What Is Life? Wonders of Life


What Is Life?

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This creature is a wonder of life.

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A voracious predator,

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this male has lived underwater for nearly five months,

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feeding, growing, preparing for this moment.

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He's about to undertake

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one of the most remarkable transformations

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in the natural world.

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From aquatic predator... to master of the air.

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The brief adult life of a dragonfly

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is amongst the most energetic in nature.

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Dragonflies are the most remarkable animals.

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You can see their incredible agility in flight

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just watching them skim across the surface of this pond.

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They can pull two and a half G in a turn,

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and they can fly at 15 mph,

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which is fast for something that big.

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They've been around on Earth since before the time of the dinosaurs,

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and in that time they've been fine-tuned by natural selection

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to do what they do - which is to catch their prey on the wing.

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So, dragonflies are beautiful pieces of engineering.

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They're intricate, complex machines.

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But is that all they are?

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Because once their brief lives are over, their vitality will be gone.

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And this raises deep questions.

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What is it that makes something alive?

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And how did life begin in the first place?

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So, what is the difference between the living and the dead?

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What is life?

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I've come to one of the most isolated regions of the Philippines

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to visit the remote hilltop town of Sagada.

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It's a two-day drive from the capital, Manila,

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over some of the country's roughest roads

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that wind their way 1,500 metres up into the hills.

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This is a place

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where the traditional belief is that mountain spirits give us life

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and that our souls return to the mountain when we die...

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..and where the people who live here still imagine that

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the spirits of the dead walk among the living.

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Tonight is November 1st, and here in Sagada -

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in fact across the Philippines - that means it's the Day of the Dead.

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That's the day when people come to this graveyard on a hillside

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and, well, celebrate the lives of their relatives.

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The people light fires to honour and warm the departed,

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inviting their souls to commune with them.

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Now, not matter how unscientific it sounds,

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this idea that there's some kind of soul or spirit or animating force

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that makes us what we are and that persists after our death is common.

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Virtually every culture, every religion,

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has that deeply-held belief.

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And there's a reason for that - because it feels right.

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I mean, just think about it. It's hard to accept that when you die

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you will just stop existing and that you are, your life,

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the essence of you, is just really something

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that emerges from an inanimate bag of stuff.

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Don't get too close.

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You can see that these people feel

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not only do they come to celebrate the lives of their relatives,

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but they're coming in some sense to communicate with them.

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Their relatives, even though their physical bodies have died,

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are still in some sense here.

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When you think about it, that's not so easy to dismiss.

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If we are to state that science can explain everything about us,

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then it's incumbent on science to answer the question,

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what is it that animates living things?

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What is the difference between a piece of rock

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that's carved into a gravestone and me?

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For millennia, some form of spirituality has been evoked

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to explain what it means to be alive, and how life began.

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It's only recently

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that science has begun to answer these deepest of questions.

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In February 1943,

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the physicist Erwin Schrodinger gave a series of lectures in Dublin.

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Now, Schrodinger is almost certainly most famous

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for being one of the founders of quantum theory.

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But in these lectures, which he wrote up in this little book,

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he asked a very different question - What Is Life?

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And right up front, on page one, he says precisely what it isn't.

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It isn't something mystical, says Schrodinger.

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There isn't some magical spark that animates life.

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Life is a process.

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It's the interaction between matter and energy

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described by the laws of physics and chemistry.

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The same laws that describe

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the falling of the rain or the shining of the stars.

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So, the question is,

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how is that this magnificent complexity that we call life

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could have assembled itself on the surface of a planet

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which itself formed

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from nothing more than a collapsing cloud of gas and dust?

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To Schrodinger, the answer had to lie in the way living things process

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one of the universe's most elusive properties - energy.

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Energy is a concept that's central to physics,

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but because it's a word we use every day

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its meaning has got a bit woolly.

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I mean, it's easy to say what it is in a sense.

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Obviously this river has got energy because over decades and centuries

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it's cut this valley through solid rock.

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But while this description sounds simple,

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in reality things are a little more complicated.

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For me, the best definition is that

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it's the length of the space time four vector and time direction,

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but that's not very enlightening, I'll grant you that.

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Over the years,

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the nature of energy has proved notoriously difficult to pin down.

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Not least because it has the seemingly magical property

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that it never runs out.

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It only ever changes from one form to another.

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Take the water in that waterfall.

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At the top of the waterfall,

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it's got something called gravitational potential energy,

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which is the energy it possesses

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due to its height above the Earth's surface.

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See, if I scoop some water out of the river into this beaker,

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then I'd have to do work to carry it up to the top of the waterfall.

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I'd have to expend energy to get it up there.

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So it would have that energy as gravitational potential.

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I can even do the sums for you.

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Half a litre of water has a mass of half a kilogram,

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multiply by the height, that's about five metres,

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the acceleration due to gravity's about ten metres per second squared.

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So that's half times five times ten is 25 joules.

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So I'd have to put in 25 joules

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to carry this water to the top of the waterfall.

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Then if I emptied it over the top of the waterfall,

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then all that gravitational potential energy

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would be transformed into other types of energy.

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Its sound, which is pressure waves in the air.

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There's the energy of the waves in the river. And there's heat.

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So it'll be a bit hotter down there

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because the water's cascading into the pool

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at the foot of the waterfall.

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Buy the key thing is energy is conserved,

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it's not created or destroyed.

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So, because energy is conserved,

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if I were to add up all the energy in the water waves,

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all the energy in the sound waves,

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all the heat energy at the bottom of the pool,

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then I would find that it would be precisely equal

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to the gravitational potential energy at the top of the falls.

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What's true for the waterfall is true for everything in the universe.

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It's a fundamental law of nature,

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known as the first law of thermodynamics.

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And the fact that energy is neither created nor destroyed

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has a profound implication.

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It means energy is eternal.

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The energy that's here now has always been here,

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and the story of the evolution of the universe

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is just the story of the transformation of that energy

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from one form to another,

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from the origin of the first galaxies

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to the ignition of the first stars

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and the formation of the first planets.

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Every single joule of energy in the universe today

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was present at the Big Bang, 13.7 billion years ago.

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Potential energy held in primordial clouds of gas and dust

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was transformed into kinetic energy

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as they collapsed to form stars and planetary systems,

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just like our own solar system.

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In the Sun,

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heat from the collapse initiated fusion reactions at its core.

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Hydrogen became helium.

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Nuclear-binding energy was released, heating the surface of the Sun,

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producing the light that began to bathe the young Earth.

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And at some point in that story, around four billion years ago,

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that transformation of energy led to the origin of life on Earth.

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Around 350 kilometres south of Sagada, this is Lake Taal.

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Despite its sleepy, languid appearance,

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this landscape has been violently transformed by energy.

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When I think of a volcano,

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I usually think of a pointy, fiery mountain

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with a little crater in the top.

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Probably a bit like that one.

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But actually this entire lake is the flooded crater of a giant volcano.

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It began erupting only about 140,000 years ago,

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and in that time it's blown 120 billion cubic metres of ash and rock

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into the Earth's atmosphere.

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This crater is 30 kilometres across and in places 150 metres deep.

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That's a cube of rock

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five kilometres by five kilometres by five kilometres

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just blown away.

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It's a big volcano.

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Taal Lake is testament to the immense power

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locked within the Earth at the time of its formation.

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Since the lake was created,

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a series of further eruptions formed the island in the centre.

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And at its heart

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is a place where you can glimpse the turmoil of the inner Earth,

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where energy from the core still bubbles up to the surface...

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..producing conditions similar to those that may have provided

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the very first spark of life.

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The water in this lake is different from drinking water

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in a very interesting way.

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See, if I test this bottle of water with this,

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which is called universal indicator paper,

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then you see immediately that it goes green.

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And that means that it's completely neutral.

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It's called PH7 in the jargon.

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But then look what happens when I test the water from the lake.

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Now the indicator paper stays orange.

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In fact, it might have gone a bit more orange.

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So that means that this is acid. It's about PH3.

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At the most basic level,

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the energy trapped inside the Earth is melting rocks.

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And when you melt rock like this you produce gases.

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A lot of carbon dioxide,

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and in this case of this volcano, a lot of sulphur dioxide.

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Now, sulphur dioxide dissolves in water

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and you get H2SO4, sulphuric acid.

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Now, what I mean when I say that water is acidic?

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Well, water is H2O - hydrogen and oxygen bonded together.

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But actually when it's liquid it's a bit more complicated than that.

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It's actually a sea of ions.

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So H-plus ions, that's just single protons.

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And OH-minus ions, that's oxygen and hydrogen bonded together,

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all floating around.

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Now, when something's neutral, when the PH is seven,

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that means that the concentrations of those ions

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are perfectly balanced.

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When you make water acidic,

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then you change the concentration of those ions and, to be specific,

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you increase the concentration of the H-plus ions of the protons.

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So, this process of acidification has stored the energy of the volcano

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as chemical potential energy.

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The volcano transforms heat from the inner Earth into chemical energy

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and stores it as a reservoir of protons in the lake.

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And this is the same way energy is stored

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in a simple battery or fuel cell.

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These bottles contain a weak acid

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and are connected by a semi-permeable membrane.

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Passing an electric current through them has a similar effect

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to the volcano's energy bubbling up into the lake.

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It causes protons to build up in one of the bottles.

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You can think of it, I suppose, like a waterfall,

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where the protons are up here waiting to flow down.

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All you have to do to release that energy

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and do something useful with it is complete the circuit.

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Which I can do by just connecting a motor to it.

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There you go. Look at that.

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That's the protons cascading down the waterfall

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and driving the motor around.

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It actually works!

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Quite remarkable, actually.

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Now, the fuel cell produces and exploits

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its proton gradient artificially. But there are places on Earth

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where that gradient occurs completely naturally.

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Here, for example.

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So we've got the proton reservoir over there,

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the acidic volcanic lake.

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If you look that way, there's another lake,

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and the reaction of the water with the rocks on the shore

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make that lake slightly alkaline,

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which is to say that there's a deficit of protons down there.

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So here's the waterfall,

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a reservoir of protons up there, a deficit down there.

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If you could just connect them,

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then you'd have a naturally occurring geological fuel cell.

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And it's thought that the first life on our planet

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may have exploited the energy released

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in those natural proton waterfalls.

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What do you think? It's good, isn't it?

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These are pictures from deep below the surface

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of the Atlantic Ocean, somewhere between Bermuda and the Canaries.

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And it's a place known as the Lost City.

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You can see why.

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Look at these huge towers of rock, some of them 50-60 metres high,

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reaching up from the floor of the Atlantic and into the ocean.

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It's what's known as a hydrothermal vent system.

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So these things are formed by hot water and minerals and gases

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rising up from deep within the Earth.

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But the reason it's thought that life on Earth may have begun

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in such structures is because

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these are a very unique kind of hydrothermal vent

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called an alkaline vent.

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And, about four billion years ago, when life on Earth began,

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seawater would have been mildly acidic.

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So, here is that proton gradient, that source of energy for life.

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You've got a reservoir of protons in the acidic seawater

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and a deficit of protons around the vents.

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And the vents don't just provide an energy source.

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They're also rich in the raw materials life needs.

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Hydrogen gas, carbon dioxide

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and minerals containing iron, nickel and sulphur.

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But there's more than that.

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See, these vents are porous - there are little chambers inside them -

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and they can act to concentrate organic molecules.

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You've got everything inside these vents.

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You've got concentrated building blocks of life

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trapped inside the rock.

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And you've got that proton gradient,

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you've got that waterfall that provides the energy for life.

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So this could be where your distant ancestors come from.

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And places like these could be the places where life on Earth began.

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The first living things might have started out

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as part of the rock that created them.

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Simple organisms that exploited energy

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from the naturally-occurring proton gradients in the vents.

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And we think this because

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living things still get their energy using proton gradients today.

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Deep within ourselves,

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the chemistry the first life exploited in the vents

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is wrapped up in structures called mitochondria -

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microscopic batteries that power the processes of life.

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This is a picture of the mitochondria

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from the little brown bat.

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This is a picture of the mitochondria from a plant.

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It's actually a member of the mustard family.

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This is a picture of the mitochondria in bread mould.

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And this of mitochondria inside a malaria parasite.

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So, the fascinating thing is that all these animals and plants,

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and in fact virtually every living thing on the planet,

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uses proton gradients to produce energy to live. Why?

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Well, the answer is probably

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because all these radically different forms of life

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share a common ancestor.

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And that common ancestor was something that lived in

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those ancient undersea vents, four billion years ago,

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where naturally-occurring proton gradients

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provided the energy for the first life.

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So, if you're looking for a universal spark of life,

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then this is it.

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The spark of life is proton gradients.

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In those four billion years, that spark has grown into a flame.

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And a few simple organisms clustered around a hydrothermal vent

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have evolved to produce all the magnificent diversity

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that covers the Earth today.

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Today, life on Earth is so diverse,

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it covers so much of the planet that you can find places like this lake,

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where it's effectively its own sealed ecosystem.

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It's saltwater, it's connected to the sea,

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but it's only connected through small channels through the rock.

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So that means that the marine life in here is effectively isolated.

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This is the Golden Jellyfish,

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a unique sub-species only found in this one lake on this one island,

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in the tiny Micronesian Republic of Palau.

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They used to live like most jellyfish,

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cruising the open ocean, catching tiny creatures, zooplankton,

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in their long tentacles.

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But today their tentacles have all but disappeared

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because the Golden Jellyfish

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have evolved to do something that very few other animals can do.

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It really is incredible.

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There are, I want to say millions of jellyfish,

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as far as you can see,

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all the way down till the light vanishes there are jellyfish.

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And you can see they've congregated in the sun.

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If you go over there to where the lake's in shade,

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there are just none.

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They're in this pool of light, beneath the sun.

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There are millions of them.

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Beautifully elegant things just floating around.

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I'm not being unduly hyperbolic, it's quite remarkable.

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MAKES MUFFLED NOISE

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This lake is home to over 20 million jellyfish.

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Whose success comes down to a remarkable adaptation.

0:31:020:31:05

Their bodies play host to thousands of other organisms -

0:31:080:31:12

photosynthetic algae that harvest energy directly from sunlight.

0:31:120:31:17

The jellyfish engulf the algae as juveniles,

0:31:260:31:29

and by adulthood algal cells make up around 10% of their biomass.

0:31:290:31:35

Grouped into clusters of up to 200 individuals,

0:31:370:31:41

they live inside the jellyfish's own cells.

0:31:410:31:44

The Golden Jellyfish uses algae

0:31:500:31:53

to get most of its energy from photosynthesis.

0:31:530:31:56

They go to the surface and gently... Wow, there's one there.

0:32:100:32:13

They're gently turning.

0:32:130:32:15

The reason they do that is to give all their algae

0:32:150:32:18

an equal dose of sunlight.

0:32:180:32:21

So they're quite democratic creatures,

0:32:230:32:25

just making sure they get as much food as they can.

0:32:250:32:29

They just come up you, jellying around, photosynthesising.

0:32:290:32:34

They tell me they don't sting.

0:32:410:32:43

But I'm sure I've got a tingling from it.

0:32:430:32:46

And it's not just their anatomy

0:32:510:32:53

that's adapted to harvest solar energy.

0:32:530:32:55

Every morning as the sun rises,

0:32:570:32:59

the jellyfish begin to swim towards the east.

0:32:590:33:02

As the sun tracks across the sky, they move back again towards the west,

0:33:070:33:12

where they spend their night.

0:33:120:33:13

So the jellyfish have this beautiful, intimate

0:33:190:33:24

and complex relationship with the position of the sun in the sky.

0:33:240:33:28

As sunlight is captured by their algae,

0:33:320:33:35

it's converted into chemical energy.

0:33:350:33:38

Energy they use to combine simple molecules,

0:33:400:33:44

water and carbon dioxide, to produce are far more complex one.

0:33:440:33:48

Glucose.

0:33:500:33:51

Once absorbed by the jellyfish, glucose and other molecules

0:33:520:33:57

not only power their daily voyage across the lake,

0:33:570:34:00

they provide the basic building blocks the jellyfish

0:34:000:34:04

use to grow the elegant and complex structures of their bodies.

0:34:040:34:08

So the jellyfish, through their symbiotic algae,

0:34:180:34:22

absorb the light, the energy from the sun, and they use it to live,

0:34:220:34:27

to power their processes of life.

0:34:270:34:29

And that's true, directly or indirectly,

0:34:290:34:32

for every form of life on the surface of our planet.

0:34:320:34:36

But things are a little bit more interesting than that,

0:34:360:34:39

because energy is neither created nor destroyed.

0:34:390:34:43

So life doesn't eat it somehow, it doesn't use it up,

0:34:430:34:48

it doesn't remove it from the universe.

0:34:480:34:50

So what does it do?

0:34:500:34:51

To understand how energy sustains life,

0:34:560:34:59

you have to understand exactly what happens to it as the cosmos evolves.

0:34:590:35:04

POWERFUL EXPLOSION BOOMS

0:35:110:35:14

In the first instance after the Big Bang

0:35:140:35:16

there was nothing in the universe but energy.

0:35:160:35:19

As it changed from one form to another, galaxies, stars

0:35:260:35:30

and planets were born.

0:35:300:35:32

But while the total amount of energy in the universe stays constant,

0:35:370:35:42

with every single transformation something does change.

0:35:420:35:46

The energy itself becomes less and less useful.

0:35:480:35:52

It becomes ever more disordered.

0:35:520:35:54

And you can see this process in action as energy from the sun

0:35:580:36:02

hits the surface of the Earth.

0:36:020:36:04

So think about think about this sand on the beach,

0:36:080:36:10

it's been under the glare of the sun all day,

0:36:100:36:13

it's been absorbing its light which has been heating it up,

0:36:130:36:16

and now that the sun is dipping below the horizon,

0:36:160:36:19

then the sand is still hot to the touch

0:36:190:36:21

because it's re-radiating all the energy that it absorbed as heat

0:36:210:36:26

back into the universe.

0:36:260:36:29

The key word there is "all". All the energy.

0:36:290:36:33

If it didn't do that then it'd just gradually heat up

0:36:330:36:36

day after day after day,

0:36:360:36:37

and eventually, I suppose, the whole beach would melt.

0:36:370:36:40

So what's changed?

0:36:400:36:42

Well, it's the quality of the energy, if you like.

0:36:420:36:46

Think about it.

0:36:460:36:48

If as much energy is coming back off this sand now as it absorbed from the sun,

0:36:480:36:52

then it should be giving me a suntan.

0:36:520:36:54

I should need sun cream if I sit looking at this beach all night.

0:36:540:36:58

And obviously I don't.

0:36:580:36:59

The difference is that this energy is of a lower quality.

0:36:590:37:04

It can do less.

0:37:040:37:06

It's heat, which is a very low quality of energy indeed.

0:37:060:37:10

So what the sand's done is take highly ordered,

0:37:100:37:13

high quality energy from the sun

0:37:130:37:15

and convert it to an equal amount of low quality disordered energy.

0:37:150:37:21

This descent into disorder

0:37:280:37:30

is happening across the entire universe.

0:37:300:37:33

As time passes, every single joule of energy is converted into heat.

0:37:450:37:51

The universe gradually cools towards absolute zero.

0:37:540:37:59

Until with no ordered energy left, the cosmos grinds to a halt

0:37:590:38:04

and every structure in it decays away.

0:38:040:38:08

Yet whilst the universe is dying, everywhere you look life goes on.

0:38:190:38:24

It's a deep paradox that Schroedinger was well aware of

0:38:260:38:30

when he wrote his book in 1943.

0:38:300:38:33

"How can it be," writes Schroedinger,

0:38:360:38:38

"That the living organism avoids decay?"

0:38:380:38:41

In other words, how can it be that life seems to continue to build

0:38:410:38:46

increasingly complex structures

0:38:460:38:48

when the rest of the universe is falling to bits, is decaying away?

0:38:480:38:54

Now, that's a paradox, because the universe is falling to bits,

0:38:540:39:00

it is tending towards disorder.

0:39:000:39:03

That is enshrined in a law of physics called

0:39:030:39:06

the Second Law Of Thermodynamics.

0:39:060:39:09

And I think most physicists believe that it's the one

0:39:090:39:12

law of physics that will never be broken.

0:39:120:39:16

The key to understanding how life obeys the laws of thermodynamics

0:39:310:39:36

is to look at both the energy it takes in

0:39:360:39:38

and the energy it gives out.

0:39:380:39:41

This is a thermal camera, so hot things show up as red,

0:39:460:39:50

and cold things show up as blue.

0:39:500:39:52

COCKEREL CROWS

0:39:520:39:54

So what you're seeing here is that the chicken is hotter

0:39:540:39:57

than its surroundings.

0:39:570:39:59

Now, heat is a highly disordered form of energy,

0:39:590:40:02

so the chicken is radiating disorder out into the wider universe.

0:40:020:40:09

By converting chemical energy into heat,

0:40:120:40:15

life transforms energy from an ordered to a disordered form,

0:40:150:40:20

in exactly the same way as every other process in the universe.

0:40:200:40:25

COCKEREL CROWS

0:40:290:40:31

In fact, every single human being

0:40:330:40:35

can generate 6,000 times more heat per kilogram than the sun.

0:40:350:40:40

And it's by converting so much energy from one form to another

0:40:440:40:48

that life is able to hang on to a tiny amount of order for itself.

0:40:480:40:54

Just enough to resist the inevitable decay of the universe.

0:40:540:40:59

COCKEREL CROWS

0:40:590:41:02

So it's no accident that living things are hot

0:41:020:41:04

and export heat to their surroundings.

0:41:040:41:07

Because it's an essential part of being alive.

0:41:070:41:11

Living things borrow order from the wider universe,

0:41:110:41:15

and then they export it again as disorder.

0:41:150:41:18

But it's not precisely in balance.

0:41:180:41:20

They have to export more disorder

0:41:200:41:23

than the amount of order they import.

0:41:230:41:25

That is the content of the Second Law Of Thermodynamics.

0:41:250:41:28

And living things have to obey the Second Law

0:41:280:41:31

because they're physical structures, they obey the laws of physics.

0:41:310:41:36

Just by being alive, we too are part of the process of energy

0:41:410:41:46

transformation that drives the evolution of the universe.

0:41:460:41:50

We take sunlight that has its origins at the very start of time,

0:41:540:41:59

and transform it into heat that will last for eternity.

0:41:590:42:04

So, far from being a paradox,

0:42:090:42:11

living things can be explained by the laws of physics.

0:42:110:42:16

The very same laws that describe the falling of the rain

0:42:160:42:20

and the shining of the stars.

0:42:200:42:21

The dragonfly draws its energy from proton gradients,

0:42:440:42:48

the fundamental chemistry that powers life.

0:42:480:42:52

But the real miracles are the structures

0:42:560:42:59

they build with that energy.

0:42:590:43:01

Borrowing order to generate cells.

0:43:060:43:08

Arranging those cells into tissues.

0:43:100:43:13

And those tissues into the intricate architecture of their bodies.

0:43:150:43:19

So we've developed a quite detailed understanding

0:43:230:43:26

of the underlying machinery that powers these dragonflies,

0:43:260:43:31

and indeed all life on Earth.

0:43:310:43:33

And whilst we don't have all the answers, it is certainly safe to say

0:43:330:43:36

that there's no mysticism required.

0:43:360:43:38

You don't need some kind of magical flame

0:43:380:43:41

to animate these little machines.

0:43:410:43:43

They operate according to the laws of physics,

0:43:430:43:47

and I think they're no less magical for that.

0:43:470:43:49

Yet the dragonfly will only maintain this delicate balancing act for so long.

0:43:540:43:59

Because all living things share the same fate.

0:44:010:44:04

Each individual will die.

0:44:090:44:11

But life itself endures.

0:44:140:44:17

DRAGONFLIES BUZZ

0:44:180:44:22

This is because there's something that separates life

0:44:250:44:28

from every other process in the universe.

0:44:280:44:31

BOAT ENGINE CHUGS

0:44:360:44:40

WILD ANIMAL ROARS

0:44:420:44:46

MONKEYS CHATTER

0:44:460:44:50

This is the Malaysian state of Sabah,

0:44:520:44:54

on the northern tip of the island of Borneo.

0:44:540:44:57

It's one of the most bio-diverse places on the planet.

0:44:590:45:03

INSECT BUZZES

0:45:030:45:05

Home to 15,000 plant species...

0:45:050:45:08

..3,000 species of tree...

0:45:100:45:12

..420 species of bird...

0:45:140:45:16

..and 222 species of mammals.

0:45:190:45:22

-Including those.

-ELEPHANTS ROAR LOUDLY

0:45:230:45:27

Borneo's rainforests contain trees that are thought to live

0:45:310:45:34

for more than 1,000 years.

0:45:340:45:36

But the forest itself has existed for tens of millions of years.

0:45:410:45:45

The reason it persists is because each generation of animal and plant

0:45:510:45:56

passes the information to recreate itself on to the next generation.

0:45:560:46:01

And that's possible

0:46:030:46:04

because of a molecule found in every cell of every living thing.

0:46:040:46:09

A molecule called DNA.

0:46:110:46:14

Now, all I need to isolate my DNA is some washing up liquid,

0:46:250:46:32

a bit of salt, and the chemist's best friend, vodka.

0:46:320:46:38

Now, to get a sample of DNA I can just use myself.

0:46:380:46:42

If I just swill my tongue around on the edge of my cheek,

0:46:420:46:47

I'll dislodge some cheek cells into my saliva.

0:46:470:46:50

DOG BARKS OUTSIDE

0:46:510:46:53

LAUGHS

0:46:550:46:57

I missed the test tube.

0:46:570:46:59

There we are. A physicist doing an experiment.

0:46:590:47:01

STIFLES LAUGHTER

0:47:050:47:06

Then I add a bit of washing up liquid.

0:47:070:47:12

Now, what this will do is it will break open those cheek cells

0:47:120:47:17

and it will also degrade the membrane that surrounds

0:47:170:47:21

the cell nucleus that contains the DNA.

0:47:210:47:25

Salt will encourage the molecules to clump together.

0:47:250:47:30

DNA is insoluble in alcohol.

0:47:310:47:35

So you should get a layer of alcohol

0:47:350:47:42

with DNA molecules precipitated out.

0:47:420:47:44

Yeah. There, can you see?

0:47:490:47:54

Those strands of white.

0:47:540:47:57

And so in that cloudy, almost innocuous looking solid

0:47:570:48:03

are all the instructions needed to build a human being.

0:48:030:48:08

So that is what makes life unique.

0:48:120:48:17

Only living things have the ability to encode

0:48:270:48:31

and transmit information in this way.

0:48:310:48:33

And the consequences of that profoundly affect

0:48:360:48:40

our understanding of what it is to be alive.

0:48:400:48:43

This rainforest is part of the Sepilok Forest Reserve,

0:48:440:48:48

and in here somewhere are some of our closest genetic relatives.

0:48:480:48:53

Shh-shh.

0:49:060:49:08

There, there, can you see?

0:49:110:49:13

Orang-utans are highly specialised for a life lived in the forest canopy.

0:49:200:49:25

Their arms are twice as long as their legs.

0:49:260:49:30

And all four limbs are incredibly flexible.

0:49:300:49:33

Each one ending in a hand whose curved bones

0:49:330:49:38

are perfectly adapted for gripping branches.

0:49:380:49:41

These adaptations are encoded in information

0:49:440:49:48

passed down in their DNA.

0:49:480:49:50

LAUGHS GENTLY

0:49:550:49:56

He's got a hat on.

0:49:560:49:57

He has actually just put a hat on.

0:50:000:50:02

This is the orang-utan's genetic code.

0:50:160:50:20

It was published in 2011,

0:50:200:50:22

and there are over three billion letters in it.

0:50:220:50:27

If flip through it...

0:50:270:50:29

..look at that.

0:50:320:50:33

Now, it's composed of only four letters, A, C, T and G,

0:50:350:50:39

which are known as bases.

0:50:390:50:41

They're chemical compounds. They're molecules.

0:50:410:50:44

And the way it works is beautifully simple.

0:50:440:50:48

They're grouped into threes, called codons,

0:50:480:50:51

and some of them just tell the code reader, if you like,

0:50:510:50:56

how to start, or where to start and when...

0:50:560:50:59

and when it's going to stop.

0:50:590:51:01

LAUGHS

0:51:030:51:05

He's fast.

0:51:070:51:08

So you'd have a start and a stop.

0:51:110:51:14

In between, each group of three codes for a particular amino acid.

0:51:140:51:19

Now, amino acids are the building blocks of proteins,

0:51:210:51:24

which are the building blocks of all living things.

0:51:240:51:29

So you would just read along,

0:51:290:51:32

you'd find, start, stop, and then

0:51:320:51:35

you'd go along in threes, build amino acid, build amino acid,

0:51:350:51:38

build amino acid, build amino acid,

0:51:380:51:40

stitch those together into a protein,

0:51:400:51:42

and if you keep doing that,

0:51:420:51:44

eventually you'll come out with one of those.

0:51:440:51:48

It's not that simple of course. But the basics are there.

0:51:520:51:57

This code, written in there, are the instructions to make him.

0:51:590:52:04

To faithfully reproduce those instructions

0:52:130:52:16

for generation after generation,

0:52:160:52:18

the orang-utans and, and indeed all life on Earth,

0:52:180:52:21

rely on a remarkable property of DNA.

0:52:210:52:24

Its incredible stability and resistance to change.

0:52:250:52:29

Every time a cell divides, its DNA must be copied.

0:52:340:52:38

And the genetic code is highly resistant to copying errors.

0:52:380:52:42

The little enzymes, the chemical machines that do the copying,

0:52:420:52:45

on average make only one mistake in a billion letters.

0:52:450:52:49

I mean, that's like copying out the Bible about 280 times

0:52:490:52:53

and making just one mistake.

0:52:530:52:55

That fidelity means adaptations are faithfully transmitted

0:53:000:53:04

from parent to offspring.

0:53:040:53:06

And so while we think of evolution as a process of constant change,

0:53:080:53:13

in fact the vast majority of the code is preserved.

0:53:130:53:17

So even though we're separated from the orang-utans

0:53:190:53:22

by nearly 14 million years of evolution,

0:53:220:53:26

what's really striking is just how similar we are.

0:53:260:53:30

And those similarities are far more than skin deep.

0:53:310:53:35

Orang-utans are surely one of the most human of animals.

0:53:380:53:42

And they share many behavioural traits that you would

0:53:420:53:47

define as being uniquely human.

0:53:470:53:49

They nurture their young for eight years before they let them

0:53:510:53:54

go on their own into the forest.

0:53:540:53:56

In that time the infants learn which fruits are safe to eat

0:53:560:54:00

and which are poisonous.

0:54:000:54:02

Which branches will hold their weight and which won't.

0:54:020:54:06

And they can do all that because they have a memory,

0:54:060:54:09

they can remember things that happened to them in their life,

0:54:090:54:12

they can learn from them,

0:54:120:54:14

and they can pass them on from generation to generation.

0:54:140:54:17

And that deep connection extends far beyond our closest relatives.

0:54:240:54:28

Because our DNA contains the fingerprint

0:54:300:54:33

of almost four billion years of evolution.

0:54:330:54:37

BIRDS SING

0:54:370:54:40

If I draw a tree of life for the primates,

0:54:430:54:46

then we share a common ancestor with the chimps, Bonobos.

0:54:460:54:52

About four to six million years ago.

0:54:520:54:55

And if you compare our genetic sequences you find

0:54:550:55:01

that our genes are 99% the same.

0:55:010:55:07

You go back to the split with gorillas,

0:55:070:55:11

about six to eight million years ago and again,

0:55:110:55:14

if you compare our genes you find that they are 98.4% the same.

0:55:140:55:21

Back in time again, common ancestor with our friends over there,

0:55:230:55:27

the orang-utans, then our genes are 97.4% the same.

0:55:270:55:34

And you could carry on all the way back in time.

0:55:340:55:36

You could look for our common ancestor with a chicken,

0:55:360:55:40

and you'd find that our codes are about 60% the same.

0:55:400:55:44

And in fact, if you look for any animal, like him,

0:55:440:55:48

a little fly, or a bacteria, something that seems superficially

0:55:480:55:53

completely unrelated to us, then you'll still find sequences

0:55:530:55:57

in the genetic code which are identical to sequences in my cells.

0:55:570:56:01

So this tells us that all life on Earth is related,

0:56:010:56:07

it's all connected through our genetic code.

0:56:070:56:10

DNA is the blueprint for life.

0:56:200:56:23

But its extraordinary fidelity means it also contains a story.

0:56:250:56:30

And what a story it is.

0:56:300:56:32

The entire history of evolution from the present day

0:56:350:56:39

all the way back to the very first spark of life.

0:56:390:56:43

And it tells us that we're connected, not only to every plant

0:56:460:56:51

and animal alive today, but to every single thing that has ever lived.

0:56:510:56:58

The question, what is life,

0:57:210:57:23

is surely one of the grandest of questions.

0:57:230:57:26

And we've learnt that life isn't really a thing at all.

0:57:260:57:29

It's a collection of chemical processes that can harness

0:57:290:57:33

a flow of energy to create local islands of order,

0:57:330:57:36

like me and this forest,

0:57:360:57:39

by borrowing order from the wider universe

0:57:390:57:42

and then transmitting it from generation to generation

0:57:420:57:46

through the elegant chemistry of DNA.

0:57:460:57:49

And the origins of that chemistry

0:57:490:57:51

can be traced back four billion years,

0:57:510:57:54

most likely to vents in the primordial ocean.

0:57:540:57:58

And, most wonderfully of all, the echoes of that history,

0:57:580:58:02

stretching back for a third of the age of the universe,

0:58:020:58:06

can be seen in every cell of every living thing on Earth.

0:58:060:58:11

And that leads to what I think is the most exciting idea of all,

0:58:110:58:15

because far from being some chance event ignited by a mystical spark,

0:58:150:58:20

the emergence of life on Earth might have been

0:58:200:58:23

an inevitable consequence of the laws of physics.

0:58:230:58:27

And if that's true,

0:58:270:58:28

then a living cosmos might be the only way our cosmos can be.

0:58:280:58:32

# Just remember you're a tiny little person on a planet

0:58:460:58:52

# In a universe expanding and immense

0:58:520:58:55

# That life began evolving and dissolving and resolving

0:58:570:59:01

# In the deep primordial oceans by the hydrothermal vents

0:59:010:59:05

# Our Earth which had its birth almost five billion years ago

0:59:050:59:09

# From out a collapsing cloud of gas

0:59:090:59:12

# Grew life which was quite new

0:59:120:59:15

# And eventually led to you

0:59:150:59:16

# In only 3.5 billion years or less. #

0:59:160:59:20

WHISTLING TO END OF SONG

0:59:200:59:22

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