Browse content similar to 21/12/2017. Check below for episodes and series from the same categories and more!
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Hello and welcome to
The One Show with Matt Baker. | 0:00:15 | 0:00:17 | |
And Alex Jones. | 0:00:17 | 0:00:18 | |
Our guests tonight are the heads
of two families with a lot | 0:00:18 | 0:00:21 | |
on their plate this Christmas. | 0:00:21 | 0:00:24 | |
He's the leader of the notorious
Brannings of Albert Square. | 0:00:24 | 0:00:28 | |
She's the March family matriarch
in a new TV version of the classic | 0:00:28 | 0:00:32 | |
book "Little Women". | 0:00:32 | 0:00:33 | |
And together they're the stars
of Boxing Day telly. | 0:00:33 | 0:00:36 | |
It's Jake Wood and Emily Watson! | 0:00:36 | 0:00:39 | |
CHEERING AND APPLAUSE
Welcome, both. | 0:00:42 | 0:00:51 | |
So the Perov you are the headlines
for boxing night. Yes, Christmas | 0:00:51 | 0:00:56 | |
Day, EastEnders and Day. So where
will you both be watching, or will | 0:00:56 | 0:01:01 | |
you indeed be watching? I'm going to
be on the road, driving, visiting | 0:01:01 | 0:01:07 | |
relatives. Jake Connor please tell
us that the Trail is going out at | 0:01:07 | 0:01:18 | |
the moment are total wind-up and
it's going to be joy and light, a | 0:01:18 | 0:01:23 | |
lovely nativity scene? Walford?
Possibly not. Sorry to say. Isn't it | 0:01:23 | 0:01:29 | |
people coming together for a lovely
lunch, low-key? No, not an | 0:01:29 | 0:01:35 | |
Eastenders. I saw it yesterday, some
of the best episodes I've been | 0:01:35 | 0:01:39 | |
involved in in 12 years in the soap.
I'm really excited. And the ultimate | 0:01:39 | 0:01:43 | |
feeling coming out was sadness, head
in hands? Get your tissues ready, | 0:01:43 | 0:01:49 | |
there are tear-jerkers, lots of
drama in Walford. They are | 0:01:49 | 0:01:53 | |
explosive, we've seen. How do you
feel about the tabloids? There's a | 0:01:53 | 0:01:56 | |
lot of talk, spoilers in both shows,
pre-empting what's about to happen. | 0:01:56 | 0:02:02 | |
Do you thing that helps, or do you
think you should be left? With | 0:02:02 | 0:02:06 | |
Little Women, we know. We haven't
changed the ending. Thankfully. It | 0:02:06 | 0:02:14 | |
can be really annoying. Especially
with Eastenders or any six. Yeah, | 0:02:14 | 0:02:19 | |
there's a fine line between giving
people a little taster of what's to | 0:02:19 | 0:02:24 | |
come not wanting to spoil it. A show
like Eastenders, there is such a | 0:02:24 | 0:02:29 | |
demand for content, people want to
know what's happening so the press | 0:02:29 | 0:02:32 | |
department to a fantastic job of
letting people know enough but | 0:02:32 | 0:02:35 | |
hopefully not spoiling it. It's so
hard now with Twitter and everything | 0:02:35 | 0:02:38 | |
like that. If you go on Twitter
after the show, you will get a | 0:02:38 | 0:02:43 | |
complete rundown of what's just
happened. We'll get it out of your | 0:02:43 | 0:02:47 | |
during the next half-hour! There
will be no surprises! They've bought | 0:02:47 | 0:02:51 | |
something along, haven't they? They
have, exclusive clips from both | 0:02:51 | 0:02:56 | |
shows, we will unwrap them and enjoy
them later. | 0:02:56 | 0:03:03 | |
Tomorrow is "Frantic Friday" -
the day when rush hour commuters | 0:03:03 | 0:03:05 | |
and families on the big Christmas
getaway combine to create | 0:03:05 | 0:03:08 | |
traffic jam chaos. | 0:03:08 | 0:03:09 | |
In those jams will be tonnes
of lorries, and there are some | 0:03:09 | 0:03:12 | |
you really don't want to be stuck
behind, because they're pumping out | 0:03:12 | 0:03:14 | |
illegal levels of fumes. | 0:03:14 | 0:03:16 | |
Here's JJ. | 0:03:16 | 0:03:22 | |
There's a crackdown taking place on
Britain's motorways. The DVSA task | 0:03:22 | 0:03:27 | |
forces pulling over suspect drugs
and taking them apart. They are | 0:03:27 | 0:03:35 | |
hunting down haulage companies whose
lorries are being illegally driven | 0:03:35 | 0:03:38 | |
because they are hiding a piece of
kit designed to get around emissions | 0:03:38 | 0:03:42 | |
regulations. That will affect
multiple manufacturers. What are the | 0:03:42 | 0:03:51 | |
DVSA doing here? It's an
intelligence led operation, we're | 0:03:51 | 0:03:54 | |
looking at a device that is
unfortunately becoming quite | 0:03:54 | 0:04:00 | |
prevalent. What is it? It's an
additive, when mixed with the | 0:04:00 | 0:04:05 | |
exhaust it will remove pollutants
out of the exhaust system. What does | 0:04:05 | 0:04:09 | |
it do? It will trick the engine to
think that everything is working | 0:04:09 | 0:04:13 | |
properly. Engines with this system
cannot function when the liquid | 0:04:13 | 0:04:18 | |
isn't in use but the box enables the
trucks to be driven. The driver | 0:04:18 | 0:04:23 | |
claims he's got all of his receipts.
But why cheat a system which is | 0:04:23 | 0:04:31 | |
helping the environment? Every time
you fill up with diesel you will | 0:04:31 | 0:04:34 | |
generally fill up with this as well
and there's a cost of that haulage | 0:04:34 | 0:04:39 | |
operators can save thousands of
pounds by adding this. But the | 0:04:39 | 0:04:44 | |
well-trained team to know what
they're looking for. Is not | 0:04:44 | 0:04:48 | |
particularly difficult to find. What
we will do now is trick the engine | 0:04:48 | 0:04:51 | |
management unit to believe that it's
working. There's no -- there is | 0:04:51 | 0:05:00 | |
nothing going through the system so
you have the harmful particulates | 0:05:00 | 0:05:04 | |
going through the exhaust. I'm
meeting Steve Halfon, who's brought | 0:05:04 | 0:05:12 | |
along a friend. Who is your mate?
This is Justin, taking a sample of | 0:05:12 | 0:05:18 | |
the air and drawing it into his
lungs. He has a number of sensors | 0:05:18 | 0:05:23 | |
that measure for carbon dioxide,
carbon monoxide, particles, all the | 0:05:23 | 0:05:28 | |
nasties, including nitrogen dioxide.
We get him strapped him? Yeah, let's | 0:05:28 | 0:05:34 | |
do it. We had to a quiet country
lane so Steve and Justin can show me | 0:05:34 | 0:05:40 | |
what readings they get from
relatively clean air. At the minute | 0:05:40 | 0:05:44 | |
we are seeing 600 particles per
cubic centimetre, so this is telling | 0:05:44 | 0:05:48 | |
you it's nice clean air. Then it's
the motorway. See what it's like | 0:05:48 | 0:05:53 | |
behind an older lorry that isn't
required to have an emissions | 0:05:53 | 0:05:56 | |
reduction system fitted. What are we
getting right now? As we get close | 0:05:56 | 0:06:01 | |
to the vehicle in front we should...
There we go, they are going up | 0:06:01 | 0:06:05 | |
already. We're looking at 6000
particles per cubic centimetre, | 0:06:05 | 0:06:12 | |
7000, 8000, 9000, 10,000. 15,000.
Seriously? I think when I'm in my | 0:06:12 | 0:06:18 | |
car the environment is completely
clean. You don't taste it or smell | 0:06:18 | 0:06:21 | |
it but there's pollution in the cab
right now? Yeah. But what happens to | 0:06:21 | 0:06:26 | |
the readings when we follow a modern
lorry? This is a 17 plate, it's | 0:06:26 | 0:06:32 | |
going to be brand-new. Yeah, we can
see through the readings at the | 0:06:32 | 0:06:36 | |
minute, so we're looking at about
1500 particles. That's ten times | 0:06:36 | 0:06:43 | |
less emissions than the older truck!
That must be working to regulation. | 0:06:43 | 0:06:48 | |
2017 vehicle of that size would
definitely have a system on it. Back | 0:06:48 | 0:06:55 | |
at the inspection centre the team
have made another fine. What this | 0:06:55 | 0:06:59 | |
particular operator has done,
there's a new piece of wire here | 0:06:59 | 0:07:02 | |
that you can see, new insulation
tape. If you follow that wire | 0:07:02 | 0:07:06 | |
around, you can see the white box
flashing on the chassis. That's it, | 0:07:06 | 0:07:10 | |
there. What will happen with this is
the vehicle examiner will compile a | 0:07:10 | 0:07:14 | |
report and the authorities will deal
with the operator. They have the | 0:07:14 | 0:07:18 | |
powers to remove somebody's
authority to operate. What about the | 0:07:18 | 0:07:21 | |
rest of the vehicle, has it been
looked at? We will continue to do a | 0:07:21 | 0:07:26 | |
check. We no one of the indicator
light is out and there a fault with | 0:07:26 | 0:07:30 | |
the brakes, so it's not a good day
for the driver. Over two days the | 0:07:30 | 0:07:40 | |
DVSA 62 vehicles and found six had
been tampered with. They'll be given | 0:07:40 | 0:07:43 | |
ten days to remove the devices.
What's your message to someone who | 0:07:43 | 0:07:45 | |
might use a cheat device, or already
is? If they are on a vehicle, we'll | 0:07:45 | 0:07:51 | |
find them. It was shocking, watching
that count to go up as they went on | 0:07:51 | 0:07:56 | |
to the motorway behind the lorry,
but this is something that you are | 0:07:56 | 0:07:59 | |
really worried about, Emily? Yeah,
the Guardian ran an article about | 0:07:59 | 0:08:03 | |
this last year sometime and you
could put the postcode of your | 0:08:03 | 0:08:07 | |
schooling and where my kids go to
school it way over the limit of what | 0:08:07 | 0:08:12 | |
is safe. I mean, really shocking.
Gosh. There's not more being done. | 0:08:12 | 0:08:19 | |
It's a really worrying thing. Jake,
your character, Max, was known as a | 0:08:19 | 0:08:27 | |
dodgy car dealer. This is brilliant,
this. We found this advert that you | 0:08:27 | 0:08:32 | |
do in America and it's on apparently
all the time in every single | 0:08:32 | 0:08:37 | |
outbreak, where you play a gecko
selling car insurance. Yeah, car | 0:08:37 | 0:08:43 | |
insurance, I've been doing the voice
since before I started on | 0:08:43 | 0:08:47 | |
Eastenders, 2005 I started, a long
run. Let's have a look. We need to | 0:08:47 | 0:08:52 | |
see it. Greetings from the Windy
city of Chicago. People here sure | 0:08:52 | 0:08:57 | |
are friendly but some have had a
hard time understanding my accent. | 0:08:57 | 0:09:01 | |
APPLAUSE
Very good, Geico. It's from Dick Van | 0:09:01 | 0:09:08 | |
Dyke, isn't it? It's great fun doing
that, the CGI is very clever and | 0:09:08 | 0:09:13 | |
when I'm watching the adverts, there
must be about 200 now, I can see | 0:09:13 | 0:09:16 | |
some of my mannerisms. Some of the
stuff he does is like me doing | 0:09:16 | 0:09:21 | |
stuff. Well, who knew? Let's get
back to Max. Is a horrible piece of | 0:09:21 | 0:09:26 | |
work, isn't it? Absolutely horrible!
Well, it's the truth, but the thing | 0:09:26 | 0:09:32 | |
is, Jake, you are the actor playing
him. You like to think that he has | 0:09:32 | 0:09:36 | |
some redeeming qualities. We can't
see them. But you stand by that, | 0:09:36 | 0:09:41 | |
even now, when he's gone a bit mad?
Max is always misguided in what he | 0:09:41 | 0:09:48 | |
does. I think if anyone has been
watching the show for any length of | 0:09:48 | 0:09:52 | |
time knows this storyline is
probably the continuation of who | 0:09:52 | 0:09:56 | |
killed Lucy storyline, Max was
sentenced to 20 years in prison for | 0:09:56 | 0:10:00 | |
something he didn't do and feels
very betrayed by everyone in the | 0:10:00 | 0:10:03 | |
whole community. Max is very upset
with everyone and has gone over this | 0:10:03 | 0:10:08 | |
last year to exact revenge, really,
so the stuff playing out now and | 0:10:08 | 0:10:11 | |
Christmas day is the culmination of
that kind of stuff. If you look at | 0:10:11 | 0:10:15 | |
the reasons why he is doing what
he's doing, he's got genuine reasons | 0:10:15 | 0:10:18 | |
to be upset, but I agree with you,
some of the things he does aren't | 0:10:18 | 0:10:22 | |
the best things. Very dark. That's
Max. It's all building, as we speak. | 0:10:22 | 0:10:29 | |
Here's a moment from tonight's
episode, that you've brought along | 0:10:29 | 0:10:32 | |
with you. This is when Max reunites
with Ian Beale in the Square. What | 0:10:32 | 0:10:37 | |
do you want, Max? Old mates. I
thought Wilmot Brown was your mate, | 0:10:37 | 0:10:47 | |
oh, no, he's dumped you, hasn't he.
That's not very nice. I know what | 0:10:47 | 0:10:53 | |
you're up to. Do you? You think you
know what's going on in my head? | 0:10:53 | 0:11:01 | |
APPLAUSE
Straight after us. Max isn't keen, | 0:11:01 | 0:11:11 | |
but lots of people share that
opinion of eel picked -- Ian Beale. | 0:11:11 | 0:11:17 | |
Max is a bit unhinged, he feels very
isolated and is out to get revenge. | 0:11:17 | 0:11:23 | |
He tries to kill Ian this week, some
great episodes. You said this -- | 0:11:23 | 0:11:32 | |
just now that storyline has been
going on for years. How does it | 0:11:32 | 0:11:36 | |
affect you as an actor when you're
doing heavy, dark scenes, four long | 0:11:36 | 0:11:41 | |
days on end? You do look exhausted.
A lot of that is make-up, to be | 0:11:41 | 0:11:45 | |
fair. Yeah, often the storylines are
very intense, as you say. Long | 0:11:45 | 0:11:52 | |
hours, very draining. I think you
have to have a good switch off | 0:11:52 | 0:11:56 | |
mechanism. As soon as I dried out
the studios I'm just died and I want | 0:11:56 | 0:12:00 | |
to be home the kids. -- as soon as I
drive out of the studios, I'm just | 0:12:00 | 0:12:05 | |
dad will stop you don't want to take
Max Banning home with you. Your son, | 0:12:05 | 0:12:15 | |
Buster, is in the audience tonight.
What is he like when he comes home | 0:12:15 | 0:12:20 | |
from work? Well, compared to
EastEnders, he's an amazing dad. | 0:12:20 | 0:12:23 | |
He's kind will stop he is a doubt
that you would love to have. | 0:12:23 | 0:12:28 | |
APPLAUSE
Lovely! Do you know what, we know | 0:12:28 | 0:12:34 | |
that as well because we know what
he's like, sitting here. Thank you,. | 0:12:34 | 0:12:39 | |
That is the best Christmas present
you could ever wish for. Thank you, | 0:12:39 | 0:12:45 | |
and Q Buster. Very proud of the
kids. | 0:12:45 | 0:12:49 | |
All week we've been travelling
the country gathering your Christmas | 0:12:49 | 0:12:51 | |
thank you messages. | 0:12:51 | 0:12:52 | |
So far we've stopped in Aberdeen,
Wrexham, and Bristol. | 0:12:52 | 0:12:54 | |
Now it's Belfast's turn. | 0:12:54 | 0:13:00 | |
I'd just like to thank my
hospitality teacher for bringing us | 0:13:00 | 0:13:03 | |
to Belfast. Happy Christmas. I'd
like to thank the teachers and staff | 0:13:03 | 0:13:09 | |
at the primary school who have
assisted greatly with my son, who is | 0:13:09 | 0:13:14 | |
dyslexic. He's our African Grey
parrot that we've had for ten years. | 0:13:14 | 0:13:17 | |
Two weeks ago he was stolen but with
the help of the public and the | 0:13:17 | 0:13:21 | |
police we were able to get Barney
back and I'd like to thank everybody | 0:13:21 | 0:13:25 | |
that helped us. My daughter Sophie
was born with the news that she | 0:13:25 | 0:13:32 | |
needed a heart transplant.
Thankfully within four months with | 0:13:32 | 0:13:36 | |
being on the register we received a
hard. This is the first Christmas | 0:13:36 | 0:13:39 | |
where Sophie is healthy so myself
and my husband would like to say | 0:13:39 | 0:13:42 | |
thank you to the donor family, who
in their darkest moment made a | 0:13:42 | 0:13:47 | |
difficult decision which saved our
daughter's life. We are from the | 0:13:47 | 0:13:52 | |
football club, the cold, singing
carols and two special people at the | 0:13:52 | 0:13:56 | |
rugby club would like to give thanks
to, Joe, our physiotherapist and on | 0:13:56 | 0:14:00 | |
my right, Aline, our head chef.
Merry Christmas. # jingle bells, | 0:14:00 | 0:14:06 | |
jingle bells, jingle all all the Way
#. | 0:14:06 | 0:14:09 | |
Ruben kind Lee asked his friends to
donate presents to the cats and dogs | 0:14:09 | 0:14:15 | |
at the century instead of for
himself. Why did you do that? | 0:14:15 | 0:14:20 | |
Because I want to be a zoo keeper
when I grow up. We want to say thank | 0:14:20 | 0:14:24 | |
you, they are very generous gifts.
Ms Thompson is our principle. I | 0:14:24 | 0:14:28 | |
would like to thank her for
motivating me at a time when I | 0:14:28 | 0:14:32 | |
needed that push. Thank you, Miss
Thomson, for helping me to improve | 0:14:32 | 0:14:36 | |
my English. Thank you for setting up
the anti-bullying scheme in the | 0:14:36 | 0:14:39 | |
school, it has helped so many
people. Thank you, Ms Thompson, | 0:14:39 | 0:14:44 | |
Merry Christmas.
APPLAUSE | 0:14:44 | 0:14:46 | |
Brilliant. No homework for them the
first week back. I hope they have a | 0:14:46 | 0:14:53 | |
nice Christmas, especially baby
Sophie, her first Christmas. | 0:14:53 | 0:14:59 | |
Let's talk about Little Women, which
is on for three nights starting on | 0:14:59 | 0:15:04 | |
Boxing Day. I love the book. You
speak to so many women and everybody | 0:15:04 | 0:15:09 | |
goes, that was my favourite book
throwing up - did you want to be Jo? | 0:15:09 | 0:15:16 | |
I wanted to be Jo. To be fair I did
not know too much about it, so for | 0:15:16 | 0:15:21 | |
anybody else who might be in a
similar position, how do you | 0:15:21 | 0:15:24 | |
describe the story but doing it is
about a family in America, there are | 0:15:24 | 0:15:33 | |
four teenage daughters, and it's
basically them growing up. But in an | 0:15:33 | 0:15:38 | |
incredibly difficult political time,
in the middle of the civil war and | 0:15:38 | 0:15:41 | |
her dad is away and the mother is
raising them by herself. And all the | 0:15:41 | 0:15:47 | |
terrible trials and tribulations
that it is to be a teenage girl, and | 0:15:47 | 0:15:52 | |
it's just this house full of teenage
smelly angst, and all the dramas | 0:15:52 | 0:15:56 | |
that they go through. You play the
mum. Campbell and I think the way | 0:15:56 | 0:16:04 | |
that they're raising them is really
interesting, it's very thoughtful | 0:16:04 | 0:16:07 | |
and considered, and the first thing
you see them do is, they give away | 0:16:07 | 0:16:13 | |
their Christmas back first to a
family of refugees. I don't know how | 0:16:13 | 0:16:16 | |
that would go down in your house but
I'm not sure it would go down so | 0:16:16 | 0:16:21 | |
well in mine! There's this effort to
make their children be thoughtful | 0:16:21 | 0:16:26 | |
and profound people, and it is ahead
of its time in that way. Let's see | 0:16:26 | 0:16:31 | |
you in action. Father doesn't have a
temper, does he? He's so wise and so | 0:16:31 | 0:16:45 | |
patient. No want is without their
trials. But his strengths speak to | 0:16:45 | 0:16:52 | |
my weaknesses in should don't cry,
money, you didn't even cry when | 0:16:52 | 0:16:59 | |
father left for Washington in his
uniform. I gave my best to the | 0:16:59 | 0:17:05 | |
country I love and saved my tears
until he was gone. Sometimes we | 0:17:05 | 0:17:10 | |
simply have to do the bravest thing.
There are four very young actresses | 0:17:10 | 0:17:21 | |
in, some of them this was their
first job, one in particular, the | 0:17:21 | 0:17:25 | |
daughter of Uma Thurman? Yeah, she's
amazing, she's 20, she's just left | 0:17:25 | 0:17:33 | |
college, and she's kind of so full
of energy, she is just like Jo if | 0:17:33 | 0:17:39 | |
you remember the character. She's
full of thoughts and ideas and | 0:17:39 | 0:17:43 | |
talking all the time and her arms
and legs are slightly too long and | 0:17:43 | 0:17:46 | |
she's always falling over herself.
There were four of them in their | 0:17:46 | 0:17:53 | |
early 20s. So were you like a mum
offset as well? I was, absolutely. | 0:17:53 | 0:18:00 | |
When you go onto a set there are so
many people with different agendas | 0:18:00 | 0:18:03 | |
of how they want things to be, and
just to be able to be single-minded | 0:18:03 | 0:18:07 | |
and focused on what your job is is
really, really hard. Just to be able | 0:18:07 | 0:18:13 | |
to tell them, you look after
yourself and tell everybody else to | 0:18:13 | 0:18:15 | |
go away... It is set in New England,
but where did you feel it? We filmed | 0:18:15 | 0:18:21 | |
it in Ireland, in think the hottest
summer that has had. It was winter | 0:18:21 | 0:18:28 | |
in New England! We had snow, there
was a frozen lake. We were bowling | 0:18:28 | 0:18:40 | |
40lb off petticoats every day, which
was a killer. Amazing job they had | 0:18:40 | 0:18:45 | |
done to make it look... It doesn't
look real there but in other... It | 0:18:45 | 0:18:53 | |
looks really amazing. Can't wait to
see this. Little Women begins on | 0:18:53 | 0:18:59 | |
Boxing Day at 8pm on BBC One and it
continues on the 27th and the 28th, | 0:18:59 | 0:19:05 | |
all on BBC One. And you can feast on
it, three in a row! | 0:19:05 | 0:19:10 | |
Christmas came early
for scientists in Edinburgh, | 0:19:10 | 0:19:11 | |
when Joy Milne walked
through the door. | 0:19:11 | 0:19:13 | |
For 200 years the search has been
on for a way of detecting | 0:19:13 | 0:19:16 | |
Parkinson's disease. | 0:19:16 | 0:19:17 | |
For Joy, it turned out the answer
was right in front of her nose. | 0:19:17 | 0:19:26 | |
I'm in a tiny, tiny branch of the
population, somewhere between a dog | 0:19:26 | 0:19:31 | |
and a human. I thought, that's quite
nice, I can smell better than most | 0:19:31 | 0:19:37 | |
humans! I'm Joy Milne, I'm 67P and I
smell Parkinson's UK Trina husband | 0:19:37 | 0:19:46 | |
was a doctor, I was a nurse. I
sensed a strange smell when he was | 0:19:46 | 0:19:52 | |
around, and it caused some tension
because I said he wasn't brushing | 0:19:52 | 0:19:58 | |
his teeth, he wasn't showering and
so on and so forth, so I just had to | 0:19:58 | 0:20:02 | |
be quiet. But then we went to a
Parkinson's meeting and my nose just | 0:20:02 | 0:20:10 | |
thought, wow! Joy can distinguish
the Parkinson's smells from the | 0:20:10 | 0:20:17 | |
samples we have taken from patients
and if she smells it we will then | 0:20:17 | 0:20:20 | |
know right away what that molecule
is. You are a wonder, Joy. You can | 0:20:20 | 0:20:27 | |
smell it on other people and now we
are here, it's amazing! We would | 0:20:27 | 0:20:32 | |
like to thank you for your
friendship and many happy memories | 0:20:32 | 0:20:35 | |
over the years - that was from his
funeral. It's horrible watching your | 0:20:35 | 0:20:43 | |
partner change like that, it really
is. If we get the test right, it | 0:20:43 | 0:20:51 | |
will never get to that stage,
because at that stage of diagnosis, | 0:20:51 | 0:20:58 | |
68% to 70% of the real damage is
already done. The not going to find | 0:20:58 | 0:21:03 | |
a cure for it, but to stop or
alleviate it, it's just going to be | 0:21:03 | 0:21:07 | |
tremendous. And Joy is here with us,
along with the scientist Professor | 0:21:07 | 0:21:17 | |
Perdita Barran. And we've just
noticed that Jake has moved away | 0:21:17 | 0:21:22 | |
from the so far, because he's
wearing very strong aftershave, and | 0:21:22 | 0:21:25 | |
we need Joy's knows to be in tiptop
condition! We have got some swabs | 0:21:25 | 0:21:34 | |
here, what is on them? These come
from participants in our clinical | 0:21:34 | 0:21:40 | |
trial. It is just cause and the
nurse has taken them and wiped them | 0:21:40 | 0:21:47 | |
quite firmly on the back of a person
with Parkinson is. Well, this one is | 0:21:47 | 0:21:53 | |
from someone with Parkinson is, this
one is from a control subject. And | 0:21:53 | 0:21:58 | |
what is on them is the substance
that will be on your back. Joy, | 0:21:58 | 0:22:03 | |
would you mind opening both samples
and just tell us what you're | 0:22:03 | 0:22:09 | |
smelling and the difference between
both, for you? For me, that is very | 0:22:09 | 0:22:16 | |
strong. I could see the reaction in
your face. Yes, that one is very | 0:22:16 | 0:22:20 | |
strong, it is very strong. Do you
mind if we have a go? Let's get the | 0:22:20 | 0:22:26 | |
other one as well, just to see if
you can smell a difference - can you | 0:22:26 | 0:22:31 | |
smell it? Yes. Yes. You see, that's
completely different, all I can | 0:22:31 | 0:22:38 | |
smell on that one is the gauze.
Yeah, it does smell more musky but | 0:22:38 | 0:22:46 | |
to me there is not a massive
difference. It's very, very strong. | 0:22:46 | 0:22:50 | |
And you grade the smell? 1-5. And
that one is...? That is a 4-5, | 0:22:50 | 0:23:04 | |
definitely. How will this change
away Parkinson's can be diagnosed? | 0:23:04 | 0:23:10 | |
What she is smelling is the
molecules and a kind of greasy | 0:23:10 | 0:23:15 | |
substance where you get spots when
you're a teenager. And in that there | 0:23:15 | 0:23:22 | |
are lots of molecules and some of
them smell, so we take those samples | 0:23:22 | 0:23:26 | |
and we take off the sebum and we
separate the molecules to find out | 0:23:26 | 0:23:32 | |
what they are. And there are about
6000 and most of them would be the | 0:23:32 | 0:23:36 | |
same, but but the people with
Parkinson is have some that there | 0:23:36 | 0:23:41 | |
are more of. And so we have a
fingerprint, if you like. Joy, when | 0:23:41 | 0:23:47 | |
you meet people and come into
contact with them, how close do you | 0:23:47 | 0:23:50 | |
have to be in order to get that
smell? If we are at level five I | 0:23:50 | 0:23:56 | |
would smell it where Alex is now,
quite easily. Otherwise, it can be | 0:23:56 | 0:24:04 | |
on their hands, things they've done
in the day. And with what you've | 0:24:04 | 0:24:08 | |
been through with your husband and
what have you, do you feel like you | 0:24:08 | 0:24:11 | |
want to tell that person? I can't,
we had a discussion within the | 0:24:11 | 0:24:16 | |
research group and it would be
unethical because the test is not | 0:24:16 | 0:24:19 | |
there. It would not be ethical in
medicine and I couldn't do it. But | 0:24:19 | 0:24:28 | |
it must feel like quite a wait of
responsibility as a me you still | 0:24:28 | 0:24:31 | |
know? Yes, I do. But I suppose the
fact that you've continued with it | 0:24:31 | 0:24:37 | |
and you're doing this work is going
to help so many other people, I | 0:24:37 | 0:24:43 | |
suppose that's the key? Yes, all
around the world. And what is next? | 0:24:43 | 0:24:47 | |
That signature that I talked about,
some of the molecules are | 0:24:47 | 0:24:51 | |
distinctive to people with Parkinson
is a geek we've looked at people at | 0:24:51 | 0:24:54 | |
the very early stage. Unfortunately,
that is too late, we are not going | 0:24:54 | 0:25:00 | |
to stop the disease, but our next
stage is to go to even earlier | 0:25:00 | 0:25:05 | |
stages of it, so people, who are
some reason might have a | 0:25:05 | 0:25:10 | |
neurological event which means they
might get Parkinson is, so we want | 0:25:10 | 0:25:13 | |
to try and take the diagnosis as
early as possible. And then to | 0:25:13 | 0:25:18 | |
prolong each stage as much as
possible? And there we hope the | 0:25:18 | 0:25:21 | |
treatment will be more effective. It
really is fascinating to meet you, | 0:25:21 | 0:25:26 | |
van. And thank you so much for that
clip of that film, but you can see | 0:25:26 | 0:25:30 | |
the full documentary, on the
iPlayer, called The Woman Who Can | 0:25:30 | 0:25:36 | |
Smell Parkinson's. | 0:25:36 | 0:25:40 | |
A choir in Oxford called
the Pro Musica Singers | 0:25:40 | 0:25:42 | |
are celebrating their 40th
anniversary, so we've helped them | 0:25:42 | 0:25:44 | |
do something special
to mark the occasion. | 0:25:44 | 0:25:46 | |
And this is the end result -
a performance spreading Christmas | 0:25:46 | 0:25:48 | |
cheer around the city, that visits
12 churches in just 11 hours. | 0:25:48 | 0:25:58 | |
# Once in royal David's city
# Stood a lonely cattle shed... | 0:25:59 | 0:26:17 | |
# In a now for his bed...
# That mother mild | 0:26:17 | 0:26:30 | |
# Jesus Christ, the little child
# He came down to earth from a | 0:26:30 | 0:26:39 | |
heaven | 0:26:39 | 0:26:49 | |
#
# And his shelter was a stable | 0:26:53 | 0:27:01 | |
# Tears and smiles
# Through our eyes... | 0:27:34 | 0:27:45 | |
Merry Christmas! Voice of an angel,
Jake, singing along! And we are | 0:27:56 | 0:28:10 | |
actually going to finish on a
duff-duff... EastEnders, 2018, are | 0:28:10 | 0:28:21 | |
you staying or are you going? I
guess tuned in... That sounds | 0:28:21 | 0:28:26 | |
ominous! If it is the end of the
story, it spin story. I certainly | 0:28:26 | 0:28:34 | |
think there is a future for Max, I
never thought he was irredeemable, | 0:28:34 | 0:28:39 | |
the things that he did but
obviously, that decision is out of | 0:28:39 | 0:28:42 | |
my hands. And Emily, we look forward
to seeing you on the BBC with Sir | 0:28:42 | 0:28:48 | |
Anthony Hopkins. Haven't they been
fantastic tonight?! EastEnders is | 0:28:48 | 0:28:55 | |
coming up straight after us. Emily
will be on on Boxing Day. We asked | 0:28:55 | 0:29:03 | |
you to send in your dancing videos
and you've given Strictly winner Joe | 0:29:03 | 0:29:10 | |
McFadden a run for his money! | 0:29:10 | 0:29:16 |