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Transcript


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Hello, I'm Dara O'Briain.

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Welcome to the show which seeks out

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the very latest ground-breaking ideas in science

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and attempts to answer some of the most fundamental questions

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in the cosmos.

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Tonight - are we entering a whole new era of DIY science?

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Powerful, affordable technology is available to us all

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and it's ushering in a whole new era of creativity,

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so are we all scientists now?

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This is the place where we find out how great ideas are changing

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the world we live in.

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Welcome to Science Club.

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APPLAUSE

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Good evening and welcome to the show.

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We've got a terrific programme for you tonight,

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some fabulous guests later on,

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and I'll be joined by the regular team

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and Professor Mark Miodownik - our resident experimentalist

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and demos guru who will be having a bit of a shock later in the show.

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-We've got the best demo we've ever had on Science Club.

-Fantastic.

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-And it may genuinely hurt.

-LAUGHTER

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On the show tonight we're looking at how science is moving out of the lab

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and onto the street and involving all of us

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and how we're all becoming citizen scientists

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and what extraordinary feats we can achieve together.

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Science journalist Alok Jha is in San Francisco to see

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how people-power could create a cheap but effective earthquake alert

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which will give vital extra seconds warning

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if the Big One is on its way.

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Professor Mark Miodownik

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reveals an ingenious way of making the world a bit safer.

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-Whoa.

-Wow.

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And in a brilliant piece of DIY science

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Doctor Helen Czerski reveals

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how one man is helping the mosquitoes turn on their own

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in order to combat dengue fever.

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All right, off you go, little mosquitoes.

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But first - how much do you think about your health?

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You may weigh yourself every now and again,

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take your blood pressure occasionally,

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sign up for the odd flu jab.

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But if you've got one of these,

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you've got the ability to monitor your entire body 24/7.

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Will that make us fighting fit?

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Or is it going to make hypochondriacs of us all?

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Mark's been finding out.

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In the last few years a whole new swath of gadgets

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laden with hi tech sensors have hit the market

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which are, I'm told,

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set to transform what we know about ourselves.

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Here they all are, these gadgets I'm going to use

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to track my biological functions day in day out.

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Well, not all of them, but still, you get the idea.

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But before I start I've got a confession to make -

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I am the sort of person who,

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when I get a headache in the middle of the night,

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I'm convinced it's a brain tumour, and I've been wrong so far,

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but I'm really interested to know whether this stuff,

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and knowing more about myself,

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helps allay those fears or makes things worse.

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So, for better or worse,

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I'm going to get to know myself in ways I never imagined.

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That's it, I'm all wired up.

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Wish me luck.

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Over the next few days

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the gadgets will be measuring my heart rate,

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how much exercise I'm getting and even my sleep patterns.

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It's odd and a little disconcerting at first

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because the urge is to constantly check and see what's going on.

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I just put this heart rate monitor on as I was walking around the building

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and noticed something quite disturbing

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which is my heart rate is really...

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alarmingly high by just walking up some stairs.

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'Brilliant.

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'Less than a few hours in

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'and I'm already feeling undermined by the monitoring.

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'The thing is there's no escape from it.'

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My task for tonight is to put on the X4 Sleep Profiler and monitor...

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my sleep.

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I know what you're thinking - I look ridiculous.

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But I'm not the only one -

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there are thousands of people across the world

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monitoring themselves day in day out.

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The Quantified Self is a movement

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to incorporate technology and data acquisition

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into every aspect of your daily life.

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It combines wearable senses with life logging and surveillance.

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'Now, if enough people do this kind of thing

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'it might help monitor populations and help find links between behaviour

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'and general health and wellbeing.

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'But personally,

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'I worry it's a bit unhealthy, a bit, well...

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'self-obsessive.'

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Morning.

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According to the data...

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I got seven hours and 38 minutes sleep.

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My meditation rating is just abysmal, but my attention is good.

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It's interesting, but I don't quite know what it means.

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It feels a bit like I'm sort of overwhelmed by the data.

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I'm not sure I can cope with doing any more monitoring.

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It's exhausting knowing so much about myself.

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Just filled in my biometrics into the stress app

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and I find that I'm 49% stressed.

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What does that mean?

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Does that mean I should go for a walk?

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'OK, so let's see what all this monitoring means.'

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Breathing rate - I breathe pretty well, it looks like.

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OK.

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I'm seeing a graph of force of each foot

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and they're definitely different.

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That's the first thing that strikes you - that I do not walk evenly,

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I have not got an even gait.

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Now I'm going to have a look at the sleep report.

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Snoring... Oh, my God!

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..30% of the night. That is appalling!

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Now I'm feeling overwhelmed with all this data,

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I don't know what to do with it.

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'I could see how this monitoring malarkey could have benefits,

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'like working out how much you're sitting still,

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'or keeping tabs on what you've eaten.

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'It might even pick up early signs of an illness.

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'But for me it's all a bit too much.'

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I have a funny walk apparently and I've got a sleep disorder,

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and for someone like me, who's a worrier anyway,

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that's a bit much frankly, so I'm glad this experiment is over.

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APPLAUSE

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-Mark, it does appear like a bit of a hypochondriac's charter.

-I think so.

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I think for people themselves, they could suffer with this data

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and not really know how to manage it and get really worried about it.

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But in terms of it monitoring whole populations,

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this is potentially very important

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because small correlations between behaviour and outcome

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-could be discovered this way.

-OK.

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Let's get some proper home-made science

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because we do tend to have you doing all sorts of experiments here.

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Now, lightning. Lightning strikes 240,000 people a year.

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Yeah, worldwide,

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and it kills about 24,000 people a year which is a huge number.

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This, by the way, is a map of lightning strikes across the world.

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It's intriguing. Not over the ocean.

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Very much not over northern Europe for example.

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Not over the deserts in Africa.

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But if you're in Florida, Florida is extremely high

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because it's a landmass that extends into the Tropics

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and it's a place where a lot of people hold up iron...

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-as they're playing golf.

-LAUGHTER

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And the general advice is - don't go under trees,

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don't hide under...

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Yeah, we thought we would demo why that is a problem.

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Imagine you're out in a field, you see a thundercloud above you...

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The hotdog by the way represents you and me and anyone normal.

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This is just plastic, it's non-conducting.

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-This represents a tree?

-Yeah, a bit of wood.

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Let's say you see this thundercloud,

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which is represented by this Tesla coil,

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so we've got a high voltage here, maybe 40 or 50,000 volts, OK?

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-Right.

-It comes over and it decides to lightning over you.

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What it's doing is finding the easiest path to the ground.

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It's looking for highly conductive things like bags of water.

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The tree is not as desirable for it, but they tend to be tall.

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But they can hit the tree and jump over to you.

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What you want to do is get low to the ground -

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that is the best advice you can get.

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But even then, it can hit you and what you don't want it to do is

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go through any vital organs to try and get to the ground.

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Because the effect when it hits a human body,

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a lot of the time it doesn't even go through the body,

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-it will pass over the surface.

-Yeah.

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If you're lucky it will go round your skin and go through to the ground.

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-It will still pass in that pattern, won't it?

-Oh, right.

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So, you see that lightning pattern? That's it finding a path,

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lowest energy path, so it's exploring lots of roots

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and that's what you think of as a lightning fern-like pattern,

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so it's a fractal pattern, actually.

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And you can see that when people get struck by lightning.

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It actually burns the outside of their... Yeah, here we go.

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These are sort of fern-like fractal patterns.

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And is that still the lightning trying to find a path?

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Yes. If you're unlucky it will go through the core of your body

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and then it will interfere with either your heart rhythm

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or your lungs and if it stops those two you die.

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So a lot of people die from heart failure

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or from asphyxiation, weirdly.

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And if it doesn't kill you that way...

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it will just boil you because the amount of current

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going through a lightning bolt is enough to just

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heat your body up and boil it.

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What we can try and simulate now is, if you get struck by lightning

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and it goes through your core.

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This is actually quite dangerous, this bit.

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Yeah, don't do this at home.

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Just to reassure everyone,

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this is not connected yet, even though I've plugged it in,

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-until these two buttons are pressed.

-OK.

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So that's a gherkin.

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Imagine that's you, you get hit by lightning

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and now it's going through the core of your being.

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So first of all, you see it boiling quite quickly

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because there's a huge amount of current going through there.

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So it's boiling up, steam's coming out,

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and then it starts breaking down the very fabric of the gherkin,

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which could be you. LAUGHTER

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And then... the temperatures go...

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-Wow, that's quick to boil, isn't it?

-Yeah.

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-Come on.

-Oh, yes.

-There we go.

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And then it's so hot you're getting light come off it,

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and that light is a particular orange/yellow

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-which you might recognise, Dara.

-Street light.

-Yeah.

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-Sodium light.

-Yeah. And that is sodium from the salt in the gherkin.

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Wow.

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-Ow.

-LAUGHTER

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It's quite a few thousand degrees probably inside there.

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-Is it OK to go in?

-Yep.

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That's the effect it will actually have on flesh.

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But is there a vivid way of seeing the actual path?

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Why does lightning happen?

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It's a high charge trying to get through the air,

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the air is an insulator, so how does it get through?

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It has to break down the air and make it into a conductor.

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And there's a really fantastic demo which I would like to show you

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which sort of reproduces that situation. This is...

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Let's say this is a piece of air.

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It's actually Perspex, but they're both insulators.

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And we've irradiated it with electrons,

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so there's lots of electrons in here.

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You can't see them, but there's a high voltage in there.

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They've got nowhere to go cos this is an insulator, they can't get out,

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and this is the same with lightning.

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There's a huge amount of charge, it's looking for somewhere to go.

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The electrons are sitting quite happily at the moment,

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so how do we shake them out of that?

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We need to give them a high potential,

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basically a concentration point,

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and I'm going to hit it with a hammer.

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OK, let's bring the lights down so we can see this.

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Oh, that's quite moody actually.

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LAUGHTER

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You tell me when.

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-We're ready to go.

-OK.

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Although that looks like a crack, it's not. If you look at it very...

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There's some more lightning.

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There's still lightning occurring as it goes along.

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Cos it's still giving power to the electrons. My God.

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-How long does that go on for?

-It can go on for hours

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because bits of the electrons that are marooned in this insulator

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are finding this path

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which it creating by breaking down this insulator,

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melting it basically, vaporising it.

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So little holes are what you see here, feathery holes.

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And these patterns...

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You saw that on the people who are burnt,

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you saw that on their skin, cos that's exactly the same process.

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Here's the same effect in slow motion.

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So hitting it with a hammer creates that effect.

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Let's see it.

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That is the flash of huge temperatures.

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That's tens of thousands of degrees centigrade

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because it vaporises the insulator.

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And then that creates that fern-like pattern

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and all the electrons are channelled down to Earth

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which is why this hammer was connected to it.

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-That is incredible.

-And it's still going.

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Wow.

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OK, let's bring the lights up.

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We really should meet somebody who's been struck by lightning.

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Eric Brocklebank, I believe we have him here. Eric, are you here?

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-Eric, you had...

-APPLAUSE

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It's all very well to talk through this in theory,

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-this actually happened to you, didn't it?

-It certainly did, yes.

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-Where were you?

-I was on a airbase with air cadets.

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-You were out in the open?

-Out in the open.

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They were doing marching practice, were they?

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They were doing a marching practice on parade ground.

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We had a storm come in, put my collar up

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and the first flash went whizzing past me

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and hit the perimeter fence which was at the side of me.

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I signalled to the cadets, they ran for cover under trees,

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which was the wrong thing to do.

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We now know that's a bad thing to do.

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Don't go that.

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I went and got transport for them, collected them

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and took them to what I thought was safety.

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An interesting point, the correct thing to do would have been...

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Try and get to a vehicle, a metal vehicle

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cos that acts a Faraday cage.

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If that gets hit by lightning

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the electricity will go on the outside of it

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and protect the occupants.

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It's weird, yeah.

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Don't go to a tent with a long pole.

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Yes. Where did you go? A tent, wasn't it?

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I then took these cadets, put them to safety

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and took four cadets with me

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to get them something nice and hot to drink and something to eat.

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-Went in to get the sausages.

-But you were in the tent?

-I was in the tent.

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Took a sausage out...boom.

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Came straight through the tent, got the tongs into my hand,

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melted into there, up my arms, down my side, across my hips,

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blowing holes in my feet as it left my body.

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And how long were you in hospital?

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One hospital for the first two, three days

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until I was transferred then to a major hospital who could deal with

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the internal injuries that I'd got.

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That's incredible. Thank you, Eric for coming in. And Mark Miodownik.

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-Thank you very much.

-APPLAUSE

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Not all of nature's forces can be simulated on a table top,

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but for even the most destructive, acting collectively may be key

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to a greater chance of survival than ever.

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The San Andreas Fault in California

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faces a estimated 99% chance of a major quake

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in the next 30 years.

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And the search is always on for an early warning system

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which normally costs a fortune.

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However, simple ideas shown that the solution may be no bigger

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than a mobile phone.

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Alok Jha reports.

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Our understanding of earthquakes

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comes from expensive equipment buried deep underground.

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This bunker contains some of

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the most sensitive seismic equipment on the globe.

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If there was a magnitude five earthquake

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on the other side of the planet, this would see it.

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This incredible piece of kit

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has helped us understand the anatomy of an earthquake

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and revealed something amazing.

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When an earthquake ruptures along a fault line,

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two types of energy waves emanate from the epicentre.

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The first wave, the primary or P-wave travels fastest.

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The secondary or S-wave is slower,

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but it's the real destructive force.

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Seismologist Richard Allen explains

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how the time lag between the two waves

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is the basis of an earthquake early warning system.

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If you're about 100 kilometres from the earthquake

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then the difference between the P-wave and the S-wave

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is sort of 10 to 20 seconds.

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Tens of seconds, that doesn't seem like a huge amount of time.

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It's not a lot of time, but you can do a lot.

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So, for example, you can take cover as an individual.

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Things like train systems can start to decelerate the trains.

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Airports stop planes from landing.

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Any kind of manufacturing facility

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can shut down its sensitive equipment

0:15:320:15:34

so that everybody can get back online more quickly

0:15:340:15:36

after an earthquake.

0:15:360:15:38

The problem is, even here in San Francisco,

0:15:400:15:42

where hundreds of thousands of people live directly on

0:15:420:15:45

the San Andreas Fault zone

0:15:450:15:47

the current sensor network isn't good enough

0:15:470:15:49

to send reliable warnings out to the public.

0:15:490:15:52

The challenge we have is that we have gaps in our sensor coverage,

0:15:520:15:55

so we really need to increase the number of sensors

0:15:550:15:58

so that we can improve the speed and quality of the early warning system.

0:15:580:16:02

Building thousands more seismometer stations at about 80,000 each

0:16:020:16:07

isn't really feasible.

0:16:070:16:10

But luckily for Californians a much cheaper solution

0:16:100:16:13

might just be around the corner.

0:16:130:16:15

Doctor Elizabeth Cochran is a LA-based geophysicist

0:16:170:16:21

who's passionate about teaching earthquake science

0:16:210:16:24

to her local community.

0:16:240:16:25

So we're going to try and demonstrate

0:16:250:16:27

our different kinds of waves.

0:16:270:16:30

She's figured out a way to use a cheap 40 seismometer

0:16:310:16:35

to transform a regular laptop into an earthquake monitoring station.

0:16:350:16:39

Here we have a sensor

0:16:390:16:41

and it's actually connected into the laptop just by USB port.

0:16:410:16:46

Any time I move the sensor

0:16:460:16:47

it sends the information into the laptop

0:16:470:16:50

and we can see the readout here on the screen.

0:16:500:16:52

We're actually using these sensors

0:16:520:16:55

to record moderate to large earthquakes here in California

0:16:550:16:59

and around the world.

0:16:590:17:00

But Elizabeth's real breakthrough

0:17:010:17:04

is to recruit a network of thousands of volunteers to host these sensors.

0:17:040:17:09

All they need to do is plug them into their laptops,

0:17:090:17:12

take them down and then they'll start sending vital earthquake data

0:17:120:17:16

to a central computer for analysis.

0:17:160:17:19

This is so tiny.

0:17:190:17:21

How does this compare to your professional equipment?

0:17:210:17:23

This is quite a bit less sensitive, but it has some benefits -

0:17:230:17:28

they're pretty low cost and we can have them say

0:17:280:17:31

in every block or in every house.

0:17:310:17:33

How does this become part of an early warning network then?

0:17:330:17:36

What these sensors do is

0:17:360:17:38

they fill in-between our large network sensors

0:17:380:17:43

and we can get more records faster

0:17:430:17:46

and get the location of the magnitude much more accurately.

0:17:460:17:50

Every additional piece of information we have

0:17:500:17:53

will allow us to have longer warning times.

0:17:530:17:56

Already, Elizabeth has recruited over 2,000 citizen scientists.

0:17:560:18:01

One day she hopes to have sensor networks on every block

0:18:010:18:05

in Los Angeles and across every fault zone in the world.

0:18:050:18:09

But I think the real significance of what she's achieved

0:18:090:18:12

goes beyond earthquakes.

0:18:120:18:14

This might be small,

0:18:140:18:16

but I think it opens up a new era in science

0:18:160:18:18

when research isn't confined to universities

0:18:180:18:21

and expensive laboratories but it's something we can all take part in.

0:18:210:18:24

It opens up scientific discovery to everybody.

0:18:240:18:27

APPLAUSE

0:18:310:18:33

Alok, this is very dramatic claim to make,

0:18:330:18:35

of new eras opening in science.

0:18:350:18:38

How powerful is this kind of thinking?

0:18:380:18:40

It's easy to think that

0:18:400:18:41

something so small is just a toy that we're all using,

0:18:410:18:45

and therefore it's not of any use to scientists,

0:18:450:18:48

but you heard there,

0:18:480:18:49

Doctor Cochran talking about the fact that these sensors,

0:18:490:18:53

because they're easily available and cheap, 40 each,

0:18:530:18:56

and you can put them in lots and lots of different places,

0:18:560:18:59

it allows them to collect much more information,

0:18:590:19:02

and actually, it's useful information.

0:19:020:19:04

The US Geological Survey have funded her to do this

0:19:040:19:07

and so therefore,

0:19:070:19:08

they're thinking this is a useful way of collecting information

0:19:080:19:11

across large areas without having to put in

0:19:110:19:14

those enormous 80,000 seismometers

0:19:140:19:16

that we saw at the beginning.

0:19:160:19:17

So it's real stuff.

0:19:170:19:19

We're joined now by Doctor Hilary Geoghegan from UCL.

0:19:190:19:22

Doctor Hilary,

0:19:220:19:23

this is the direction we seem to be going in a lot of projects now,

0:19:230:19:26

crowd-sourcing information,

0:19:260:19:28

getting data points from enthusiastic amateurs

0:19:280:19:31

who wish to join in the research.

0:19:310:19:32

Yeah, that's definitely true, people are passionate about science,

0:19:320:19:36

people want to contribute, people want to feel part of science

0:19:360:19:39

and there are a variety of science projects

0:19:390:19:42

that allow people to do that now.

0:19:420:19:44

What are the factors in terms of getting people involved in this?

0:19:440:19:46

I know you've studied people's enthusiasm

0:19:460:19:49

and how that can be marshalled.

0:19:490:19:50

You can see why people in this part of the world

0:19:500:19:53

want to be part of an early warning system for earthquakes,

0:19:530:19:56

so how do we get more people involved in projects which have

0:19:560:19:59

obviously less of a tug in matters and that?

0:19:590:20:02

Well, in the UK there's an initiative called OPAL,

0:20:020:20:05

called Open Air Laboratories that's based in Imperial College,

0:20:050:20:10

and they're working with government scientists on a new

0:20:100:20:13

tree health survey, which is to monitor pests and diseases in the UK

0:20:130:20:17

that some that are here yet, some that are not,

0:20:170:20:20

but they want to develop a group of citizens across the country

0:20:200:20:23

that will be able to take part and identify these pests.

0:20:230:20:26

So it's like eyes and ears on the ground, really,

0:20:260:20:28

that scientists just can't get that

0:20:280:20:29

sort of geographical coverage on their own.

0:20:290:20:31

We can't trust this with the traditional image of a scientist

0:20:310:20:34

going out and collecting specimens themselves.

0:20:340:20:36

And that just takes a long time, it's deliberative.

0:20:360:20:38

This is what Darwin did to make his great theories.

0:20:380:20:41

But imagine if Darwin had an army of people out there

0:20:410:20:43

that could help him collect all that information.

0:20:430:20:46

He'd have probably got to evolution by natural selection WAY quicker.

0:20:460:20:49

LAUGHTER

0:20:490:20:50

Are scientists actively looking for projects

0:20:500:20:52

that they can marshal the public support in?

0:20:520:20:55

Astronomers have been doing this for a while now,

0:20:550:20:57

so Galaxy Zoo is the famous one where you have to...

0:20:570:20:59

You gets lots and lots of images of what look like galaxies

0:20:590:21:02

and you have to decide whether they're elliptical ones,

0:21:020:21:06

spiral ones or so on, and our brains are much better at doing this

0:21:060:21:09

than computers are, hence we can do it.

0:21:090:21:11

And it's incredibly popular,

0:21:110:21:13

and that's diversified into all sorts of other projects.

0:21:130:21:15

All this stuff needs lots of effort from people and we can all help.

0:21:150:21:19

Something we didn't see in the VT, there is a quake readiness.

0:21:190:21:22

There's a general atmosphere of quake readiness in that part of the world.

0:21:220:21:25

You would have to be quake ready in that part of the world.

0:21:250:21:29

You took part in a training module, as it were, for...

0:21:290:21:32

Would you call it that?

0:21:320:21:34

They put you in a room and they made it slide around, essentially.

0:21:340:21:37

It's footage worth seeing. This is a quake simulator, isn't it?

0:21:370:21:41

Yeah, that's right.

0:21:410:21:42

Certain people in that part of the world are trained in what to do

0:21:420:21:45

if they feel and earthquake - get under tables and so on.

0:21:450:21:47

But you sometimes need to just feel it to really get the impact.

0:21:470:21:52

What force of quake is that?

0:21:520:21:55

This is simulating a magnitude eight earthquake. You can see...

0:21:550:21:59

There is it. LAUGHTER

0:21:590:22:01

It looks less impressive when you see it.

0:22:010:22:04

From the outside is doesn't look great, Alok.

0:22:040:22:06

This is simulating a magnitude eight earthquake.

0:22:060:22:09

The idea is that they take this round to schools, businesses and offices,

0:22:090:22:13

to show that buildings pretty much nowadays

0:22:130:22:15

are good at surviving earthquakes.

0:22:150:22:16

It's the stuff inside that gets thrown around,

0:22:160:22:19

so you need to have all that fixed.

0:22:190:22:21

The apples and everything were falling all over the place.

0:22:210:22:23

I just want to point something out,

0:22:230:22:25

that the guy who did that for us said that

0:22:250:22:28

no-one can stand in a magnitude eight earthquake.

0:22:280:22:31

I think that you'll find, if you go through all the rushes,

0:22:310:22:33

not once did I fall over in that thing, so there you go.

0:22:330:22:35

LAUGHTER

0:22:350:22:37

-You are quake ready. Stamp.

-I am.

0:22:370:22:39

Thank you, Alok and Doctor Hilary Geoghegan.

0:22:390:22:42

APPLAUSE

0:22:420:22:46

Still to come on tonight's show,

0:22:470:22:49

how hacking techniques are giving science power

0:22:490:22:52

back to the people.

0:22:520:22:54

Fighting mosquitoes bearing deadly diseases -

0:22:540:22:56

the British scientists with the ingenious idea.

0:22:560:22:58

And how crash-testing was once very DIY.

0:23:000:23:03

Now, Helen, there's another piece of technology which marshals crowds,

0:23:050:23:09

but often in a very literal sense.

0:23:090:23:11

I mean, look at that screen - if I step on this

0:23:110:23:13

on it pops. What exactly is going on here?

0:23:130:23:15

This works on a very simple principle -

0:23:150:23:17

the idea that whenever you squeeze something, you're putting energy into it

0:23:170:23:21

and if you're clever you can use that energy for something else afterwards.

0:23:210:23:24

People might be familiar with these, they're little torches

0:23:240:23:27

and you can squeeze them for a while

0:23:270:23:29

and doing that stores up enough energy so that when you press

0:23:290:23:32

the button you get light out of it.

0:23:320:23:34

And this works on a similar idea,

0:23:340:23:36

so whenever you step on the ground, you squeeze it a little bit.

0:23:360:23:39

It can save up four or five joules of energy just a little bit,

0:23:390:23:42

but just think about how many steps you take in a day.

0:23:420:23:45

Lots and lots and lots,

0:23:450:23:46

so the idea is that you can put these out in places where, you know,

0:23:460:23:50

bridges, pavements, stations, all that kind of thing,

0:23:500:23:53

and all that walking-around energy that people are just wasting,

0:23:530:23:57

effectively, can then be used for something,

0:23:570:23:59

and this can save energy that's useful for other stuff.

0:23:590:24:02

It won't drive a high-voltage thing like a washing machine

0:24:020:24:05

or a...you know, but it could work lights for example.

0:24:050:24:08

Yeah, lots of the technology we have now available, like LED lights

0:24:080:24:11

and displays and little computers, require really low voltages,

0:24:110:24:15

so that's perfect for this.

0:24:150:24:17

And the other thing is it generates energy exactly where it's needed.

0:24:170:24:20

So, say you can imagine having a street with street lamps

0:24:200:24:23

that only lit up when someone was actually needing the street lamp,

0:24:230:24:25

when they were walking underneath.

0:24:250:24:27

We ran a little experiment here where we got our studio audience,

0:24:270:24:30

120 people arriving in,

0:24:300:24:32

and we put a line of these together.

0:24:320:24:34

What sort of power was generated anyway?

0:24:340:24:36

So, for our 120 people,

0:24:360:24:38

they generated 18,000 joules of energy,

0:24:380:24:41

which is enough to charge up four mobile phones

0:24:410:24:44

or to run the LED lights that would light a room for 24 hours,

0:24:440:24:48

so a useful amount of energy

0:24:480:24:49

which people didn't even know they were giving away.

0:24:490:24:51

Thank you very much, Helen, and, indeed, thanks to you.

0:24:510:24:54

APPLAUSE

0:24:540:24:57

We like to think we're very much

0:25:040:25:06

proponents of the field of lo-fi science,

0:25:060:25:08

but it does look like there's a whole culture of DIY science

0:25:080:25:12

going on at the moment.

0:25:120:25:14

Here we have the Newcastle Maker Faire,

0:25:140:25:16

the place to show off your very own techy breakthroughs.

0:25:160:25:19

This is a robot that knits.

0:25:190:25:20

It isn't just people making things in sheds, however.

0:25:200:25:23

There's a growing movement who describe themselves as hackers,

0:25:230:25:26

not in the old computer science term,

0:25:260:25:28

but people who liberate technology,

0:25:280:25:30

apply imagination and possibly have world-changing results.

0:25:300:25:33

Mark's gone to see what's going on.

0:25:330:25:36

We've been using tools for thousands of years,

0:25:370:25:40

but recently those tools have become a lot more sophisticated

0:25:400:25:44

and our relationship with them has changed.

0:25:440:25:46

Back in the day, we understood how the gadgets in our lives worked -

0:25:480:25:51

we could take them apart, we could fix them.

0:25:510:25:53

But these days, modern gadgets, well, they're altogether much more complex.

0:25:530:25:57

We don't really understand how they work.

0:25:570:25:59

They could be powered by magic.

0:25:590:26:01

And that makes us afraid to take them apart

0:26:010:26:03

and to try and repair them,

0:26:030:26:04

but it doesn't have to be that way.

0:26:040:26:06

Mitch Altman is a virtual reality pioneer and inventor from California.

0:26:080:26:12

And, as a hacker, he's part of a new movement

0:26:120:26:15

that's all about unlocking the potential of technology for yourself.

0:26:150:26:19

Well, hacking is more than just about computers,

0:26:200:26:23

it's about pretty much anything.

0:26:230:26:25

Cos hacking is taking what exists, anything,

0:26:250:26:28

and improving upon it and sharing it.

0:26:280:26:31

And the lure of getting creative with technology

0:26:310:26:34

is bringing people together.

0:26:340:26:36

Hackerspaces are physical places

0:26:360:26:39

with supportive community for people to explore and do what they love.

0:26:390:26:43

They're everywhere.

0:26:430:26:44

There were about 50 five years ago and now there's almost 1,4000.

0:26:440:26:48

Wow. That's a huge explosion.

0:26:480:26:51

Hackerspaces may be multiplying fast

0:26:510:26:54

but what does all this playfulness really achieve?

0:26:540:26:58

It's easy to write this off as just a bit of fun,

0:26:590:27:01

but there's something much more important going on.

0:27:010:27:04

The urge to make things is fundamentally human,

0:27:040:27:07

and the hacker community are reclaiming the right to make stuff

0:27:070:27:10

from whatever you can lay your hands on.

0:27:100:27:12

It's a chance for everybody to unleash their inner geek.

0:27:140:27:17

And I'm going to have a crack myself

0:27:170:27:19

by transforming a piece of off-the-shelf technology

0:27:190:27:22

into something completely different.

0:27:220:27:25

It's not designed to be taken apart.

0:27:260:27:29

That's more like it.

0:27:290:27:30

That in the middle is what we're looking for.

0:27:300:27:34

That is the CCD chip.

0:27:340:27:35

Instead of looking outwards, we're going to look inwards.

0:27:380:27:42

OK, I've got a bit of an unfair advantage -

0:27:420:27:45

in our workshop I can speed up the hacking process with a laser cutter.

0:27:450:27:49

Yay!

0:27:530:27:54

Finally, after a couple of hours, I've managed to turn a £5 webcam

0:27:540:27:59

into a high-powered electronic microscope.

0:27:590:28:02

Oh, tell me that's not a worm.

0:28:050:28:08

Oh, my goodness.

0:28:080:28:10

So this is a microscopic worm in some pond water which we're seeing

0:28:100:28:14

via an electronic microscope that WE made

0:28:140:28:18

by just hacking a webcam.

0:28:180:28:20

And I think that's just incredible

0:28:200:28:22

because it's not just about having a microscope,

0:28:220:28:24

we can all have microscopes,

0:28:240:28:25

we've got loads of high-powered microscopes in this university,

0:28:250:28:28

but it's the act of turning one object into another,

0:28:280:28:31

that you learn so much, it's magical and it empowers you,

0:28:310:28:34

and that is the beauty of hacking.

0:28:340:28:36

But let's face it, this is still just mucking about.

0:28:380:28:41

The true power of hacking is that the same ideas can be applied

0:28:410:28:45

in a way they can actually make a difference to someone's life.

0:28:450:28:48

At Imperial College, Doctor Aldo Faisal

0:28:500:28:53

wants to bring cutting-edge medical technology to the masses.

0:28:530:28:57

Incredibly, this robot arm is being controlled by my eye movement alone.

0:28:580:29:03

Whoa.

0:29:050:29:07

That is a weird feeling. It's like being a cyborg slightly.

0:29:070:29:10

I mean, this is the closest I've ever felt to being a cyborg.

0:29:100:29:13

For someone unable to use their arms,

0:29:130:29:15

something like this could be life-changing.

0:29:150:29:17

But commercial eye-tracking systems are intrusive

0:29:180:29:21

and cost £20,000 to £25,000.

0:29:210:29:24

So Aldo starting hacking to make his

0:29:250:29:28

high-end system user-friendly and much cheaper.

0:29:280:29:31

The whole system, as you see mounted here, cost £9.95.

0:29:310:29:35

That's incredible! That's really impressive.

0:29:350:29:38

-And the software can run on a normal computer?

-Yeah.

0:29:380:29:40

These are two standard cameras that you can plug into your USB port

0:29:400:29:45

and basically any PC can operate this system that we've developed.

0:29:450:29:48

Aldo customised high-speed cameras from a popular games console

0:29:500:29:53

originally designed for tracking your tennis shots or dance moves.

0:29:530:29:57

He's transformed a recreational toy into something

0:29:580:30:01

that can transform lives.

0:30:010:30:03

And the value of hacking doesn't stop there.

0:30:030:30:06

And what about for research people? I mean, you're doing this with kind of cheap kit.

0:30:060:30:10

Is there an advantage for you to use ubiquitous technology?

0:30:100:30:13

I think it just spawns creativity, as once it's so cheap,

0:30:130:30:16

you just start to think of all sorts of applications

0:30:160:30:18

because you sort of don't have to take it so seriously any more.

0:30:180:30:21

And that's where real innovation, creativity is unlocked.

0:30:210:30:24

Not only is hacking empowering for the masses,

0:30:250:30:28

but it can produce sophisticated new technology with real-world value

0:30:280:30:33

at an astonishingly low cost.

0:30:330:30:35

APPLAUSE

0:30:350:30:39

-This is the microscope you made?

-Yeah.

0:30:390:30:42

It's an ordinary webcam that you took apart.

0:30:420:30:44

Basically reversing the lens system using the same detector as a webcam.

0:30:450:30:49

-It took us an hour.

-Really?

-Yes.

0:30:490:30:51

Just an ordinary webcam that you can turn into a microscope that you can plug into any computer.

0:30:510:30:56

-Yeah.

-That's ridiculous!

-It is. It is staggering, actually.

0:30:560:30:59

Yeah. This is particularly ridiculous. What is this called?

0:30:590:31:02

This is called the beet box. A college of mine made it.

0:31:020:31:06

And what it is is just some vegetables

0:31:060:31:08

that you can turn into sound.

0:31:080:31:10

VEGETABLES BEAT RHYTHM

0:31:100:31:13

LAUGHTER

0:31:130:31:15

Have a go.

0:31:150:31:16

VEGETABLES BEAT RHYTHM

0:31:160:31:18

-You've got rhythm.

-Thank you very much. Not much!

0:31:180:31:21

There's nothing strange or weird, no pressure-sensitive pads?

0:31:210:31:23

They're normal, ordinary vegetables.

0:31:230:31:26

There's two interesting things about this... Apart from the fact that it's just...

0:31:260:31:29

You can grab anywhere on...

0:31:290:31:32

It's very moreish as a thing to play with.

0:31:320:31:34

-The fennel's particularly good, I think.

-The fennel is good.

0:31:340:31:38

And it's driven by this, which I think is one of the kind of things

0:31:380:31:42

that's going to revolutionise hacking or model-making or hobby-making

0:31:420:31:46

and computer programming - this is the Raspberry Pi,

0:31:460:31:49

which came from Cambridge University, didn't it?

0:31:490:31:51

Yeah, it was a spin-out from Cambridge.

0:31:510:31:53

These guys realised is that you can make a fully functioning computer,

0:31:530:31:56

and that is a fully functioning computer

0:31:560:31:58

with a full operating system and output for about 30 or 40 quid.

0:31:580:32:02

All you have to do is plug in a keyboard and plug it into a monitor

0:32:020:32:05

-and you're up and away.

-That's fantastic.

0:32:050:32:07

And that's what's in here.

0:32:070:32:09

Although the interface is not a keyboard, it's vegetables.

0:32:090:32:12

What exactly is THIS measuring off the vegetables?

0:32:120:32:15

There's a Raspberry Pi in here connected to some speakers

0:32:150:32:18

and some wires which are cunningly hidden into a set of nails.

0:32:180:32:23

The nails go into the vegetables, and all the Raspberry Pi is doing

0:32:230:32:27

is monitoring the capacitance, so how much charge these have got on them.

0:32:270:32:31

And because they're full of water, they're quite sensitive conductors,

0:32:310:32:34

and you're full of water, so when you touch them the capacitance changes.

0:32:340:32:38

In the instant you touch the vegetable, it becomes

0:32:380:32:40

the collective capacitance of you

0:32:400:32:42

and the vegetable rather than just the vegetable itself.

0:32:420:32:44

-So that reading will dramatically change.

-Yeah.

0:32:440:32:46

And that's how your iPad

0:32:460:32:48

and your touch screen works on your other smartphones too.

0:32:480:32:51

This is imaginative and fun and it illustrates a point,

0:32:510:32:54

but more seriously, there are teaching resources,

0:32:540:32:57

digital teaching resources that you can hack.

0:32:570:33:00

In the developing world, this is a projector made of a lunch box

0:33:000:33:05

and a hacked mobile phone.

0:33:050:33:07

It is astonishing what you can do and how useful this could be

0:33:070:33:10

and a cheap way to develop things.

0:33:100:33:13

It's an important point about the Raspberry Pi is, this is not

0:33:130:33:15

-a for-profit organisation, this is charity selling these.

-Yeah.

0:33:150:33:19

It's fantastic. Thanks very much. Mark Miodownik.

0:33:190:33:21

APPLAUSE

0:33:210:33:25

Now here's Helen with this week's top stories

0:33:250:33:27

from the world of science.

0:33:270:33:29

First up is an invention that could change the way

0:33:320:33:34

we look after our health.

0:33:340:33:36

Scientists in Japan have managed to embed hundreds of electronic sensors

0:33:360:33:39

into a super thin film that's not only durable, it's stretchy.

0:33:390:33:45

A patch like this could replace all the bundles of tubes

0:33:450:33:49

and wires that we currently use to monitor everything from heart rate

0:33:490:33:52

to muscle activity.

0:33:520:33:54

The patch could be worn like a second skin anywhere on the body

0:33:540:33:57

or even inside it.

0:33:570:33:59

The spotlight is on bees at the moment

0:34:040:34:06

because their numbers are falling,

0:34:060:34:08

but scientists think they've finally worked out

0:34:080:34:10

how their beautiful geometric honeycomb is made.

0:34:100:34:13

You can see here that each cell starts as a circular tube

0:34:130:34:16

made of beeswax, and then special heater bees use their wing muscles,

0:34:160:34:20

vibrate them and heat the wax up.

0:34:200:34:23

As the wax softens, it's actually surface tension that pulls it out

0:34:230:34:27

towards the corners to make these beautiful hexagons that are

0:34:270:34:30

so regular they almost look man-made.

0:34:300:34:33

Something that's intrigued me this week

0:34:360:34:39

is this video made by a team from Switzerland.

0:34:390:34:41

These are droplets of liquid, and it looks as though

0:34:410:34:43

they're being suspended in zero gravity but they're not.

0:34:430:34:46

They're actually being levitated by sound waves

0:34:460:34:49

coming from this speaker here.

0:34:490:34:51

For the first time, this technique is being used to mix liquids together

0:34:510:34:54

without them touching anything that could contaminate them.

0:34:540:34:57

This could radically change how we handle everything,

0:34:570:35:00

from DNA samples to hazardous chemicals.

0:35:000:35:02

Still to come, Mark shows how to make the world a safer place.

0:35:050:35:11

-Whoa!

-Wow!

-Brilliant!

0:35:110:35:14

And the British scientist whose ingenious idea

0:35:140:35:17

could save us from a deadly disease.

0:35:170:35:19

All right, off you go, little mosquitoes.

0:35:190:35:22

Now it's time for our unsung heroes of science.

0:35:250:35:28

This week we dedicate it to two men who really did do it for themselves.

0:35:280:35:32

Larry Patrick and Colonel John Stapp.

0:35:320:35:36

Back in the 1950s before crash-test dummies had been invented,

0:35:360:35:39

scientists had to experiment on themselves.

0:35:390:35:41

That's Colonel John Stapp on the rocket sled.

0:35:410:35:44

The rocket sled was an invention

0:35:440:35:46

specifically to design harnesses for pilots.

0:35:460:35:48

And he was the man who sat in it as it accelerated from standstill

0:35:480:35:51

to 632 miles per hour in five seconds.

0:35:510:35:56

He still holds the record for the fastest man on rails.

0:35:560:35:59

Not only did it accelerate, it decelerated from 632 in 1.4 seconds.

0:35:590:36:05

That's him slowing down there.

0:36:050:36:06

Which meant that he went under 43 Gs as it slowed down.

0:36:060:36:12

The equivalent of being driven into a wall at 120 miles per hour.

0:36:120:36:17

The good colonel suffered broken ribs, broken arms and legs,

0:36:170:36:20

he even suffered temporary blindness,

0:36:200:36:22

but in doing so, moved on the technology of harnesses for pilots,

0:36:220:36:27

and then in the more civil realm, we have Larry Patrick.

0:36:270:36:32

Larry was going a similar kind of job for car companies,

0:36:320:36:35

also working on a sled.

0:36:350:36:37

This is Crazy Larry Rides Again.

0:36:370:36:40

Not only did he go on the sled, he allowed himself to be hit by

0:36:400:36:43

ten kilogram weights in the chest,

0:36:430:36:45

to be hit by metal bars in the knees.

0:36:450:36:48

Here he is being thwacked again.

0:36:480:36:50

We'll see him on the sled in a second.

0:36:500:36:52

And between the two of them, they pioneered airbags,

0:36:520:36:55

safety harnesses and, probably most important to their health

0:36:550:36:58

and wellbeing, the use of crash-test dummies.

0:36:580:37:00

LAUGHTER

0:37:000:37:01

It's worth noting that despite all of the pain

0:37:010:37:04

they put themselves through, Patrick died at 85, Stapp at 89.

0:37:040:37:08

They lived long and happy, healthy lives.

0:37:080:37:10

And now we have our unsung heroes over here, and I think their place

0:37:100:37:12

is richly deserved on the board here along with our other unsung heroes.

0:37:120:37:16

APPLAUSE

0:37:160:37:18

Mark, one of the innovations of car safety took a long time to

0:37:180:37:21

get to the market, didn't it?

0:37:210:37:23

Yeah, the airbag, which we're going to demo in a minute.

0:37:230:37:25

In the 1950s, they sort of had the idea, and as they sort of tried

0:37:250:37:30

to make it a reality, the first thing was how to get it to go off.

0:37:300:37:33

So, first it was manual, they had this canister of gas, and a bag,

0:37:330:37:37

and they thought if you're in a crash you just have to pull this lever.

0:37:370:37:40

But of course you haven't got the reactions, no-one has,

0:37:400:37:43

to actually do that. So that didn't really work.

0:37:430:37:45

And then they had to develop things called accelerometers

0:37:450:37:48

which could judge when you were in a crash and then deploy the safety.

0:37:480:37:52

But then there was another problem which is the canister of gas doesn't deploy

0:37:520:37:55

fast enough to stop you hitting the windscreen

0:37:550:37:57

or the steering wheel, and so it wasn't for a while

0:37:570:38:00

until they got the current solution, which is a chemical reaction

0:38:000:38:03

between sodium azide and potassium nitrate, and that does it

0:38:030:38:07

so fast that it can actually slow you down and protect you.

0:38:070:38:11

Does it run an electric current through, how does it initiate this?

0:38:110:38:14

Yeah, so it's a little electric current,

0:38:140:38:16

it initiates the reaction and a huge amount of gas is produced very,

0:38:160:38:19

very fast indeed - in 20 milliseconds so to put that into perspective,

0:38:190:38:22

blinking is about 120 milliseconds so it's within a blink of an eye,

0:38:220:38:26

it's out, it's ready to protect you. Did you want to have a look at this?

0:38:260:38:29

-Yeah.

-It is a fantastic piece of technology

0:38:290:38:31

and it's saved thousands of lives. We need this.

0:38:310:38:34

Because, ironically, we need safety gear!

0:38:340:38:37

LAUGHTER

0:38:370:38:40

This will bang, by the way, so you may want to cover your ears.

0:38:400:38:44

Do you want to do a running commentary of the accident?

0:38:440:38:46

Oh, what a lovely day out we're having, Mark, you and me driving...

0:38:460:38:49

Oh, my God! What's that horse doing on the road?

0:38:490:38:51

BANG

0:38:510:38:53

-Wow.

-That really is not as safe as I expected it to be.

0:38:530:38:57

LAUGHTER

0:38:570:38:59

Instead of actually just the bag coming,

0:38:590:39:01

the entire steering column...

0:39:010:39:04

will take off.

0:39:040:39:06

And actually, this is another thing, is that it turns out that

0:39:080:39:11

actually all of this fumes is actually a problem for...

0:39:110:39:15

-rescue.

-What is this? Nitrogen... What is it?

0:39:150:39:18

COUGHING

0:39:180:39:21

-You don't die in the crash, but you choke to death.

-Yes.

0:39:220:39:26

This is disgusting.

0:39:260:39:28

It's very impressive. Well done, Mark.

0:39:280:39:30

I really see why that has taken off as a safety measure.

0:39:300:39:34

We just hadn't tied that down right.

0:39:360:39:38

Reassure people at home as we weep through the cloud of smoke...

0:39:380:39:42

Is that gas? What's burning my throat?

0:39:440:39:46

That is talcum powder which is used to lubricate

0:39:460:39:49

-the deployment of the bag, amazingly.

-Wow.

0:39:490:39:52

We can see in slow motion, actually. This is lives being saved.

0:39:520:39:56

And that's the steering column...

0:39:590:40:01

Oh, my, that's quite elegant, isn't it?

0:40:010:40:03

-It looks quite Apollo, doesn't it?

-Yes.

0:40:030:40:06

Let's presume the technology works.

0:40:060:40:09

You can see why they waited 40 years.

0:40:090:40:11

We can use it for that,

0:40:110:40:12

-but of course now we can use it for other things as well.

-Exactly.

0:40:120:40:15

And the sensors, those accelerometers,

0:40:150:40:17

they're microscopic now, they're tiny little things.

0:40:170:40:19

You can put them on you so you can start making clothing that becomes

0:40:190:40:22

an airbag, or a helmet that's not a helmet but becomes one in a crash.

0:40:220:40:25

Is this what this is?

0:40:250:40:27

This is another good example of DIY science to a certain extent

0:40:270:40:30

because this is not some massive company who made this.

0:40:300:40:32

No, some design students in Sweden.

0:40:320:40:34

This, have a look at this, this is the...

0:40:340:40:37

I'm going to take a guess, the Hovding,

0:40:370:40:39

and it will go round your neck as you cycle.

0:40:390:40:42

Now, that does not look like a helmet.

0:40:420:40:43

Let's have a look. We've got someone who's going to try.

0:40:430:40:46

Let's check that we've got everything.

0:40:460:40:47

-Oh, wheel.

-Let me take that.

0:40:470:40:49

That would be very ironic if the safety feature

0:40:490:40:51

in that steering wheel managed to knock over our cyclist.

0:40:510:40:54

Let's bring on our cyclist.

0:40:540:40:55

-Whoa.

-Wow.

0:40:590:41:00

Brilliant.

0:41:000:41:02

That's fantastic, look at that.

0:41:020:41:04

APPLAUSE

0:41:040:41:06

-Do you feel...? Just thumbs up. Do you feel fine?

-Yeah, great.

0:41:120:41:15

That's great.

0:41:150:41:17

-And before you hit the ground, you could feel that?

-Yeah, definitely.

0:41:170:41:21

As soon as I was coming off, bang.

0:41:210:41:24

Yeah, a few milliseconds.

0:41:240:41:27

It's got several sensors, it recognises something's wrong,

0:41:270:41:29

deploys the helium, bang, and you get a fashion statement at the same time.

0:41:290:41:33

Hm, maybe.

0:41:330:41:34

But, no. I heard of this, that it might be...

0:41:340:41:38

Often I find myself slamming on the brakes

0:41:380:41:41

cos I haven't quite got to the lights,

0:41:410:41:43

I would like not to suddenly be beside a car with a massive

0:41:430:41:45

white Darth Vader,

0:41:450:41:48

good side of the Force, helmet on me.

0:41:480:41:52

This where the very fast computing power of small microchips

0:41:520:41:56

with these sensors starts to make...

0:41:560:41:59

It knows when it's crashed

0:41:590:42:01

and when you're just trying to run the lights, these things can be made

0:42:010:42:04

to understand when it's a crash and when it's not a crash.

0:42:040:42:07

-Thank you very much.

-Thank you very much.

-A pleasure, thank you.

0:42:070:42:10

APPLAUSE

0:42:100:42:11

Here is our most clever example of DIY science -

0:42:150:42:19

using a dangerous animal's own genes to destroy its threat.

0:42:190:42:23

Helen Czerski went to Brazil to find out how.

0:42:230:42:26

600 miles north of Rio de Janeiro in Brazil,

0:42:310:42:34

scientists are breeding the most dangerous animal in the world.

0:42:340:42:38

An animal that has killed more humans than any other in history.

0:42:400:42:44

Every week 100,000 mosquitoes are born here.

0:42:500:42:54

But these are no ordinary mossies.

0:42:560:42:58

They've been engineered by a team of British and Brazilian scientists

0:42:580:43:02

for a mission that could save millions of lives.

0:43:020:43:07

These mosquitoes are part of a battle against a disease which is becoming

0:43:070:43:10

even harder to control over malaria and that's dengue fever.

0:43:100:43:15

It's a disease for which there's no cure and no vaccine.

0:43:150:43:18

It's an agonising virus which can reduce your blood pressure

0:43:180:43:22

so much your organs start to fail, and it can be fatal.

0:43:220:43:25

Dengue already affects over 100 million people every year.

0:43:290:43:34

It's become an epidemic here in Brazil.

0:43:340:43:37

But what makes dengue so dangerous is the way it's spreading.

0:43:370:43:41

No longer confined to the Tropics, it's the fastest growing

0:43:420:43:45

mosquito-borne disease in the world.

0:43:450:43:49

And last year, it reached as far as southern Italy.

0:43:490:43:51

The only way to stop this disease spreading is by wiping out

0:43:550:43:59

the mosquito population that transmits it,

0:43:590:44:01

and that's really difficult because of how quickly they reproduce.

0:44:010:44:05

Female mosquitoes only mate once in their ten-day life,

0:44:070:44:11

but when they do, they can produce up to 500 offspring.

0:44:110:44:15

To fight back, you need to intervene at this crucial moment.

0:44:180:44:21

And that's exactly what the ones being bred here can do.

0:44:210:44:26

They're the descendents of a very special kind of mosquito

0:44:270:44:31

created 5000 miles away.

0:44:310:44:34

In this Oxfordshire lab ten years ago,

0:44:370:44:39

Doctor Luke Alphey made a remarkable discovery -

0:44:390:44:43

how to genetically modify the dengue-carrying mosquito

0:44:430:44:47

so its offspring would self-destruct.

0:44:470:44:50

I thought up a way to use genetics to control pest insects.

0:44:500:44:54

If we could modify the male mosquito

0:44:540:44:56

so he passes a gene through the sperm to the fertilised egg

0:44:560:45:00

that stops the fertilised egg developing into an adult mosquito

0:45:000:45:04

then that will be fewer adult mosquitoes in the next generation.

0:45:040:45:08

To insert the lethal gene that will stop the offspring developing,

0:45:080:45:12

mosquito eggs are micro-injected with modified DNA.

0:45:120:45:16

You can imagine mosquitoes aren't very big

0:45:170:45:19

and their eggs are correspondingly rather smaller

0:45:190:45:22

and so that's quite a difficult operation.

0:45:220:45:24

The transformed mosquitoes are also given a fluorescent marker

0:45:260:45:30

so they can be tracked.

0:45:300:45:32

We actually arranged for them to die at this larva stage.

0:45:350:45:38

So these are baby mosquitoes.

0:45:380:45:39

These ones all have the lethal gene

0:45:390:45:41

so none of these are going to make it through to adult.

0:45:410:45:43

Luke's discovery had huge potential.

0:45:450:45:48

But there was a problem.

0:45:480:45:49

If the transformed mosquitoes

0:45:530:45:55

were to have any impact on the wild population,

0:45:550:45:57

millions of them needed to be bred.

0:45:570:46:00

But that was impossible if the offspring were programmed to die.

0:46:000:46:04

The team needed a way to override the very genetic modification

0:46:060:46:09

that they had created.

0:46:090:46:11

This is the solution to the problem - this innocuous looking liquid.

0:46:130:46:17

It's an antidote.

0:46:180:46:19

It's basically a switch for the lethal gene.

0:46:190:46:22

If you give this to a mosquito that's programmed to die,

0:46:220:46:25

it will live.

0:46:250:46:27

But if you take it away, the mosquito will die.

0:46:270:46:30

Fed to the mosquitoes from birth,

0:46:310:46:33

the antidote gives the team precise control over the lethal gene.

0:46:330:46:37

They can turn it on and off.

0:46:370:46:39

It means that millions of the transformed mosquitoes

0:46:410:46:44

can be kept alive into adulthood and bred where they're most needed,

0:46:440:46:48

like here in Brazil.

0:46:480:46:49

Field manager Doctor Andrew McKemey oversees this process.

0:46:510:46:55

Every week he and his team can produce 100,000 mosquitoes

0:46:570:47:01

primed for the mission they've been born for.

0:47:010:47:04

After the precision engineering of the lab,

0:47:140:47:17

this final stage is surprisingly low-tech.

0:47:170:47:20

All right, off you go, little mosquitoes.

0:47:200:47:23

Simple as that.

0:47:250:47:26

There are some lazy ones left in there that won't go.

0:47:260:47:29

This is where over a decade of research pays off.

0:47:300:47:33

These mosquitoes carry the lethal gene

0:47:350:47:37

and that means they'll go out here, they'll mate with females

0:47:370:47:40

and those offspring won't be able to survive without the antidote.

0:47:400:47:45

And out here, that antidote just isn't there. The offspring will die.

0:47:450:47:50

Every time I come to the field and do the release,

0:47:570:47:59

it amazes me that these males will actually go out

0:47:590:48:02

and find all the females in all those tiny crevices,

0:48:020:48:05

in the roofs, under beds, in people's cupboards,

0:48:050:48:08

in wardrobes, and they are the best thing to actually find females

0:48:080:48:12

and mate with them

0:48:120:48:13

and that leads to the decline of the population.

0:48:130:48:16

The team has been testing this process here for two years

0:48:160:48:20

and the results are dramatic. In some areas,

0:48:200:48:23

they've managed to wipe out 85% of the mosquito population

0:48:230:48:28

and that will radically reduce the spread of dengue fever.

0:48:280:48:31

APPLAUSE

0:48:350:48:37

Thank you very much, Helen.

0:48:370:48:38

We're also joined by Doctor James Logan,

0:48:380:48:41

senior lecturer in medical entomology

0:48:410:48:43

at the London School of Hygiene and Tropical Medicine.

0:48:430:48:45

Helen, does this work?

0:48:450:48:47

Yes, and in fact they did an earlier study in the Cayman Islands

0:48:470:48:50

and they basically eliminated the mosquito population of that species

0:48:500:48:53

in that area, they were gone.

0:48:530:48:55

How do you feel about this?

0:48:550:48:56

I mean, this level of tampering, are you impressed by it,

0:48:560:48:58

or is there some element of...?

0:48:580:49:00

To be quite honest, I'm really excited by it

0:49:000:49:02

because I think it has a really good future.

0:49:020:49:05

Other scientists and Oxitech are in fact working on

0:49:050:49:08

malaria mosquitoes as well and that's a very exciting area.

0:49:080:49:11

You do all the work in the labs,

0:49:110:49:15

you get to the point where you've created the mosquito,

0:49:150:49:17

but once you've got it, it's then very, very easy

0:49:170:49:20

to take it around the world and let it breed.

0:49:200:49:22

These aren't the ones obviously that have been genetically modified,

0:49:220:49:25

-but they're the same family of mosquito, aren't they?

-They are.

0:49:250:49:28

So these are aedes aegypti,

0:49:280:49:29

dengue fever mosquitoes and yellow fever mosquitoes.

0:49:290:49:32

They don't have dengue fever right now

0:49:320:49:34

and they're not genetically modified,

0:49:340:49:36

but I brought them along from my lab.

0:49:360:49:38

This is one of those boxes in which I could if I wish to put my hand in.

0:49:380:49:41

-But I will be bitten.

-You will be bitten. You're very welcome to...

0:49:410:49:44

-No, I'm OK.

-Are you sure? They're very hungry.

0:49:440:49:46

I have no desire to be bitten.

0:49:460:49:48

If you don't want to do it, I'll do it.

0:49:480:49:50

-Go on then.

-I'm braver than you.

0:49:500:49:51

Yeah, all right, don't put it like that.

0:49:510:49:54

I'll do it. They look relaxed.

0:49:540:49:56

I presume I'm not going to leave it in here for long,

0:49:560:49:59

so let's make sure we've got a camera rolling on this.

0:49:590:50:01

-Don't try this at home.

-Yeah.

-It's not advisable.

0:50:010:50:04

These are male, aren't they?

0:50:040:50:05

Rather than female, they don't carry malaria, am I right?

0:50:050:50:08

If they were male, they wouldn't bite you,

0:50:080:50:09

cos it's only the females that bite, so these are definitely females

0:50:090:50:12

and they're definitely hungry.

0:50:120:50:14

-On you go.

-They are already excited.

0:50:140:50:16

I'll just hold this to make sure none escape.

0:50:160:50:19

Oh, immediately.

0:50:190:50:21

What they are doing is basically sensing your smell,

0:50:210:50:24

your body odour from your hands and they're straight in there.

0:50:240:50:28

-Look at that.

-That one on your knuckle's going to hurt.

0:50:280:50:31

-Oh, thanks, great.

-LAUGHTER

0:50:310:50:33

Let's get it out.

0:50:330:50:34

-They don't hang around, do they?

-No. They're straight in there.

0:50:340:50:37

There is a glorious tradition, of what I've just dipped into there,

0:50:370:50:40

of scientists, not that I am one, injecting themselves or being...

0:50:400:50:42

Of using themselves.

0:50:420:50:44

You have as well, haven't you?

0:50:440:50:46

Well, self-experimentation is my thing,

0:50:460:50:49

I do that sort of thing on a daily basis pretty much.

0:50:490:50:51

But the other thing that I have done is I gave myself hookworm,

0:50:510:50:55

intestinal worms, and there was a reason for this.

0:50:550:50:58

I don't have them now, it's fine.

0:51:000:51:03

So basically, what intestinal worms can do is

0:51:030:51:05

they can modulate your immune system,

0:51:050:51:08

so I have a food allergy and I can't eat bread without being quite ill.

0:51:080:51:12

So when I gave myself hookworm, I gave myself 50 worms,

0:51:120:51:15

and they did modulate my immune system and I was able to eat pizza

0:51:150:51:18

for the first time in years without being ill, which was incredible.

0:51:180:51:21

-Wow, I mean, it's a glorious bit of scientific tradition.

-It is indeed.

0:51:210:51:25

It seems doctors and medics in particular are into this.

0:51:250:51:29

In the 19th century, people developing anaesthetics

0:51:290:51:33

seemed to test them on each other.

0:51:330:51:35

The Nobel Prize winner in 2004, 2005...

0:51:350:51:38

Barry Marshall. He had this idea that ulcers were caused by bacteria.

0:51:380:51:42

No-one believed him in the '90s at all. He was pilloried.

0:51:420:51:46

And so he decided the only way to prove it was to test it on himself.

0:51:460:51:49

He drank a broth of the particular bacteria and he got ulcers.

0:51:490:51:54

-Newton put a needle in his eye, didn't he?

-Bodkin.

0:51:540:51:57

-Why did he put a bodkin in his eye?

-Just to see what happened.

0:51:570:52:02

Nothing did.

0:52:020:52:04

And he kept his sight,

0:52:040:52:05

fortunately for the rest of us and for the rest of physics.

0:52:050:52:08

That's remarkable. By the way, this is beginning to itch.

0:52:080:52:11

-Yes, it might do.

-Yeah, thanks.

0:52:110:52:14

This is an experiment that we should probably mention.

0:52:140:52:17

I'll be intrigued to see how many of you follow me on this.

0:52:170:52:19

This is a filtering system which says that the mesh is so fine

0:52:190:52:23

it will filter out all bacteria and viruses.

0:52:230:52:29

To test this, this is Thames river water

0:52:290:52:33

that we've got. It looks very, very appealing.

0:52:330:52:35

What would you get out of this?

0:52:350:52:37

Anyone know what's going to be in this?

0:52:370:52:38

Weil's disease probably, I don't know. I'm just guessing here.

0:52:380:52:42

Weil's disease would be in it. Let's have a look.

0:52:420:52:44

-E coli.

-E coli, definitely, cos sewerage goes into the river.

0:52:440:52:47

Salmonella,

0:52:470:52:49

campylobacter, enterococcus, enterovirus.

0:52:490:52:52

Not a cocktail you want.

0:52:520:52:54

No, it isn't. Let's see how well we do.

0:52:540:52:56

This is the footage we have to show that we definitely took this

0:52:560:52:59

from the Thames earlier on.

0:52:590:53:00

We have footage of somebody scooping this out. Oh, my lord, look at that.

0:53:000:53:04

Are some of the big bacteria at the bottom, are they?

0:53:050:53:09

Is that the way it works.

0:53:090:53:10

Apparently eight pushes are enough.

0:53:100:53:13

Nine, ten, just making sure.

0:53:180:53:22

So this is apparently is enough

0:53:220:53:23

and I'm hoping someone will shout in my ear if it isn't.

0:53:230:53:26

There we go.

0:53:260:53:29

OK.

0:53:290:53:31

-It looks great.

-It does look good, doesn't it?

0:53:320:53:35

So which scientist wants to try it themselves?

0:53:350:53:37

LAUGHTER

0:53:370:53:38

-I'll try it.

-You'll try it?

-Yeah, go on.

0:53:380:53:42

It looks much better than that.

0:53:420:53:44

That's an incredible filter, look at that.

0:53:440:53:47

I think we should look at it under the microscope first.

0:53:470:53:50

I honestly don't trust your microscope.

0:53:500:53:53

Oh.

0:53:540:53:56

Dara's right in there.

0:53:560:53:58

You took most of that.

0:53:580:54:00

SPEAKING OVER EACH OTHER

0:54:020:54:06

It tastes really fresh.

0:54:060:54:08

Yeah, it does, yeah. That's really, really good.

0:54:080:54:11

The filter is thin enough to filter everything out.

0:54:110:54:15

It's remarkably good.

0:54:150:54:16

By the way, speaking of technology, we mentioned twice,

0:54:160:54:19

it came up repeatedly, about the technology we use.

0:54:190:54:21

You have yours there.

0:54:210:54:23

This is the sensor from the seismology experiment

0:54:230:54:25

-we talked about earlier.

-Why is it so good?

0:54:250:54:28

There's something interesting we mentioned before,

0:54:280:54:30

this tiny little sensor which you can plug into your computer,

0:54:300:54:33

senses movement essentially. 40 it costs.

0:54:330:54:36

If you think about the big ones, they cost 40,000, 50,000.

0:54:360:54:40

And the reason this is so cheap is because of the games industry.

0:54:400:54:44

The sensor in there is the same as

0:54:440:54:46

the sensor you get in games controllers.

0:54:460:54:48

And because they sell millions and millions and millions,

0:54:480:54:52

the technology became very cheap

0:54:520:54:54

and scientist thought to themselves, "We'll have a bit of that,"

0:54:540:54:57

and took it off and they can use it for actual science,

0:54:570:54:59

and that's just one example of technology.

0:54:590:55:01

The same thing occurred in the film you were talking about

0:55:010:55:03

where tracking with his eye movements to control a robot,

0:55:030:55:06

-again it's a sensor from a video game controller.

-Games consoles.

0:55:060:55:09

And in fact, you know, the chips that drive the graphics are

0:55:090:55:12

being increasingly used for all sorts of applications,

0:55:120:55:14

cos they are so incredibly powerful and they are so cheap

0:55:140:55:17

because they sell by the millions.

0:55:170:55:18

And they have these interfaces that you can program,

0:55:180:55:21

so we're about to enter... You're really itching, aren't you?

0:55:210:55:25

-That's the worst thing you can do, is itch your bites.

-Really?

-Yeah.

0:55:250:55:29

Yeah, thanks. Your advice was to put my hand in there in the first place.

0:55:290:55:34

The games industry that supplied us with the information

0:55:340:55:37

also supplies the format which works for crowdsourcing.

0:55:370:55:41

Because if you make them in the form of a game,

0:55:410:55:43

people are more likely to join in.

0:55:430:55:45

And the fact they can do it without even knowing that

0:55:450:55:48

that's what they're doing.

0:55:480:55:49

And there's several games out there which are just fun as games.

0:55:490:55:52

The nice thing is you don't have to get involved

0:55:520:55:54

in the science if you don't want to, but once you've learned

0:55:540:55:57

what you've done, you might get more involved afterwards.

0:55:570:55:59

They're finding that a lot of people are playing these games

0:55:590:56:02

and after a while they sort of get curious about what it is

0:56:020:56:04

they're doing and they've already achieved something in science.

0:56:040:56:07

My favourite piece of crowdsourcing is that in astronomy,

0:56:070:56:10

one of the interesting results in astronomy occurred

0:56:100:56:13

because people are really suspicious of the Russian police force.

0:56:130:56:16

So people in Russia who drive have dashboard cameras and then when

0:56:160:56:20

the meteorite struck in Russia we had hundreds of different views...

0:56:200:56:24

Which looked like Hollywood movies.

0:56:240:56:26

Yeah, they all looked like special effects. We have some of them here.

0:56:260:56:30

And the reason is all cars in Russia...

0:56:300:56:32

-DARA SNEEZES.

-Excuse me.

0:56:320:56:34

I've got gastroenteritis and malaria at the moment.

0:56:340:56:37

People drive with dashboard cameras on

0:56:370:56:39

because they want to use them in possible court cases.

0:56:390:56:42

Look at that.

0:56:420:56:45

That's astonishing.

0:56:450:56:46

And they all come with GPS and they all come with a time on them.

0:56:460:56:50

And so it was a fantastic resource for seeing

0:56:500:56:52

the trail of a meteor as it struck.

0:56:520:56:54

Just thank you all very, very much for everything tonight.

0:56:540:56:57

I want to thank all our team here, Mark, Alok and Helen.

0:56:570:57:01

And our special guest Doctor James Logan

0:57:010:57:03

and earlier on we had Doctor Hilary Geoghegan as well.

0:57:030:57:05

Thank you all very, very much for coming along.

0:57:050:57:07

Please get involved with the citizen science projects.

0:57:070:57:10

More information as always can be found on our website.

0:57:100:57:13

We'll see you next week for more on Science Club.

0:57:130:57:15

Don't forget, doesn't matter if you've been bitten

0:57:150:57:17

by a malaria-carrying mosquito or you've drank Thames water,

0:57:170:57:20

weirdly enough, the thing that really hurts is the talcum powder.

0:57:200:57:23

We'll see you next week on Science Club. Thank you very much.

0:57:230:57:26

APPLAUSE

0:57:260:57:28

Next time we'll be spinning forward to the future

0:57:300:57:33

to meet the latest in humanoid robots

0:57:330:57:36

taking part in one of the most ambitious science projects

0:57:360:57:39

ever undertaken.

0:57:390:57:41

And naturally we'll be checking out the future of fashion.

0:57:410:57:44

-You impaled them on the giant spikes of the dress?

-Yeah.

0:57:440:57:48

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0:58:100:58:13

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