of the pharmacy | 0:01:36 | 0:01:38 | |
through 50 remarkable years, | 0:01:38 | 0:01:41 | |
Barber & Goodman's High Street shop is approaching the end of the 19th century. | 0:01:41 | 0:01:45 | |
The pharmacy has now moved into a new era of scientific understanding. | 0:01:47 | 0:01:51 | |
Old ideas of what caused disease and how to treat it have faded away, | 0:01:51 | 0:01:56 | |
and the foundations of modern medicine are firmly in place. | 0:01:56 | 0:02:01 | |
This is what the whole of the 19th century, in a sense, ends up as. It's a culmination. | 0:02:01 | 0:02:05 | |
It comes up to this, doesn't it? | 0:02:05 | 0:02:06 | |
And all of a sudden, we have this scientific knowledge. | 0:02:06 | 0:02:09 | |
The pharmacist has the expertise. | 0:02:09 | 0:02:11 | |
We're stocking branded products, probably for the first time. We're not making them ourselves any more. | 0:02:11 | 0:02:16 | |
Pharmacists are starting to look like... Well, department stores. | 0:02:16 | 0:02:19 | |
One discovery that led to a whole new range of products | 0:02:21 | 0:02:24 | |
was the understanding of pain relief. | 0:02:24 | 0:02:26 | |
For thousands of years, medicinal plants had been used to control pain, | 0:02:26 | 0:02:31 | |
but by the end of the 19th century, scientists had shown | 0:02:31 | 0:02:35 | |
that the pain-killing properties of some plants | 0:02:35 | 0:02:37 | |
were due to a chemical called salicylic acid. | 0:02:37 | 0:02:41 | |
Nick and herbalist Eleanor Gallia are on the hunt | 0:02:42 | 0:02:45 | |
for one of the most effective of these natural painkillers. | 0:02:45 | 0:02:49 | |
So, what's this plant we're seeking? | 0:02:50 | 0:02:52 | |
Meadowsweet. | 0:02:52 | 0:02:53 | |
And what was it used for? | 0:02:53 | 0:02:56 | |
Digestive, calming digestive. | 0:02:56 | 0:03:00 | |
Very popular in rheumatism. Pain relief. | 0:03:00 | 0:03:04 | |
I keep thinking I see little bits of it. | 0:03:04 | 0:03:07 | |
It's very small at the moment. | 0:03:07 | 0:03:09 | |
There's some here, actually. | 0:03:09 | 0:03:11 | |
More of it here. | 0:03:13 | 0:03:15 | |
So, the effects depend partly on the time of the year | 0:03:15 | 0:03:19 | |
when it's picked, and obviously the parts of the plant which are picked? | 0:03:19 | 0:03:23 | |
Was that something which herbalists and chemists and druggists would have paid attention to? | 0:03:23 | 0:03:28 | |
Hugely. Very, very important. Especially so when, traditionally, herbalists were collecting | 0:03:28 | 0:03:33 | |
their own herbs, then dispensing their own herbs and making up tinctures and medicines. | 0:03:33 | 0:03:37 | |
-So, shall we pick some meadowsweet then? -Yes, let's. | 0:03:37 | 0:03:40 | |
Remembering all the time that this is just the very young growth. | 0:03:40 | 0:03:45 | |
It's used quite specifically in rheumatism and the pain that comes from that. | 0:03:45 | 0:03:48 | |
But really, the main action, the anti-acid action, which is... | 0:03:48 | 0:03:52 | |
It's got a lovely soothing action on the inside of the stomach. | 0:03:52 | 0:03:56 | |
It helps the mucosa, the alkali which protects the gut from | 0:03:56 | 0:04:00 | |
the acid that's produced in the whole digestive process. | 0:04:00 | 0:04:02 | |
We can make an infusion out of it, make it like a tea? | 0:04:02 | 0:04:06 | |
Yes. | 0:04:06 | 0:04:08 | |
With the rise of industrialisation and the expansion of towns, | 0:04:14 | 0:04:18 | |
what you've got, really, is a lot of people in one place. | 0:04:18 | 0:04:22 | |
And pharmacies have a whole new group of people, urban dwellers, | 0:04:22 | 0:04:27 | |
that they're trying to cater to. | 0:04:27 | 0:04:29 | |
No longer just a provider of drugs and remedies, | 0:04:29 | 0:04:32 | |
the Victorian pharmacy now sold a wide range of products | 0:04:32 | 0:04:36 | |
which wouldn't look out of place in today's chemist shops. | 0:04:36 | 0:04:41 | |
When you walk into a pharmacy nowadays, | 0:04:41 | 0:04:43 | |
you're seeing over 100 years of history in front of you. | 0:04:43 | 0:04:46 | |
People wonder why there are things like perfumes in pharmacies, | 0:04:46 | 0:04:49 | |
why there are, you know, products to do with dentistry | 0:04:49 | 0:04:53 | |
or some of them selling glasses, and so on, | 0:04:53 | 0:04:56 | |
and all these were activities which were happening in the Victorian era. | 0:04:56 | 0:05:00 | |
Towards the end of Victoria's reign, an emerging middle class | 0:05:03 | 0:05:07 | |
with an increased disposable income looked to the pharmacy for more than just cures. | 0:05:07 | 0:05:13 | |
They wanted to be pampered too. | 0:05:13 | 0:05:14 | |
The pharmacists' expertise with chemicals left them well placed | 0:05:14 | 0:05:18 | |
to take advantage of this consumer boom. | 0:05:18 | 0:05:21 | |
Perfumier Alec Lawless is going to give Ruth | 0:05:21 | 0:05:24 | |
a lesson in perfume making. | 0:05:24 | 0:05:26 | |
You've brought some amazing stuff. | 0:05:26 | 0:05:29 | |
This is things from the first perfumier's trade. | 0:05:29 | 0:05:32 | |
Things for making perfumes. | 0:05:32 | 0:05:34 | |
I suppose in the earlier periods, | 0:05:34 | 0:05:36 | |
perfume was very much the reserve of the super-rich. | 0:05:36 | 0:05:40 | |
-Then that changes now? -It changes dramatically. | 0:05:40 | 0:05:43 | |
What characterised this age was the beginning of mass production and branding. | 0:05:43 | 0:05:48 | |
You could sell an eau de cologne | 0:05:48 | 0:05:51 | |
and nobody was going to say, "You can't call that an eau de cologne." | 0:05:51 | 0:05:55 | |
There were several perfumes like that. One was called Jockey Club. | 0:05:55 | 0:05:59 | |
There was another called Mille Fleurs | 0:05:59 | 0:06:02 | |
and another called New-mown Hay. | 0:06:02 | 0:06:03 | |
Basically these names became known as perfume. | 0:06:03 | 0:06:08 | |
The other thing was the pharmacist - | 0:06:08 | 0:06:10 | |
because they'd been university trained, | 0:06:10 | 0:06:13 | |
they liked experimenting and they had this whole cornucopia. | 0:06:13 | 0:06:17 | |
A lot of the things that were used in apothecaries for medicine | 0:06:17 | 0:06:21 | |
were also perfume ingredients. | 0:06:21 | 0:06:23 | |
-I recognise most of the things. We've got a drawer full of myrrh sitting over there. -There you go. | 0:06:23 | 0:06:28 | |
-That's sandalwood, isn't it? -Sandalwood. | 0:06:28 | 0:06:31 | |
We've got a drawer of that up that end. | 0:06:31 | 0:06:33 | |
Many of these are ingredients we have medicinally in the pharmacy anyway. | 0:06:33 | 0:06:38 | |
How easy would it be for us as, you know, local pharmacists, | 0:06:38 | 0:06:42 | |
to invent a perfume of our own? | 0:06:42 | 0:06:45 | |
Well, a lot of them did and I'm sure like a lot of recipes at the time, | 0:06:45 | 0:06:49 | |
these recipes come down. | 0:06:49 | 0:06:51 | |
But it's basically what you had in the fridge. THEY CHUCKLE | 0:06:51 | 0:06:55 | |
Could you give us some advice on how to make our own? | 0:06:55 | 0:06:58 | |
What sort of things should we do and perhaps even a name - | 0:06:58 | 0:07:01 | |
what sort of name would be appropriate? | 0:07:01 | 0:07:03 | |
Maybe we should pay homage to Queen Victoria in some way. | 0:07:03 | 0:07:07 | |
That would tie in very nicely with | 0:07:07 | 0:07:11 | |
parts of the Empire. | 0:07:11 | 0:07:13 | |
India - I mean, this is East Indian sandalwood, finest... | 0:07:13 | 0:07:18 | |
-That's powerful. -It's one of the finest of all perfume ingredients | 0:07:18 | 0:07:22 | |
-and, of course, Queen Victoria is the Empress of India. -"Empress of India." | 0:07:22 | 0:07:27 | |
I have to say, it sounds a lot nicer than Jockey Club. | 0:07:27 | 0:07:30 | |
Now we have to decide how to make it smell nice. | 0:07:30 | 0:07:33 | |
There were two oils and essences that were highly revered at the time | 0:07:33 | 0:07:40 | |
but still not used in perfumery, because of the exorbitant cost. | 0:07:40 | 0:07:44 | |
One of them was Rose Otto and the other one was sandalwood. | 0:07:44 | 0:07:47 | |
We're going to use both of those | 0:07:47 | 0:07:49 | |
because we want our perfume to be really posh. | 0:07:49 | 0:07:52 | |
Yes, but also relatively cheap to make | 0:07:52 | 0:07:57 | |
that we can sell for a high profit. | 0:07:57 | 0:07:59 | |
Oh, good point. OK. | 0:07:59 | 0:08:01 | |
-We can put some other... I'm going to put coriander in there. -That sounds a bit cheaper. | 0:08:01 | 0:08:05 | |
That's a really nice little top note. | 0:08:05 | 0:08:07 | |
The daft thing is, when I said I was doing this, the boys wanted to have a go too. | 0:08:07 | 0:08:11 | |
Boys and perfume? | 0:08:11 | 0:08:14 | |
Nick and Tom both want to have a go too. We thought we might all have a go. | 0:08:14 | 0:08:18 | |
Why don't we split the perfume into top notes, middle notes and base notes | 0:08:18 | 0:08:23 | |
and each of you can have a play around | 0:08:23 | 0:08:26 | |
and come up with the combination for each of those that you like the best. | 0:08:26 | 0:08:31 | |
OK. I'll have a go with that. | 0:08:31 | 0:08:33 | |
Pharmacists were creating perfumes because they had the raw materials - | 0:08:33 | 0:08:38 | |
they had the plant products, the aromatic products, | 0:08:38 | 0:08:42 | |
the essences - and also, they needed to make money. | 0:08:42 | 0:08:45 | |
-Some money to deposit. -Certainly, sir. -Thank you. | 0:08:45 | 0:08:50 | |
'If you look in the chemists and druggists of the time, | 0:08:50 | 0:08:53 | |
'you'll see pages of bankruptcies. It was an expensive thing to be in.' | 0:08:53 | 0:08:58 | |
You needed to stock your shop, you needed to buy the shop, or rent it, | 0:08:58 | 0:09:01 | |
so they had a lot of outgoings | 0:09:01 | 0:09:03 | |
and they needed the income to keep going as well. | 0:09:03 | 0:09:05 | |
They were diversifying into any areas to do with their knowledge | 0:09:05 | 0:09:08 | |
of chemicals and so on, which allowed them to make income. | 0:09:08 | 0:09:12 | |
-Thank you very much. -Thank you very much. Have a good day. Bye-bye. | 0:09:12 | 0:09:15 | |
Hello, Eleanor. How are you? | 0:09:28 | 0:09:30 | |
-Perfect timing - kettle's just boiled. -Ah, fantastic! | 0:09:30 | 0:09:33 | |
-So, any chance of some of this meadowsweet tea? -For sure. | 0:09:33 | 0:09:37 | |
See what it was like, | 0:09:37 | 0:09:39 | |
being a Victorian taking some natural medicine. | 0:09:39 | 0:09:42 | |
Yes. | 0:09:42 | 0:09:43 | |
It was quite difficult in Victorian times with pain control. | 0:09:43 | 0:09:46 | |
I mean, partly, pain was thought to be sent there by God | 0:09:46 | 0:09:50 | |
so there's an issue about it. | 0:09:50 | 0:09:53 | |
When they introduced chloroform | 0:09:53 | 0:09:55 | |
to stop the pain of childbirth, | 0:09:55 | 0:09:57 | |
there was a lot of religious leaders against it, | 0:09:57 | 0:10:01 | |
saying it was stopping God's work being done. | 0:10:01 | 0:10:04 | |
So they were quite a barrier to it. | 0:10:04 | 0:10:06 | |
-Wow! -And so, the movement against it... | 0:10:07 | 0:10:11 | |
was quite strong. People were saying, "This is against God's way." | 0:10:11 | 0:10:15 | |
Most of the natural products were used for pain control - | 0:10:15 | 0:10:20 | |
well, there were only natural products - were opium and cannabis. | 0:10:20 | 0:10:24 | |
Queen Victoria had cannabis for her period pains. | 0:10:24 | 0:10:28 | |
-What did the vicar say about that? -I don't know. I think perhaps they didn't tell him. | 0:10:28 | 0:10:33 | |
Fantastic. | 0:10:33 | 0:10:35 | |
Thank you. | 0:10:36 | 0:10:37 | |
Mm. | 0:10:41 | 0:10:43 | |
-It's quite restorative as just a smell, isn't it? -Yes, it's lovely. | 0:10:43 | 0:10:47 | |
Almondy. | 0:10:47 | 0:10:48 | |
-Good health, Nick. -Cheers. | 0:10:51 | 0:10:54 | |
Good health. This is very good. | 0:10:54 | 0:10:56 | |
I was prepared for a bit of a witch's brew, but this is good. | 0:11:00 | 0:11:03 | |
Plants like meadowsweet, and also willow, | 0:11:07 | 0:11:09 | |
had long been used to control pain. | 0:11:09 | 0:11:13 | |
But by the end of the 19th century, | 0:11:13 | 0:11:15 | |
the active ingredient, salicylic acid, | 0:11:15 | 0:11:18 | |
could be extracted using the latest laboratory techniques. | 0:11:18 | 0:11:22 | |
By isolating salicylic acid from meadowsweet and willow, | 0:11:23 | 0:11:28 | |
they could produce a range of painkilling medicines. | 0:11:28 | 0:11:31 | |
It is the key ingredient in modern, non-prescription painkillers such as aspirin. | 0:11:32 | 0:11:37 | |
This is the source of salicylic acid. It's willow bark. | 0:11:38 | 0:11:42 | |
Just from normal willow trees? | 0:11:42 | 0:11:44 | |
Normal willow trees. | 0:11:44 | 0:11:46 | |
That, if you chew it... | 0:11:48 | 0:11:50 | |
It's quite bitter, isn't it? | 0:11:52 | 0:11:54 | |
Hippocrates, in 400 BC, | 0:11:54 | 0:11:56 | |
was prescribing an infusion of willow leaves, not the bark - | 0:11:56 | 0:12:01 | |
you can use the leaves of the willow tree, as well as the bark - | 0:12:01 | 0:12:04 | |
to ease the pain of childbirth. | 0:12:04 | 0:12:06 | |
2,500 years we have known this is a painkiller. | 0:12:06 | 0:12:09 | |
Salicylic acid can reduce pain, it also is antipyretic. | 0:12:09 | 0:12:13 | |
Right, so it reduces fever, if you are hot and feverish. | 0:12:13 | 0:12:17 | |
It is anti-inflammatory. | 0:12:17 | 0:12:19 | |
Things like rheumatism or if you have an inflamed area of your body - | 0:12:19 | 0:12:23 | |
-your gums can be inflamed, all sorts of areas. -It'll help treat that. | 0:12:23 | 0:12:26 | |
It's a bit of a wonder drug. | 0:12:26 | 0:12:28 | |
It is, isn't it? | 0:12:28 | 0:12:30 | |
It's still used in wart treatments. | 0:12:30 | 0:12:33 | |
It's used in strong concentration, to like 60%, | 0:12:33 | 0:12:37 | |
to burn off warts. | 0:12:37 | 0:12:39 | |
The first step is to grind this bark down. | 0:12:39 | 0:12:43 | |
If Nick and scientist Mike Bullivant can extract | 0:12:43 | 0:12:46 | |
the salicylic acid from the willow bark, | 0:12:46 | 0:12:48 | |
then Nick can make up painkillers to sell in the pharmacy. | 0:12:48 | 0:12:52 | |
-Having ground it... -How are we going to get it out? -..the next step is to add some ether. | 0:12:52 | 0:12:57 | |
Ether? Why are we using ether? | 0:12:57 | 0:12:59 | |
The ether is a solvent that will dissolve the salicylic acid. | 0:12:59 | 0:13:03 | |
After allowing the mixture to settle, | 0:13:06 | 0:13:09 | |
the solution is filtered to remove all the willow fibres. | 0:13:09 | 0:13:14 | |
What's coming through the filter funnel | 0:13:14 | 0:13:17 | |
should be an ether solution of salicylic acid and other things. | 0:13:17 | 0:13:24 | |
And the next step is getting rid of those other things, | 0:13:24 | 0:13:29 | |
so we're left with as pure a salicylic acid as possible. | 0:13:29 | 0:13:32 | |
Do you think this would have been worth it for the pharmacist, | 0:13:32 | 0:13:36 | |
in terms of the cost of the ingredients and stuff, | 0:13:36 | 0:13:38 | |
and the yield of salicylic acid that they get out? | 0:13:38 | 0:13:42 | |
The yield's really low - I suspect we're going to get a very low yield. | 0:13:42 | 0:13:45 | |
-Right. -Don't expect too much. | 0:13:45 | 0:13:47 | |
-But, yeah, I think it would have been, perhaps, economical if you had the time. -Yeah. | 0:13:47 | 0:13:52 | |
-Because the willow bark is free. -Yeah. | 0:13:52 | 0:13:54 | |
It takes time and patience, doesn't it? | 0:13:54 | 0:13:56 | |
Oh! Like life... | 0:13:56 | 0:13:58 | |
take your time. | 0:13:58 | 0:13:59 | |
-In goes the ether and salicylic acid and other things. -And other things. | 0:14:07 | 0:14:12 | |
To isolate the salicylic acid from all the other chemicals in the bark, | 0:14:12 | 0:14:16 | |
it's first turned into a salt by adding sodium carbonate - | 0:14:16 | 0:14:20 | |
better known as washing soda. | 0:14:20 | 0:14:23 | |
If I give a good shake, that's just getting the two layers mixed up as much as you possibly can. | 0:14:23 | 0:14:28 | |
The two layers are separated out. | 0:14:28 | 0:14:31 | |
Perfect. | 0:14:36 | 0:14:37 | |
Then Mike adds dilute sulphuric acid | 0:14:37 | 0:14:40 | |
to turn the salt into solid salicylic acid. | 0:14:40 | 0:14:44 | |
Whoa! See, that's neutralising the sodium carbonate | 0:14:46 | 0:14:50 | |
and converting it back to acid, you see? | 0:14:50 | 0:14:53 | |
It's changing the colour | 0:14:55 | 0:14:57 | |
-and do you see that white solid coming down? -Yes, absolutely. | 0:14:57 | 0:15:00 | |
-Now, that salicylic acid that's forming - can you see? -Yep. | 0:15:00 | 0:15:04 | |
A white, feathery solid. | 0:15:04 | 0:15:06 | |
So it's not looking too bad at the moment. | 0:15:06 | 0:15:10 | |
It's heartening that we've got some salicylic acid. | 0:15:10 | 0:15:13 | |
It's amazing - just three or four stages, | 0:15:13 | 0:15:15 | |
going from...pieces of plant | 0:15:15 | 0:15:18 | |
all the way through to a pure chemical. | 0:15:18 | 0:15:21 | |
-Just leave that to settle. -Fantastic. | 0:15:21 | 0:15:25 | |
If you look back to the start of the period - | 0:15:25 | 0:15:27 | |
like, sort of early 19th century, medicine is very much a personal thing. | 0:15:27 | 0:15:31 | |
You know, sort of, maybe take your family recipe to the pharmacist | 0:15:31 | 0:15:35 | |
to get it made up. | 0:15:35 | 0:15:36 | |
And compare that with the end of the century, | 0:15:36 | 0:15:39 | |
when you're kind of putting yourself in the hands of a community of specialists | 0:15:39 | 0:15:43 | |
who have trained for a long time and built up a different kind of authority. | 0:15:43 | 0:15:49 | |
It's no longer "What my parents did", | 0:15:49 | 0:15:52 | |
now it's, "Who has the knowledge?" | 0:15:52 | 0:15:54 | |
In a time when most people walked everywhere, | 0:15:58 | 0:16:02 | |
relief from foot pain was in high demand. | 0:16:02 | 0:16:06 | |
Local businessman Richard Eley | 0:16:06 | 0:16:08 | |
has come to see what the Victorian Pharmacy could offer for his problem. | 0:16:08 | 0:16:12 | |
Well, I have a rather painful, but rather small, corn | 0:16:12 | 0:16:16 | |
on the inside of my little toe. | 0:16:16 | 0:16:18 | |
Oh, I see. Yeah, you can sort of see a sore area. | 0:16:18 | 0:16:22 | |
The pain goes from my little toe up to my knee, | 0:16:22 | 0:16:25 | |
to the point where I have considered having my little toe amputated. | 0:16:25 | 0:16:29 | |
Really, as bad as that? | 0:16:29 | 0:16:30 | |
It offers Ruth an opportunity to find another use for salicylic acid. | 0:16:30 | 0:16:35 | |
In stronger concentrations, | 0:16:35 | 0:16:37 | |
the chemical Nick and Mike have made as a painkiller | 0:16:37 | 0:16:40 | |
can also be used to remove warts and corns. | 0:16:40 | 0:16:44 | |
Well, the Victorian wonder-drug for this - | 0:16:44 | 0:16:47 | |
the thing that they thought was going to transform the care - | 0:16:47 | 0:16:50 | |
was salicylic acid. | 0:16:50 | 0:16:52 | |
Ah, salicylic acid! | 0:16:52 | 0:16:54 | |
And in fact, I've got... | 0:16:54 | 0:16:56 | |
Actually, this is a modern preparation of salicylic acid. | 0:16:56 | 0:17:01 | |
There's a few other things in here to carry the acid. | 0:17:01 | 0:17:05 | |
You can have it in a liquid form | 0:17:05 | 0:17:07 | |
-or put on little corn plasters that you applied. -Yes. | 0:17:07 | 0:17:10 | |
You'd get a little tin with medicated corn plasters. | 0:17:10 | 0:17:14 | |
-So, it's just... -Just at the side there. | 0:17:14 | 0:17:17 | |
Just there, yeah? That little area. There we go. | 0:17:17 | 0:17:20 | |
That should whiten as it dries | 0:17:20 | 0:17:24 | |
and you get a skin over it. | 0:17:24 | 0:17:25 | |
It holds the active ingredient against the affected part. | 0:17:25 | 0:17:31 | |
-It does actually burn the skin away? -Yeah, it sort of slowly... | 0:17:31 | 0:17:35 | |
kills the whole area and that allows the... | 0:17:35 | 0:17:38 | |
virus, basically, to be lifted out. | 0:17:38 | 0:17:41 | |
So... | 0:17:41 | 0:17:42 | |
Now you see it, now you don't. | 0:17:42 | 0:17:45 | |
Basically, you take that away | 0:17:45 | 0:17:48 | |
and a drop every day on the same spot. | 0:17:48 | 0:17:51 | |
-A drop every day keeps the corn away. -That's the theory. | 0:17:51 | 0:17:54 | |
Nick is ready to use the same chemical - | 0:17:58 | 0:18:00 | |
the salicylic acid he and Mike made - to prepare some cachets, | 0:18:00 | 0:18:04 | |
thin rice-paper capsules that he can fill with the finished drug. | 0:18:04 | 0:18:08 | |
As a modern pharmacist, it's a skill he's never needed to learn before. | 0:18:08 | 0:18:12 | |
There you are, Nick. Here's your salicylic acid. | 0:18:14 | 0:18:17 | |
-Fantastic. Well done. -Last time you saw it, it was in a filter funnel and it looked like that. | 0:18:17 | 0:18:21 | |
I said I'd purify it by re-crystallising it. | 0:18:21 | 0:18:24 | |
-That was the result. -They're fantastic - really long needles. | 0:18:24 | 0:18:27 | |
You wanted it really pure. So I took that, | 0:18:27 | 0:18:30 | |
the needles, and re-crystallised them. What I've ended up is really pure needles, which I've ground up. | 0:18:30 | 0:18:35 | |
-You asked for it ground and that's it. There's your pure salicylic acid. -Fantastic. | 0:18:35 | 0:18:40 | |
I'm going to stick them in these cachets. | 0:18:40 | 0:18:42 | |
I'm going to have to mix that... It'd be such a small amount in each one, | 0:18:42 | 0:18:45 | |
I'll mix it with something which is OK to swallow like citric acid, | 0:18:45 | 0:18:50 | |
grind them together, | 0:18:50 | 0:18:51 | |
make a nice mixture and then we just... | 0:18:51 | 0:18:53 | |
put an amount in each of these cachets. | 0:18:53 | 0:18:57 | |
Then we put the other half in this, | 0:18:57 | 0:19:00 | |
close it up and they stick together. | 0:19:00 | 0:19:04 | |
You know those sweets - flying saucers, they were called, or spaceships. | 0:19:04 | 0:19:08 | |
Two halves of rice paper with some sherbet in the middle. | 0:19:08 | 0:19:12 | |
Stick them in your mouth and they dissolve and the sherbet's released. | 0:19:12 | 0:19:15 | |
This rice paper, as you know, once it gets wet - | 0:19:15 | 0:19:18 | |
a bit of acid on it - it will fall apart and release the powder. | 0:19:18 | 0:19:23 | |
Ready for action. | 0:19:23 | 0:19:25 | |
There you are. Don't use either of those, cos they're impure. | 0:19:25 | 0:19:28 | |
That's what you work with. | 0:19:28 | 0:19:29 | |
Brilliant. Thanks very much, mate. See you later. | 0:19:29 | 0:19:32 | |
Let's see how this goes. | 0:19:42 | 0:19:45 | |
This will be the top half of each cachet. | 0:19:50 | 0:19:53 | |
They're quite delicate, so I'm a bit worried about cracking them. | 0:19:53 | 0:19:57 | |
I don't quite know how far to press them in. | 0:19:57 | 0:19:59 | |
Quite a tight fit. | 0:19:59 | 0:20:00 | |
Fingers crossed. | 0:20:05 | 0:20:06 | |
Dampness there. | 0:20:08 | 0:20:10 | |
Press these down and hope. | 0:20:13 | 0:20:15 | |
-HE CHUCKLES -That's all we can do at this stage. | 0:20:15 | 0:20:18 | |
And now, fingers crossed... | 0:20:18 | 0:20:21 | |
Yay! Look at that. | 0:20:23 | 0:20:25 | |
Fantastic. | 0:20:25 | 0:20:27 | |
Now, you use this thing to push them out as well. | 0:20:27 | 0:20:30 | |
I'm really pleased about this. I didn't think... | 0:20:32 | 0:20:35 | |
it would work anywhere near as well as that. | 0:20:35 | 0:20:39 | |
Look at that - perfect cachets, holding together. | 0:20:39 | 0:20:42 | |
POWDER RATTLES | 0:20:42 | 0:20:44 | |
You can hear the powder inside. | 0:20:44 | 0:20:46 | |
What we have been through is just, erm... | 0:20:46 | 0:20:50 | |
a remarkable process, really, | 0:20:50 | 0:20:53 | |
which doesn't happen nowadays. | 0:20:53 | 0:20:55 | |
It's the sort of thing which... Everything's manufactured and standardised. | 0:20:55 | 0:20:59 | |
We started with willow bark - a natural product - | 0:20:59 | 0:21:02 | |
and we've chemically extracted the key element | 0:21:02 | 0:21:06 | |
and we've put the salicylic acid in here, | 0:21:06 | 0:21:10 | |
in this dose form, ready to give to a patient, | 0:21:10 | 0:21:14 | |
or as a Victorian person would give to a patient. | 0:21:14 | 0:21:17 | |
Salicylic acid was an effective painkiller, | 0:21:21 | 0:21:23 | |
but could be a stomach irritant. | 0:21:23 | 0:21:25 | |
The big breakthrough came in 1899 when aspirin, | 0:21:26 | 0:21:29 | |
a chemically altered version of it with less side effects, | 0:21:29 | 0:21:32 | |
was released onto the market. | 0:21:32 | 0:21:34 | |
Whatever the content, | 0:21:34 | 0:21:36 | |
cachets allowed pharmacists to dispense a pre-measured dose. | 0:21:36 | 0:21:40 | |
The practical problem for the patient was swallowing them. | 0:21:40 | 0:21:44 | |
Student Tom Chandler has volunteered to try one out. | 0:21:44 | 0:21:47 | |
..powder's put inside, in two halves... | 0:21:47 | 0:21:50 | |
The texts of the time would say, "Just take it down like an oyster." | 0:21:50 | 0:21:54 | |
OK. Is there any more advice than that you can give me? | 0:21:54 | 0:21:57 | |
-If you're not an oyster eater, it's not very helpful really. -No! | 0:21:57 | 0:22:00 | |
-I think you're going to have to work it out for yourself. Are you willing to give it a go? -Yeah, why not? | 0:22:00 | 0:22:05 | |
-Dunk it in the water. -OK, just get a bit wet. | 0:22:05 | 0:22:07 | |
-That's it. -Is that enough? -Yep. | 0:22:07 | 0:22:09 | |
-In your mouth, back of the tongue. -OK. | 0:22:09 | 0:22:11 | |
And swig it down, swallow it. | 0:22:12 | 0:22:15 | |
Ugh! | 0:22:15 | 0:22:17 | |
It feels like it's stuck about here. | 0:22:17 | 0:22:19 | |
-Oh, my goodness. -It's big, isn't it? | 0:22:19 | 0:22:22 | |
-Yeah. -You wouldn't get a modern tablet that size. | 0:22:22 | 0:22:25 | |
But as it softens with the water and the moisture of your body, | 0:22:25 | 0:22:29 | |
it will start deforming and be easier to go down. | 0:22:29 | 0:22:31 | |
Yeah, I can feel it sort of, like, moving. | 0:22:31 | 0:22:34 | |
-Whereabouts is it now? -It's about here, getting slightly lower. | 0:22:34 | 0:22:38 | |
It'll work its way down, and in reality, | 0:22:38 | 0:22:41 | |
you'd have a biscuit or a piece of bread with it | 0:22:41 | 0:22:43 | |
or something like that, if it were stuck. | 0:22:43 | 0:22:45 | |
It physically knocks it down into the stomach, | 0:22:45 | 0:22:49 | |
then dissolves and releases the drug and cures your headache, hopefully. | 0:22:49 | 0:22:54 | |
Thank you very much. | 0:22:54 | 0:22:55 | |
I bet you're glad science has moved on and now we have aspirin tablets. | 0:22:55 | 0:22:59 | |
I'm so glad. Small things rather than those, definitely. | 0:22:59 | 0:23:03 | |
Nick, Ruth and Tom are receiving a crash course in perfume making | 0:23:07 | 0:23:11 | |
as they try to create a scent | 0:23:11 | 0:23:13 | |
that would have appealed to the Victorian nose. | 0:23:13 | 0:23:15 | |
19th Century perfumiers applied scientific ideas to the ancient art of perfume making. | 0:23:15 | 0:23:21 | |
They used musical terms to describe how a scent should be constructed. | 0:23:21 | 0:23:26 | |
This symphony of smell | 0:23:26 | 0:23:27 | |
was made up of three separate mixtures of fragrant oils, | 0:23:27 | 0:23:31 | |
known as the top, middle and base notes, | 0:23:31 | 0:23:34 | |
which evaporate at different rates on the skin. | 0:23:34 | 0:23:37 | |
Perfumier Alec Lawless has given Tom the job | 0:23:37 | 0:23:40 | |
of making up the long-lasting base note. | 0:23:40 | 0:23:42 | |
It seems that two of these are a lot stronger than the other three. | 0:23:42 | 0:23:46 | |
-Yes. -I was wondering if I'm sort of making... Is it the base note? -Yes. | 0:23:46 | 0:23:51 | |
What's the idea? Is it... | 0:23:51 | 0:23:52 | |
These things are the most tenacious and the reason for that is | 0:23:52 | 0:23:56 | |
-that they're heavier molecules than the top or the middle notes. -OK. | 0:23:58 | 0:24:01 | |
So, they're going to retard the evaporation of the perfume. | 0:24:01 | 0:24:04 | |
So it's the bits that comes out last, basically. | 0:24:04 | 0:24:08 | |
This will be what's left on the skin. | 0:24:08 | 0:24:11 | |
Nick has been entrusted with the most expensive ingredients. | 0:24:11 | 0:24:15 | |
The smell is so intense that it's driving out anything else... | 0:24:15 | 0:24:20 | |
These are the middle notes, the floral heart - | 0:24:20 | 0:24:23 | |
the main personality of the perfume. | 0:24:23 | 0:24:27 | |
These guys are really expensive. | 0:24:27 | 0:24:29 | |
The powerful fragrances are proving a little too much for Ruth. | 0:24:29 | 0:24:34 | |
The lady is very sensitive and delicate. | 0:24:34 | 0:24:36 | |
You told me these were not overpowering. You lied. They are... | 0:24:36 | 0:24:40 | |
-I'm sorry. -OK. | 0:24:40 | 0:24:43 | |
You're obviously incredibly sensitive. | 0:24:45 | 0:24:47 | |
I smelt all four of them first, | 0:24:47 | 0:24:50 | |
-by which time my nose was beginning to burn. -Yeah. OK. | 0:24:50 | 0:24:53 | |
And then I thought, well, the one that I liked best still was the bergamot oil | 0:24:53 | 0:24:57 | |
so I put more of that in. | 0:24:57 | 0:24:58 | |
You mentioned the lime was particularly strong, so I put the least of that in. | 0:24:58 | 0:25:02 | |
-I'm going to go for that one. -The second one. -Number two. | 0:25:02 | 0:25:05 | |
If the team's efforts can be combined into a popular perfume, | 0:25:05 | 0:25:08 | |
then the Empress of India scent | 0:25:08 | 0:25:11 | |
could be a real money-spinner for the pharmacy. | 0:25:11 | 0:25:13 | |
Now, in order to have some sort of structure, | 0:25:13 | 0:25:17 | |
these would be blended. Roughly... | 0:25:17 | 0:25:20 | |
50% of it is going to be the floral heart, | 0:25:20 | 0:25:25 | |
20% the top notes and 30% the base notes. | 0:25:25 | 0:25:29 | |
just as a rule of thumb. | 0:25:29 | 0:25:32 | |
I'm also going to put some musk in there | 0:25:32 | 0:25:34 | |
and one or two other things. | 0:25:34 | 0:25:37 | |
THEY CHUCKLE | 0:25:37 | 0:25:38 | |
Making it entirely your own. | 0:25:38 | 0:25:40 | |
They were too expensive to let you play with. | 0:25:40 | 0:25:43 | |
Alec blends the three sets of fragrant oils together | 0:25:43 | 0:25:48 | |
to produce the finished perfume. | 0:25:48 | 0:25:50 | |
If you wave it around a bit to encourage the oxygen to... | 0:25:54 | 0:26:00 | |
accelerate the evaporation. | 0:26:00 | 0:26:02 | |
I didn't smell either of your two independently, and this certainly smells very different from mine, | 0:26:04 | 0:26:09 | |
-when it's blended. -That's all right. -It's quite complex. | 0:26:09 | 0:26:12 | |
I think it's really funny tha you chaps are enjoying the perfume more than me. | 0:26:12 | 0:26:16 | |
-THEY LAUGH -It's great fun! | 0:26:16 | 0:26:18 | |
All we need to do now is get that properly bottled | 0:26:18 | 0:26:22 | |
and a nice label on it | 0:26:22 | 0:26:23 | |
and start making some money out of it. | 0:26:23 | 0:26:25 | |
Exactly. We can have different dilutions for different people. | 0:26:25 | 0:26:29 | |
-Different classes. -Yes. | 0:26:29 | 0:26:32 | |
Ruth is keen to find out if the Empress of India will be a hit with the ladies of the town. | 0:26:35 | 0:26:39 | |
Good morning! | 0:26:39 | 0:26:41 | |
Hello. | 0:26:41 | 0:26:43 | |
-Ooh, hello. -Hello. | 0:26:43 | 0:26:45 | |
I wonder if you could help me. | 0:26:45 | 0:26:47 | |
I'm doing a bit of market research about perfume. | 0:26:47 | 0:26:50 | |
-I love perfume. -Really? -I do, yes. | 0:26:50 | 0:26:53 | |
-That's a very fine bottle. I do like that. -It's nice, isn't it? | 0:26:53 | 0:26:56 | |
Let me know what you really think. It's quite a potent one. | 0:26:56 | 0:27:00 | |
Just have a little sniff and see what you think. | 0:27:00 | 0:27:02 | |
-Ooh, yeah, it is, in't it? -Strong, isn't it? -It's quite strong. | 0:27:02 | 0:27:06 | |
It's lovely. Yes. It's quite flowery. | 0:27:06 | 0:27:09 | |
-If I just pop just a tiny little bit on there. -Yep. | 0:27:09 | 0:27:13 | |
Hmm! | 0:27:15 | 0:27:16 | |
Oh! Ooh! | 0:27:16 | 0:27:17 | |
-It is a strong one, isn't it? -Mm. | 0:27:17 | 0:27:19 | |
-It's growing on me. -Well, that's a good sign. | 0:27:19 | 0:27:22 | |
Not nice, is it? Not nice. I think it's more for you than for me. | 0:27:22 | 0:27:27 | |
One of the things the perfumier said to me | 0:27:27 | 0:27:29 | |
-was that it smells different on everybody. -Yes. | 0:27:29 | 0:27:31 | |
-Oh, it's beautiful. -Yes? -It smells quite expensive. | 0:27:31 | 0:27:36 | |
It would have been expensive at the time. | 0:27:36 | 0:27:39 | |
In the Victorian period, | 0:27:39 | 0:27:40 | |
you would begin to see perfume getting a little bit cheaper, | 0:27:40 | 0:27:44 | |
so people like school mistresses could afford, occasionally, a little bit of perfume. | 0:27:44 | 0:27:48 | |
-I'm going to have some for Christmas. -You really think this something you would actually enjoy, | 0:27:48 | 0:27:53 | |
-that would stand up against a modern perfume? -Definitely - it's quite a strong, powerful smell. | 0:27:53 | 0:27:58 | |
This is quite flowery, which is lovely. Thank you for popping in. | 0:27:58 | 0:28:01 | |
Next time, on Victorian Pharmacy, | 0:28:04 | 0:28:07 | |
the 19th century draws to a close. | 0:28:07 | 0:28:09 | |
That's good, keep it up. The faster the better. | 0:28:09 | 0:28:12 | |
The team embrace the inventions and some secrets of the time. | 0:28:12 | 0:28:16 | |
This is one of the most exciting things I think I've found in the pharmacy. | 0:28:16 | 0:28:21 | |
And with a massive expansion of products and services, | 0:28:21 | 0:28:26 | |
they'll take a giant step into the 20th century. | 0:28:26 | 0:28:28 | |
Watch the birdie, keep still. | 0:28:28 | 0:28:31 | |
And towards the high street pharmacy we know today. | 0:28:31 | 0:28:34 | |
Subtitles by Red Bee Media Ltd | 0:28:38 | 0:28:41 | |
E-mail [email protected] | 0:28:41 | 0:28:44 |